ROMANIA. HIV/AIDS statistical data 30 June PDF Free Download

ROMANIA HIV/AIDS statistical data 30 June 2013

The following information are the synthesis of a collecting process based on HIV/AIDS charts, delivered by nine Regional HIV Centers and Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania- National Institute for Infectious Diseases Prof.dr.Matei Balş Bucharestresponsible for processing specific HIV/AIDS data

County distribution by Regional Centers for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI PROF.DR. MATEI BALŞ REGIONAL CENTER BUCHAREST ARGEŞ BUZĂU DAMBOVIŢA GALAŢI IALOMIŢA PRAHOVA ILFOV VÂLCEA CRAIOVA REGIONAL CENTER CONSTANŢA REGIONAL CENTER DOLJ GORJ MEHEDINŢI OLT CONSTANŢA TULCEA VRANCEA V. BABEŞ BUCHAREST REGIONAL CENTER BRĂILA CĂLĂRAŞI GIURGIU TELEORMAN V.BABEŞ- BUCHAREST IAŞI REGIONAL CENTER BACĂU BOTOŞANI IAŞI NEAMŢ SUCEAVA VASLUI BRAŞOV REGIONAL CENTERL BRAŞOV COVASNA HARGHITA TÂRGU MUREŞ REGIONAL CENTER ALBA BISTRIŢA NĂSĂUD MUREŞ SIBIU BIHOR CLUJ REGIONAL CENTER CLUJ MARAMUREŞ SATU MARE SĂLAJ TIMIŞOARA REGIONAL CENTER ARAD CARAŞ SEVERIN HUNEDOARA TIMIŞ

Ministry of Health National Institute for Infectious Diseases Prof. Dr. Matei Bals Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania General data at June 30, 2013 Total no. of cases (Cumulative 1985-2013) of which: 18.797 HIV/AIDS Cases in children (0-14 years at date of diagnosis) 9931 HIV/AIDS Cases in adults (> 14 years at date of diagnosis) 8866 Total number of AIDS deaths 6219 Lost from records: HIV/AIDS children + adults 618 Number of PLWHA 11.960 Total no. of AIDS cases (CUMULATIVE 1985-2013) 13.141 AIDS Cases in Children (0-14 years at date of diagnosis) 8032 AIDS Cases in Adults (> 14 years at date of diagnosis) 5109 Total No. of HIV cases (CUMULATIVE 1992-2013) 5656 HIV Cases in Children (0-14 years at date of diagnosis) 1899 HIV Cases in Adults (> 14 years at date of diagnosis) 3757 HIV/AIDS cases diagnosed between 01.01-01.06.2013 371 New HIV notified cases 227 New AIDS notified cases 144 Number of deaths registered in 2013 (01.01-01.06.2013) 64 Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Ministry of Health National Institute for Infectious Diseases PROF.DR.MATEI BALŞ Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania General data at June 30, 2013 Patients in active surveillance 10.261 Children (0-14 years*) 329 Adolescents and adults (> 14 years*) 9.932 Patients in antiretroviral treatment (ART) 7.934 Children (0-14 years*) 208 Adolescents and adults (> 14 years*) 7.726 Patients who received ART prophylaxis 442 Patients who discontinued ART during the first semester of 2013 (own volition or death) 264 *current age; including children perinatally exposed to HIV, under surveillance Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Pyramid of ages Cumulative number at 31 December 2012 Age at diagnosis/notification date Cumulative number 1985-2012 Current age Cumulative number 1985-2012 No. cases No. cases Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

