Plan of the course. Integrated Clinical Module: Part 1. Academic year 2015/2016. izv. prof. dr. sc. Davorka Lukas

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UNIVERSITY OF ZAGREB SCHOOL OF MEDICINE Plan of the course Integrated Clinical Module: Part 1 Academic year 2015/2016

I. COURSE AIMS 1. COURSE AIMS: To introduce students to diseases that are prevalent in tropical and developing countries, to teach them aboat the epidemiology, causative organisms, clinical features, diagnosis, treatment and prevention of these diseases. The importance of pre-travel advice of travelers to endemic regions will be emphasized, as well as the importance of implementation of diagnostic and treatment algorithms, in a case of the occurrence of certain symptoms upon their return. To explore issues of migration medicine, indicate the importance of evaluating the health status of immigrants During exercise, special attention will be paid to proper examination of patients and taking appropriate epidemiological history Through seminars and practical work to teach students the methods of bacteriological, virological, parasitological and radiological diagnosis of tropical and travel diseases II. COURSE STRUCTURE Course hours: Lectures: 20 Seminar: 28 Special clinical practicals: 12 Total hours: 60 Lectures (L): 20 Seminars (S): 20 Practicals (P): 20 Total: 60 III. PLAN OF THE COURSE AND COURSE SCHEDULE BLOCKS OF THE COURSE Number of blocks: 1 Block number Start End 1. 21.3.2016 1.4.2016

BLOCKS OF THE COURSE SHEME Block 1 Date Time Group Course hours Theme type Monday 21.3.2016. 09:00-10:30; Mala predavaonica 1 Lectures Malaria: epidemiology, disease causative agent, transmission, clinical features, diagnosis and treatment Teasching staff Malaria: case presentaion of uncomplicated and complicated malaria and different treatment strategies. Malaria prevention. Mala predavaonica 1 Special clinical Malaria: thin blood film examination, study of parasite practicals morphology and species identification; Tuesday 22.3.2016. 09:00-10:30; Mala predavaonica 1 Lectures Visceral leishmaniasis (VL), cutaneous and mucosal leishmaniasis epidemiology, disease causative agent, transmission, clinical features, diagnosis and treatment Mala predavaonica 1 Special clinical practicals Visceral leishmaniasis (VL), cutaneous and mucosal leishmaniasis case presentaion of differnet clinical features, diagnosis and treatment Visceral leishmaniasis (VL), cutaneous and mucosal leishmaniasis: stained bone marrow aspirate examination and detection of leishmania amastigotes Wednesday 23.3.2016. 09:00-09:45; Mala predavaonica 1 Lectures South American trypanosomiasis - Chagas disease: epidemiology, disease causative agent, transmission, clinical features, diagnosis, treatment and prevention. 10:45-11:30; Mala predavaonica 1 Lectures South American trypanosomiasis - Chagas disease: case presentaion of differnet clinical features, diagnosis and treatment African trypanosomiasis: epidemiology, disease causative agent, transmission, clinical features, diagnosis, treatment and prevention Thursday 24.3.2016. 08:00-09:30; Mala predavaonica 1 Lectures Dengue. Yellow fever: epidemiology, disease causative agent, transmission, clinical features, diagnosis, treatment and prevention 09:45-11:15; Dengue. Yellow fever: case presentaion of differnet clinical features, diagnosis and treatment Mala predavaonica 1 Lectures Viral haemorrhagic fevers prof. dr. sc. Alemka Markotić Friday 25.3.2016. 09:00-10:30; Mala predavaonica 1 Lectures Schistosomiasis. Filariasis Leprosy. Tuberculosis Rabies. Tetanus Tuesday 29.3.2016. 09:00-10:30; Mala predavaonica 1 Lectures Gastrointestinal infections: dr. sc. Mirjana Balen Topić Mala predavaonica 1 Seminar Gastrointestinal infections: case presentaion dr. sc. Mirjana Balen Topić Mala predavaonica 1 Special clinical practicals Gastrointestinal infections: parasitology laboratory, diagnostic methods Suzana Bukovski- Simonoski Wednesday 30.3.2016. HIV infection in the tropics and developing countries: case presentaion Šime Zekan, dr. med. Mala predavaonica 1 Seminar HIV infection in the tropics and developing countries Klaudija Višković 16:00-17:30; Mala predavaonica 1 Lectures HIV infection in the tropics and developing countries: epidemiology, disease causative agent, transmission, clinical features, diagnosis and treatment prof. dr. sc. Josip Begovac Thursday 31.3.2016. 09:00-10:30; A traveller returnig from tropical country with: fever

