Asthma/COPD Update with Inhaler Workshop October 8, 2017 Nathan Samsa, DO, Pharm D, RPh, FACOI
None Disclosures
Agenda Asthma Updates COPD Updates Inhaler Workshop
Medication Acronyms SABA: Short acting beta agonist LABA: Long acting beta agonist LAMA: Long acting muscarinic antagonist ICS: Inhaled corticosteroid
Asthma Updates
Asthma Updates SMART Trial aftermath Guidelines (GINA, ERS/ATS) FeNO testing Biologics
SMART Trial 2006: The Salmeterol Multicenter Asthma Research Trial Compared salmeterol vs. placebo added to usual care Subjects: 26,355 patients >12 years of age Nelson HS, Weiss ST, Bleeker ER, et al. The Salmeterol Multicenter Research Trial: A Comparison of Usual Pharmacotherapy for Asthma or Usual Pharmacotherapy Plus Salmeterol. Chest. 2016. 129: 15-26.
SMART Findings No significant difference between the two for: Overall safety Respiratory-related deaths (50 vs 36) Life-threatening experiences HOWEVER Nelson HS, Weiss ST, Bleeker ER, et al. The Salmeterol Multicenter Research Trial: A Comparison of Usual Pharmacotherapy for Asthma or Usual Pharmacotherapy Plus Salmeterol. Chest. 2016. 129: 15-26.
Salmeterol Is Evil Small increase in respiratory-related deaths (24 vs 11) Small increase in asthma-related deaths (13 vs 3) Majority were in African-Americans (20 vs 5) All were statistically significant So based on 15 more patients deaths with salmeterol from this subset population Nelson HS, Weiss ST, Bleeker ER, et al. The Salmeterol Multicenter Research Trial: A Comparison of Usual Pharmacotherapy for Asthma or Usual Pharmacotherapy Plus Salmeterol. Chest. 2016. 129: 15-26.
Innocent Bystanders
BELT Trial Evaluated tiotropium vs. LABA in addition to inhaled corticosteroids (ICS) in black population over 18 months Tiotropium + ICS (n = 532) LABA + ICS (n = 538) Weschler ME, Yawn BP, Fuhlbrigge AL, et al. Anticholinergic vs Long-Acting β-agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma. JAMA. October 27, 2015. 314(16): 1720-1730.
BELT Findings No difference in clinical outcomes, including FEV 1 No significant difference with non-asthma and asthma-related adverse effects (P = 0.16) 3 deaths occurred, all in tiotropium group Weschler ME, Yawn BP, Fuhlbrigge AL, et al. Anticholinergic vs Long-Acting β-agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma. JAMA. October 27, 2015. 314(16): 1720-1730.
AUSTRI Trial Evaluated safety of adding salmeterol to fluticasone in adults and adolescents (ages 12) Fluticasone only (n = 5834) Black (n = 856; 15%) Fluticasone + salmeterol (n = 5845) Black (n = 870; 15%) Stempel DA, Raphiou IH, Kral KM, et al. Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone. NEJM. May 12, 2016. 374: 1822-1830.
AUSTRI Findings Asthma exacerbations Fluticasone only (n = 597) Fluticasone + salmeterol (n = 480) Adding salmeterol reduced exacerbations 16-32% Asthma exacerbations in black patients Fluticasone only (n = 79) Fluticasone + salmeterol (n = 79) Stempel DA, Szefler SJ, Pederson S, et al. Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma. NEJM. September 1, 2016. 375: 840-849.
VESTRI Trial Evaluated safety of adding salmeterol to fluticasone in children (ages 4-11) Fluticasone only (n = 3101) Black (n = 511; 16.5%) Fluticasone + salmeterol (n = 3107) Black (n = 539; 17.3%) Stempel DA, Raphiou IH, Kral KM, et al. Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone. NEJM. May 12, 2016. 374: 1822-1830.
VESTRI Findings Asthma exacerbations Fluticasone only (n = 309) Fluticasone + salmeterol (n = 265) Asthma exacerbations in black patients Fluticasone only (n = 21) Fluticasone + salmeterol (n = 27) Stempel DA, Szefler SJ, Pederson S, et al. Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma. NEJM. September 1, 2016. 375: 840-849.
VESTRI Findings Serious asthma-related events Fluticasone only (n = 21) Fluticasone + salmeterol (n = 27) No deaths! Salmeterol + fluticasone is non-inferior to fluticasone alone Correlates to AUSTRI findings in children Stempel DA, Szefler SJ, Pederson S, et al. Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma. NEJM. September 1, 2016. 375: 840-849.
