R e s e a r c h S t r a t e g y

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Sheffield Teaching Hospitals NHS Foundation Trust Academic Directorate of Urology R e s e a r c h S t r a t e g y

Academic Directorate of Urology Research Strategy Contents 1. Executive Summary 2. Current Research Strengths 3. Research Themes 4. Medical Education 5. Research Strategy Executive Summary The Department of Urology is one of the largest and busiest units within the UK. Staff include those employed by the Universities of Sheffield and Sheffield Hallam, and are well connected at the national and international level. Strengths include the large patient workload, diverse research interests, non-nhs research infrastructure and staff enthusiasm. Weaknesses are the lack of NHS research support (both nursing and clerical) and clinical time available to aid research. There is great potential to increase clinical research activity and patient recruitment, if better support was provided.

Current Research Strengths The directorate is one of the largest Academic Urology Units in the United Kingdom and has the privilege of hosting several NIHR appointments to train urological academics dealing with all aspects of urological practice. The department has a strong national and international profile (Europe and Worldwide). Ranked in the top 5 Academic Urology centres outside North America (European Urology 61(3), March 2012, 435 439). We host four senior appointments with academic positions and an international profile, including the peer reviewed appointments as Secretary General of the European Association of Urology (16,000+ members), Editor in Chief of the journal European Urology (highest ranked urological or surgical journal worldwide), Editor of the journal Neurourology and Urodynamics (journal of the International continence Society and the American Society of Urodynamics and Female Urology) We have four main research themes: Oncology Service redesign Quality of life and Functional urology that cover basic, translational and clinical research. We are one of the UKs largest (robotic) cancer centres, and provide a tertiary referral service in the fields of andrology, endourology, laparoscopy, reconstructive urology, spinal injuries and female urology. Strong history of recruitment to national portfolio funded trials.

Research Themes Our current research strengths match those of our research themes. Across Oncology and Functional urology we have several tiers of research active staff and strong academic collaborations both within Sheffield, within the UK and internationally. Within these themes we have four key themes: 1) Oncology: Prostate cancer: clinical trials and translational science into novel biomarkers Bladder and urothelial cancer: clinical trials and transitional science Genetics and personalized medicine: genomics in uro-oncology 2)Service Redesign: Pathway redesign in suspected prostate and bladder cancer. NIHR programme development grant to examine delivery of NICE guidelines exercise in advanced prostate cancer.

Research Themes 3) Quality of Life: Devices for Dignity programme: The department is strongly linked with Devices for Dignity (http://www.devicesfordignity.org.uk/focusareas/urinary). Prof Chapple is the theme lead for the urology theme within D4D, and there are a number of active research projects ongoing. Development of new PROMS (patient reported outcome measure) in bladder cancer Interventions for survivorship in prostate cancer Lead Derek J Rosario 4) Functional Urology Tissue engineering: Function and Pharmacology of the lower urinary tract Therapies to treat Lower Urinary Tract Symptoms Female Urology Andrology and male sexual dysfunction Endo-urology

Medical Education The Urology department has a strong track record in the delivery of medical education. The department has close links with the University of Sheffield Medical School and delivers all lecture based urology teaching to phase 1, 2 and phase 3b undergraduates. The Urology department has students attached to them throughout the academic year encompassing ICE, phase 2, phase 3b, phase 4 as well as student selected component students. There is weekly scheduled teaching for students within the department that is consultant delivered and undergraduate urology is lead from within the Urology department by Ms K Linton. The department contributes to yearly student examinations by the submission of SAQ and OSCE questions and examiners.

Research Strategy The aim of our research activity is to improve patient care, through developing and evaluating new approaches to the management of urinary tract disorders. We are well positioned to achieve this aim, given that we are one of the largest urological departments in the United Kingdom and amongst the best recognised in terms of clinical research, with an established tract record in basic science and clinical research. We intend to build upon these foundations to develop our research infrastructure, obtain further funding and to achieve our aim of improving patient care. We believe that this will provide enormous benefits to research activity within Sheffield Teaching Hospitals and for the clinical services we provide to our patients. The four themes that we have adopted are areas in which we feel we have particular strengths. 12

Sheffield Teaching Hospitals NHS Foundation Trust