EDUCATION University of Colorado Denver, Colorado Clinical and Translational Sciences Institute, Clinical Science Graduate Program, M.S. in Clinical Science. Expected completion May 2018. Stony Brook University School of Medicine, Stony Brook, New York. M.D. May 2010 New York University, College of Arts and Science, New York, New York. B.S. in Neural Science, Minors in Philosophy and Psychology. Cum Laude, May 2006 POSTGRADUATE TRAINING University of Colorado Denver, Aurora, Colorado. Behavioral Neurology Fellowship, 2015-2017 University of Colorado Denver, Aurora, Colorado. Movement Disorders Fellowship, 2014-2015 Rush University Medical Center, Chicago, Illinois. Neurology Residency, 2011-2014 Rush University Medical Center, Chicago, Illinois. Internal Medicine Internship, 2010-2011 ACADEMIC APPOINTMENTS Assistant Professor, Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, 2017-present EMPLOYMENT Staff Neurologist, Fee-Basis, Denver VA Medical Center, 2015-2017 CERTIFICATION AND LICENSURE Diplomate, American Board of Neurology and Psychiatry (Neurology), 2014-present Diplomate, United Council for Neurologic Subspecialties, Behavioral Neurology and Neuropsychiatry, 2016-present State of Colorado Medical License, 2013-present State of Illinois Medical License, 2010-2014 HONORS AND AWARDS National Institute of Health Loan Repayment Program Award, National Institute of Neurological Disorders and Stroke, 2017-2019 Leadership for Innovative Team Science (LITeS) program, Colorado Clinical and Translational Sciences Institute, 2017-2018 International Congress Travel Grant Award, Movement Disorders Society, 2017 Resident Scholarship to the Annual Meeting, American Academy of Neurology, 2014 1
Rush Neurology Resident Teacher of the Year Award, 2013 New York University Founder s Day Award, 2006 United Hospital Fund Volunteer Service Award 2005 NYU President s C-Team Century Club Award, 2004 PROFESSIONAL SOCIETY MEMBERSHIPS American Neuropsychiatric Association, 2016-present International Parkinson and Movement Disorder Society, 2014-present Colorado Society of Clinical Neurologists, 2014-present American Academy of Neurology, 2007-present President, Student Interest Group in Neurology, Stony Brook University School of Medicine chapter, 2007-2008 COMMITTEE ASSIGNMENTS University of Colorado School of Medicine Faculty Senate, 2017-2019 University of Colorado Department of Neurology Residency Selection Committee, 2017-present TEACHING EXPERIENCE Applied Neurologic Physical Therapy Elective, University of Colorado School of Medicine, Physical Therapy Program, July 2017 Functional Movement Disorders Neurology Resident Didactics, University of Colorado School of Medicine, June 2017 Neuropsychiatric Aspects of Movement Disorders AP Psychology, Peak to Peak High School, Lafayette, CO, January 2017 Introduction to Behavioral Neurology Nervous System block, University of Colorado School of Medicine, August 2016 Delirium and Dementia Camp Neuro, University of Colorado School of Medicine, June 2015, June 2016 1. Introduction to Behavioral Neurology 2. Neuropsychological Assessment Physical Medicine and Rehabilitation Residency Didactics, University of Colorado School of Medicine, June 2016 A Practical Approach to Dementia Diagnosis and Treatment General Neurology Teaching Elective, Rush University Medical Center, 2013-2014 Developed and refined a new elective rotation for senior neurology residents that focused on teaching 2
medical students on the General Neurology Service Teaching Assistant, Nervous System Block, Rush Medical College, Spring 2014 Led small group case-based discussions, assisted with brain gross anatomy sessions, and contributed clinical knowledge to basic science lectures MENTORING EXPERIENCE Regis University Neuroscience Undergraduate Internship Mentor Abigail Simpson, 2016-2017 University of Colorado Denver, Masters Thesis Defense Committee Hannah Redwine, 2017 RESEARCH SUPPORT Source: Michael J. Fox Foundation (MJFF) Project Title: Can baseline functional abilities predict future cognitive decline in Parkinson's disease? Role: Principal Investigator Purpose: Determine the predictive ability of a performance-based cognitive functional assessment for cognitive decline in Parkinson