SCID-I (for DSM-IV-TR) Current MDE (JAN 2007) Mood Episodes A. 5

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SCID-I (for DSM-IV-TR) Current MDE (JAN 2007) Mood Episodes A. 5 Did this begin soon after someone close to you died? E. Not better accounted for by bereavement, i.e., after the loss of a loved one, the symptoms persist for longer than 2 months or are characterized by marked functional impairment, morbid preoccupation with worthlessness, suicidal ideation, psychotic symptoms, or psychomotor retardation. SIMPLE BEREAVE- MENT *PAST MAJOR DEPRES- SIVE A. 12 1 3 A27 NOT SIMPLE BEREAVE- MENT CONTINUE WITH NEXT ITEM MAJOR DEPRESSIVE EPISODE CRITERIA A, C, D AND E ARE CODED 3. *PAST MAJOR DEPRES- SIVE A. 12 1 3 A28 CURRENT MAJOR DEPRES- SIVE EPISODE How many separate times in your life have you been (depressed/ OWN WORDS) nearly every day for at least 2 weeks and had several of the symptoms that you described, like (SXS OF WORST EPISODE)? Total number of Major Depressive Episodes, including current (CODE 99 IF TOO NUMEROUS OR INDISTINCT TO COUNT.) NOTE: TO RECORD DETAILS OF PAST EPISODES, J. 9 (OPTIONAL). IF ASSESSING CURRENT MDE SPECIFIERS, CONTINUE ON NEXT PAGE; IF NOT, *CURRENT MANIC EPISODE,* PAGE A. 18 A29

SCID-I (for DSM-IV-TR) Past MDE (JAN 2007) Mood Episodes A. 17 (Did this begin soon after someone close to you died?) E. The symptoms are not better? 1 3 A78 accounted for by [Simple] Bereavement, i.e., after the loss of a loved one, AT SIMPLE the symptoms persist for longer LEAST BEREAVEthan 2 months or are characterized ONE MENT EPISODE by marked functional impairment, NOT morbid preoccupation with SIMPLE worthlessness, suicidal ideation, psychotic symptoms or psychomotor BEREAVE- MENT retardation. IF UNKNOWN: Has there been any other time when you were (depressed /OWN WORDS) like this that did not occur after someone close to you died? IF YES: *PAST MAJOR DEPRESSIVE EPISODE,* A. 12 AND CHECK WHETHER THERE HAS BEEN ANY OTHER MAJOR DEPRESSIVE EPISODE THAT WAS NOT BETTER ACCOUNTED FOR BY BEREAVEMENT. IF SO, ASK ABOUT THAT EPISODE. IF NO: *CURRENT MANIC EPISODE,* A. 18. CONTINUE BELOW MAJOR DEPRESSIVE EPISODE CRITERIA A, C, D, AND E ARE CODED 3. *CURRENT MANIC A. 18 1 3 A79 PAST MAJOR DEPRES- SIVE EPISODE How old were you when PAST MAJOR DEPRESSIVE EPISODE) started? Age at onset of Past Major Depressive Episode coded above. A80 How many separate times in your life have you been (depressed/own WORDS) nearly every day for at least 2 weeks and had several of the symptoms that you described like (SXS OF WORST EPISODE)? Total number of Major Depressive Episodes (CODE 99 IF TOO NUMEROUS OR INDISTINCT TO COUNT). NOTE: TO RECORD DETAILS OF OTHER PAST EPISODES, J. 9 (OPTIONAL). A81

