UCB presentation. Investor Relations April 24, 2014

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Transcription:

UCB presentation Investor Relations April 24, 2014

Disclaimer and safe harbor 2 Forward-looking statements: This presentation contains forward-looking statements based on current plans, estimates and beliefs of management. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including estimates of revenues, operating margins, capital expenditures, cash, other financial information, expected legal, political, regulatory or clinical results and other such estimates and results. By their nature, such forward-looking statements are not guarantees of future performance and are subject to risks, uncertainties and assumptions which could cause actual results to differ materially from those that may be implied by such forward-looking statements contained in this press release. Important factors that could result in such differences include: changes in general economic, business and competitive conditions, the inability to obtain necessary regulatory approvals or to obtain them on acceptable terms, costs associated with research and development, changes in the prospects for products in the pipeline or under development by UCB, effects of future judicial decisions or governmental investigations, product liability claims, challenges to patent protection for products or product candidates, changes in laws or regulations, exchange rate fluctuations, changes or uncertainties in tax laws or the administration of such laws and hiring and retention of its employees. UCB is providing this information as of the date of this presentation and expressly disclaims any duty to update any information contained in this presentation, either to confirm the actual results or to report a change in its expectations. There is no guarantee that new product candidates in the pipeline will progress to product approval or that new indications for existing products will be developed and approved. Products or potential products which are the subject of partnerships, joint ventures or licensing collaborations may be subject to differences between the partners. Also, UCB or others could discover safety, side effects or manufacturing problems with its products after they are marketed. Moreover, sales may be impacted by international and domestic trends toward managed care and health care cost containment and the reimbursement policies imposed by third-party payers as well as legislation affecting biopharmaceutical pricing and reimbursement.

Inspired by patients. Driven by science. 3 Focus: Central Nervous System & Immunology R&D expenses 2013: 25% of revenue Over 584 000 patients treated with UCB s core medicines, CVN Operations in more than 40 countries Approximately 8 700 employees globally

UCB s growth prospects confirmed 4 Cimzia, Vimpat, Neupro Emerging markets Superior and sustainable value Mature product portfolio Schematic picture

UCB s five strategic growth priorities 5 Status: first 3 months 2014 ן 1. Grow Cimzia, Vimpat and Neupro CVN combined sales: 318 million (+29%, +33% at constant rates) ן 2. Build emerging markets and Japan BRICMT 1-1% (+11% at constant rates); Japan -9% (+75% excl. allergy and currency effects) Agreement with Biogen Idec for multiple sclerosis and hemophilia therapies in Asia ן 3. Advance UCB s rich late-stage pipeline Top 2 in late-stage pipeline productivity² Returned global rights of tozadenant to Biotie ן 4. Deliver breakthrough medicines to the clinic Breakthrough innovation collaboration with Sanofi to replace selected biologic agents with small molecules to potentially treat a wide range of immune-mediated diseases Growing super-network fostering borderless innovation ן 5. Reach competitive profitability Financial targets 2014 confirmed, on track for long-term targets 1 Brazil, Russia, India, China, Mexico and Turkey 2 Phase 3 NME/R&D expenses, U.S. and EU biopharma companies 3 Partial-onset seizures

Cimzia performance 6 Reaching more patients million 3M 2014 3M 2013 Actual Constant North America 102 76 33% 39% Europe 49 36 36% 37% Japan 3 4-19% -7% Emerging markets 1 1 1 24% 35% Rest of the World 5 5 8% 17% Total Cimzia 160 122 31% 36% U.S. Crohn s disease (CD) Rheumatoid arthritis (RA) Psoriatic arthritis (PsA) - Sep. 2013 Ankylosing spondylitis (AS) - Oct. 2013 EU Rheumatoid arthritis (RA) Axial spondyloarthritis (incl. AS) - Oct. 2013 Psoriatic arthritis (PsA) - Nov. 2013 Japan launched March 2013 (partner: Astellas) 1 Emerging markets: Brazil, Russia, India, China, Mexico and Turkey Cimzia available to patients in 47 countries, including Japan, Brazil, Russia, Mexico & Turkey Numbers may not add due to rounding

