Rahman Jamal MD (UKM), MRCP (Ire), PhD (Lond), GDHM (Spore) PJN, DPNS, ANS Universiti Kebangsaan Malaysia rahmanj@ppukm.ukm.edu.my rahman1960@gmail.com
RESEARCH CLUSTERS CANCER AND STEM CELL MECHANISM OF DISEASES REGENERATIVE MEDICINE ANTIOXIDANTS & METABOLISM HEALTH AND MEDICAL TECHNOLOGY NICHE BIOACTIVE NATURAL PRODUCTS BIOMEDICAL ENGINEERING HEALTH AND BURDEN OF DISEASES
Strong representation across many faculties Researchers from Faculty of Medicine Faculty of Health Sciences Faculty of Dentistry Faculty of Pharmacy Faculty of Engineering Faculty of Science and Technology UKM Medical Molecular Biology Institute
Key strengths (I): Mainly basic and translational Anti-oxidants Bone Neuro Cancer Tissue engineering Health Economics Epidemiology: NCDs Ageing Toxicology & environmental health Nutrition & dietetics Energy and physical activity Drug discovery & natural products Drug delivery Dental research Rehabilitation Audiology & speech
Key strengths (II): Mainly clinical plus some basic research Endocrinology (diabetes, hypertension) Cardiology (angio, ECHO, myocardial infarction) Neurology (epilepsy, stroke, Parkinson s) Orthopaedics (rehabilitation, tissue engineering) ENT (hearing & Cochlear Implant) Psychiatry (sexual dysfunction, depression) Surgery (breast, thyroid, urology, colorectal) O&G (fetomaternal & diabetes) Opthalmology (retinal diseases)
Cardiovascular diseases: Predictors for CVS risk Augmentation index, Vasera analysis, etc. Identification of ECG predictors or arrhythmias Validation of a 70-gene cardiac panel Protective variants for HDL and LDL Prof. Oteh Maskon, Dr. Azian Murad, Prof. Rahman Jamal, Dr. Syakima Ab Mutalib, et al.
Obesity: Risk factors, assessment & physical activity FFQ and nutritional status Eating practices, sleep habits, physical activity Large-scale validation of variants BMI and mortality, cancers, etc. Prof. Suzana Sahar, Prof. Poh Bee Koon, Dr. Azian Murad, Prof. Rahman Jamal, et al.
Diabetes Predictive markers for complications (nephropathy, etc.) Intervention for pre-diabetes in the rural settings Natural Products CVS risk and metabolic syndrome Prof. Norazmi Kamaruddin, Prof. Halim Ghafur, Prof. Wu Loo Ling, Prof. Norlaila Mustafa, Prof. Ibrahim Jantan, Prof. Shamsul Azhar, et al
1000-Malaysian Genomes: Cancer and Rare Diseases Integrated analysis: Genomics, transcriptomics, proteomics Biomarker discovery using the Cohort samples Next-generation sequencing of cancers NGS and exome sequencing of rare diseases Prof. Rahman Jamal, Prof. Syed Zulkifli, Prof. Zarina Abd Latiff, Prof. Lokman Mohd Noh, Prof. Isa Rose, Dr. Syakima Ab Mutalib, et al
The Malaysian Cohort: An innovative population laboratory GIS coordinates for 106,527 participants 44 % Malays ( ), 33% Chinese ( ), 15% Indians ( ), 8% others ( ) Demographic data Environmental exposure Biophysical data Biospecimens Follow-up data (after 5 years) Menggunakan Aplikasi Geographical Information System (GIS), Arch GIS 9.0 Jamal et al, Int J Epid 2014
Mortality due to cancers Types of cancer Frequency Percent 1 Lung cancer 84 18.2 2 Breast cancer 69 14.9 3 Hepatoma/ Liver cancer 47 10.2 4 Colorectal cancer 34 7.4 5 Stomach/ Gastrointestinal Stromal Tumor (GIST) 29 6.3 6 Pancreatic cancer 22 4.8 7 Nasopharyngeal cancer 22 4.8 8 Unknown cancer 22 4.8 9 Brain cancer 19 4.1 10 Lymphoma/ Non-Hodgkin Lymphoma (NHL) 17 3.7 11 Leukemia 17 3.7 12 Ovarian cancer 16 3.5 13 Cervical cancer 13 2.8 14 Thyroid cancer 9 1.9 15 Renal cell carcinoma 8 1.7 16 Uterine/ endometrium cancer 5 1.1 17 Osteosarcoma/Bone cancer 4 0.9 18 Oral cancer 4 0.9 19 Prostate cancer 3 0.6 20 Bladder cancer 3 0.6 21 Others 15 2.2 TOTAL 462 100% Januari 2015
Biobank: Largest in SEA Main Biobank 2 satellite Biobanks (as back-up)
Primary Immunodeficiency Disorders (PID) 1:1200 Objectives Unraveling association of genetic and functional immune studies of PID from Malaysian patients Methods Immunological tests Whole exome sequencing Whole genome sequencing Principal investigator Prof. Lokman Mohd Noh Co-researchers Prof. Zarina Abd Latiff Prof. Rahman Jamal UK Collaborators Prof. Helen Chapel (Oxford)
Co-morbidity of NCDs and Infectious Diseases Helicobacter pylori and gastric cancer (Dr. Alfizah Hanafiah) The Malaysian Microbiome in health and disease (Dr. Neoh Hui Min) Diabetes and meloidosis (Prof. Dr. Sheila Nathan)
Wellness and ageing Anti-oxidants & degenerative diseases (Prof. Suzana Makpol) Regenerative medicine (Prof. Ruszymah Idrus) Bone health & metabolism (Prof. Ima Nirwana Sulaiman) Dental Health (Assc. Prof. Tuti Ningseh) Nutrition and physical activity (Prof. Suzana Shahar) Health Economics (Prof. Sharifah Ezat)
Neurosciences Parkinson s disease (Prof. Norlinah Ibrahim) Stroke (Prof. Norlinah Ibrahim) Bipolar disease & schizophrenia (Assc. Prof. Chan Lai Fong) Epilepsy (Prof. Dato Raymond Azman Ali)