SCID-I (for DSM-IV-TR) Current Manic (JAN 2007) Mood Episodes A. 18 *CURRENT MANIC MANIC EPISODE CRITERIA IF THOROUGH OVERVIEW OF PRESENT ILLNESS PROVIDES NO BASIS FOR SUSPECTING A CURRENT MANIC, MIXED, OR HYPOMANIC EPISODE, CHECK HERE AND *PAST MANIC EPISODE,* A. 28. A82 In the last month has there been a period of time when you were feeling so good, high, excited, or hyper that other people thought you were not your normal self or you were so hyper that you got into trouble? IF YES: What was it like? (Did anyone say you were manic?) (Was that more than just feeling good?) IF NO: In the last month, have you had a period of time when you were feeling irritable or angry every day for at least several days? What was it like? (Did you find yourself often starting fights or arguments?) A. A distinct period [lasting at least 4 days] of abnormally and persistently elevated, expansive, or irritable mood, Check if: elevated, expansive mood irritable mood? 1 2 3 A83 *PAST MANIC A. 28 A84 A85 How long did that last? (As long as 1 week?) (Did you have to go into a hospital?) lasting at least 1 week (or any duration if hospitalization is necessary). NOTE: IF ELEVATED MOOD LASTS LESS THAN 1 WEEK, CHECK WHETHER IRRITABLE MOOD LASTS AT LEAST 1 WEEK BEFORE SKIPPING TO A. 24.? 1 2 3 A86 *CURRENT HYPOMANIC A. 24

SCID-I (for DSM-IV-TR) Current Manic (JAN 2007) Mood Episodes A. 19 FOCUS ON THE WORST PERIOD IN THE PAST MONTH OF THE CURRENT EPISODE FOR THE FOLLOWING QUESTIONS. IF UNCLEAR: During (EPISODE), when were you the most (OWN WORDS FOR MANIA)? B. During the period of mood disturbance, three (or more) of the following symptoms have persisted (four if the mood is only irritable) and have been present to a significant degree: During that time how did you feel about yourself? (More self-confident than usual?) (Any special powers or abilities?) did you need less sleep than usual? (How much sleep did you get?) IF YES: Did you still feel rested? were you much more talkative than usual? (Did people have trouble stopping you or understanding you? Did people have trouble getting a word in edgewise?) were your thoughts racing through your head? (What was that like?) were you so easily distracted by things around you that you had trouble concentrating or staying on one track? (Give me an example of that.) how did you spend your time? (Work, friends, hobbies?) (Were you especially productive or busy during that time?) (Were you so active that your friends or family were concerned about you?) IF NO INCREASED ACTIVITY: Were you physically restless? (How bad was it?) (1) inflated self-esteem or grandiosity (2) decreased need for sleep (e.g., feels rested after only 3 hours of sleep) (3) more talkative than usual or pressure to keep talking (4) flight of ideas or subjective experience that thoughts are racing (5) distractibility (i.e., attention too easily drawn to unimportant or irrelevant external stimuli) (6) increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation Check if: increase in activity psychomotor agitation? 1 2 3 A87? 1 2 3 A88? 1 2 3 A89? 1 2 3 A90? 1 2 3 A91? 1 2 3 A92 A93 A94

SCID-I (for DSM-IV-TR) Current Manic (JAN 2007) Mood Episodes A. 22 How many separate times in your life were you (HIGH/OWN WORDS) and had [ACKNOWLEDGED MANIC SYMPTOMS] for at least a week (or were hospitalized)? Number of Manic Episodes, including current (CODE 99 IF TOO INDISTINCT OR NUMEROUS TO COUNT) NOTE: TO RECORD DETAILS OF PAST EPISODES, J. 14 (OPTIONAL). A100 *CURRENT MANIC EPISODE SPECIFIERS* *WITH POSTPARTUM ONSET* IF UNKNOWN: When did (MANIC SYMPTOMS) start? *WITH CATATONIC FEATURES* BY OBSERVATION OR HISTORY WITH POSTPARTUM ONSET Onset of Episode within 4 weeks postpartum. CATATONIC FEATURES CRITERIA The clinical picture is dominated by at least two of the following: (1) motoric immobility as evidence by catalepsy (including waxy flexibility) or stupor DESCRIBE SPECIFIC BEHAVIOR:? 1 3 A101 WITH POSTPARTUM ONSET? 1 2 3 A102 (2) excessive motor activity (that is apparently purposeless and not influenced by external stimuli) DESCRIBE SPECIFIC BEHAVIOR:? 1 2 3 A103

