October 19th 21st 2017 Palazzo Brancaccio Rome (Italy) International Symposium on: Organized by: University of Rome Tor Vergata FINAL PROGRAM

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Organized by: University of Rome Tor Vergata International Symposium on: EACCME event reference number LEE17-00219 October 19th 21st 2017 Palazzo Brancaccio Rome (Italy) FINAL PROGRAM

PRESIDENT OF THE MEETING Mario Cazzola University of Rome Tor Vergata Paola Rogliani University of Rome Tor Vergata SCIENTIFIC SECRETARIAT Nicola A. Hanania (USA) Maria Gabriella Matera (IT) Clive Page (UK) PROMOTED BY Fondazione Internazionale Menarini Centro Direzionale Milanofiori I-20089 Rozzano (Milan, Italy) Edificio L Strada 6 Phone: +39 02 55308110 Fax: +39 02 55305739 E-mail: milan@fondazione-menarini.it www.fondazione-menarini.it ORGANIZING SECRETARIAT Marben S.r.l. Via Melzi d Eril, 20 I-20154 Milan (Italy) Phone: +39 02 3491732 Fax: +39 02 3401629 www.marben.it 3

PROGRAMME THURSDAY, OCTOBER 19 TH 2017 - AFTERNOON OPENING CEREMONY 02:00 p.m. 02:20 p.m. Chairperson: 02:40 p.m. Mario Cazzola (Rome, IT), Paola Rogliani (Rome, IT) Welcome addresses Giuseppe Novelli (Rome, IT) Health and Innovative Research: Mission and Goals for the University facing the Emerging Challenges Mario Cazzola (Rome, IT) Peter J. Barnes (London, UK) The evolution of bronchodilation over time: from Ephedra equisetina to MABAs SESSION I - PHARMACOLOGY OF BRONCHODILATORS 03:25 p.m. 03:55 p.m. 04:25 p.m. 05:00 p.m. 05:45 p.m. Achille Patrizio Caputi (Messina, IT), Girolamo Pelaia (Catanzaro, IT) Andrea Bianco (Campobasso, IT), Luigino Calzetta (Rome, IT) Reynold A. Panettieri (Philadelphia, USA) The physiological rationale for using bronchodilators Maria Gabriella Matera (Naples, IT) The pharmacological optimization of bronchodilation Clive Page (London, UK) Emerging classes of bronchodilators 4

FRIDAY, OCTOBER 20 TH 2017 MORNING SESSION II - GENERAL QUESTIONS TO BE ADDRESSED TO OPTIMISE USE OF BRONCHODILATORS IN COPD. I. Giorgio Walter Canonica (Milan, IT), Stefano Centanni (Milan, IT) Pierachille Santus (Milan, IT), Alessandro Vatrella (Salerno, IT) 09:00 a.m. 09:30 a.m. 10:00 a.m. 10:30 a.m. 10:45 a.m. Marc Miravitlles (Barcellona, ES) Is it appropriate to treat all COPD patients with long-acting bronchodilators? Nicolas Roche (Paris, F) Is it better to start with a β2-agonist or with an antimuscarinic agent? Claudio Tantucci (Brescia, IT) Is it useful to use a bronchodilator with a rapid onset of action? COFFEE BREAK SESSION III - GENERAL QUESTIONS TO BE ADDRESSED TO OPTIMISE USE OF BRONCHODILATORS IN COPD. II. 11:15 a.m. 11:45 a.m. 12:15 p.m. 12:45 p.m. 01:00 p.m. Francesco Blasi (Milan, IT), Claudio F. Donner (Borgomanero, IT) Fulvio Braido (Milan, IT), Carlo Gulotta (Turin, IT) Dave Singh (Manchester, UK) Is once- or twice-daily dosing referable? Roland Buhl (Mainz, GE) When can we add a second bronchodilator with a different mechanism of action? J. Christian Virchow (Rostock, GE) When must we add an ICS? LUNCH 5

