MILAN CARDIOLOGY. Milan (Italy), February, 18 th - 20 th, Organized by. Promoted by PRELIMINARY PROGRAM

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Milan Cardiology February 18 th - 20 th, 2016 MILAN CARDIOLOGY Milan (Italy), February, 18 th - 20 th, 2016 Organized by Promoted by PRELIMINARY PROGRAM San Raffaele Congress Centre (Via Olgettina, 58)

Milan Cardiology February 18 th - 20 th, 2016 Dear Colleagues, it is a great pleasure to invite you to the International Congress Milan Cardiology, to be held on February 18 th - 20 th, 2016 at the Ospedale San Raffaele in Milan. This third meeting will provide an in depth update on some of the hottest topics in Cardiology. We decided to link pathophysiology information with clinical example whenever possible, in order to offer an update focused mostly in the pratical aspect of our discipline. All this will be only possible through an outstanding international Faculty that will see together some of the world s experts in the field. I hope that the Milan Cardiology 2016 will be an extremely productive meeting, able to provide you with a valid opportunity to improve your understanding of this complex and rapidly evolving area of medicine. I look forward to welcoming you in Milan next February. Paolo G. Camici Chairman 2

Under the Auspices of Associazione Nazionale Medici Cardiologi Ospedalieri Brigham and Women s Hospital Società Italiana di Cardiologia Sistema Sanitario Regione Lombardia Università Vita-Salute San Raffaele Chairman Paolo G. Camici Full Professor of Cardiology, Università Vita-Salute San Raffaele (Milan, Italy) Head of Myocardial Diseases Center, Ospedale San Raffaele (Milan, Italy) Scientific Committee Ottavio Alfieri, Domenico Cianflone, Antonio Colombo, Marcelo Fernando Di Carli, Peter Libby, Alberto Margonato, Marc Pfeffer, Paul Ridker, Ornella E. Rimoldi, Hiroaki Shimokawa Promoted by Fondazione Internazionale Menarini Centro Direzionale Milanofiori I-20089 Rozzano (Milan, Italy) Edificio L - Strada 6 Phone +39 02 55308110 - Fax +39 02 55305739 E-mail: milan@fondazione-menarini.it www.fondazione-menarini.it Organising Secretariat 3 Acheloís Via Olgettina, 58 - I-20132 Milan (Italy) Phone +39 02 2643 6227 - Fax +39 02 2643 3754 E-mail: info@milancardiology.com www.milancardiolology.com

Thursday, February 18 th 2016 - Morning 09.00-09.30 Introduction from Local Authorities SESSION 1 Chairmen: Atherosclerosis, Inflammation and Plaque Vulnerability P. Libby (Boston, USA) C.N. Bairey Merz (Los Angeles, USA) 09.30-09.45 J. Chapman (Paris, F) LDL - How low can and should we go 09.45-10.00 G. Pasterkamp (Utrecht, NL) Is the vulnerable plaque receding? The impact of sex differences on natural history and therapeutic efficacy 10.00-10.15 J.C. Kaski (London, UK) Chronic inflammation and rapid CAD progression 10.15-10.30 P. Libby (Boston, USA) Lipid-inflammation interface 10.30-10.45 F. Crea (Rome, IT) Plaque Vulnerability and Inflammation 10.45-11.00 Discussion 11.00-11.20 Coffee break 4

Thursday, February 18 th 2016 - Morning SESSION 2 Chairmen: Risk Prediction and Reduction: Old Certainties and Novel Promises P.M. Ridker (Boston, USA) M. Volpe (Rome, IT) 11.20-11.35 U. Landmesser (Berlin, D) HDL and coronary heart disease 11.35-11.50 M. Volpe (Rome IT) Lifetime risk in hypertension 11.50-12.05 N. Cook (Boston, USA) Controversies emerged from the 2013 AHA/ACC cholesterol guidelines 12.05-12.20 A. Lerman (Rochester, USA) Mitochondrial dysfunction 12.20-12.35 P.M. Ridker (Boston, USA) Anti-inflammatory therapies 12.35-12.50 Discussion 12.50-14.00 Lunch 5

