Humberto Coto, M.D., FACP, FACC CURRICULUM VITAE

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Humberto Coto, M.D., FACP, FACC CURRICULUM VITAE PERSONAL Date of Birth July 3, 1948 Place of Birth Costa Rica, Central America EDUCATION 1973 1976 M.D. Degree Autonomous University of Guadalajara Guadalajara, Mexico 1970 1972 Pre-Medical Boise State College Boise, Idaho POST-GRADUATE MEDICAL EDUCATION TEACHING EXPERIENCE 1/1977 12/1977 Internship Max Peralta Hospital Cartago, C.R. University of Costa Rica Costa Rica, Central America 2/1978 1/1979 Social Service Autonomous University of Guadalajara Cardiology Department, Guadalajara, Mexico 7/1979 10/1979 Residency Internal Medicine Texas Tech University School of Medicine El Paso, Texas 11/1979 6/1982 Residency Internal Medicine East Tennessee State University Quillen-Dishner College of Medicine Tennessee 7/1982 6/1984 Cardiology Fellowship University of Louisville School of Medicine Louisville, Kentucky 7/1983 6/1984 Research Fellowship Cardiology American Heart Association, Kentucky Affiliate Louisville, Kentucky 1984-1988 Assistant Professor of Medicine University of Louisville, Cardiology Division Louisville, KY 1988-1990 Clinical Assistant Professor University of Kentucky Lexington, KY

2 1988-1990 Clinical Assistant Professor University of Louisville Louisville, KY 1991-1996 Clinical Assistant Professor University of South Florida Tampa, FL 1999 21004 Nova Southern university College of Osteopathic Medicine, Fort Lauderdale, Florida. Clinical Assistant Professor 1995 - Present ACLS Instructor, American Heart Association LICENSURE 1990 1/31/2005 Florida ME 0047485 CERTIFICATIONS 9/1984 Diplomate American Board of Internal Medicine 11/1987 ABIM, Subspecialty Board of Cardiovascular Disease MEMBERSHIPS 11/1999 ABIM, Subspecialty Board of Interventional Cardiology American Medical Association Florida Medical Association Hillsborough County Medical Association American Heart Association American College of Physicians American College of Cardiology 2004-05/2005 Investigator Clinical Research of West Florida, Inc. 2727 W. MLK Jr. Blvd., Suite 460 33607 7/2001 - Present Interventional Cardiologist Cardiac Care Clinic of Tampa Bay 4600 North Habana, Suite 4 33614 1/2001 6/2001 Interventional Cardiologist Cardiac Care Clinic of Tampa Bay 2801 West Waters Ave., Suite B 33614 4/1998 12/2000 Interventional Cardiologist Health Centers of Excellence, Inc.

3 1/1994 4/1998 Interventional Cardiologist HeartCare Institute of Tampa 1994 1996 Director Coronary Care Unit University Community Hospital UCH 1994 1996 Chairman Internal Medicine Department Town & Country Hospital 1992 1993 Director Mobile Cardiac Catheterization Laboratory Centurion Hospital of Carrollwood 11/1990 12/1993 Interventional Cardiologist Cardiology of Tampa HOSPITAL AFFILIATIONS AND APPOINTED POSITIONS: Courtesy Memorial Hospital of Tampa Tampa, FL St. Joseph s Hospital Tampa, FL Tampa General Hospital Tampa, FL Town & Country Medical Center Tampa, FL University Community Hospital Tampa, FL Vencor Hospital Tampa, FL Courtesy Veterans Administration Medical Center Hospital Tampa, FL 1984-1986 Director, Cardiac Catheterization Laboratory VAMC, Louisville 1986-1988 Co-Director, Interventional Cardiology University of Louisville 1992-1993 Director, Mobile Cardiac Catheterization Laboratory Centurion Hospital of Carrollwood Tampa, FL 1994-1996 Director, Coronary Care Unit University Community Hospital, UCH 1994-1996 Chairman, Internal Medicine Department