New HIV/AIDS Cases 1 January-30 June 2013

County distribution of new HIV/AIDS cases, diagnosed during 01.01-30.06.2013 LEGEND 3 3 3 5 1 6 3 Children (0-14 yaers) Adults and Adolescents (> 14 years) 13 1 8 Ilfov: 14 adults 3 children 2 4 7 26 12 3 6 4 2 1 9 5 3 26 1 1 6 1 6 3 1 5 1 10 164 1 1 2 4 1 4 4 6 5 1 1 17 Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Gender distribution of new HIV/AIDS cases diagnosed between 01.01 30.06.2013 102 (27%) 269 (73%) MALE FEMALE Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of HIV/AIDS cases by age group and gender, diagnosed between 01.01-30.06.2013 70 60 58 54 50 40 45 42 33 30 20 15 26 22 20 19 10 0 5 1 2 2 < 1 year 1-4 years 6 15-19 years 20-24 years 25-29 years 30-34 years 35-39 years 8 7 6 40-49 years >=50 years MALE FEMALE Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of new HIV/AIDS cases in children by probable route of transmission, diagnosed between 01.01-30.06.2013 7 7 6 5 4 3 3 2 1 0 Mother-to-child MALE FEMALE Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

New HIV/AIDS cases distribution by probable route of transmission Distribution of new HIV/AIDS cases in adults by probable route of transmission, diagnosed between 01.01-30.06.2013 120 113 100 95 80 64 60 53 40 29 20 0 5 0 2 HOMO/BISEXUAL IDUs HETEROSEXUAL UNKNOWN MALE FEMALE Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Values of CD4 lymphocytes in new HIV/AIDS cases diagnosed during the first semester of 2013 Cells/mm 3 Total no. of new cases 371 22% 11% 22% 34% < 100 101-200 201-500 > 500 No data 11% Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş Values of CD4 lymphocytes in new HIV/AIDS cases diagnosed during the first semester of 2013- adults Cells/mm 3 MALE FEMALE 21% 11% 21% 27% 8% 23% 11% 1 36% 31% < 100 101-200 201-500 > 500 Not assessed < 100 101-200 201-500 > 500 Not assessed Total cases: 266 Total cases: 95

Viral load values in new HIV/AIDS cases, diagnosed during the first semester of 2013 - adults Copies/ml MALE FEMALE 12% 13% 26% 10% 13% 35% 40% 51% <10000 10001-100000 100001-500000 >500000 <10000 10001-100000 100001-500000 >500000 Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

New cases of HIV infection acquired through injecting drug use (January-June 2013) by age group Age group Male Female Total 15-19 years 10 2 12 20-24 years 14 8 22 25-29 years 30 7 37 30-34 years 30 10 40 35-39 years 11 1 12 40-49 years 3 3 50 4 1 5 Total 102 29 131

New cases of HIV infection acquired through injecting drug use (January-June 2013) by county County Male Female Total Arges 1 1 Bucharest 83 24 107 Brasov 1 1 Constanta 3 3 Gorj 1 1 Hunedoara 1 1 Ialomita 1 1 Ilfov 3 3 6 Mures 1 1 Neamt 1 1 Olt 1 1 Prahova 1 1 Timis 3 3 Tulcea 1 1 Vâlcea 2 2 Total 102 29 131

HBV, HCV, syphilis infections in HIV+IDUs Tested for Number of tested patients % AgHBs 2 1,52% VHC 85 64,88% AgHBs + VHC 12 9,16% Syphilis 17 12,97%

Injecting drug users detected with HIV infection during January-June 2013, previously tested for HIV (to the current HIV positive test) Year of previous HIV test No. of patients 2013 1 2012 10 2011 6 2010 2 2009 1 2007 3 2005 2 2004 1 Total no. of previously tested IDUs 26

New cases of HIV/AIDS infection reported and registered by the National HIV/AIDS data base during 2009-2013 vs New cases of HIV/AIDS infection in IDUs reported and registered by the National HIV/AIDS Data base during 2009-2013 Number of HIV infection cases Number of HIV infections in IDUs IV YEAR 2009 2010 2011 2012 January- June 2013 240 283 417 502 227 5 6 102 177 85 Number of AIDS cases 263 252 316 319 144 Number of AIDS cases in IDUs 3 9 39 81 46 Total no. of HIV/AIDS cases 503 535 733 821 371 Total number of HIV/AIDS infection cases in IDUs 8 15 141 258 131