Cimzia RA in-market performance (Feb. 2014) 7 8% U.S. - Cimzia RA growth 3.6% U.S. - Cimzia RA R3M TRx Share U.S. 7% 6% 5% 4% 3% 2% 1% 1.3% market share 3.5% 3.1% 7.3% 3.5% 3.5% 3.4% 3.4% In-Market growth and share based on TRx Shares calculated based on RA Anti-TNF market In-market growth is calculated for MAT Feb 14 vs. MAT Feb 13 Market share is calculated for R3M Feb 14 0% Anti-TNF All Biologics Cimzia 3.3% Feb'13 Apr'13 Jun'13 Aug'13 Oct'13 Dec'13 Feb'14 40% EU - Cimzia RA growth 9.0% EU - Cimzia RA R3M Patient Share EU 35% 30% 25% 20% 15% 10% 5% 11.2% market share 8.8% 14.8% 35.1% 8.5% 8.0% 7.5% In-Market growth and share based on Exit Patients Shares calculated based on RA Anti-TNF market In-market growth is calculated for Feb 14 vs. Feb 13 Market share is calculated for R3M Feb 14 0% Anti-TNF All Biologics Cimzia 7.0% Feb'13 Apr'13 Jun'13 Aug'13 Oct'13 Dec'13 Feb'14 RA: Rheumatoid arthritis Source EU - IMS MIDAS + local UK HMSL data Source US - US IMS NPA data

Vimpat performance 8 New indication to come million 3M 2014 3M 2013 Actual Constant North America 78 66 17% 22% Europe 25 20 22% 22% Emerging markets 1 1 1 49% 64% Rest of the World 1 1 65% 84% Total Vimpat 105 88 19% 23% Epilepsy POS² Adjunctive therapy: When monotherapy is no longer enough Monotherapy: under review by U.S. FDA (filed Oct. 2013) 1 Emerging markets: Brazil, Russia, India, China, Mexico and Turkey 2 Partial onset seizures Vimpat available to patients in 38 countries, including Russia, India & Mexico

Vimpat in-market performance (Feb. 2014) 9 25% U.S. - Vimpat growth 3.0% U.S. - Vimpat - R3M TRx Share 20% 2.9% In-Market growth and share based on TRx U.S. 15% 10% market share 2.9% 23.5% 2.8% 2.7% In-market growth is calculated for MAT Feb 14 vs. MAT Feb 13 Market share is calculated for R3M Feb 14 5% 2.6% 0% 3.8% Market Vimpat 2.5% Feb'13 Apr'13 Jun'13 Aug'13 Oct'13 Dec'13 Feb'14 30% EU - Vimpat growth 2.0% EU Vimpat - R3M TDx Share 25% In-Market growth and share based on TDx EU 20% 15% 10% market share 1.8% 26.6% 1.8% 1.6% In-market growth is calculated for MAT Feb 14 vs. MAT Feb 13 Market share is calculated for R3M Feb 14 5% 0% 0.8% Market Vimpat 1.4% Feb'13 Apr'13 Jun'13 Aug'13 Oct'13 Dec'13 Feb'14 Source EU - IMS MIDAS Source US - US IMS NPA data

Neupro performance 10 million 3M 2014 3M 2013 Actual Constant North America 14 6 > 100% > 100% Europe 32 29 11% 11% Japan 5 1 > 100% > 100% Emerging markets 1 0 0-2% 9% Rest of the World 1 0 49% 64% Total Neupro 52 36 43% 45% Parkinson s disease (PD) Impact across the motor and underlying symptoms of Parkinson s disease Restless legs syndrome (RLS) Powerful and lasting symptom relief for restless legs syndrome Latest launches: Strong, on-going performance U.S. (July 2012); Japan (February 2013 by Otsuka) 1 Emerging markets: Brazil, Russia, India, China, Mexico and Turkey Neupro available in 41 countries, including Japan, Russia & Mexico Numbers may not add due to rounding

Neupro in-market performance (Feb. 2014) 11 8% U.S. - Neupro PD growth 6.4% U.S. - Neupro PD R3M TRx Share U.S. 7% 6% 5% 4% 3% 2% market share 6.2% 7.0% 6.2% 6.0% 5.8% 5.6% 5.4% In-market growth and share based on TRx Shares calculated based on PD Key Competitors markets In-market growth is calculated for Current R6M vs. Previous R6M In-market share is calculated for R3M Feb 14 1% 5.2% 0% 0.7% 0.7% Market Competitors Neupro 5.0% Feb'13 Apr'13 Jun'13 Aug'13 Oct'13 Dec'13 Feb'14 EU - Neupro PD growth EU5 Neupro PD- R3M TDx Share 20% 15.0% EU 18% 16% 14% 12% 10% 8% 6% 4% 2% market share 14.6% 4.1% 3.5% 17.2% 14.5% 14.0% 13.5% In-market growth and share based on TDx Shares calculated based on PD Key Competitors markets In-market growth is calculated for MAT Feb 14 vs. MAT Feb 13 Market share is calculated for R3M Feb 14 0% Market Competitors Neupro 13.0% Feb'13 Apr'13 Jun'13 Aug'13 Oct'13 Dec'13 Feb'14 Source EU - IMS MIDAS Source US - US IMS NPA data

