Program Agenda. Ottawa Heart Research Conference (OHRC): Steadying the Future of Atrial Fibrillation. Thursday, June 2 nd (Day 1)

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Ottawa Heart Research Conference (OHRC): Steadying the Future of Atrial Fibrillation Thursday, June 2 nd (Day 1) 8:00 am Welcome Message Drs. David Birnie, Peter Liu, and Thierry Mesana 8:15 9:35 am Session 1: Exercise, Lifestyle, Obesity, Primary Prevention of AF Chair: Dr. Calum Redpath 8:15 am Basic Science Insights into Exercise, Lifestyle, Obesity, Primary Prevention of AF Dr. Peter Backx, University of Toronto 8:35 am Aggressive Risk Factor Modification to Reduce Atrial Fibrillation: Is the Evidence Conclusive? Dr. Ratika Parkash, Dalhousie University 8:55 am Can Exercise Improve Quality of Life in Patients with Permanent AF? Dr. Jennifer Reed, University of Ottawa Heart Institute 9:15 am Panel Discussion 9:35 10:55 am Session 2: Rotors and AF/Atrial Remodeling Chair: Dr. Pablo Nery 9:35 am The Atrial Remodeling Determinants of Rotor Dynamics in AF Dr. Stanley Nattel, Montreal Heart Institute 9:55 am Fibrosis: Cause or Consequence to Persistent AF? Dr. José Jalife, University of Michigan 10:15 am Mapping and Ablating Rotors in the EP Lab; Where are we and where are we going? Dr. Damien Redfearn, Queen s University 10:35 am Panel Discussion 10:55 am Health Break 11:15 12:35 Session 3: Genetics/Biomarkers/miRNA Chair: Dr. Robert Lemery 11:15 am Personalizing Care for Atrial Fibrillation: The Promise of Gene-Guided Strategies Dr. Jason Roberts, University of Western Ontario 11:35 am Potential Novel Interactions to Prevent AF Progression Dr. Stanley Nattel, Montreal Heart Institute 11:55 am Early Detection of the AF Substrate Dr. Peter Liu, University of Ottawa Heart Institute 12:15 Panel Discussion

12:35 Lunch 1:35 2:35 Professor Martin Green Keynote Lecture: Stroke Risk Reduction in Atrial Fibrillation: Past, Present, Future Dr. Gregory Lip, University of Birmingham 2:35 Health Break 2:50 4:00 Session 4: Key Clinical Research Directions in Atrial Fibrillation Chair: Dr. Martin Green 2:50 Ten Most Important AF Related Stroke Clinical Research Questions in 2016: CPSIN and More Dr. Jeff Healey, McMaster University 3:10 Cardiac Arrhythmia Network (CANet); Canada s Opportunity to Become World Leader in AF Clinical Research Dr. Anthony Tang, University of Western (CANet) 3:30 Panel Discussion 3:50 Day 1 Concluding Remarks Dr. David Birnie 4:00 Adjournment OHRC/Toronto-Ottawa Heart Summit & Eastern Ontario Cardiovascular Summit Co-hosting a Clinical Day for Specialists Friday, June 3 rd (Day 2) 8:00 am Official Welcome and Introduction Drs. Peter Liu and Michael Farkouh 8:15 9:35 am Session 1: Ablation for Atrial Fibrillation (Who, How and When) Chair: Dr. David Birnie 8:15 am Who and How to Ablate Paroxysmal AF: Current Perspectives and Future Directions Dr. Hugh Calkins, Johns Hopkins Hospital 8:45 am Who and How to Ablate Persistent and Permanent AF: Current Perspectives and Future Directions Dr. Atul Verma, Southlake Regional Health Centre 9:15 am Panel Discussion