Values of CD4 lymphocytes in injecting drug users, diagnosed with HIV infection during the first semester of 2013 (cell/mmc) 26% 10% 21% 9% 34% <100 100-200 201-500 >=500 No data Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Evolution of HIV/AIDS infection in Romania 1985-2013

HIV/AIDS incidence in children and adults during 1985-2013 (at 100.000) 6 5 5.19 4.98 5.43 4.83 5.65 4 4.13 3.91 3.64 4.1 3 2 1 0 2.78 2.27 1.76 1.5 1.43 1.09 1.17 1.22 1.12 1.06 1.3 1.25 1.24 0.84 0.83 0.7 0.73 0.59 0.52 0.59 0.54 0.59 0.39 0.45 0.43 0.2 0.29 0.27 0.21 0.27 0.08 0.08 0.09 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Children Adults Children 2012: 0, 59/100.000 Adults 2012: 4,1/100.000 Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of HIV/AIDS cases in PLWHA by age group, current age and gender at June 30, 2013 (cumulative no. 1985-2013) Gender Age group Male Female TOTAL < 1 year 2 6 8 1-4 years 23 26 49 5-9 years 31 37 68 10-12 years 25 36 61 13-14 years 5 4 9 15-19 years 133 88 221 20-24 years 2533 2280 4813 25-29 years 1253 881 2134 30-34 years 549 380 929 35-39 years 544 426 970 40-49 years 818 658 1476 50-59 years 487 309 796 60 years 268 159 427 TOTAL 6671 5289 11960 Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Tendencies in HIV routes of transmission in Romania 2007-2013 HIV route of transmission 31 December 2007 31 December 2008 31 December 2009 31 December 2010 31 December 2011 31 December 2012 30 June 2013 Mother-to-child transmission MSM (Men who have sex with men) 8 (2%) 7 (1%) 20 (4%) 25 (5%) 21 (3%) 21 (2,6%) 10 (3%) 14 (3%) 40 (8%) 44 (9%) 60 (11%) 95 (13%) 89 (10,8%) 44 (12%) IDU (Injecting drug users) 4 (1%) 3 (1%) 7 (1,4%) 14 (3%) 131 (18%) 252 (30,6%) 124 (33%) MSM/IDU 1 (<0,5%) 5 (1%) 6 (1%) 9 (2%) Heterosexual 352 (79%) 397 (76%) 383 (77%) 399 (75%) 440 (61%) 414 (50%) 177 (48%) Unknown 67 (15%) 71 (14%) 43 (8,6%) 32 (6%) 28 (4%) 39 (5%) 7 (2%) Total 445 522 497 531 720 821 371 Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Tendencies in HIV routes of transmission in Romania 2007-2009 2007 2008 1% 15% 2% 3% 79% MTCT MSM Heterosexual IDU Unknown 1% 13% 2% 8% 76% Vertical MSM Heterosexual IDU Unknown 2009 1% 8% 4% 9% Vertical MSM Heterosexual IDU 78% Unknown Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Tendencies in HIV routes of transmission in Romania 2010-2013 2010 2011 3% 6% 5% 11% Vertical 19% 3% 3% 14% Vertical MSM MSM Heterosexual Heterosexual IDU IDU 75% Unknown 61% Unknown 31% 5% 3% 12% 2012 Vertical MSM 33% 2% 3% 2013 14% Vertical MSM Heterosexual Heterosexual IDU IDU 49% Unknown 48% Unknown Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of AIDS cases by gender at June 30, 2013 (cumulative number 1985-2013) 5571 7570 MALE FEMALE Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of AIDS cases by age group and gender at June 30, 2013 (cumulative number 1985-2013) 2000 1800 1851 1600 1527 1400 1359 1200 1000 800 1038 886 699 680 706 855 600 535 511 