SCID-I (for DSM-IV-TR) Current Hypomanic (JAN 2007) Mood Episodes A. 24 *CURRENT HYPOMANIC HYPOMANIC EPISODE CRITERIA IF CRITERIA ARE MET FOR A CURRENT MANIC EPISODE, CHECK HERE AND GO TO THE NEXT MODULE. A107a (When you were [HIGH/IRRITABLE/ OWN WORDS], did it last for at least 4 days?) Have you had more than one time like that? (When were you the most [HIGH /IRRITABLE/OWN WORDS]?) FOCUS ON THE MOST EXTREME PERIOD IN THE PAST MONTH OF THE CURRENT EPISODE FOR THE FOLLOWING QUESTIONS. (During this time...) A. A distinct period of persistently elevated, expansive or irritable mood, lasting throughout at least 4 days, that is clearly different from the usual nondepressed mood. Check if: elevated, expansive mood irritable mood B. During the period of mood disturbance, three (or more) of the following symptoms have persisted (four if the mood is only irritable) and have been present to a significant degree:? 1 2 3 A108 *PAST MANIC A. 28 A109 A110 how did you feel about yourself? (More self-confident than usual?) (Any special powers or abilities?) did you need less sleep than usual? (How much sleep did you get?) IF YES: Did you still feel rested? were you much more talkative than usual? (Did people have trouble stopping you or understanding you? Did people have trouble getting a word in edgewise?) were your thoughts racing through you head? (What was that like?) (1) inflated self-esteem or grandiosity (2) decreased need for sleep (e.g., feels rested after only 3 hours of sleep) (3) more talkative than usual or pressure to keep talking (4) flight of ideas or subjective experience that thoughts are racing? 1 2 3 A111? 1 2 3 A112? 1 2 3 A113? 1 2 3 A114

SCID-I (for DSM-IV-TR) Current Hypomanic (JAN 2007) Mood Episodes A. 25 were you so easily distracted by things around you that you had trouble concentrating or staying on one track? (Give me an example of that.) how did you spend your time? (Work, friends, hobbies?) (Were you especially productive or busy during that time?) (Were you so active that your friends or family were concerned about you?) IF NO INCREASED ACTIVITY: Were you physically restless? (How bad was it?).. did you do anything that could have caused trouble for you or your family? (Buying things you didn t need?) (Anything sexual that was unusual for you?) (Reckless driving?) (5) distractibility (i.e., attention too easily drawn to unimportant or irrelevant external stimuli) (6) increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation Check if: increase in activity psychomotor agitation (7) excessive involvement in pleasurable activities which have a high potential for painful consequences (e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments) AT LEAST THREE B SXS ARE CODED 3 (FOUR IF MOOD ONLY IRRITABLE).? 1 2 3 A115? 1 2 3 A116 A117 A118? 1 2 3 A119 1 3 A120 *PAST MANIC A. 28 *CURRENT HYPOMANIC CRITERION C* IF NOT KNOWN: Was this very different from the way you usually are (when you re not depressed?) (How were you different? At work? With friends?) C. The episode is associated with an unequivocal change in functioning that is uncharacteristic of the person when not symptomatic.? 1 2 3 A121 *PAST MANIC A. 28

SCID-I (for DSM-IV-TR) Past Manic (JAN 2007) Mood Episodes A. 28 *PAST MANIC MANIC EPISODE CRITERIA NOTE: IF CURRENTLY ELEVATED OR IRRITABLE MOOD BUT FULL CRITERIA ARE NOT MET FOR A MANIC EPISODE, SUBSTITUTE THE PHRASE Has there ever been another time... IN EACH OF THE SCREENING QUESTIONS BELOW. Have you ever had a period of time when you were feeling so good, high, excited, or hyper that other people thought you were not your normal self or you were so hyper that you got into trouble? IF YES: What was it like? (Did anyone say you were manic?) (Was that more than just feeling good?) IF NO: Have you ever had a period of time when you were feeling irritable or angry every day for at least several days? What was it like? (Did you find yourself often starting fights or arguments?) A. A distinct period [lasting at least 4 days] of abnormally and persistently elevated, expansive or irritable mood... Check if: elevated, expansive mood irritable mood? 1 2 3 A126 *DYS- THYMIC DISOR- DER* A. 38 A127 A128 When was that? What was it like? How long did that last? (As long as 1 week?) (Did you need to go to the hospital?) Have you had more than one time like that? (Which time was the most extreme?) IF UNCLEAR: Have you had any times like that in the past year? lasting at least 1 week (or any duration if hospitalization is necessary). NOTE: IF ELEVATED MOOD LASTS LESS THAN 1 WEEK, CHECK WHETHER IRRITABLE MOOD LASTS AT LEAST 1 WEEK BEFORE SKIPPING TO A. 24. NOTE: IF THERE IS EVIDENCE FOR MORE THAN ONE PAST EPISODE, SELECT THE WORST ONE FOR YOUR INQUIRY ABOUT PAST MANIC EPISODE. IF THERE WAS AN EPISODE IN THE PAST YEAR, ASK ABOUT THAT EPISODE EVEN IF IT WAS NOT THE WORST.? 1 2 3 A129 *PAST HYPOMANIC A. 33