UCB's development pipeline 12 Life cycle management Phase 2 Phase 3 Filing Epilepsy POS 1 Ped. adj. Therapy 2017 Monotherapy (EU) Q4 2014 Adj. therapy (Asia) H1 2015 Monotherapy (U.S.) Oct. 2013 Epilepsy PGTCS 2 Plegridy Adj. Therapy Juvenile RA H1 2016 Exxelerate H1 2016 C-early H2 2016 AxSpA (U.S.) Feb. 2013 Multiple sclerosis Hemophilia A Hemophilia B Tysabri Tecfidera daclizumab Eloctate Alprolix For development in PR China (In-licensed from Biogen Idec) 1 Partial onset seizures 2 Primary generalized tonic-clonic seizures

UCB delivers growth 13 Status: first 3 months 2014 Expected peak sales at least 1.5 billion 1 Inflammatory arthritis indications and Crohn s disease Total net sales of 160 million (+31%) Expected peak sales at least 1.2 billion 1 Epilepsy partial onset seizures (adjunctive therapy) Total net sales of 105 million (+19%) Expected peak sales at least 400 million 1 Parkinson s disease and restless legs syndrome Total net sales of 52 million (+43%) Combined expected CVN peak sales at least 3.1 billion 1 1 Second half of the decade

Keppra performances 14 On-going erosion in Europe million 3M 2014 3M 2013 Actual Constant North America 46 47-2% 2% Europe 72 82-12% -12% Japan 21 14 53% 77% Emerging markets 1 19 18 2% 12% Rest of the World 9 11-10% -2% Total Keppra 167 171-2% 2% Loss of exclusivity U.S. - November 2008 (Keppra XR - September 2011) Europe - September 2010 Japan: market exclusivity until 2018 Sizeable franchise going forward! 1 Emerging markets: Brazil, Russia, India, China, Mexico and Turkey Numbers may not add due to rounding

UCB: Building emerging markets and Japan 15 Emerging markets Agreement with Biogen Idec to commercialize multiple sclerosis and hemophilia therapies in Asia Emerging markets* net sales: 68 million (-1%) +11% at constant rates UCB Japan Net sales of 59 million (-9%; +2% at constant rates) +75% at constant rates (excl. allergy) E Keppra net sales: 21 million (+53%) Neupro net sales: 5 million (vs. 1 million in Q1 2013) *Brazil, Russia, India, China, Mexico, Turkey 1 Excludes allergy and FX effects

UCB's development pipeline 16 New molecular entities Phase 1 Phase 2 Phase 3 Filing brivaracetam epilepsy POS 1 / adj. therapy epratuzumab systemic lupus erythematosus romosozumab (sclerostin antibody) osteoporosis in postmenopausal women CDP7657 (CD40L antibody) systemic lupus erythematosus UCB5857 immunological diseases UCB4940 immunological diseases Phase 3 results H2 2014 Phase 3 results Q1 2015 (Partner: Immunomedics) Phase 3 results H1 2016 (Partner: Amgen) Results H2 2014 (Partner: Biogen Idec) Results Q2 2014 1 Partial onset seizures

UCB s promising early pipeline 17 Early pipeline holds breakthrough potential Discovery: Breakthrough innovation collaboration with Sanofi discovery and development of innovative anti-inflammatory small molecules to replace selected biologic agents with small molecules to potentially treat a wide range of immune-mediated diseases Three Phase 1 compounds with significant differentiation potential: 2 NBEs: CDP7657 (anti-cd40l) in systemic lupus erythematosus first results in H2 2014 UCB4940, immunological diseases 1 NCE: UCB5857, immunological diseases first results in Q2 2014 NBE: new biological entity NCE: new chemical entity