527 520 400 200 0 374 298 262 256 < 1 year 1-4 years 5-9 years 10-14 years 15-19 years 20-29 years 30-39 years 40-49 years 50-59 years >=60 years 117 86 54 MALE FEMALE Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Probable route of transmission in children diagnosed with AIDS at June 30, 2013 (cumulative number 1989-2013) 3000 2981 2500 2180 2000 1500 1000 1014 696 500 0 381 343 262 174 0 1 MTCT NOSOCOMIAL** UNKNOWN MALE FEMALE *persons who received blood transfusions at the end of 1980s-beginning of 1990s. **persons with repeated admissions and/or parenteral treatments at the end of 1980s-beginning of 1990s. Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Probable route of transmission in adolescents and adults diagnosed with AIDS (>14 years at date of diagnosis) at 30 June, 2013 (cumulative number 1985-2013) 2000 1800 1868 1600 1400 1482 1200 1000 800 600 400 571 468 200 0 201 0 141 44 151 183 HOMO/BISEXUAL IDU BLOOD AND DERIVATES* HETEROSEXUAL UNKNOWN MALE FEMALE * persons who received blood transfusions at the end of 1980s-beginning of 1990s Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of AIDS cases in women by age group and year of diagnosis 1985-2012 90 80 70 60 50 40 30 20 10 0 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 15-19 ANI 20-29 ANI 30-39 ANI 40-49 ANI >50 ANI Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of HIV cases by gender at June 30, 2013 (cumulative number 1992-2013) 2498 3158 MALE FEMALE Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of HIV cases by age group and gender at June 30, 2013 (cumulative number 1992-2013) 900 892 800 700 672 660 600 500 400 431 391 377 348 396 300 200 230 321 241 100 59 59 131 103 131 99 62 38 15 0 < 1 AN 1-4 YEARS 5-9 YEARS 10-14 YEARS 15-19 YEARS 20-29 YEARS 30-39 YEARS 40-49 YEARS 50-59 YEARS >=60 YEARS MALE FEMALE Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Probable route of transmission in children infected with HIV (0-14 years at date of diagnosis) at June 30, 2013 (cumulative number 1992-2013) 700 635 600 554 500 400 300 200 172 156 100 110 114 80 76 0 MTCT BLOOD AND DERIVATES* 1 0 0 1 NOSOCOMIAL** IDU HETEROSEXUAL UNKNOWN MALE FEMALE *persons who received blood transfusions at the end of 1980s-beginning of 1990s. **persons with repeated admissions and/or parenteral treatments at the end of 1980s-beginning of 1990s. Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Probable route of transmission in adolescents and adults with HIV infection (>14 years at date of diagnosis) at June 30, 2013 (cumulative number 1992-2013) 1400 1200 1250 1293 1000 800 600 400 362 308 200 187 157 0 0 72 53 75 MSM/BISEXUAL IDU BLOOD AND DERIVATES* HETEROSEXUAL UNKNOWN MALE FEMALE *persons who received blood transfusions at the end of 1980s- beginning of 1990s. Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of HIV infection cases in women by year of diagnosis and age (1992-2012) Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