SCID-I (for DSM-IV-TR) Past Manic (JAN 2007) Mood Episodes A. 29 FOCUS ON THE WORST PERIOD OF THE EPISODE THAT YOU ARE INQUIRING ABOUT. IF UNCLEAR: During (EPISODE), when were you the most (OWN WORDS FOR MANIA)? B. During the period of mood disturbance, three (or more) of the following symptoms have persisted (four if the mood is only irritable) and have been present to a significant degree: During that time... how did you feel about yourself? (More self-confident than usual?) (Any special powers or abilities?) did you need less sleep than usual? (How much sleep did you get?) IF YES: Did you still feel rested? were you much more talkative than usual? (Did people have trouble stopping you or understanding you? Did people have trouble getting a word in edgewise?) were your thoughts racing through your head? (What was that like?) were you so easily distracted by things around you that you had trouble concentrating or staying on one track? (Give me an example of that.) how did you spend your time? (Work, friends, hobbies?) (Were you especially productive or busy during that time?) (Were you so active that your friends or family were concerned about you?) IF NO INCREASED ACTIVITY: Were you physically restless? (How bad was it?) (1) inflated self-esteem or grandiosity (2) decreased need for sleep (e.g., feels rested after only 3 hours of sleep) (3) more talkative than usual or pressure to keep talking (4) flight of ideas or subjective experience that thoughts are racing (5) distractibility (i.e., attention too easily drawn to unimportant or irrelevant external stimuli) (6) increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation Check if: increase in activity psychomotor agitation? 1 2 3 A130? 1 2 3 A131? 1 2 3 A132? 1 2 3 A133? 1 2 3 A134? 1 2 3 A135 A136 A137

SCID-I (for DSM-IV-TR) Past Manic (JAN 2007) Mood Episodes A. 32 MANIC EPISODE CRITERIA A, B, D AND E ARE CODED 3 1 3 A142 *DYSTHYMIC DISORDER* A. 38 PAST MANIC EPISODE How old were you when (PAST MANIC EPISODE) started? Age at onset of Past Manic Episode coded above A143 How many separate times in your life were you (HIGH/OWN WORDS) and had [ACKNOWLEDGED MANIC SYMPTOMS] for a period of time (or were hospitalized? Number of Manic Episodes (CODE 99 IF TOO INDISTINCT OR NUMEROUS TO COUNT) NOTE: TO RECORD DETAILS OF OTHER PAST EPISODES, J. 14 (OPTIONAL). NEXT MODULE A144