3 months key financial highlights 18 On track to deliver FY 2014 guidance million 3M 2014 3M 2013 Actual Constant Revenue 840 799 5% 9% Net sales CVN 318 247 29% 33% Cimzia 160 122 31% 36% Vimpat 105 88 19% 23% Neupro 52 36 43% 45% Keppra 167 171-2% 2% FY 2014 outlook confirmed Revenue ~ 3.5 3.6 billion REBITDA ~ 740-770 million Core EPS ~ 1.90 2.05 based on ~ 192 million shares

Appendix

UCB FY 2013 financial highlights 20 Growth of core medicines a strong foundation Revenue 3.4 billion Continued sales growth of the core medicines: Cimzia, Vimpat and Neupro Keppra generic erosion in Europe Adverse exchange rate impacts actual rates -1% constant rates +2% Total operating expenses Lower marketing & selling expenses 1 856 million -4% -1% Stable R&D expenses Recurring EBITDA 689 million +1% +9% Net profit 200 million -18% -3% 29% tax rate Recommended gross dividend 1.04 per share +2% Core earnings per share (EPS) 1.93 * EBITDA: Earning before interests, taxes, depreciation and amortization charges * Based on 182 million weighted average shares outstanding

Cimzia performance 2013 21 Reaching more patients million FY 2013 FY 2012 Actual Constant North America 379 321 18% 22% Europe 168 133 26% 28% Japan 20 - >100% >100% Emerging markets 1 6 1 >100% >100% Rest of the World 22 12 83% 92% Total Cimzia 594 467 27% 32% U.S. Crohn s disease (CD) Rheumatoid arthritis (RA) Psoriatic arthritis (PsA) - Sep. 2013 Ankylosing spondylitis (AS) - Oct. 2013 EU Rheumatoid arthritis (RA) Axial spondyloarthritis (incl. AS) - Oct. 2013 Psoriatic arthritis (PsA) - Nov. 2013 1 Brazil, Russia, India, China, Mexico and Turkey Cimzia available to patients in 47 countries, including Japan, Brazil, Russia, Mexico & Turkey Numbers may not add due to rounding

Vimpat performance 2013 22 New indication to come million FY 2013 FY 2012 Actual Constant North America 314 251 25% 29% Europe 87 76 15% 16% Emerging markets 1 4 2 55% 58% Rest of the World 6 5 25% 33% Total Vimpat 411 334 23% 27% Epilepsy POS² Adjunctive therapy: When monotherapy is no longer enough Monotherapy: Filing in the U.S. (Oct. 2013) 1 Brazil, Russia, India, China, Mexico and Turkey 2 Partial onset seizures Vimpat available to patients in 38 countries, including Russia, India & Mexico

Neupro performance 2013 23 million FY 2013 FY 2012 Actual Constant North America 40 15 >100% >100% Europe 129 114 13% 14% Japan 9 1 >100% >100% Emerging markets 1 2 1 64% 66% Rest of the World 3 2 50% 53% Total Neupro 182 133 37% 39% Parkinson s disease (PD) Impact across the motor and underlying symptoms of Parkinson s disease Restless legs syndrome (RLS) Powerful and lasting symptom relief for restless legs syndrome Latest launches: Strong, on-going performance U.S. (July 2012); Japan (February 2013 by Otsuka) 1 Brazil, Russia, India, China, Mexico and Turkey Neupro available in 41 countries, including Japan, Russia & Mexico Numbers may not add due to rounding

Keppra performances 2013 24 Net sales -15% million FY 2013 FY 2012 Actual Constant North America 223 236-5% -2% Europe 315 451-30% -30% Japan 62 47 32% 67% Emerging markets 1 71 64 12% 16% Rest of the World 40 41-2% 2% Total Keppra 712 838-15% -12% Loss of exclusivity U.S. - November 2008 (Keppra XR - September 2011) Europe - September 2010 Japan: launch of E Keppra pediatric + dry syrup Sizeable franchise going forward! 1 Brazil, Russia, India, China, Mexico and Turkey Numbers may not add due to rounding

Recurring EBITDA 2013 25 Lower marketing and selling, stable R&D expenses million Actual Variance FX 2013 2012* Actual Constant Revenue 3 411 3 462-1% 2% Net sales 3 049 3 070-1% 3% Royalty income and fees 172 168 2% 5% Other revenue 190 224-15% -12% Gross profit 2 297 2 378-3% 2% Marketing and selling expenses -802-875 8% 4% R&D expenses -856-861 1% -2% G&A expenses -205-198 -3% -5% Other operating income 7 0 n.m. n.m. Total operating expenses -1 856-1 962 4% 1% Recurring EBIT 441 444-1% 12% Amortization of intangible assets 184 176 4% 6% Depreciation charges 64 64 0% 1% Recurring EBITDA 689 684 1% 9% * Restated EBIT: Earnings before interest and taxes EBITDA: Earning before interests, taxes, depreciation and amortization charges

