Neuroendocrine Tumours

Neuroendocrine Tumours

Suayib Yalcin Kjell Öberg Editors Neuroendocrine Tumours Diagnosis and Management

Editors Suayib Yalcin Department of Medical Oncology Hacettepe University Cancer Institute Ankara, Turkey Kjell Öberg Department of Endocrine Oncology Uppsala University Hospital Uppsala, Sweden ISBN 978-3-662-45214-1 DOI 10.1007/978-3-662-45215-8 ISBN 978-3-662-45215-8 (ebook) Library of Congress Control Number: 2015941427 Springer Heidelberg New York Dordrecht London Springer-Verlag Berlin Heidelberg 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer-Verlag GmbH Berlin Heidelberg is part of Springer Science+Business Media (www.springer.com)

Contents 1 Introduction to Neuroendocrine Tumours........................ 1 Suayib Yalcin 2 History of Neuroendocrine Tumors.............................. 7 Paula Marincola and Eric H. Liu 3 Epidemiology of Neuroendocrine Tumors....................... 23 Saadettin Kilickap and Kadir Mutlu Hayran 4 Molecular Biology of Neuroendocrine Tumors................... 35 Aldo Scarpa, Vincenzo Corbo, Stefano Barbi, Ivana Cataldo, and Matteo Fassan 5 Genetic Syndromes Associated with Neuroendocrine Tumours...... 51 Wouter W. de Herder and Gerlof D. Valk 6 Pathological Evaluation and Classification of Digestive Neuroendocrine Tumours.......................... 59 Anne Couvelard 7 Circulating Biomarkers in Neuroendocrine Tumours.............. 77 Kjell Öberg 8 Cross-Sectional Imaging of Neuroendocrine Tumours............. 97 Shema Hameed, Mark Wills, and Andrea Rockall 9 Nuclear Medicine Imaging in Neuroendocrine Tumors........... 131 Andreas Kjaer 10 Neuroendocrine Tumors of the Lung.......................... 143 Dan Granberg 11 Overview of Gastrointestinal Neuroendocrine Tumours.......... 165 Ece Esin, Tugba Akin Telli, and Suayib Yalcin 12 Insulinoma................................................ 179 Simona Grozinsky-Glasberg, Petachia Reissman, and David J. Gross v

vi Contents 13 Gastrinoma............................................... 199 Janice L. Pasieka and Anthony J. Chambers 14 VIPoma and PPoma........................................ 223 Christian Rolfo, Giuseppe Bronte, Leonor Leider, Patrick Pauwels, Konstantinos Papadimitriou, Antonio Russo, and Marc Peeters 15 Glucagonoma.............................................. 233 Suayib Yalcin, Cenk Sokmensuer, and Ece Esin 16 Somatostatinoma........................................... 251 James M.L. Williamson 17 Less Common Types of Pancreatic Neuroendocrine Tumors................................................... 271 Young Suk Park 18 Nonfunctioning Pancreatic Neuroendocrine Tumors............. 275 Anna Koumarianou and Nicola Fazio 19 Gastroenteropancreatic Neuroendocrine Carcinoma............. 299 Halfdan Sorbye 20 The Multiple Endocrine Neoplasia Syndromes.................. 317 Simona Grozinsky-Glasberg and David J. Gross 21 Thyroid Cancer............................................ 353 E. Nilüfer Güler, Murat Fani Bozkurt, Serdar Ozbas, and Suayib Yalcin 22 Medullary Thyroid Cancer.................................. 389 Aydin Ciltas, Yusuf Gunaydin, and Mustafa Benekli 23 Diagnosis and Management of Adrenocortical Carcinomas........ 403 Bulent Orhan, Omer Dizdar, and Suayib Yalcin 24 Pheochromocytoma and Paraganglioma....................... 419 Eleonora P. Corssmit and Leonie T. van Hulsteijn 25 Surgical Approach in the Treatment of Neuroendocrine Tumours................................. 437 Göran Åkerström, Peter Stålberg, Olov Norlén, and Per Hellman 26 Liver-Directed Therapies in Neuroendocrine Tumors............ 475 Magaly Zappa, Annie Sibert, Mohamed Abdel-Rehim, Olivia Hentic, Maxime Ronot, Marie-Pierre Vullierme, Valérie Vilgrain, and Philippe Ruszniewski 27 Peptide Receptor Radionuclide Therapy....................... 491 Murat Fani Bozkurt

Contents vii 28 Management of Hormonal Symptoms......................... 501 Beata Kos-Kudla 29 Carcinoid Syndrome........................................ 513 Saadettin Kilickap and Suayib Yalcin 30 Somatostatin Analogs and Interferon in the Treatment of Neuroendocrine Tumors................................... 523 Jonathan Strosberg 31 Chemotherapy............................................. 535 Barbro Eriksson 32 Targeted Therapies......................................... 551 Marianne Ellen Pavel 33 Societies and Guidelines for Neuroendocrine Tumors............. 563 Kjell Öberg Index......................................................... 567