University of Groningen Apoptosis and autoantibodies in systemic lupus erythematosus Bijl, Marc IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2001 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Bijl, M. (2001). Apoptosis and autoantibodies in systemic lupus erythematosus Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 31-12-2017
APOPTOSIS AND AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS Marc Bijl
The studies in this thesis were supported by grant NSN C95.1482 from the Dutch Kidney foundation. The publication of this thesis was financially supported by: Boehringer Ingelheim B.V. Groningen Utrecht Institute for Drug Exploration GUIDE Merck Sharp & Dohme B.V. Novartis Pharma B.V. Pharmacia B.V. Roche Nederland B.V. Stichting Ontwikkeling Klinische Immunologie Groningen Wyeth-Lederle B.V. Cover illustration: apoptotic Jurkatt cells binding to and internalised by cultured human macrophages. Apoptosis and autoantibodies in Systemic Lupus Erythematosus Marc Bijl Thesis University Groningen ISBN 90-367-1431-1 M. Bijl All rights reserved Printed by Ridderprint B.V., Ridderkerk, The Netherlands
RIJKSUNIVERSITEIT GRONINGEN APOPTOSIS AND AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS PROEFSCHRIFT ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. D.F.J. Bosscher, in het openbaar te verdedigen op woensdag 30 mei 2001 om 16.00 uur door Marc Bijl geboren op 13 december 1961 te Arnhem
Promotor: Prof. dr. C.G.M. Kallenberg Co-promotor: Dr. P.C. Limburg ISBN: 90-367-1431-1
Beoordelingscommissie: Prof. dr. J.H.M. Berden Prof. dr. J.W.J. Bijlsma Prof. dr. M.H. van Rijswijk Paranimfen: Gerda Horst Siebren Schaafsma
Contents Chapter I: General introduction and aim of the thesis 1 page Chapter II: Patients with systemic lupus erythematosus with high plasma levels of sfas risk relapse J Rheumatol 1999;26:60-7 9 Chapter III: Do elevated levels of serum soluble Fas contribute to the persistence of activated lymphocytes in systemic lupus erythematosus? J Autoimmunity 1998;11:457-63 25 Chapter IV: Fas expression on peripheral blood lymphocytes of systemic lupus erythematosus (SLE) patients: relation to lymphocyte activation and disease activity Submitted for publication 39 Chapter V: Effects of smoking on activation markers, Fas expression and apoptosis of peripheral blood lymphocytes Eur J Clin Invest, accepted for publication 51 Chapter VI: Anti-CD3-induced and anti-fas-induced apoptosis in systemic lupus erythematosus (SLE) Clin Exp Immunol 2001;123:127-32 61 Chapter VII: Expression of costimulatory molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus Ann Rheum Dis, accepted for publication 75
Chapter VIII: IgG subclass distribution of autoantibodies differs between renal and extra-renal relapses in patients with systemic lupus erythematosus Submitted for publication 85 Chapter IX: Fc receptor polymorphisms in systemic lupus erythematosus: association with disease and in vivo clearance of immune complexes Arthritis Rheum 2000;43:2793-800 101 Chapter X: New insights into the pathogenesis of systemic lupus erythematosus (SLE): the role of apoptosis (review) Submitted for publication 117 Chapter XI: Summary and conclusions 133 Chapter XII: Nederlandse samenvatting 141 Dankwoord 153 Curriculum Vitae 156