Date Time Group Course hours type Theme Teasching staff A traveller returnig from tropical country with: rash A traveller returnig from tropical country with: diarrhoea Friday 1.4.2016. 09:00-10:30; Venomous bites and stings: epidemiology, clinical features, diagnosis, treatment and prevention Malaria Cutaneous tropical diseases. Tropical ulcer. Buruli ulcer. Cutaneous larva migrans. Myiasis. Drancunculiasis Mala predavaonica 1 Lectures Migration medicine. Refugee health 2 h (L): epidemiology, disease causative agent, transmission, clinical features, diagnosis and treatment 2 h (S): case presentaion of uncomplicated and complicated malaria and different treatment strategies. Malaria prevention. 2 h (P): thin blood film examination, study of parasite morphology and species identification; Visceral leishmaniasis (VL), cutaneous and mucosal leishmaniasis 2 h (L) epidemiology, disease causative agent, transmission, clinical features, diagnosis and treatment 2 h (P): stained bone marrow aspirate examination and detection of leishmania amastigotes South American trypanosomiasis - Chagas disease African trypanosomiasis Dengue. Yellow fever Viral haemorrhagic fevers

Schistosomiasis. Filariasis Leprosy. Tuberculosis 2 h (S) epidemiology, disease causative agent, transmission, clinical features, diagnosis, treatment and prevention Rabies. Tetanus 2 h (S) epidemiology, disease causative agent, transmission, clinical features, diagnosis, treatment and prevention Venomous bites and stings 2 h (S) epidemiology, clinical features, diagnosis, treatment and prevention Gastrointestinal infections: Cholera. Bacillary dysentery. Protozoal infections (Amoebiasis, Giardiasis). Intestinal cestode infections and cysticercosis. Soil-transmitted helminths. Hydatid disease 2 h (P): parasitology laboratory, diagnostic methods HIV infection in the tropics and developing countries 2 h (L) epidemiology, disease causative agent, transmission, clinical features, diagnosis and treatment 2 h (S): case presentaion of various clinical features of opportunistic diseases, diagnosis and treatment 2 h (S): radiologic methods in diagnosis tropical diseases Cutaneous tropical diseases. Tropical ulcer. Buruli ulcer. Cutaneous larva migrans. Myiasis. Drancunculiasis. 2 h (S) epidemiology, disease causative agent, transmission, clinical features, diagnosis and treatment A traveller returnig from tropical country with:

1. fever 2h P 2. rash 2h P 3. diarrhoea 2h P Migration medicine. Refugee health 2h (P) Travel medicine. Pre-travel advice for immunocompetent and special needs traveller, children, and pregnant women travelling to endemic countries, on the prevention, self-treatment. Travel vaccines 2h(L), 4h(P) Lectures will take place in the University Hospital for Infectious diseases (The Big Lecture Room) Mirogojska 8, 10 000 Zagreb LEARNING OUTCOMES At the end of the course students should be able to: Recognize most common diseases and syndromes in tropical and developing countries Analyze clinical, laboratory findings and treatment options Recognize the most prevalent health risks for travelers to tropical and developing countries and give advise on travelers diseases prevention Use available literature on tropical and travel medicine IV. EXAMINATIONS There is one Final Exam In order to approach the final exam, students have to have certificate that they have completed this course. The final exam will consist of 40 multiple-choice questions. 6. COURSE GRADES Final exam : 5 = excellent (A) 4 = very good (B) 3 = good (C) 2 = satisfactory (D)

Fail (F) V./I. LIST OF LECTURERS AND TEACHING STAFF 1. prof. dr. sc. Josip Begovac 2. prof. dr. sc. Mihael Skerlev 3. prof. dr. sc. Adriana Vince 4. dr. sc. Mirjana Balen Topić 5. doc. dr. sc. Marija Santini 6. Šime Zekan, dr. med. 7. dr. sc. Marko Kutleša V./II EXTERNAL ASSOCIATES: 1. prof. dr. sc. Alemka Markotić 2. Klaudija Višković 3. Suzana Bukovski-Simonoski V./III UNTENURED LECTURERS: 1. 2. izv. prof. dr. sc. Arjana Tambić Andrašević VI. LITERATURE Obligatory 01. Geoff Gill, Nick Beeching. Tropical Medicine. Lecture Notes: 6th ed. 2009. Published by Blackwell Publishing Additional Gordon C Cook, Alimuddin I Zumla. Manson's Tropical Diseases, 22nd Edition. Published by Saunders of Elsevier Ltd., London, UK, 2009. Handouts for seminars and practical work Additional readings (suggested by lecturer)