Net profit 2013 26 million Actual Variance FX 2013 2012* Actual Constant Recurring EBIT 441 444-1% 12% Impairment charges -29-10 >-100% >-100% Restructuring expenses -32-40 18% 17% Gain on disposals 23 31-28% -28% Other non-recurring income 0-7 n.m. n.m. Total non-recurring income / expenses (-) -38-26 -50% -53% EBIT 403 418-3% 9% Net financial expenses -121-155 22% 22% Income tax expenses (-) / credit -87-35 >-100% >-100% Profit from continuing operations 195 228-14% 2% Net profit (including non-controlling interests) 200 245-18% -3% * Restated EBIT: Earnings before interest and taxes

Core earnings per share (EPS) 2013 27 million Actual Variance FX 2013 2012* Actual Constant Net profit attributable to UCB shareholders 207 249 1-17% -4% + After-tax non-recurring items and 37 33 9% 17% financial one-offs - Profit / loss (-) from discontinued -5-17 74% 74% operations + After-tax amortization of intangibles 112 112 0% 1% Core net profit 351 377-7% 3% Weighted average number of shares (basic) 182.2 179.3 2% n.m. Core EPS 1.93 2.10-8% 1% * Restated 1 Adjusted for the Meizler business combination

IFRS 10 impact on 2013 28 IFRS 10 effective 1 January 2014 Concept of control whether an entity should be included within consolidated financial statements UCB will consolidate two additional entities which manage clinical trials Expected impact (un-audited) Higher R&D expenses Lower net profit for the Group; higher net profit allocation to non-controlling interests million 2013 (as reported) 2013 (pro-forma, un-audited) Revenue 3 411 3 411 R&D expenses as % of revenue 25% 26% Recurring EBITDA 689 653 Net Profit 200 143 Net Profit to equity holders of UCB S.A. 207 160 Net Profit to non-controlling interest -7-17 Weighted number of shares outstanding 182 182 Core EPS 1.93 1.67 EBITDA: Earning before interests, taxes, depreciation and amortization charges EPS: Earnings per share

Geographic and therapeutic breakdown 29 2013 net sales: 3 049 million Europe 36%

Cimzia in RA To provide information for evidence-based decisions in bio/dmard naive patients 30 EXXELERATE C-EARLY H2H: relative efficacy of certolizumab pegol and adalimumab 12 weeks & 104 weeks Approx. 900 adult patients First results H1 2016 To achieve remission or low disease activity as soon as possible and optimize CZP treatment in early RA remitters 52 weeks & 104 weeks Approx. 800 adult patients with early stage of the disease (<1 year) First results H2 2016

Cimzia in Psoriatic Arthritis (PsA) 31 Approved and launched in 2013 *statistical significant Q2W Q4W Cimzia in patients with adult onset active PsA demonstrated a clinically relevant and statistically significant improvement at week 12 in the signs and symptoms of PsA.

Epilepsy most common serious neurological disorder 32 Strong need for new treatment options High unmet medical need in ~1/3 of treated epilepsy patients Epilepsy types and treatment algorithm Monotherapy Add-on therapy 50% 25-30% Partial Onset Seizures (POS) 29% 27% 20-25% Controlled on 1st monotherapy Primary Generalised Seizures (PGTCS) 25% 19% Uncontrolled despite 2-3 AEDs Controlled on more than 1 AED

Romosozumab in bone loss disorders 33 Potential for a change of treatment paradigms Collaborative project with Amgen Phase 3 program in osteoporosis in postmenopausal women initiated First results expected first half 2016 Study of naturally occurring human disorder leads to a potential new drug therapy Strong phase 2 results in osteoporosis in postmenopausal women Positive treatment effect observed, statistically significant Favorable comparison with active comparators, teriparatide and alendronate Normal Sclerosteosis

Epratuzumab in SLE EMBODY 34 Phase 3 program First results Q1 2015 Placebo EMBODY 1 Emab 600 mg weekly Emab 1200 mg every other week Placebo EMBODY 2 Emab 600 mg weekly Emab 1200 mg every other week Emab IV dosing Week 0 12 24 36 48