Is There A Class Effect? Salmeterol vindicated? What about formoterol? NEJM 9/1/2016: Evaluated safety of adding formoterol to budesonide (ages 12) Fluticasone only (n = 5766) Black (n = 407; 6.9%) Fluticasone + salmeterol (n = 5785) Black (n = 396; 6.8%) Peters SP, Bleeker ER, Canonica GW, et al. Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone. NEJM. September 1, 2016. 375: 850-860.
Study Findings Risk of asthma exacerbation Budesonide only (n = 633, 10.8%) Budesonide + formoterol (n = 539, 9.2%) Asthma-related deaths Budesonide only (n = 0) Budesonide + formoterol (n =2, <0.1%) Peters SP, Bleeker ER, Canonica GW, et al. Serious Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone. NEJM. September 1, 2016. 375: 850-860.
Overall Findings No evidence that LABA on top of inhaled corticosteroid increases risk of asthma-related death No data on lone LABA compared to ICA or ICA + LABA
GINA 2017
GINA Stepwise Approach
GINA ICS
NAEPP Guidelines Classification National Asthma Education and Prevention Program: Expert panel report III. 2007 Mild intermittent Mild persistent Moderate persistent Severe persistent Symptoms 2d/wk >2d/wk, not QD QD QD multiple times Nighttime awakenings 2x/mo 3-4x/mo >1x/wk, not nightly QD SABA use 2d/wk >2d/wk, not QD, not >1x/d QD QD multiple times Limitation None Mild Moderate Severe FEV 1 >80% >80% 60-80% <60%
ICD-10 Classification: Mild intermittent asthma: J45.2x Mild persistent asthma: J45.3x Moderate persistent asthma: J45.4x Severe persistent asthma: J45.5x Unspecified asthma: J45.90x Severity (x) Uncomplicated: 0 Exacerbation: 1 Status asthmaticus: 2
FeNO Fractional concentration of exhaled nitric oxide Modestly associated with eosinophilic airway inflammation Can be seen in other eosinophilic states w/o asthma Not elevated in neutrophilic asthma phenotype Decreased in smokers Does not help rule in or out asthma
FeNO cont. Recommended neither by GINA nor ERS/ATS ERS/ATS 2014: We suggest that clinicians do not use FeNO in addition to clinical criteria to guide therapy in adults or children with severe asthma (conditional recommendation, very low quality evidence). 1 GINA 2017: At present, neither sputum- nor FENOguided treatment is recommended for the general asthma population. (Evidence A) 2 1. Chung KF, Wenzel SE, Brozek JL et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014. 43: 343-373. 2. 2. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2017. Available from: www.ginasthma.org
FeNO Interpretation: ICS Naïve
FeNO Interpretation: On ICS
Biologics In Asthma Omalizumab (Xolair ) Mepolizumab (Nucala ) Reslizumab (Cinqair )
Omalizumab Anti-IgE antibody For patients who failed ICS Baseline IgE 30-700 IU/mL Limited information in treatment >700 IU/mL Note: 1 IU/mL = 2.5ng/mL
Omalizumab cont. Goal is to reduce IgE <10 IU/mL Cannot use IgE levels to monitor; levels increase due to IgE-anti-IgE complexes May take up to 1 year for IgE levels to decrease Issues: Anaphylaxis Questionable increased cancer risk Developed soon after starting therapy pre-existing?
Mepolizumab, Reslizumab Interleukin-5 (IL-5) antibody IL-5 responsible for differentiation and growth of eosinophils Mepolizumab Eosinophil count 150 cells/μl within 6 weeks of therapy Eosinophil count 300 cells/μl within past 12 months Reslizumab Eosinophil count 400 cells/μl
COPD Updates
COPD Updates GOLD 2017 Azithromycin in COPD Asthma-COPD overlap syndrome
GOLD 2017
GOLD Scales
GOLD ABCD
GOLD Treatment Algorithm
Azithromycin In COPD Macrolides have anti-inflammatory properties Evaluated number of exacerbations of azithromycin 250mg daily vs placebo (n = 1577) Placebo: 1.83 exacerbations/year Azithromycin: 1.48 exacerbations/year P = 0.01 Concern about QTc prolongation/cardiac issues Albert RK, Connett J, Baily WC, et al. Azithromycin for Prevention of Exacerbations of COPD. NEJM. August 25, 2011. 365(8): 689-698.