s disease and to delineate risk factors of future cognitive decline in PD Total Award: $164,988 Period of Support: 2017-2019 Source: Michael J. Fox Foundation (MJFF) Project Title: Validation of a performance-based assessment of functional ability related to cognition in Parkinson s disease Role: Principal Investigator Purpose: Evaluate the ability of the UCSD Performance-Based Skills Assessment to identify functional impairment as related to cognition in Parkinson s disease Total Award: $165,975 Period of Support: 2015-2017 Source: Patient Centered Outcome Research Institute (PCORI): Improving Healthcare Systems Project Title: Does Outpatient Palliative Care Improve Patient-Centered Outcomes in Parkinson's Disease? Role: Co-Investigator Purpose: This proposal supports a 3 center randomized controlled trial to evaluate the effectiveness of outpatient team-based palliative care versus usual care for Parkinson s disease. Total Award: $1,965,022 Period of Support: 2015-2018 Source: ProjectSpark Spark Grant Project Title: Home-based neurologic music therapy for management of behavioral symptoms of dementia Role: Principal Investigator Purpose: This award will provide funding to conduct a feasibility trial for empowering caregivers of community living persons with dementia to improve behavioral management and avoid nursing home placement Total Award: $7,200 Period of Support: 2016-2017 3
RESEARCH EXPERIENCE Site Principal Investigator, University of Colorado Denver 1. Clinical Trial: 17S-MC-HBEH: Effect of LY3154207 on Cognition in Mild-to-Moderate Parkinson s Disease Dementia (PDD), The PRESENCE Study Sponsor: Eli Lilly and Company Dates: November 2017-May 2019 Site Co-Principal Investigator, University of Colorado Denver, Lewy Body Dementia Association Research Center of Excellence, 2017-present Sub-Investigator, University of Colorado Denver, Rocky Mountain Alzheimer s Disease Center, 2015- present 1. Leukine Phase II trial for Alzheimer s disease, PIs: Huntington Potter, PhD and Jonathan Woodcock, MD 2. Aducanumab Phase III trial for Early Alzheimer s Disease (EMERGE), Site PI: Jonathan Woodcock, MD, Sponsor: Biogen Fellowship Research Project, University of Colorado Denver, Sections of Movement Disorders and Behavioral Neurology, 2014-2017 Performance-based Functional Assessment for Evaluation of Cognitive Impairment in Parkinson s Disease, Mentor: Benzi Kluger, MD Residency Research Project, Rush University Medical Center, Division of Movement Disorders, 2011-2014 Neuropsychological Assessment for Diagnosis of Mild Cognitive Impairment in Parkinson s Disease, Mentor: Jennifer Goldman, MD Research Assistant, New York University, Department of Cognitive Neuroscience, Phelps Lab, 2004-2006 Effect of Emotional Information on Working Memory, PI: Sara Levens, PhD REVIEW AND REFEREE WORK Ad hoc reviewer, The Journal of Neuropsychiatry and Clinical Neurosciences Ad hoc reviewer, Brain and Cognition Ad hoc reviewer, Parkinsonism & Related Disorders PUBLICATIONS Peer Reviewed Journal Articles Holden SK, Finseth T, Sillau SH, Berman BD. Progression of MDS-UPDRS scores over five years in de novo Parkinson disease from the PPMI cohort. Movement Disorders Clinical Practice 2017, e-pub ahead of print. Holden SK, Jones WE, Baker KA, Boersma IM, Kluger BM. Outcome measures for Parkinson s disease dementia: a systematic review. Movement Disorders Clinical Practice 2016 Jan-Feb;3(1):9-18. Goldman JG, Holden S, Ouyang B, Bernard B, Goetz CG, Stebbins GT. Diagnosing PD-MCI by MDS Task Force criteria: how many and which neuropsychological tests? Movement Disorders 2015 Mar;30(3):402-406. 4