SCID-I (for DSM-IV-TR) Past Hypomanic (JAN 2007) Mood Episodes A. 33 *PAST HYPOMANIC (When you were [HIGH/IRRITABLE/ OWN WORDS], did it last for at least 4 days?) What was it like? Have you had more than one time like that? (Which time was the most extreme?) IF UNCLEAR: Have you had any times like that in the past year? HYPOMANIC EPISODE CRITERIA A. A distinct period of sustained elevated, expansive, or irritable mood, lasting throughout at least 4 days, that is clearly different from the usual nondepressed mood. Check if: elevated, expansive mood irritable mood NOTE: IF THERE IS EVIDENCE FOR MORE THAN ONE PAST EPISODE, SELECT THE WORST ONE FOR YOUR INQUIRY ABOUT PAST HYPOMANIC EPISODE. IF THERE WAS AN EPISODE IN THE PAST YEAR, ASK ABOUT THAT EPISODE EVEN IF IT WAS NOT THE WORST.? 1 2 3 A145 *DYS- THYMIC DIS- ORDER* A. 38 A146 A147 FOCUS ON THE WORST PERIOD OF THE EPISODE THAT YOU ARE INQUIRING ABOUT. IF UNCLEAR: During (EPISODE), when were you the most (OWN WORDS FOR HYPOMANIA)? B. During the period of mood disturbance, three (or more) of the following symptoms have persisted (four if the mood is only irritable) and have been present to a significant degree: During that time... how did you feel about yourself? (More self-confident than usual?) (Any special powers or abilities?) did you need less sleep than usual? (How much sleep did you get?) IF YES: Did you still feel rested? were you much more talkative than usual? (Did people have trouble stopping you or understanding you? Did people have trouble getting a word in edgewise?) were thoughts racing through your head? (What was that like?) (1) inflated self-esteem or grandiosity (2) decreased need for sleep (e.g., feels rested after only 3 hours of sleep) (3) more talkative than usual or pressure to keep talking (4) flight of ideas or subjective experience that thoughts are racing? 1 2 3 A148? 1 2 3 A149? 1 2 3 A150? 1 2 3 A151

SCID-I (for DSM-IV-TR) Past Hypomanic (JAN 2007) Mood Episodes A. 34 During that time were you so easily distracted by things around you that you had trouble concentrating or staying on one track?.. how did you spend your time? (Work, friends, hobbies?) (Were you especially productive or busy during that time?) (Were you so active that your friends or family were concerned about you?) IF NO INCREASED ACTIVITY: Were you physically restless? (How bad was it?).. did you do anything that could have caused trouble for you or your family? (Buying things you didn t need?) (Anything sexual that was unusual for you?) (Reckless driving?) (5) distractibility (i.e., attention too easily drawn to unimportant or irrelevant external stimuli) (6) increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation Check if: increase in activity psychomotor agitation (7) excessive involvement in pleasurable activities which have a high potential for painful consequences (e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments) NOTE: BECAUSE OF THE DIFFICULTY OF DISTING- UISHING NORMAL PERIODS OF GOOD MOOD FROM HYPOMANIA, REVIEW ALL ITEMS CODED 3 IN CRITERIA A AND B AND RECODE ANY EQUIVOCAL JUDGMENTS. AT LEAST THREE B SXS ARE CODED 3 (FOUR IF MOOD ONLY IRRITABLE).? 1 2 3 A152? 1 2 3 A153? 1 2 3 A154 1 3 A155 IF NOT ALREADY ASKED: Has there been any other time when you were (high/irritable/own WORDS) and had even more of the symptoms that I just asked you about? IF YES: RETURN TO *PAST HYPOMANIC EPISODE, * A. 33, AND INQUIRE ABOUT THAT EPISODE. IF NO: *DYSTHYMIC DISORDER, * A. 38. CONTINUE ON NEXT PAGE

SCID-I (for DSM-IV-TR) Past Hypomanic (JAN 2007) Mood Episodes A. 37 HYPOMANIC EPISODE CRITERIA A, B, C, D, E, AND F ARE CODED 3. 1 3 A160 *DYSTHYMIC DISORDER* A. 38 PAST HYPO- MANIC EPI- SODE How old were you when (PAST HYPOMANIC EPISODE) started? Age at onset of Past Hypomanic Episode coded above. A161 How many separate times in your life were you (high/irritable/own WORDS) and had [ACKNOWLEDGED MANIC SYMPTOMS] for a period of time? Total number of Hypomanic Episodes (CODE 99 IF TOO INDISTINCT OR NUMEROUS TO COUNT). NOTE: TO RECORD DETAILS OF PAST EPISODES, J. 18 (OPTIONAL). NEXT MODULE A162