FRIDAY,OCTOBER 20 TH AFTERNOON SESSION IV - THERAPEUTICS OF BRONCHODILATORS 02:00 p.m. 02:30 p.m. 03:00 p.m. 03:30 p.m. 04:00 p.m. Maria Pia Foschino Barbano (Foggia, IT), Pierluigi Paggiaro (Pisa, IT) Marco Contoli (Ferrara, IT), Alexandru Corlateanu (Chișinău, MD) Gaetano Caramori (Messina, IT) The role of bronchodilators in the management of asthma Andrea Rossi (Verona, IT) The role of bronchodilators in the management of COPD Fernando J. Martinez (New York, USA) Bronchodilators focused on treatable traits in airway diseases COFFEE BREAK SESSION V - BRONCHODILATORS AND PHYSICAL ACTIVITY 04:30 p.m. 05:00 p.m. 05:30 p.m. Enrico Clini (Modena, IT), Paolo Palange (Rome, IT) Fabiano di Marco (Milan, IT), Josuel Ora (Rome, IT) Denis O Donnell (Kingston, CDN) Assessing the exercise response to bronchodilators Vito Brusasco (Genoa, IT) Use of bronchodilation in athletes and the abuse of bronchodilators KEYNOTE LECTURE 06:00 p.m. Luca Richeldi (Rome, IT) Jadwiga A. Wedzicha (London, UK) Preventing acute exacerbations of COPD according to their nature 6

SATURDAY, OCTOBER 21 ST 2017 MORNING SESSION VI - CONTROVERSIES SURROUNDING BRONCHODILATORS. I. 09:00 a.m. 09:30 a.m. 10:00 a.m. 10:30 a.m. 11:15 a.m. Massimo Pistolesi (Florence, IT), Nunzio Crimi (Catania, IT) Federico Lavorini (Florence, IT), Elisiana Carpagnano (Foggia, IT) Omar S. Usmani (London, UK) Which device for which patient? Nicola Scichilone (Palermo, IT) Bronchodilators in older patients Salvatore Cuzzocrea (Messina, IT) Pharmacogenetics of airway obstruction and bronchodilators COFFEE BREAK SESSION VII - BRONCHODILATORS AND CARDIOVASCULAR DISEASE. II. 11:30 a.m. 12:00 a.m. 12:30 p.m. Leonardo M. Fabbri (Modena, IT), Antonio Spanevello (Varese, IT) Angelo G. Corsico (Pavia, IT), Ermanno Puxeddu (Rome, IT) Nicola A. Hanania (Houston, USA) Bronchodilators and cardiovascular disease Guy Brusselle (Ghent, B) Bronchodilators and polypharmacy KEYNOTE LECTURE Paola Rogliani (Rome, IT) 01:15 p.m. 02:15 p.m. 02:45 p.m. 03:30 p.m. Bartolomé Celli (Boston, USA) Outcomes and markers for evaluating the effectiveness of bronchodilators: From lung function to multidimensional grading systemsa Paola Rogliani (Rome, IT), Mario Cazzola (Rome, IT) Concluding Remarks C.M.E. EVALUATION TEST 7

GENERAL INFORMATION MEETING VENUE Palazzo Brancaccio - Viale del Monte Oppio, 7-00184 Roma. REGISTRATION HOURS The Registration Desk will be open during the following hours: Thursday, October 19th Friday, October 20 th Saturday, October 21 st from 01.00 p.m. to 06.00 p.m. from 08.00 a.m. to 07.00 p.m. from 08.00 a.m. to 03.30 p.m. OFFICIAL LANGUAGE English. Simultaneous translation will not be provided. REGISTRATIONS The registration is free of charge. Please confirm the participation to the Organizing Secretariat (Marben S.r.l. Phone: +39 02 3491732 Fax: +39 02 3401629. E-mail: iolivares@marben.it) within Friday, October 13rd, 2017. ITALIAN CME ACCREDITATION Reference ID 198404 N. 11,9 Italian CME credits The CME credits will be awarded only after full attendance of all sessions. Completion of the Registration Form, the Learning & Assessment questionnaires are compulsory. EUROPEAN ACCREDITATION EACCME event reference number LEE17-00219 N. 15 European CME credits TECHNICAL FACILITIES A Slide Center with PCs (Windows and Macintosh operating systems) will be available for Speakers to preview and finalize their presentations. Speakers are kindly requested to submit their presentations to the Slide Center technicians at least one hour before their talks. SLIDE CENTRE OPENING HOURS: Thursday, October 19 th from 01.00 p.m. to 06.00 p.m. Friday, October 20 th from 08.00 a.m. to 07.00 p.m. Saturday, October 21 st from 08.00 a.m. to 03.30 p.m. LUNCHES AND COFFEE BREAKS Lunches and coffee breaks will be provided within the conference premises. ATTENDANCE CERTIFICATE The attendance certificate will be issued at the accreditation desk following full attendance at the Conference. 8

NOTE

NOTE

Fondazione Internazionale Menarini Symposia: n. 355