HBV, HCV and HBV+HCV in children infected with HIV, during 1989-2013 250 200 HBV HCV HBV+HCV No. cases 150 100 0 50 Year of diagnosis 0 '89 '90 '91 '92 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13 HBV 63 179 91 74 111 97 131 149 216 171 174 167 105 35 12 0 3 0 0 0 0 0 0 0 0 HCV 1 6 3 6 9 3 8 8 14 5 10 9 6 4 1 0 1 0 0 0 0 2 1 1 2 H B V+H C V 1 5 1 5 6 2 4 4 11 2 4 4 3 1 0 0 0 0 0 0 0 0 0 0 Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

HBV, HCV and HBV+HCV in adults infected with HIV, during 1989-2013 120 100 80 No.cases 60 40 20 Year of diagnosis 0 '85 '86 '87 '88 '89 '90 '91 '92 '93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09 '10 '11 '12 '13 HBV 1 0 1 2 7 16 10 5 11 22 29 40 27 39 59 47 47 85 103 65 62 57 42 59 50 47 17 19 20 HCV 0 0 0 0 1 1 1 1 3 5 8 10 3 14 4 12 12 20 16 20 23 17 9 20 13 19 33 90 114 HBV+HCV 0 1 0 1 0 0 1 0 1 1 1 3 1 0 1 3 3 3 6 6 5 2 3 2 4 3 7 15 12 Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

HIV related illnesses 01.01 30.06.2013 Sarcom Kaposi Sepsis recurent Limfom Burkitt Limfom nespecificat Tuberculoza extrapulmonara Tuberculoza pulmonara Leucoencefalopatia multifocala progresiva Criptosporidioza Criptococoza Boala sau retinita CMV Infectii bacteriene recurente Toxoplasmoza Pneumonie recurenta Encefalopatie HIV Pneumonie cu pneumocistis carinii Sindrom wasting Candidoza pulmonara: bronhii/trahee/plaman Candidoza esofagiana 0 10 20 30 40 50 60 70 Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Mean survival period (in months) of AIDS patients between 1990-2012 100 90 80 70 60 50 40 30 20 10 0 90 91 92 93 94 95 96 97 98 99 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Nr.luni 3 9 16 18 28 26 31 34 36 42 44 42 56 60 55 57 61 77 82 83 86 81 92 Introduction of ART bi-therapy Introduction of triple ART therapy Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

HIV Testing January-June 2013

HIV testing* in most at risk groups (MARPs) during the first semester of 2013 Risk group Negative test results Positive test results TOTAL %POSITIVE STDs (sexually transmitted diseases) 1569 55 1624 3,39 TBC 6515 61 6576 0,93 MATERNITY TESTING 241 10 251 3,98 PREGNANT WOMEN 61486 57 61543 0,09 MEDICAL STAFF 3579 3579 0,00 HEMODIALYSIS PATIENTS 1456 1456 0,00 PATIENTS WITH BLOOD TRANSFUIONS 45 45 0,00 PRENUPTIAL CHECK-UP 2360 2360 0,00 IDUs 28 5 33 15,15 INMATES 29 29 0,00 MSM 26 5 31 16,13 SWs (commercial sex workers) 30 30 0,00 HIV CONTACTS 527 61 588 10,37 SAILORS 2418 2418 0,00 DRIVERS 20 20 0,00 WORK ABROAD> 6 MONTHS 162 1 163 0,61 STAY ABROAD > 6 MONTHS 51 51 0,00 TESTING BY REQUEST 58419 616 59035 1,04 OCCASIONAL TESTING 10932 286 11218 2,55 TOTAL 149893 1157 151050 0,77 *data are sent by County Public Health Authorities Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş HIV testing* in pregnant women, by age group, during the first semester of 2013 Age group Negative test results Positive test results TOTAL 12-14 years 216 216 15-19 years 5671 3 5674 20-24 years 14360 19 14379 25-29 years 18298 22 18320 30-34 years 13337 5 13342 35-39 years 6272 4 6276 > 40 years 1456 1456 Undefined age 1876 4 1880 TOTAL 61486 57 61543 *data are sent by County Public Health Authorities

HIV testing* in blood donors during the first semester of 2013 Donor group Gender Positive test result Negative test result TOTAL First time donor Regular donor Occasional donor Male 20 31993 32013 Female 4 17359 17363 Male 2 90491 90493 Female 0 39182 39182 Male 3 25629 25632 Female 0 11350 11350 TOTAL 29 216004 216033 *data are sent by the National Institute for Transfusional Hematology PROF.C.T.NICOLAU