Thursday, February 18 th 2016 - Afternoon SESSION 3 Chairmen: Assessing the patient with Chest Pain and Normal Coronary Angiogram H. Ogawa (Kunamoto City, Japan) F. Crea (Rome, IT) 14.00-14.15 H. Shimokawa (Sendai, Japan) Provocative spasm testing 14.15-14.30 U. Sechtem (Stuttgart, D) Microvascular spasm 14.30-14.45 M. Marzilli (Pisa, IT) Ischemia beyond epicardial stenosis 14.45-15.00 P.G. Camici (Milan, IT) The spectrum of coronary microvascular dysfunction 15.00-15.15 C.N. Bairey Merz (Los Angeles, USA) Diagnostic flowchart 15.15-15.30 All Panel Cases for discussion 15.30-15.50 Coffee break 6

Thursday, February 18 th 2016 - Afternoon SESSION 4 Chairmen: Non invasive Imaging in the Management of Cardiac Patients M.F. Di Carli (Boston, USA) O.E. Rimoldi (Milan, IT) 15.50-16.05 M. Galderisi (Naples, I) Echocardiography in acute cardiovascular care 16.05-16.20 O. Gaemperli (Zurich, CH) Prognostic value of CTA for asymptomatic patients 16.20-16.35 V. Ferreira (Oxford, UK) CMR: virtual histology in cardiomyopathies 16.35-16.50 M.F. Di Carli (Boston, USA) Myocardial blood flow quantification and risk stratification of IHD 16.50-17.05 F.M. Bengel (Hannover, D) Molecular imaging for prediction of arrhythmias 17.05-17.20 All Panel Cases for discussion 7

Friday, February 19 th 2016 - Morning SESSION 5 Chairmen: Acute Coronary Syndromes A. Chieffo (Milan, IT) A. Latib (Milan, IT) 09.00-09.15 R. Virmani (Washington DC, USA) A closer look at the mechanisms: The view of the pathologist 09.15-09.30 G. Guagliumi (Bergamo, IT) A look from inside: OCT 09.30-09.45 D. Antoniucci (Florence, IT) Contemporary treatment of STEMI 09.45-10.00 D. Cianflone (Milan, IT) Optimal Pharmacologic treatment 10.00-10.15 P.G. Camici (Milan, IT) MVO and prognosis in recanalized STEMI 10.15-10.30 All Panel Cases for discussion 10.30-10.50 Coffee break 8

Friday, February 19 th 2016 - Morning SESSION 6 Chairmen: IHD: Treatments and Devices F. Romeo (Rome, IT) H. Shimokawa (Tohoku, Japan) 10.50-11.05 S. Nakamura (Tokyo, Japan) Current approaches to CTO treatment 11.05-11.20 A. Margonato (Milan, IT) Anticoagulant/antiplatelet therapy in patients undergoing non-cardiac surgery 11.20-11.35 A. Colombo (Milan, IT) New recanalization techniques 11.35-11.50 C. Tamburino (Roma, IT) Bio-Absorbable Stents 11.50-12.05 F. Romeo (Rome, IT) Cardiac assist devices 12.05-12.20 All Panel Cases for discussion 12.20-13.30 Lunch 9

Friday, February 19 th 2016 - Afternoon SESSION 7 Chairmen: Heart Failure (HF) P.A Maggioni (Florence, IT) J. Holzmeister (Zürich, CH) 13.30-13.45 M.R. Cowie (London, UK) How to risk stratify patients with HF 13.45-14.00 M. Metra (Brescia, IT) New Therapeutic Approaches for AHF 14.00-14.15 K. Swedberg (Gothenburg, S) An overview of recent HF trials 14.15-14.30 M. Pfeffer (Boston, USA) HF with preserved ejection fraction 14.30-14.45 F. Pappalardo (Milan, IT) Treatment of end stage HF 14.45-15.00 All Panel Cases for discussion 15.00-15.20 Coffee break 10