Azithromycin & Cardiac Risk Cohort evaluated 3,546,239 patients between those who took: No antibiotics (n = 1,391,180) Amoxicillin (n = 1,348,672) Azithromycin (n = 347,795); over 5 days Ciprofloxacin (n = 246,626) Levofloxacin (n = 193,906) Ray WA, Murray KT, Hall K, et al. Azithromycin and the Risk of Cardiovascular Death. NEJM. May 17, 2012. 366(20): 1881-1890.
Azithromycin & Cardiac Risk cont. Small increased risk of cardiovascular death with azithromycin (not significantly different from levofloxacin, but significantly greater than ciprofloxacin) Most pronounced in patients with underlying cardiovascular disease Ray WA, Murray KT, Hall K, et al. Azithromycin and the Risk of Cardiovascular Death. NEJM. May 17, 2012. 366(20): 1881-1890.
Does Azithromycin Increase Risk? Different cohort from Denmark evaluated 2,204,469 azithromycin prescriptions compared to no antibiotic use and penicillin V No increased risk of cardiovascular death with azithromycin compared to penicillin In fact, penicillin had more cardiac deaths (146 vs. 17) and azithromycin had a -1 adjusted absolute risk of cardiac death
Asthma-COPD Overlap Continuum of obstructive diseases, not just separate entities Features of both COPD and asthma Asthma can have negative bronchodilator response COPD can have positive bronchodilator response Not defined by GINA or GOLD Multiple definitions by other organizations Postma DS and Rabe KF. The Asthma-COPD Overlap Syndrome. NEJM. September 24, 2015. 373(13): 1241-1249.
One Attempt At Diagnosis Sin DD, Miravitlles M, Mannino D, et al. What is asthma-copd overlap syndrome? Towards a consensus statement from a round table discussion. Eur Respir J. 2016. 48: 664-673.
The Five Commandments 1) A patient with asthma may develop non-fully reversible airflow obstruction but this is not COPD, not even ACO; it is obstructive asthma. 2) A patient with asthma who smokes may also develop non-fully reversible airflow obstruction, which differs from obstructive asthma and from pure COPD. This is the most frequent type of patient with ACO. Miravitlles M. Diagnosis of asthma-copd overlap: the five commandments. Eur Respir J. 2017. 49: 1700506.
The Five Commandments 3) Some patients who smoke and develop COPD may have a genetic Th2 background (even in the absence of a previous history of asthma) and can be identified by high eosinophil counts in peripheral blood. These individuals could be included under the umbrella term of ACO. Miravitlles M. Diagnosis of asthma-copd overlap: the five commandments. Eur Respir J. 2017. 49: 1700506.
The Five Commandments 4) A patient with COPD and a positive bronchodilator test (>200 ml and >12% FEV 1 change) has reversible COPD but is not an asthmatic, or even ACO. 5) A patient with COPD and a very positive bronchodilator test (>400 ml FEV 1 change) is more likely to have some features of asthma and could also be classified as ACO. Miravitlles M. Diagnosis of asthma-copd overlap: the five commandments. Eur Respir J. 2017. 49: 1700506.
Inhaler Workshop
Inhaler Workshop Review currently available inhaled medications Discuss factors when selecting inhaled medication Critique currently available delivery devices Hands-on session
Inhaled Medications Beta (β 2 ) agonists Short acting Long acting Muscarnic (M 3 ) antagonists Short acting Long acting Inhaled corticosteroids
LAMA LABA Tiotropium (Spiriva ) HandiHaler : 9/24/04 Respimat : 9/24/14 Aclidinium (Tudorza ): 7/23/12 Umeclidinium (Incruse ): 4/30/14 Glycopyrrolate (Seebri ): 10/29/15 Salmeterol (Serevent ): 9/19/97 Arformoterol (Brovana ): 10/6/06 Formoterol (Perforomist ): 5/11/07 Indacaterol (Arcapta ): 7/1/11 Olodaterol (Striverdi ): 7/31/14
ICS Mometasone (Asmanex ) Twisthaler : 3/30/05 HFA: 4/25/14 Fluticasone Propionate (Flovent ) Diskus : 9/29/00 HFA: 5/14/04 Flunisolide (Aerospan ) 1/27/06 Budesonide (Pulmicort ) Respules : 8/8/00 Flexhaler : 7/12/06 Ciclesonide (Alvesco ): 1/10/08 Beclomethasone (Qvar ) HFA: 9//15/00 RediHaler : 8/3/17 Fluticaonse Furoate (Arnuity ): 8/20/14
LABA/ICS Salmeterol/Fluticasone Propionate (Advair ) Diskus : 8/24/00 HFA: 6/8/06 Formoterol/Budesonide (Symbicort ): 7/21/06 Formoterol/Mometasone (Dulera ): 6/22/10 Vilanterol/Fluticasone Furorate (Breo ): 5/10/13 LABA/LAMA Vilanterol/Umeclidinium (Anoro ): 12/18/13 Olodaterol/Tiotropium (Stiolto ): 5/21/15 Indacaterol/Glycopyrrolate (Utibron ): 10/29/15 Formoterol/Glycopyrrolate (Bevesepi ): 4/25/16 LABA/LAMA/ICS Vilanterol/Umeclidinium/Fluticasone Furorate (Trelegy ): 9/18/17
Discontinued inhalers Metaproterenol (Alupent ): 6/14/10 Triamcinolone (Azmacort ): 12/31/10 Pirbuterol (Maxair ): 12/31/13 Formoterol (Foradil ): 12/31/15 Nedocromil (Tilade ): 6/14/10 Cromolyn (Intal ): 12/31/10
Goals for Inhalation Deliver drug to respiratory mucosa Minimize systemic absorption
Factors Affecting Delivery Drug/formulation-related Device-related Patient/disease-related Thorrson, L and Geller D. Factors guiding the choice of delivery device for inhaled corticosteroids in the long-term management of stable asthma and COPD: Focus on budesonide. Resp Med. July, 2005. 99(7); 836-849.