9:35 10:55 am Session 2: Stroke Reduction in AF: Update for the Clinician Chair: Dr. David Birnie 9:35 am Recent Updates from the Canadian Guidelines Dr. Allan Skanes, University of Western Ontario 10:05 am Stroke Reduction in AF: Controversial Areas in AF Dr. Hugh Calkins, Johns Hopkins Hospital 10:35 am Panel Discussion 10:55 am Health Break Toronto-Ottawa Heart Summit & Eastern Ontario Cardiovascular Summit 11:15 12:55 Session 3: Heart Failure 11:15 am Implications of LCZ696 for HFrEF and HFpEF Dr. Kirkwood Adams, University of North Carolina at Chapel Hill 11:35 am New Roles of ARNI or LCZ696 in HFpEF or Post MI Remodeling and Beyond Dr. Jean Rouleau, Canadian Institutes of Health Research 11:55 am Guiding Treatment of Heart Failure with Biomarkers Dr. Alan Maisel, VA San Diego Healthcare System 12:15 Personalizing Therapy for HF Heart Rate as a Biomarker? Dr. Peter Liu, University of Ottawa Heart Institute 12:35 Panel Discussion 12:55 Lunch 2:00 Keynote Lecture: End-of-life care in Cardiac Patients Dr. Chris Simpson, Queen s University 2:30 4:10 Session 4: Intervention 2:30 Management of Chronic Total Occlusions- A 2016 Approach Dr. Brad Strauss, Sunnybrook Health Sciences Centre 2:50 Antiplatelet Therapy in Acute Coronary Intervention Patients Dr. Derek So, University of Ottawa Heart Institute 3:10 Critical Appraisal of Target Temperature Management in Out-of-hospital Cardiac Arrest Dr. Michael Le May, University of Ottawa Heart Institute 3:30 Chest Pain Syndromes and Patient Engagement Dr. Michael Froeschl, University of Ottawa Heart Institute

3:50 Active Learning Q & A with Panel 4:10 Health Break 4:25 6:00 Session 5: Recent Advances in Cardiovascular Management 4:25 TAVI Update and Implications Dr. Mark Osten, University of Toronto 4:45 Aortic Diseases Who, When, What, How? Dr. Munir Boodhwani, University of Ottawa Heart Institute 5:05 HOPE-3: Results and Implications for Practice Dr. Sheldon Tobe, Sunnybrook Health Sciences Centre 5:25 Promising Diagnostic to Direct Heart Failure Management: The IMAGE-HF Trial Dr. Rob Beanlands, University of Ottawa Heart Institute 5:45 Active Learning Q & A with Panel 6:00 Adjournment Saturday, June 4 th (Day 3) 8:00 am Official Welcome and Introduction Drs. Peter Liu and Michael Farkouh 8:10 am Keynote Lecture: Primary Care and Use of High Sensitivity Triponins Here they Come! Dr. Alan Maisel, VA San Diego Healthcare System 8:30 9:50 am Session 6: Diabetes 8:30 am SGLT2 Inhibitors and CVD in Diabetes: The EMPA-REG OUTCOME Trial Dr. Bernie Zinman, University of Toronto 8:50 am Liraglutide, a New LEADER in Type 2 DM Management? Dr. Michael Farkouh, University of Toronto 9:10 am Renal Implications of Diabetes Treatment Dr. Kim Connelly, St. Michael s Hospital 9:30 am Active Learning Q & A with Panel 9:50 am Health Break 10:20 11:50 am Session 7: Atherosclerosis 10:20 am Can we Pacify Atherosclerosis by Novel Anti-inflammatory Approaches? Dr. Jay Udell, Women s College Research Institute

10:40 11:20 am 11:20 12:00 12:00 Lunch 1:00 2:20 DEBATE on PCSK9: All High Risk Patients with Residual Elevation of LDL Should be on PCSK9 Inhibitors Pro Dr. John Mancini, University of British Columbia Con Dr. Ruth McPherson, University of Ottawa Heart Institute Rebuttal Dr. John Mancini, University of British Columbia Dr. Ruth McPherson, University of Ottawa Heart Institute Session 8: Risk Intervention 1:00 Smoking Cessation Strategies Dr. TBA 1:20 Exercise Interventions for Patients with Heart Disease: What s New? What s Promising? Dr. Robert Reid 1:40 Early Atherosclerosis Imaging: Detection and Risk Interpretation Dr. Girish Dwivedi 2:00 Active Learning Q & A with Panel 2:20 3:20 Session 9: Challenges in Managing the Geriatric Population 2:20 Frailty as a New Risk Factor for Chronic CV Risk? Dr. George Heckman, McMaster University 2:40 Geripardy! The Answer is: What is Geriatrics? Dr. Allen Huang, University of Ottawa 3:00 Active Learning Q & A with Panel 3:20 Adjournment and light refreshments