Patients in active records and antiretroviral therapy June 2013

Distribution of PLWHA in active records, by age group (%) at June 30, 2013 1% 3% 2% 37% 57% < 1 year 1-14 years 15-19 years 20-24 years 25 years Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of patients in ART by age group at June 30, 2013 5000 4500 4000 3500 3000 2500 2000 1500 1000 500 0 < 1 years 1-4 years 5-9 years 10-14 years 15-19 years 20-29 years 30-39 years 40-49 years >50 years Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Distribution of patients in ART by age group and gender at June 30, 2013 1600 1400 1200 1000 800 600 400 200 0 < 1 year 1-4 years 5-9 years 10-12 years 13-14 years 15-19 years 20-24 years 25-29 years 30-34 years 35-39 years 40-49 years 50-59 years > 60 years M ale Female Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Patients in ART by Regional Centre at June 30, 2013 VICTOR BABES 37 1317 MURES 6 304 CONSTANTA 32 805 CENTRE REGIONALE CRAIOVA IASI TIMISOARA CLUJ 8 460 26 20 9 242 708 1175 BRASOV 3 178 INBI MATEI BALS 67 2537 0 500 1000 1500 2000 2500 3000 Children Adults Source: Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania INBI Prof.Dr.M.Balş

Global evolution of HIV/AIDS epidemic

UNAIDS: How to get to ZERO: ZERO NEW HIV INFECTIONS ZERO DISCRIMINATION ZERO AIDS-RELATED DEATHS

Source: Global Update on HIV Treatment 2013: Results, impact and opportunities WHO Report in partnership with UNICEF and UNAIDS, June 2013

Source: UNAIDS WORLD AIDS DAY REPORT 2012 General global HIV/AIDS data December 2011 Total 34 million (31,4 35,9 million) PLWHA Adults Women Children < 15 years 30,7 million (28,2 32,3 million) 16,7 million (15,4 17,6 million) 3,3 million (3,1 3,8 million) People infected with HIV registered in 2011 Deaths caused by AIDS registered 2011 Total 2,5 million (2,2 2,8 million) Adults 2,2 million (1,9 2,4 million) Children < 15 years 330.000 (280.000 390.000) Total 1,7 million (1,5 1,9 ) Adults 1,5 millions (1,3 1,7 millions) Children < 15 years 230.000 (200.000 270.000)

Estimates on the number of PLWHA during 2000-2011 million 50 45 40 35 30 25 20 15 10 5 0 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 year Source: UNAIDS WORLD AIDS DAY REPORT 2012

Global estimates on adults and children infected with HIV/AIDS at December 2011 PLWHA New cases of HIV infection registered in 2011 34 million (31,4 35,9 million) 2,5 million (2,2 2,8 million) Deaths caused by AIDS registered in 2011 1,7 million (1,5 1,9 million) Source: UNAIDS WORLD AIDS DAY REPORT 2012

Estimates on the number of children and adults living with HIV infection at the end of 2011 North America 1,4 million [1,1 million 2,0 million] The Caribbean 230 000 [200 000 250 000] Latin America 1,4 million [1,1 million 1,7 million] Western and Central Europe 900 000 [830 000 1 million] Middle East and North Africa 300 000 [250 000 360 000] Sub-Saharan Africa 23,5 million [22,1 million 24,8 million Eastern Europe and Central Asia 1,4 million [1,1 million 1,8 million] Eastern Asia 830 000 [520 000 1.2 million] South and South-East Asia 4 million [3,1 million 5.2 million] Oceania 53 000 [47 000 60 000] Total no: 34,0 million [31,4 million 35,9 million] Source: UNAIDS WORLD AIDS DAY REPORT 2012