Goldman JG, Holden S, Bernard B, Ouyang B, Goetz CG, Stebbins GT. Defining optimal cutoff scores for cognitive impairment using MDS Task Force PD-MCI criteria. Movement Disorders 2013 Dec;28(14):1972-9. Invited Review Articles Persenaire MJ, Holden SK, Palmer L, Redwine H, Berk J, Woodcock JH, Anderson CA, Filley CM, Kluger BM. Implementation issues relevant to outpatient neurology palliative care. Annals of Palliative Medicine 2017, in press. Goldman JG, Holden S. Treatment of psychosis and dementia in Parkinson s disease. Current Treatment Options in Neurology 2014 Mar;16(3):281. Abstracts Holden SK, Medina LD, Hoyt B, Sillau SH, Goldman JG, Weintraub D, Kluger BM. Validation of a performance-based assessment of functional ability related to cognition in Parkinson s disease. Movement Disorders 2017. Persenaire MJ, Holden S, Kluger BM, Woodcock JH, Anderson CA, Filley CM. Palliative care: A novel approach to patients with neurodegenerative disease. The Journal of Neuropsychiatry and Clinical Neuroscience 2016;28:e57-e58. Holden S, Lewis SL. Timeliness of neurology consultations in the emergency department: a quality evaluation. Neurology 2014 Apr;82(10)Supplement. Book Chapters Holden SK, Hall DA (2017). Ataxia. In Hall D and Barton B (Eds.), Non-Parkinsonian Movement Disorders (pp 68-79). West Sussex, UK: Wiley-Blackwell. Holden S, Goldman JG (2016). Parkinson s disease. In Friedman H (Ed.), Encyclopedia of Mental Health, 2 nd Edition (pp 242-248). Waltham, MA: Elsevier. LECTURES AND PRESENTATIONS Local Lectures Dementia with Lewy bodies: How is it different from Alzheimer s disease?. Invited speaker, Rocky Mountain Alzheimer s Disease Center Research Education Event, Aurora, CO, October 2017 "Movement Disorders and Frontotemporal Dementia". Invited speaker, Michael K. Cooper Neuropsychiatry Conference on Frontotemporal Dementia, Aurora, CO, September 2017 "Validation of a Performance-based Assessment of Functional Abilities Related to Cognition in Parkinson s Disease". Chosen speaker, Movement Disorders Center Annual Research Retreat, Aurora, CO, August 2017 "Non-motor symptoms in Parkinson s disease". Invited speaker, Parkinson s Association of the Rockies, Lakewood, CO, August 2017 5
"Chat with the Pros: Non-motor symptoms in Parkinson s disease". Invited speaker, Parkinson Association of the Rockies, Grand Junction, CO, June 2017 Non-motor symptoms of Parkinson s disease. AARP Colorado Educational Webinar, November 2016 "Chat with the Pros: Parkinson s disease 101". Invited speaker, Parkinson Association of the Rockies, Pueblo, CO, November 2016 "The ABCs of Alzheimer's Disease Diagnosis: A Primer for Families". Invited speaker, Alzheimer's Association Education Symposium, Denver, CO, October 2016 "REM Behavior Disorder: From Dreams to Neurodegeneration". Invited speaker, University of Colorado Behavioral Neurology Conference, Aurora, CO, September 2016 "Non-motor symptoms in Parkinson s disease." Invited speaker, Parkinson s Association of the Rockies E3: Educate, Empower, Energize 4 th Annual Conference, Aurora, CO, September 2016 "Cognitive Assessment in Parkinson s disease". Invited speaker, University of Colorado Movement Disorders Center Conference, Aurora, CO, August 2016 "Ahead of the Curve: Non-motor symptoms in Parkinson s disease". Invited speaker, Parkinson Association of the Rockies, April 2015, May 2016, June 2016 "Treatment options for Parkinson s disease". Invited speaker, Parkinson Association of the Rockies, Aurora Support Group, April 2016 "Cognitive Changes in Parkinson s disease". Invited speaker, Parkinson Association of the Rockies. August 2014, March 2015, November 2016 "Adult-onset leukodystrophies presenting as movement disorders". Department of Neurology Grand Rounds, University of Colorado School of Medicine, Aurora, CO, December 2014 "Validation of MDS Task Force Level II Diagnostic Criteria for Mild Cognitive Impairment in Parkinson s disease". Department of Neurology Grand Rounds: Resident Research Forum, Rush University Medical Center, Chicago, IL. May 2014 Poster Presentations Simpson AE, Holden SK. Effect of anti-dementia drugs on functional abilities related to cognition in Parkinson's disease. Department of Neurology Annual Research Retreat, University of Colorado Denver, June 2017. National Presentations "Cognitive functional assessment in Parkinson s disease". Presentation to Michael J. Fox Foundation for Parkinson s Research Cognitive Advisory Committee, New York, NY, May 2017. "Determining Optimal Cutoff Scores and Neuropsychological Tests for the Diagnosis of Mild Cognitive Impairment in Parkinson's disease". Platform presentation at American Academy of Neurology Annual Meeting, Philadelphia, PA, April 2014 6
"A Loss of Language: A Case of Landau-Kleffner Syndrome". Case presentation at Neurology Resident Scholar Program, Scottsdale, AZ, September 2012 7