German Pharmacies. Figures Data Facts Legal disclosure:

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German Pharmacies Figures Data Facts 2009 Legal disclosure: Published by the ABDA Federal Union of German Associations of Pharmacists Jägerstr. 49/50 10117 Berlin Germany www.abda.de Print: blueprint berlin gmbh www.blueprint.info Sources: ABDA-Statistik Bundesministerium für Gesundheit Center for Drug Information and Pharmacy Practice Europäische Kommission Gesundheit Österreich GmbH, ÖBIG 2006 IMS HEALTH GmbH & Co. OHG infas Institut für angewandte Sozialwissenschaft GmbH Institut für Demoskopie Allensbach Pro Generika e.v. Reader's Digest Statistisches Bundesamt The Nielsen Company GmbH Verein Deutsches Arzneiprüfungsinstitut e.v. YouGovPsychonomics AG

Contents Community pharmacies Numbers of pharmacies...4 Pharmacies in the German states... 5 Trends in the number of jobs in community pharmacies... 6 7 Pharmacists and pharmacy students... 8 Pharmacy trainee positions... 9 Pharmacy services... 10 Pharmacy image... 11 Pharmacy density in Europe... 12 Community pharmacies Pharmacies in the health care system SHI expenditure on pharmaceuticals (excl. co-payments)... 14 Distribution of the value added... 15 Allocation of total SHI expenditure... 16 17 Distribution of miscellaneous costs... 18 Vaccine sales... 19 Statutory pharmacy and manufacturer rebates... 20 Rebated pharmaceuticals... 21 Co-payments for pharmaceuticals... 22 Co-pay exemptions... 23 Pharmaceuticals with and without reference price... 24 Prescribed pharmaceuticals (SHI)... 25 Pharmaceutical expenditure per SHI-member...26 27 Pharmaceutical expenditure per person... 28 Distributions of pharmacies according to turnover... 29 Structure of pharmacy sales...30 31 Structure of complementary product range... 32 Drug-related problems (DRP) concerning self-medication... 33 VAT on pharmaceuticals in the EU...34 35 2 3

Numbers of pharmacies Pharmacies in the German states Number of pharmacies (incl. subsidiaries) German state Public Independent pharmacies in 2009 pharmacies* Subsidiaries 2001 2002 2003 2004 2005 2006 2007 2008 2009 Baden-Württemberg 2,755 2,364 391 21,569 21,465 21,305 21,392 21,476 21,551 21,570 21,602 21,548 Bavaria 3,439 2,927 512 Berlin 890 741 149 Brandenburg 578 464 114 Subsidiaries Bremen 171 148 23 2001 2002 2003 2004 2005 2006 2007 2008 2009 Hamburg 459 393 66 632 1,228 1,796 2,356 2,851 3,224 Hesse 1,621 1,380 241 Mecklenburg-West Pomerania 408 347 61 Lower Saxony 2,107 1,795 312 Pharmacies opened 2001 2002 2003 186 140 122 2004 343 2005 326 2006 346 2007 2008 2009 370 360 298 North Rhine 2,507 2,152 355 Westphalia-Lippe 2,230 1,871 359 Rhineland-Palatinate 1,116 987 129 Saarland 338 301 37 Pharmacies closed Saxony 999 825 174 2001 209 2002 244 2003 2004 282 256 2005 242 2006 271 2007 2008 2009 351 328 352 Saxony-Anhalt 618 511 107 Schleswig-Holstein 735 641 94 Thuringia 577 477 100 Total 21,548 18,324 3,224 Figures as at year-end Figures as at year-end; * Pharmacies with operating licence in accordance with 2 of the Apothekengesetz (pharmacy regulations) 4 5

Trends in the number of jobs in community pharmacies Year-end 2001 2002 2003 2004 2005 2006 2007 2008 2009 Pharmacists 45,869 46,513 46,140 Of which female (%) 65.1 63.6 62.9 46,014 46,276 46,953 47,766 48,030 48,002 65.5 64.8 66.0 66.6 68.5 69.3 Pre-registration trainee pharmacists 1,748 1,520 1,387 1,431 1,534 1,518 1,506 1,327 1,287 Pharmaceutical engineers 10,294 10,218 9,600 9,602 9,266 8,292 8,413 8,196 8,056 Pharmaceutical technical assistants (PTA) 40,805 41,495 42,385 43,946 46,431 48,656 49,874 51,907 53,734 Pharmaceutical commercial employees (PCE) / other 38,614 40,091 37,636 35,812 36,454 38,355 36,026 36,020 35,769 Total jobs 137,330 139,837 137,148 136,805 139,961 143,774 143,585 145,480 146,848 6 7