Friday, February 19 th 2016 - Afternoon SESSION 8 Chairmen: Heart Failure (HF) M.R. Cowie (London, UK) M. Pfeffer (Boston, USA) 15.20-15.35 F. Gaita (Torino, IT) Management of AF in HF 15.35-15.50 L.A. Menicanti (Milano, IT) LV reshaping procedures 15.50-16.05 D. Pagano (Birmingham, UK) The quest for hibernating myocardium: still a role? 16.05-16.20 A.P. Maggioni (Florence, IT) Has the epidemiology of HF changed in the past decade? 16.20-16.35 O. Gaemperli (Zurich, CH) Non invasive imaging for stratification and treatment 16.35-16.50 All Panel Cases for discussion 17.00-17.50 Special Lectures: Introduced by P.G. Camici T.F. Lüscher (Zurich, CH) Editor in Chief of the European Heart Journal Good scientific publishing - from the idea to a publication and impact M. Metra (Brescia, IT) Editor in Chief of the European Journal of Heart Failure Recent advances in heart failure treatment 11

Saturday, February 20 th 2016 - Morning SESSION 9 Chairmen: Diseases of the Myocardium P. Elliott (London, UK) G. d Amati (Rome, IT) 09.00-09.15 P. Elliott (London, UK) The ESC Guidelines on HCM 09.15-09.30 I. Olivotto (Florence, IT) Gene mutations and clinical outcome in HCM 09.30-09.45 G. Sinagra (Trieste, IT) Pathophysiology of DCM 09.45-10.00 C. Basso (Padua, IT) Sudden death in CMP 10.00-10.15 H.P. Schultheiss (Berlin, D) Endomyocardial biopsy in suspected myocarditis: implications for treatment 10.15-10.30 All Panel Cases for discussion 10.30-10.50 Coffee break 12

Saturday, February 20 th 2016 - Morning SESSION 10 Chairmen: Valve Disease: the HEART TEAM (HT) G. La Canna (Milan, IT) J.L. Zamorano (Madrid, E) 10.50-11.05 C. Tamburino (Catania, IT) Mitral and tricuspid valves 11.05-11.20 J.L. Zamorano (Madrid, ES) Non invasive imaging in the HT 11.20-11.35 F. Maisano (Zurich, CH) Aortic valve 11.35-11.50 O. Alfieri (Milan, IT) HT: what remains to be done 11.50-12.05 A. Latib (Milan, IT) Do we need the HT for the coronaries? 12.05-12.20 All Panel How does the Heart Team work Meeting ends 13

LIST OF CHAIRMAN, SCIENTIFIC COMMITTEE AND INVITED FACULTY Ottavio Alfieri Università Vita-Salute San Raffaele Ospedale San Raffaele Milan (Italy) David Antoniucci Azienda Ospedaliera-Universitaria Careggi Firenze (Italy) C. Noel Bairey Merz Barbra Streisand Women s Heart Centre Los Angeles - CA (USA) Cristina Basso Università degli Studi di Padova Padua (Italy) Frank M. Bengel Klinikum für Nuklearmedizin Hannover (Germany) John Chapman Hôpital de la Pitié Paris (France) Alaide Chieffo Ospedale San Raffaele Milan (Italy) Domenico Cianflone Università Vita-Salute San Raffaele Ospedale San Raffaele Milan (Italy) Antonio Colombo Ospedale San Raffaele Milan (Italy) 14