Estimates on the number of children and adults infected with HIV in 2011 North America 51 000 [19 000 120 000] The Caribbean 13 000 [9 600 16 000] Latin America 83 000 [51 000 140 000] Western and Central Europe 30 000 [21 000 40 000] Middle east and North Africa 37 000 [29 000 46 000] Sub-Saharan Africa 1,8 million [1,6 milioane 2,0 millionane] Eastern Europe and Central Asia 140 000 [91 000 210 000] Eastern Asia 89 000 [44 000 170 000] Southern and Southeast Asia 280 000 [170 000 460 000] Oceania 2 900 [2 200 3 800] Total: 2,5 million [2,2 million 2,8 million] Sursa: UNAIDS WORLD AIDS DAY REPORT 2012

Estimates on deaths caused by AIDS (in children and adults) reported in 2011 North America 21 000 [17 000 28 000] The Caribbean 10 000 [8 200 12 000] America Latină 54 000 [32 000 81 000] Western and Central Europe 7 000 [6 100 7 500] Middle East and North Africa 23 000 [18 000 29 000] Sub-Saharan Africa 1,2 million [1,1 million 1,3 millionane] Eastern Europe and Central Asia 92 000 [63 000 120 000] Eastern Asia 59 000 [41 000 82 000] South and Southeast Asia 250 000 [190 000 140 000] Oceania 1 300 [< 1 000 1 800] Total: 1,7 million [1,5 million 1,9 million] Source: UNAIDS WORLD AIDS DAY REPORT 2012

Nearly 7000 people were infected with HIV every day in 2011 Over 97% originated from low income and developing countries. Almost 900 were children under 15. Approximately 6000 were people between 15-49, of which: around 47%, women around 39%, between 15-24 Source: AIDS epidemic update: December 2012

Global estimates on HIV and AIDS figures in children (<15 years) at the end of 2011 Children living with HIV Children newly infected 3,3 millionane (3,1 3,8 millionane) 330 000 (280 000 30 000) with HIV in 2011 Deaths caused by AIDS în 2011 230 000 (200.000 270.000) Source: UNAIDS WORLD AIDS DAY REPORT 2012

Source: UNAIDS WORLD AIDS DAY REPORT 2012 Regional statistical data December 2011 Region PLWHA (children+adults) Newly infected adults and children Prevalence in adults (15-49 years) [%] Adults+children: AIDS deaths Sub-Saharan Africa 23.5 milion (22,1-24,8 million) 1,8 million (1,6-2,0 million) 4,9% (4,6% - 5,1%) 1,2 million (1,1 1,3 million) Middle East and North Africa 300 000 (250 000 360 000) 37 000 (29 000 46 000) 0,2% (0,1% - 0,2%) 23 000 (18 000 29 000) South and South East Asia 4,0 million (3,1 5,2 million) 280 000 (170 000 460 000) 0,3% (0,2% - 0,4%) 250 000 (190 000 340 000) East Asia 830 000 (590 000 1,2 million) 89 000 44 000 170 000) 0,1% (<0,1% - 0,1%) 59 000 (41 000 82 000) South America 1,4 million (1,1 1,7 million) 83 000 (51 000 140 000) 0,4% (0,3% - 0,5%) 54 000 (32 000 81 000) The Caribbean 230 000 (200 000 250 000) 13 000 (9 600 16 000) 1,0% (0,9% - 1,1%) 10 000 (8 200 12 000) Eastern Europe and Central Asia 1,4 million (1,1 1,8 million) 140 000 (91 000 210 000) 0,8% (0,6% 1,0%) 92 000 (63 000 120 000) Central and Western Europe 900 000 (830 000 1,0 milion) 30 000 (21 000 40 000) 0,2% (0.2% - 0,3%) 7 000 (6 100 7 500) North America 1,4 million 1,1 2,0 million) 51 000 (19 000 120 000) 0,6% (0,5% - 1,0%) 21 000 (17 000 28 000) Oceania 53 000 (47 000 60 000) 2 900 (2 200 3 800) 0,3% (0,2% - 0,3%) 1 300 (<1 000 1 800) TOTAL 34,0 million (31,4 35,9 million) 2,5 million (2,2 2,8 million) 0,8% (0,7% - 0,8%) 1,7 million (1,5 1,9 million)