Drug/Formulation Issues Drug potency Pharmacokinetics Particle size Propellant Additives Viscosity Thorrson, L and Geller D. Factors guiding the choice of delivery device for inhaled corticosteroids in the long-term management of stable asthma and COPD: Focus on budesonide. Resp Med. July, 2005. 99(7): 836-849.
Device Issues Deposition properties Particle size Ease of use Accuracy of dosage Administration apparatus Thorrson, L and Geller D. Factors guiding the choice of delivery device for inhaled corticosteroids in the long-term management of stable asthma and COPD: Focus on budesonide. Resp Med. July, 2005. 99(7): 836-849.
Patient/Disease Issues Inspiratory flow rate Upper airway anatomy Lower airway obstruction Ability to use device Competency Cost Patient preference & adherence Thorrson, L and Geller D. Factors guiding the choice of delivery device for inhaled corticosteroids in the long-term management of stable asthma and COPD: Focus on budesonide. Resp Med. July, 2005. 99(7): 836-849.
Remember This?
Chlorofluorocarbons (CFCs) Used as propellants in aerosols Also refrigerants and solvents Destroyed ozone layer Montreal Protocol on Substances that Deplete the Ozone Layer September 16, 1987 Phase out CFCs
Inhalers: Ozone Killers! FDA phased out generic albuterol as of 12/31/2008 Newer albuterol products use hydrofluoroalkane (HFA) Available then as now: ProAir HFA Proventil HFA Ventolin HFA $$$ and still no generics https://www.fda.gov/drugs/drugsafety/informationbydrugclass/ucm063054.htm Accessed October 2, 2017
The Only Good Casualty
Delivery Systems Diskus Ellipta Flexhaler HandiHaler RespiClick Respimat HFA Nebulizer NeoHaler Pressair
Diskus Flovent Fluticasone propionate Serevent Salmeterol Advair Fluticasone propionate + Salmeterol
Ellipta Arnuity Fluticasone furoate Incruse Umeclidinium Anoro Umeclidinium + Vilanterol Breo Fluticasone furoate + Vilanterol Trelegy Fluticasone furoate + Vilanterol + Umeclidinium
Flexhaler Pulmicort Budesonide
HandiHaler Spiriva Tiotropium
NeoHaler Arcapta Indacaterol Seebri Glycopyrrolate Utibron Indacaterol + Glycopyrrolate
Pressair Tudorza Aclidinium
RespiClick ProAir Albuterol
Respimat Spiriva Tiotropium Striverdi Olodaterol Stiolto Tiotropium + Olodaterol Combivent Albuterol + Ipratropium
HFA ProAir Albuterol Proventil Albuterol Ventolin Albuterol Xopenex Levalbuterol
Nebulizer Albuterol Ipratropium DuoNeb Albuterol + Ipratropium Brovana Arformoterol Perforomist Formoterol Pulmicort Respules Budesonide
Device Selection Summary Chose drug(s) Based on GINA/GOLD guidelines Clinical history Dosing regimen Chose delivery system Is patient able to use it physically? Mental competence? Is it covered by insurance?
Why Care About Teaching? You can get paid for it! CPT: 94664 Document! My example: I personally instructed the patient on the use of [Inhaler Name]. Appropriate technique was demonstrated. Questions answered. Sample provided to patient.
The End Thank you for your time!