LIST OF CHAIRMAN, SCIENTIFIC COMMITTEE AND INVITED FACULTY Nancy Cook Brigham and Women s Hospital Boston - MA (USA) Martin R. Cowie Imperial College London London (United Kingdom) Filippo Crea Università Cattolica del Sacro Cuore Policlinico Universitario Agostino Gemelli Rome (Italy) Giulia d Amati Sapienza - Università di Roma Rome (Italy) Marcelo Fernando Di Carli Brigham and Women s Hospital Boston - MA (USA) Perry Elliott The Heart Hospital London (United Kingdom) Vanessa Ferreira University of Oxford Oxford (United Kingdom) Oliver Gaemperli University Hospital of Zürich Zürich (Switzerland) Fiorenzo Gaita Azienda Ospedaliera S. Giovanni Battista Torino (Italy) 15

LIST OF CHAIRMAN, SCIENTIFIC COMMITTEE AND INVITED FACULTY Maurizio Galderisi Università degli Studi di Napoli Federico II Naples (Italy) Giulio Guagliumi Azienda Ospedaliera Papa Giovanni XXIII Bergamo (Italy) Johannes Holzmeister University Hospital Zürich Zürich (Switzerland) Juan Carlos Kaski University of London London (United Kindom) Giovanni La Canna Ospedale San Raffaele Milan (Italy) Ulf Landmesser Charité - Universitätsmedizin Berlin Berlin (Germany) Azeem Latib Ospedale San Raffaele Milan (Italy) Amir Lerman Mayo Clinic Rochester - MN (USA) Peter Libby Brigham and Women s Hospital Boston - MA (USA) Thomas F. Lüscher University Hospital Zürich Zürich (Switzerland) 16

LIST OF CHAIRMAN, SCIENTIFIC COMMITTEE AND INVITED FACULTY Aldo Pietro Maggioni Centro Studi A.N.M.C.O. Florence (Italy) Francesco Maisano Klinik für Herz - und Gefässchirurgie, UniversitätsSpital Zürich Zürich (Switzerland) Alberto Margonato Università Vita-Salute San Raffaele Ospedale San Raffaele Milan (Italy) Mario Marzilli Università degli Studi di Pisa Pisa (Italy) Lorenzo A. Menicanti IRCCS Policlinico San Donato San Donato Milanese, Milan (Italy) Marco Metra Università degli Studi di Brescia Brescia (Italy) Sunao Nakamura New Tokyo Hospital Chiba (Japan) Hisao Ogawa Kumamoto University Graduate School of Medicine Kumamoto City (Japan) Iacopo Olivotto Azienda Ospedaliero-Universitaria Careggi Florence (Italy) 17

LIST OF CHAIRMAN, SCIENTIFIC COMMITTEE AND INVITED FACULTY Domenico Pagano University Hospital Birmingham-Queen Elizabeth Birmingham (United Kingdom) Federico Pappalardo Ospedale San Raffaele Milan (Italy) Gerard Pasterkamp Universiteit Utrecht Utrecht (The Netherland) Marc Pfeffer Brigham and Women s Hospital Boston (MA, USA) Paul M. Ridker Brigham and Women s Hospital Boston - MA (USA) Ornella E. Rimoldi Ospedale San Raffaele Milan (Italy) Francesco Romeo Università degli Studi di Roma Tor Vergata Rome (Italy) Heinz-Peter Schultheiss Charité Campus Benjamin Franklin Berlin (Germany) Udo Sechtem Robert-Bosch-Krankenhaus Stuttgart (Germany) Hiroaki Shimokawa Tohoku University Graduate School of Medicine Tohoku (Japan) 18

LIST OF CHAIRMAN, SCIENTIFIC COMMITTEE AND INVITED FACULTY Gianfranco Sinagra Azienda Ospedaliero-Universitaria Ospedali Riuniti Trieste (Italy) Karl Swedberg University of Gothenburg Gothenburg (Sweden) Corrado Tamburino Università degli Studi di Catania Catania (Italy) Renu Virmani Path Institute Gaithersburg - MD (USA) Massimo Volpe Sapienza - Università di Roma Ospedale Sant Andrea Rome (Italy) Jose Luis Zamorano Hospital Clínico San Carlos Madrid (Spain) 19