WHO European Region estimates on HIV/AIDS (53 countries) 2011 Reported HIV/AIDS cases (cumulative number): AIDS cases: 379.399 AIDS deaths: 199.460 HIV infection: 778.889 Source: HIV surveillance Report 2012

Features of HIV infection cases diagnosed in the European WHO Region in 2011, by geographical areas European WHO Region * West* Centre East EU/EEA Countries* Number of HIV infection cases 53974 26204 2997 24773 28038 Rate per million population 7,6 6,5 1,6 22,4 5,7 % of cases: 15-24 years age group ** 11,1% 10,1% 16,8% 11,4% 11,0% Men/women 2,0 2,9 4,3 1,3 3,0 Route of transmission ** Heterosexual 45,8% 37,9% 25,7% 56,7% 22,7% MSM 21,5% 40,1% 27,3% 1,1% 38,7% IDU 19,7% 4,2% 8,2% 37,6% 5,4% Unknown 11,6% 16,7% 35,7% 3,3% 18,7% No data: Monaco, Liechtenstein, Russian Federation and Uzbekistan *Countries that did not report age groups dissemination and routes of transmission were excluded. **Persons from Sub-Saharan Africa were excluded; the share of HIV infection transmitted through unsafe heterosexual contact is 36%. Source: HIV surveillance Report 2012

Definitions Incidence = Number of new cases X 100.000/population registered at 1 July 2012 Prevalence= Number of new and old cases X 100.000/population registered at 1 July 2012 Child= person entering 0-14 age group, based on CDC classification, revised at 5 December, 2008*. Adolescent and adult= person over 15, based on CDC classification, revised at 5 December, 2008*.

Sursa: UNAIDS WORLD AIDS DAY REPORT 2012 *Sources Global Update on HIV Treatment 2013: Results, impact and opportunities WHO Report in partnership with UNICEF and UNAIDS, June 2013 http://apps.who.int/iris/bitstream/10665/85321/1/9789241505727_eng.pdf http://apps.who.int/iris/bitstream/10665/85326/1/9789241505734_eng. Unaids World AIDS Day Report 2012 http://www.unaids.org/en/resources/campaigns/20121120_globalreport20 12/ HIV Surveillance in Europe 2011, ECDC www.ecdc.europa.eu www.euro.who.int

Source Revised surviellance Case Definition for HIV Infection Among Adults, Adolescents, and Children Aged < 18 Month sand for HIV Infection and AIDS Among Children Aged 18 Months to <13 years--- CDC, United States, 2008 http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5710a1.htm Commission Decision of 28/IV/2008 amending Decision 2002/253/Ec laying down case definitions for reporting communicable diseases to the Community network under Decision no 2119/98/EC of the European Parliament and Council Who case definitions of HIV for surveillance and Revised clinical staging and immunological Classification of HIVrelated disease in adults and Children (World Health Organization 2007) http://www.who.int/hiv/pub/guidelines/hivstaging150307.pdf

National Institute for Infectious Diseases PROF.DR.MATEI BALŞ Compartment for Monitoring and Evaluation of HIV/AIDS Data in Romania Manager: Prof.Dr. Adrian Streinu-Cercel Head of Infectious Diseases Dept. UMF Carol Davila Head of Infectious Diseases and anti-aids Committee Coordinator: Mariana Mărdărescu MD, PhD Coordinator of HIV Adults Program: Conf.Dr.Elisabeta Otilia Benea Coordinator of HIV Children Program: Dr.Sorin Petrea Statistical data operators : PC Operators : As.med. Marieta Iancu Daniela Viţelaru Sanda Vintilă Colaborators: Dr. Ionel Iosif CNSCB Romanian HIV/AIDS Center

ROMANIA. HIV/AIDS statistical data 30 June 2013