Pharmacists and pharmacy students Pharmacy trainee positions Pharmacists Pharmacists in: 2008 2009 Percentage of women Community pharmacies 48,030 48,002 69.3 Of which managers 18,751 18,324 46.7 1,287 Hospital pharmacies 1,874 1,890 60.3 Industry, administration, organisation, science 7,575 7,940 58.1 Total emloyed pharmacists 57,479 57,832 67.5 6,155 2,645 Pharmacy students 2004/2005 12,358 2005/2006 12,069 10,087 Total number of trainee positions 2006/2007 12,128 2007/2008 11,721 PCEs in training Pre-registration trainee pharmacists PTA trainees 2008/2009 12,052 8 9

Pharmacy services Pharmacy image Approximately 4 million people visit public pharmacies every day. In 2009, pharmacies 87 % of Germans have a high degree of trust in pharmacists 1 - reported a total of 7,400 suspected cases of medication risks to the Drug Commission of the German Medical Association. Main complaints referred to errors in packaging (30 %), unwanted medication effects and reports of misuse (29 %) as well as galenic deficiency (20 %). --processed some 16 million prescriptions covered by the statutory health insurance (SHI), 65 % of which were conventional, 20 % methadone, 11 % cytostatic and 4 % parenteral formulation. Training courses 82 % 65 % of Germans feel that pharmacies provide good-quality service, and consider them to be some of the best service providers in Germany 2 of Germans go to the pharmacy first when they have minor health issues 3 In 2009, approximately 119,000 people took part in nearly 2,300 training courses offered by the Council of Pharmacists more than ever before. Grade 2.4 is the mark Germans give to owner-run pharmacies and is equivalent to good 4 Night and emergency service - Approx. 2,000 pharmacies per night Grade 1.8 is the mark Germans give to owner-run pharmacies concerning healthcare of their children 5 - More than 20,000 patients per night - More than 7 million packs provided outside the regular opening hours - Especially important for children (and their parents): above-average percentage of SHI pharmaceuticals dispensed during night and emergency service is prescribed by paediatricians. Sources (representative surveys) 1 Reader's Digest 2010 2 Allensbach 2008 3 YouGovPsychonomics 2008 4 infas 2008 5 infas 2009 10 11

Pharmacy density in Europe People per pharmacy* Denmark 16,800 Sweden 10,700 Netherlands 9,400 Slovenia 7,400 Austria 6,900 Finland 6,500 Pharmacies in the health care system Czech Republic 5,500 Luxembourg 5,200 Hungary 5,000 United Kingdom 4,900 Slovakia 4,600 Estonia 4,300 Germany 3,800 Portugal 3,800 Poland 3,500 Italy 3,300 Ireland 3,000 France 2,700 Latvia 2,600 Lithuania 2,300 Spain 2,100 Belgium 2,000 Malta 1,900 Cyprus 1,700 Greece 1,200 * Germany: ABDA-Statistik 2009; all other countries: last available year according to ÖBIG 12 13

SHI expenditure on pharma ceuticals (excl. co-payments) Distribution of the value added Every 100 spent by SHI on pharmaceuticals is allocated as follows: 2007 2008 2009 4.18 (=14.9 %) 4.49 (=16.0 %) 18.32 (=65.2 %) Industry 64.00 64.50 65.20 1.10 (=3.9 %) In bn 28.095 (=100 %) Total amount spent by SHI on pharmaceuticals in 2009 Exchequer (VAT) 16.00 16.00 16.00 Pharmaceutical industry and purchased materials and services (such as raw materials) Pharmaceutical wholesalers VAT (exchequer) Pharmacies 15.90 15.50 14.90 Wholesalers 4.10 4.00 3.90 Pharmacies 14 15