GENERAL INFORMATION Meeting venue The venue of the Meeting will be the San Raffaele Congress Centre (Via Olgettina, 58 - Milan, Italy). Phone +39 02 2643 6227 - Fax +39 02 2643 3754. Secretariat during the Meeting The Secretariat will be opened at the following times: Thursday, February 18 th, from 07.30 a.m. to 05.30 p.m. Friday, February 19 th, from 08.00 a.m. to 06.00 p.m. Saturday, February 20 th, from 08.00 a.m. to 01.00 p.m. Official Language The official language of the Congress is English. Simultaneous translation Italian/ English/Italian will be provided. Registration The Meeting is free to attend. Please return the Registration form to: Acheloís - Via Olgettina 58-20132 Milan (Italy) E-mail: info@milancardiology.com - Fax: +39 02 2643 3754 or visit the official website www.milancardiology.com for the online registration. EBAC The Congress will be included in the Educational Program of the European Board for Accreditation in Cardiology. CME Credits The Congress was granted 7,5 C.M.E. credits from the Italian Ministry of Health for physicians specialized in Cardiac surgery, Cardiology, Emergency medicine, General medicine, Geriatric, Internal medicine, Metabolic disease and diabetology, Nuclear Medicine, Pharmacology and clinical toxicology, Radiodiagnostic. CME Provider - MZ Congressi Srl - ID 966 Technical facilities Facilities will be available for computer presentations and overhead projections. A slide center with PC (Powerpoint for Windows) will be available for check and preview of presentations. It is essential that speakers take their presentation to the slide center at least one hour before the session starts. It will be opened at the following times: Thursday, February 18 th, from 07.30 a.m. to 05.30 p.m. Friday, February 19 th, from 08.00 a.m. to 05.30 p.m. Saturday, February 20 th, from 08.00 a.m. to 12.30 p.m. Lunches and coffee breaks Lunches and coffee breaks will be served in the Meeting area. Certificate of attendance The certificate of attendance will be available on request at the end of the Meeting at the Secretariat. 20

Milan Cardiology February 18 th - 20 th, 2016 MILAN CARDIOLOGY Milan (Italy), February, 18 th - 20 th, 2016 Physician Postgraduate Please complete and return the entire registration form to: Acheloís S.r.l. - Via Olgettina, 58-20132 Milan - Italy e-mail: info@milancardiology.com - Fax: +39 02 2643 3754 Surname Name Institute Mailing address City Country Postal Code Phone Fax e-mail Date Signature Achelois S.r.l. and Fondazione Internazionale Menarini, as data controllers, informs you that any personal data you provide, or any data lawfully received by third parties, will be used in connection to your participation to the Congress and/or to provide you with information regarding any other compatible activities organized by us. Your image, taken during the event, may be reproduced in videos and photos of the event and published on the website and social networks of Achelois (and on the website and social networks of the event, if any) and Fondazione Internazionale Menarini. Data treatment shall mean any operation, or set of operations, carried out with or without the help of electronic or automated means, and must guarantee the confidentiality and security of your personal data. Achelois and Fondazione Internazionale Menarini, as data controllers, may avail itself to carry out any of the following procedures: press releases, communications to clients, data processing and computer-based consultation. The provision of your personal data for purposes related to your participation to the congress, including the publishing of images, is obligatory, but refusal will prevent your participation to the congress. You have the right in any moment to access, correct, integrate, refuse the treatment pursuant to section 7 of the Legislative Decree no. 196 of 30 June 2003 addressing any requests to: Achelois Srl - Via Larga 8-20122 Milano - info@milancardiology.com or to Fondazione Menarini - Centro Direzionale Milanofiori - 20089 Rozzano (MI) - Edificio L - Strada 6