Second Announcement Semmelweis. Symposium Semmelweis University, Budapest, Hungary November 6-8, 2014 Hotel Mercure Buda

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Second Announcement Semmelweis Symposium 2014 TRENDS IN PULMONOLOGY Semmelweis University, Budapest, Hungary November 6-8, 2014 Hotel Mercure Buda Conference Chair: György Losonczy General Secretaries: Gábor Horváth and Veronika Müller Secretary: Zsolt I. Komlósi

Preliminary program November 6 (Thursday) Opening Chair: György Losonczy, Semmelweis University, Budapest 8:30 Opening address Ágoston Szél, Rector of Semmelweis University I. Update on bronchial asthma and chronic obstructive pulmonary disease (COPD) Chair: Ildikó Horváth 9:00 Peter J. Barnes, Imperial College, London, UK New targets and treatments for COPD 9:25 Ildikó Horváth, Semmelweis University and National Korányi Institute, Budapest, Hungary Big data in asthma phenotyping 9:45 Paolo Paredi, Imperial College, London, UK Innovative approaches in exhaled biomarker measurements 10:10 Balázs Antus, National Korányi Institute, Budapest, Hungary Airway biomarkers in COPD 10:30 Discussion 10:40 Break II. New therapeutic concepts in obstructive lung diseases Chair: Gábor Horváth 11:00 Adam Wanner, University of Miami, USA Alpha-1 antitrypsin deficiency-related COPD 11:25 Andreas Schmid, University of Miami, USA Bronchiectasis: challenges in diagnosis and treatment 11:50 Matthias Salathe, University of Miami, USA Novel approaches to correct cystic fibrosis related airway disease: relevance to COPD? 12:15 Gábor Horváth, Semmelweis University, Budapest, Hungary Inhaled bronchodilators: mechanisms of drugs absorption in the airway 12:35 Discussion 12:45 Lunch

III. Non-invasive ventilation Chair: András Lorx 14:00 Wolfram Windisch, Merheim Lungenklinik, Cologne, Germany Home non-invasive ventilation in COPD: what is the best approach? 14:25 József Lukácsovits, Semmelweis University, Budapest, Hungary Physiological changes during low- and high-intensity non-invasive ventilation 14:45 Piero Ceriana, Pavia, Italy The difficult to- wean patient: role of rehabilitation and non-invasive ventilation 15:10 András Lorx, Semmelweis University, Budapest, Hungary The grey zone: indications and limitations of non-invasive ventilation in acute settings 15:30 Olli Polo, University of Turku, Finland Sleep apnea and the autonomic nervous system 15:55 Discussion 16:05 Break IV. Pulmonary hypertension Chair: Kristóf Karlócai 16:20 Anna Csiszár, University of Oklahoma, Oklahoma City, USA Ageing induced functional and phenotypic alterations in vascular cells 16:45 Gábor Kovács Jr., Medical University of Graz, Austria Right heart catheter at rest and exercise 17:05 Horst Olschewski, Medical University of Graz, Austria New therapies for pulmonary hypertension 17:25 Kristóf Karlócai, Semmelweis University, Budapest, Hungary Pregnancy and pulmonary hypertension 17:45 Discussion 19:00 Dinner November 7 (Friday) V. Rehabilitation Exercise physiology Chair: Attila Somfay 8:30 Richard H. Casaburi, University of California, Los Angeles, USA Pulmonary rehabilitation: a new focus on physical activity 8:55 Attila Somfay, University of Szeged, Szeged, Hungary Pharmacological and non-pharmacological interventions to reduce dynamic hyperinflation in patients with COPD

9:15 Péter Apor, Semmelweis University, Budapest Sarcopenia in pulmonology, cardiology and geriatrics 9:35 Miklós Tóth, Semmelweis University, Budapest, Hungary Exercise testing and mass-spectrometry 9:55 Discussion 10:05 Break VI. Lung cancer 1 Chair: Judit Moldvay 10:25 Paolo Boffetta, Tisch Cancer Institute, New York, USA Screening of lung cancer 11:50 Judit Moldvay, Semmelweis University, Budapest, Hungary Tight junction proteins in lung cancer 12:10 Helmuth Popper, University of Graz, Austria Molecular pathology of non-small cell lung cancer 12:35 Balázs Döme, Semmelweis University and National Korányi Institute, Budapest and Medical University of Vienna, Austria Angiogenesis in mesothelioma 12.55 Discussion 13:05 Lunch VII. Asthma in pregnancy Chair: Lilla Tamási 14:15 Christopher W.G. Redman, John Redcliffe, Oxford, UK Immunology of placentation 14:45 Lilla Tamási, Semmelweis University, Budapest, Hungary Asthma in pregnancy: immune changes and monitoring 15:00 Michael Schatz, Kaiser Permanente, San Diego, USA Asthma in pregnancy: diagnosis and treatment 15:25 János Rigó, Semmelweis University, Budapest, Hungary Medical disorders and preeclampsia 15:45 Discussion 15:55 Break VIII. Innate lymphoid cells and bronchial asthma Chair: Zsolt I. Komlósi 16:15 Mübeccel Akdis, Swiss Institute of Allergy and Asthma Research, Davos, Switzerland Mechanisms of peripheral tolerance to allergens

16:40 Zsolt I. Komlósi, Semmelweis University, Budapest, Hungary Immunoregulatory role for type 3 innate lymphoid cells 17:00 Burkhard Ludewig, St. Gallen, Switzerland Stromal cells regulate lymphoid organ development and immune responsiveness 17:25 Discussion 17:35 Break IX. Lung cancer 2 Chair: György Losonczy 17:45 Jean-Paul Sculier, Free University of Brussels, Belgium Targeted treatment of advanced stage non-small cell lung cancer 18:10 György Losonczy, Semmelweis University, Budapest, Hungary Risk and prevention of cisplatin nephrotoxicity 18:25 Chris Baylis, University of Gainesville, Florida, USA Physiology of toxic acute renal failure 18:50 Discussion 20:00 Gala Dinner (Marble Hall of the Museum of Military History, Buda Castle) November 8, Saturday X. Pulmonary complications in solid organ transplantation Chair: Veronika Müller 8:30 Uwe Heemann, Technical University Munich Optimizing immunosuppressive therapies to prevent pulmonary complications 8:55 Veronika Müller, Semmelweis University, Budapest, Hungary Pleuropulmonary changes in immunocompromized patients: infection or underlying disease? 9:15 György Lang, Semmelweis University, Budapest and Medical University of Vienna, Austria Bridge therapies from end-stage lung disease to lung transplantation 9:35 Nándor Marczin, Harefield Hospital, London, UK Optimizing donor lungs and perioperative recipient care in lung transplantation 10:00 Discussion 10:10 Break 10:25 Semmelweis Budapest Award Ceremony 11.00 Closing remarks György Losonczy