Town & Country Hospital 4 2003-2004 Chairman, Saint Joseph s Heart Institute Advisory Council 1991- Present Member Editorial Board Hillsborough County Medical Assosciation, Tampa, FL 2004-Present 2006-Present Member Executive Council Hillsborough County Medical Association, Tampa, FL Secretary Hillsborough County Medical Association. RESEARCH EXPERIENCE 1986 1991 Principal Investigator UHSC 5-83 Extended Long-term treatment with oral Cibenzoline for premature ventricular contractions 1986 1988 Principal Investigator UHSC 143-84 A comparison of Sotalol to propranolol in the treatment of patients with frequent and repetitive ventricular activity 1986 1988 Principal Investigator Valvuloplasty in aortic Stenosis in the elderly 1986 1987 Principal Investigator P.T.C.A. in acute myocardial infarction 1986 1988 Principal Investigator Echocardiography evaluation of myocardial contusion 1994 Principal Investigator Synergy III PTCA Balloon, Boston Scientific Mansfield Boston Science U. Col. University Community Hospital 1997 1998 Principal Investigator Clinical Investigation of the Medtronic Model 5072 Fixed Screw, Endocardial Pacing Lead 1998 Principal Investigator Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy (TACTICS-TIMI 18) St. Joseph s Hospital Site, A randomized, double-blind, aspirin-controlled study with two dose regimens of sibrafiban (Ro48-3657) an oral platelet glycoprotein IIb/IIIa antagonist, in patients after

acute coronary syndrome 5 Clinical outcome from prevention of post-operative arrhythmia II: Rhythmol (COPPA II); Knoll A Double-Blind, Placebo-Controlled, Parallel Design Study to determine the Effect of 75 or 100 mg of Orally Administered Azimilide Dihydrochloride versus Placebo on survival in Recent Post-Myocardial Infarction Patients at Risk of Sudden Death (ALIVE); Proctor & Gamble 1997 HART II: Heparin and Reperfusion Therapy evaluating enoxaparin and IV Heparin in the setting of Myocardial Infarction. St. Joseph s Hospital, 1995 1996 Sub-Investigator PACT: Plasminogen-Activator. Compatibility Trial 1994 1995 Sub-Investigator Gusto II Trial at University Community Hospital, 1988 1990 Sub-Investigator Chronic Arrhythmia Suppression Trial (C.A.S.T. Study) National Institute of Health; University of Kentucky 1987 1990 Sub-Investigator Survival and ventricular enlargement (S.A.V.E.) following myocardial infarction. Long term, multicenter study 1987 1988 Sub-Investigator Bisoprolol in the treatment of angina pectoris. Clinical multicenter study; Cyanamid Corp. Orbofiban in Patients with Unstable Coronary Syndromes (OPUS-TIMI 16) 11/2000 Principal Investigator REPLACE Randomized Evaluation in PCI linking Angiomax to reduce Clinical Events 11/2000 Principal Investigator Clinical Evaluation of the new DINAMAP non-invasive Blood Pressure (NIBP) Technology

Office Study 6 2001-2003 Sub-Investigator Synergy, Phase III Duke Clinical Research 2002-Present Principal Investigator Replace-2 CAD, Phase III MY-021, Phase III STELLAR, Phase III MERCURY II, Phase III 2002 2003 Sub-Investigator Timi22 - CAD, Phase IV 2003 2004 Principal Investigator Ease-0653 Lipid, Phase III STARSHIP-0007, Phase III Type II Diabetes BD Study 2003 2004 Sub-Investigator CRESTOR-0003, Phase III AstraZeneca 4522US/0003, Phase III Enoximone-021 CHF, Phase III Rosuvastatin-0007 Hispanic Lipid, Phase III Timi38 PCI, Phase III Timi36 ACS, Phase III 2004 Current Principal Investigator ARISE-042 - Atherosclerosis, Phase III Formoterol-059 COPD, Phas 10/2004-Current Principal Investigator JUPITER AstraZeneca 4522US/0011 Phase III ARTICLES AND LECTURES: Dr. Coto has published more than 100 articles in Medical Journals, magazines and national and international newspapers and given hundreds of lectures nationally and internationally in the past 25 years ٠٠٠٠