Epratuzumab Maintained improvements in disease activity for 2+ years and corticosteroid dose reductions shown* 35 Combined Treatment Response 10 10 Median CS dose mg/day (prednisone equivalent) 32.5% 40.7% 48.1% 57.2% 56.5% 60.3% 7.5 7.5 6.7 7.5 5 SL0008 Screening (N=203) Week 24 (N=177) Week 48 (N=154) Week 72 (N=138) Week 96 (N=124) Week 108 (N=116) Week 24 (N=177) Week 48 (N=157) Week 72 (N=138) Week 96 (N=125) Week 116 (N=112) Combined Treatment Response indicates patients sustained improvements across all body systems that had moderate or severe disease activity at baseline of the previous study Median corticosteroid dose showed general decrease over time from 10 mg/day at baseline of EMBLEM study, to 5 mg/day at Week 116 Number of subjects with no corticosteroid use and in lowest corticosteroid dose category (>0 to 7.5 mg/day) exceeded 50% from Week 24 No new safety signals were identified

Epratuzumab: humanized monoclonal antibody (Human IgG1) against CD22 36 IgM IgM IgD IgG Memory B pro-b pre-b immature B mature B B Blast GC B cell Plasma cell CD22 Expression Fab (CD22 Binding) epratuzumab: Modulator of B-cell function

Epratuzumab in SLE Phase 2b results presented at World Lupus Congress & ACR 2011 37 SL0007: Primary Efficacy Variable: Combined Index Response Rate at Week 12, ITT Population 50 P=0.0239 P=0.0265 45,9 43,2 40 40,5 Percent responders 30 20 21,1 30,8 26,3 23,7 10 0 Placebo, N=38 Emab 200 mg (100 mg EOW), N=39 Emab 800 mg (400 mg EOW), N=38 Emab 2400 mg (600 QW), N=37 Emab 2400 mg (1200 EOW), N=37 Emab 2400 mg Combined, N=74 Emab 3600 mg (1800 EOW), N=38 37

More growth to come from new indications 38 Phase 1 Phase 2 Phase 3 Filing First results this year UCB4940 NBE, immuno CDP7657 NBE, Lupus UCB5857 NCE, immuno Vimpat epilepsy PGTCS tozadenant PD (returned rights Mar 14) romosozumab Osteoporosis in postmenopausal women Cimzia Juvenile RA epratuzumab SLE Vimpat Epilepsy mono U.S. Cimzia AxSpa in U.S. FDA decision expected H2 2014 Vimpat epilepsy ped. Vimpat epilepsy (Asia) Vimpat Epilepsy mono EU brivaracetam Adj. epilepsy POS Phase 3 results expected in H2 2014 NBE: new biological entity SLE: systemic lupus erythematosus AS: ankylosing spondylitis NCE: new chemical entity POS: partial onset seizures PD: Parkinson s disease PGTCS: primary generalized tonic-clonic seizures AxSpA: axial spondyloarthritis

UCB: reinventing itself, leveraging a solid heritage to deliver sustainable and superior value for patients 39 Today 1928: Emmanuel Janssen establishes UCB in Brussels 1990s: approval of Keppra, a novel antiepileptic 2004: UCB acquires British biotech Celltech 2006: UCB acquires German pharma Schwarz Pharma 1936: UCB enters the United States 1980s: UCB registers its novel antihistamine Zyrtec 2005: UCB divests non-pharma business Launch of new medicines 1928 1936 1980s 1990s 2004 2005 2006 2008-2012 Today Chemical Group Primary Care Pharma Specialty Bio-Pharma Focus: CNS + immunology

Shareholder structure (March 2014) 40 Stable shareholder base, free float of 63% Free float investors by region Source: Shareholder identification analysis (November 2011), 2012 and 2013 notifications and UCB underlying ownership analysis

Your UCB Investor Relations team 41 ן Antje Witte, Vice President Investor Relations Phone: +32 2 559 9414 E-mail: antje.witte@ucb.com ן Alexandra Deschner, Investor Relations Director Phone: +32 2 559 9683 E-mail: alexandra.deschner@ucb.com ן Isabelle Ghellynck, Investor Relations Project Manager Phone: +32 2 559 9588 E-mail: isabelle.ghellynck@ucb.com ן Nathalie Deldime, Investor Relations Events Manager Phone: +32 2 559 9291 E-mail: nathalie.deldime@ucb.com