Allocation of total SHI expenditure Total SHI expenditure (in bn) Of which (%) Doctors Dentists Dentures Remedies and therapeutic aids Hospitals Administrative expenditure Misc. costs Pharmaceuticals** Of which is allocated to pharmacies based on the Drug Price Ordinance (Arzneimittelpreisverordnung) 2001 138.81 15.8 5.7 2.6 7.0 32.4 5.5 15.5 15.4 3.0 2002 143.03 15.6 5.6 2.5 6.5 32.4 5.6 16.3 15.6 2.9 2003 145.09 15.8 5.5 2.6 6.5 32.3 5.7 16.0 15.7 2.7 2004 140.18 15.3 5.4 2.6 5.9 33.9 5.8 16.6 14.5 2.5 2005 143.92 15.0 5.2 1.7 5.8 34.0 5.7 16.3 16.4 2.8 2006 148.09 15.0 5.2 1.8 5.6 34.0 5.5 16.8 16.1 2.7 2007 154.02 15.0 5.1 1.8 5.6 33.0 5.3 17.5 16.6 2.6 2008 160.94 15.0 5.0 1.8 5.7 32.7 5.1 18.2 16.6 2.6 2009* 170.79 15.2 4.8 1.8 5.6 32.7 5.2 18.2 16.4 2.5 * Provisional ** From pharmacies 16 17

Distribution of miscellaneous costs Vaccine sales* in % In m Sick pay 4.2 Transportation expenses 2.0 2006 140 182 84 799 Pregnancy, maternity 1.9 Home care 1.7 2007 300 241 170 133 1,257 Pharmaceuticals from others 1.6 2008 266 285 153 216 1,349 Social services 1.5 Ambulant & inpatient treatment, rehab 1.4 2009 171 335 149 90 1,176 Dialysis in doctors' practices 1.0 Early diagnosis measures 0.9 Others 2.0 Of which tick-borne meningoencephalitis Of which flu Of which pneumococcus Of which human papillomavirus (HPV) Total 18.2 In 2007, vaccinations were included in the SHI catalogue of required services. * Vaccine against H1N1 ("swine-flu") is not included, as settlement is undertaken by the Federal States. 18 19

Statutory pharmacy and manufacturer rebates Rebated pharmaceuticals 9,300 Number of rebate contracts 1,235 1,319 1,338 184 Involved health insurance companies 943 852 844 141 Involved pharmaceutical manufacturers 26,900 Number of rebated pharmaceuticals (Central Pharmaceutical Number) 60 % Share of rebated pharmaceuticals subject to no or reduced co-payments 2007 2008 2009 308 Mio. Rebated packs of generic pharmaceuticals In m Pharmacy rebate Manufacturer rebates (excl. rebate contracts) 20.9 Mio. Number of data sets that need to be processed by Pharmacy IT Figures as at year-end 2009 20 21

Co-payments for pharmaceuticals Co-pay exemptions Co-payments in m Number of patients who are exempt from the prescription charge (hardship cases in accordance with 62 SGB V): 6,643,362 6,837,531 2,314 2,149 1,979 1,626 1,674 1,696 2004 2008 Number of patients who exceed the annual prescription charge limit of 2 % of their gross annual income: 2004 2005 2006 2007 2008 2009 Charge per unit in 673,557 433,952 2004 2008 Number of patients who exceed the annual prescription charge limit of 1 % of their gross annual income (chronically ill patients): 3.40 3.00 2.80 2.30 2.30 2.30 5,969,805 6,403,579 2004 2005 2006 2007 2008 2009 2004 2008 22 23

Pharmaceuticals with and without reference price Prescribed pharmaceuticals (SHI) Average unit price in Prescriptions per member Pharmaceuticals per prescription Prescribed pharmaceuticals per member 2000 11.00 x 1.55 17.00 63.17 68.32 75.53 2001 11.00 x 1.55 17.00 2002 10.50 x 1.49 15.65 24.32 25.17 24.42 2007 2008 2009 Pharmaceuticals with reference price Pharmaceuticals without reference price 2003 10.20 x 1.56 15.91 2004 8.44 x 1.70 14.35 2005 8.76 x 1.72 15.07 Number of units provided in m 2006 8.53 x 1.74 14.84 2007 8.66 x 1.75 15.16 2008 8.81 x 1.76 15.51 427 245 457 466 231 229 2009 8.79 x 1.76 15.47 2007 2008 2009 Pharmaceuticals with reference price Pharmaceuticals without reference price 24 25

Pharmaceutical expenditure per SHI member 270.36 418.78 274.98 440.55 272.92 449.67 247.18 400.69 289.11 468.44 292.91 473.18 315.87 504.71 328.63 522.25 355.35 549.80 764.60 794.93 810.71 709.32 823.77 831.16 882.68 914.07 943.28 2001 2002 2003 2004 2005 2006 2007 2008 2009* Per member (excl. pensioners) in Per pensioner in Per member (incl. pensioners) in Approx. 30 % of the members are pensioners. *Provisional 26 27