SCID-I (for DSM-IV-TR) Dysthymic Disorder (JAN 2007) Mood Episodes A. 41 Just before this began, were you physically ill? IF YES: What did the doctor say? Just before this began, were you using any medications? IF YES: Any change in the amount you were using? Just before this began, were you drinking or using any street drugs? G. Not due to the direct physiological effects of a substance (e.g., a drug of abuse, medication) or to a general medical condition. IF THERE IS ANY INDICATION THAT THE DEPRESSION MAY BE SECONDARY (I.E., A DIRECT PHYSIOLOGICAL CONSEQUENCE OF A GMC OR SUBSTANCE, GO TO *GMC/SUBSTANCE*, A. 43, AND RETURN HERE TO MAKE A RATING OF 1 OR 3. Etiological general medical conditions include: degenerative neurological illnesses (e.g., Parkinson s disease, Huntington s disease, cerebrovascular disease, metabolic and endocrine conditions (e.g., B-12 deficiency, hypothyroidism, autoimmune conditions) (e.g., systemic lupus erythematosis), viral or other infections (e.g., hepatitis, mononucleosis, HIV), and certain cancers (e.g., carcinoma of the pancreas).? 1 3 A176 DUE TO SUB- STANCE USE OR GMC NEXT MODULE PRIMARY MOOD DISORDER Etiological substances include: alcohol, amphetamine, cocaine, hallucinogens, inhalants, opioids, phencyclidine, sedatives, hypnotics, anxiolytics. Medications include antihypertensives, oral contraceptives, corticosteroids, anabolic steroids, anticancer agents, analgesics, anti-cholinergics, and cardiac medications. CONTINUE BELOW IF UNCLEAR: How much do your depressed feelings interfere with your life? H. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.? 1 3 NEXT MODULE A177 DYSTHYMIC DISORDER CRITERIA A, B, C, D, E, F, G, AND H ARE CODED 3. Indicate specifier: 1 Early Onset: onset before age 21 2 Late Onset: onset age 21 or older NEXT MODULE 1 3 DYS- THYMIC DIS- ORDER A178 A179

SCID-I (for DSM-IV-TR) Due to a GMC (APR 2005) Mood Episodes A. 44 (4) THERE ARE NO ALTERNATIVE EXPLANATIONS (E.G., MOOD SYMPTOMS AS A PSYCHOLOGICAL REACTION TO THE GMC). IF UNCLEAR: How much did (MOOD SYMPTOMS) interfere with your life? E. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. NOTE: THE D CRITERION (DELIRIUM R/O) HAS BEEN OMITTED. MOOD DISORDER DUE TO GMC CRITERIA A, B/C, AND E CODED 3.? 1 2 3 A191 *SUB- STANCE INDUCED* A. 45 1 3 A192 MOOD DIS- ORDER DUE TO A GMC CHECK HERE IF CURRENT IN PAST MONTH A192a Indicate which type of symptom presentation predominates: 1 - With Major Depressive-like episode 2 - With Depressive Features (if predominant mood is depressed but the full criteria are not met for a Major depressive episode) 3 - With Manic Features 4 - With Mixed Features A193 CONTINUE ON NEXT PAGE

SCID-I (for DSM-IV-TR) Substance-Induced (JAN 2007) Mood Episodes A. 46 IF UNKNOWN: How much of (SUBSTANCE) were you using when you began to have (MOOD SYMPTOMS)? IF UNKNOWN: Have you had any other episodes of (MOOD SYMPTOMS)? IF YES: How many? Were you using (SUBSTANCES) at those times? IF UNKNOWN: How much did (MOOD SYMPTOMS) interfere with your life? (3) the mood symptoms are substantially in excess of what would be expected given the type, duration or amount of the substance used (4) there is evidence suggesting the existence of an independent non-substance-induced Mood Disorder (e.g., a history of recurrent Major Depressive Episodes) E. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. NOTE: THE D CRITERION (DELIRIUM R/O) HAS BEEN OMITTED. SUBSTANCE-INDUCED MOOD DISORDER CRITERIA A, B, C, AND E ARE CODED 3.? 1 2 3 A198 RETURN TO EPISODE BEING EVALUATED 1 3 A199 SUBSTANCE-INDUCED MOOD DISORDER CHECK HERE IF CURRENT IN PAST MONTH A199a Indicate which type of symptom presentation predominates: 1 With Depressive Features 2 With Manic Features 3 With Mixed Features A200 Indicate context of development of mood symptoms: 1 With Onset During Intoxication 2 With Onset During Withdrawal A201 RETURN TO EPISODE BEING EVALUATED