Pharmaceutical expenditure per person Distribution of pharmacies according to turnover Pharmacy share according to turnover (%) Pharmaceutical expenditure per person Total: 515 Over-the-counter pharmaceuticals 52 15 14.4 16.6 15.7 13.7 11.2 10 Prescription pharmaceuticals 463 7.5 7.3 5 5.4 3.0 1.6 1.9 1.7 <0.50 <0.75 <1.00 <1.25 <1.50 <1.75 <2.00 <2.25 <2.50 <2.75 <3.00 >3.00 Incl. VAT Turnover in m (excl. VAT) 28 29

Structure of pharmacy sales Measured in sales value: Measured per units: Pharmacy sales in 2009 (excl.vat) 39.2 bn = 100 % Prescriptions in 2009 1,426 m units = 100 % 1) 2.0 bn = 5.1 % Pharmaceuticals 35.5 bn = 90.6 % 2) 1.7 bn = 4.3 % Prescription pharmaceuticals 766 m units = 53.7 % Pharmacy-only pharmaceuticals (non-prescription) 614 m units = 43.1 % 1) 46 m = 3.2 % Prescription pharmaceuticals 30.8 bn = 78.6 % Pharmacy-only pharmaceuticals (non-prescription) 4.4 bn = 11.2 % 3) 0.3 bn = 0.8 % Prescribed 121 m units = 8.5 % Not prescribed 493 m units = 34.6 % Prescribed 1.1 bn = 2.8 % Not prescribed 3.3 bn = 8.4 % Volume of pharmaceuticals covered by SHI, private insurance and other 887 m units = 62.2 % Self-medication 539 m units = 37.8 % Value of pharmaceuticals covered by SHI, private insurance or other Self-medication 31.9 bn = 81.4 % 3.6 bn = 9.2 % 1) Supplementary assortment 2) Patient care products 3) Unrestricted OTC pharmaceuticals* 1) Unrestricted OTC pharmaceuticals* * Pharmaceuticals which may be sold outside pharmacies (e.g. by chemists) 30 31

Structure of complementary product range Drug-related problems (DRP) concerning self-medication Almost every 5th patient request for self-medication pharmaceuticals is associated with one or more drug-related problems (DRP). 0.8 72 % of DRP occur in conjunction with the four most common indications, i.e. pain, respiratory-, gastrointestinal- and skin disorders. 1.4 75 % of DRP are inappropriate self-medication, inappropriate product request, wrong dosage, and duration of drug use (including abuse) was too long. 0.3 If a patient has a medication record at the pharmacy, significantly more cases of wrong dosage and drug-drug interactions can be identified. 1.2 90 % of DRP can be resolved in pharmacies. 3.7 Total Sales in bn (excl. VAT) Medical products and therapeutic aids Hygienic and cosmetic products Vitamins and minerals Other * includes supplementary assortment and patient care products 32 33

VAT on pharmaceuticals in the EU* Tax rate for pharmaceuticals General VAT rate Tax rate for pharmaceuticals General VAT rate Denmark 25.0 25.0 Bulgaria 20.0 20.0 Germany 19.0 19.0 Greece 10.0 21.0 Latvia 10.0 21.0 Italy 10.0 20.0 Hungary 5.0 25.0 Lithuania 5.0 21.0 Portugal 5.0 20.0 Spain 4.0 16.0 Luxembourg 3.0 15.0 France Refundable pharmaceuticals 2.1 19.6 Austria 10.0 20.0 Non-refundable pharmaceuticals 5.5 Slovakia 10.0 19.0 Sweden Prescription pharmaceuticals 0.0 25.0 Estonia 9.0 20.0 Over-the-counter pharmaceuticals 25.0 Romania 9.0 19.0 Ireland Oral medication 0.0 21.5 Czech Republic 9.0 19.0 Non-oral medication 21.5 Slovenia 8.5 20.0 UK National Health Service pharmaceuticals 0.0 15.0 Finland 8.0 22.0 Over-the-counter pharmaceuticals 15.0 Poland 7.0 22.0 Belgium 6.0 21.0 Malta 0.0 18.0 Cyprus 0.0 15.0 Netherlands 6.0 19.0 * Tax rates as at 2010 34 35