THE KIDNEY, HYPERTENSION AND CARDIOVASCULAR RISK

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Menarini Foundation Symposia: 283 WWW.ARISTEA.COM/CARDIORENALRISK2016 THE KIDNEY, HYPERTENSION AND CARDIOVASCULAR RISK PROMOTED BY GENOVA, ITALY - PALAZZO DUCALE, MAY 19/21, 2016 WWW.FONDAZIONE-MENARINI.IT PRELIMINARY PROGRAMME

PRESENTATION PROMOTED BY Centro Direzionale Milanofiori Edificio L Strada 6 20089 Rozzano (Milano) Italy Ph. +39 02 55308110 Fax +39 02 55305739 E-mail milan@fondazione-menarini.it Web www.fondazione-menarini.it SCIENTIFIC SECRETARIAT Roberto Pontremoli Dipartimento di Medicina Interna IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro Largo Rosanna Benzi, 10 16132 Genova Italy ORGANIZING SECRETARIAT Via Roma, 10 16121 Genova Italy Ph. +39 010 553591 Fax +39 010 5535970 E-mail genova@aristea.com Web www.aristea.com The cardiovascular system is profoundly affected by changes in renal function. In fact, it has long been known that patients with end stage renal disease undergoing renal replacement treatment carry a dramatically higher risk of cardiovascular and cerebrovascular events as compared to the general population with normal renal function. More recently, it has been fully appreciated that even mild abnormalities in renal function such as the presece of microalbuminuria or a slight, subclinical reduction in glomerular filtration rate, already entail a significant increase in cardiovascular risk. Thus, the kidney may well be looked at as a sensor of cardiovascular risk as well as a target for treatment. This is even more important when one considers that high blood pressure and diabetes, arguably the two most important risk factors for the development of chronic kidney disease are highly prevalent in western countries and are going to be even more over the next two decades. In the U.S., it is currently estimated that over 10% of the general population has a glomerular filtration rate below 60 ml/min and an even greater percentage, about 20-30%, do have an increased urine albumin excretion. Hypertension has a bidirectional relationship with kidney damage: on the one hand it is the most important risk factor for disease progression and, on the other hand, it is the result of renal disease itself. Furthermore a subtle, subclinical abnormality in renal function has long been regarded as one of the pathogenetic mechanisms underlying the developement of primary hypertension. A better knowledge of the mechanisms underlying the relationship between arterial hypertension, renal function abnormalities and the excess cardiovascular mortality may favourably impact clinical practice at the diagnostic and therapeutic level. Many international experts in the field will attend the Meeting to discuss and present the latest advances on the topic. The Kidney, Hypertension and Cardiovascular Risk aims at providing both general practitioners and specialists with an up-to-date and in depth overview about therapeutic strategies to prevent hypertension and renal related complications as well as the associated excess of cardiovascular events. Roberto Pontremoli, President of the Meeting

SCIENTIFIC PROGRAM SCIENTIFIC PROGRAM THURSDAY, MAY 19, 2016 FRIDAY, MAY 20, 2016 15.00 Opening Ceremony 15.30 Presentation of the Meeting R. Pontremoli MAIN LECTURES Chairmen: G. Deferrari, A. Stella 16.00 The Renin Angiotensin Aldosterone system, hypertension and cardiovascular risk: an update in 2016 A. Morganti 16.45 Treatment of Chronic Heart Failure in the renal patient M. Volpe 17.30 Dietary intervention in chronic kidney disease: balancing the risks and the benefits M. Muscaritoli 18.15 Sympathetic nervous system in hypertension and chronic kidney disease G. Grassi 19.00 Open Discussion with the Opinion Leader 19.45 Welcome Cocktail 08.45 SESSION 1 The ageing kidney and cardio-metabolic risk Chairmen: P. Odetti, A. Pende Improving blood pressure control in the elderly population: the next public policy mission? G. Tocci Hypertension and cognitive dysfunction: Assessment and therapeutic strategies G. Bellelli Resistant hypertension in the elderly: drugs vs device S. Taddei Clinical use of Phoshodiesterase-5 inhibitors in the cardiorenal patient C. Ferri 10.45 Coffee Break 11.15 SESSION 2 Uric Acid and cardiorenal risk Chairmen: C. Borghi, R. Pontremoli 13.15 Lunch Uric Acid, Hypertension and Diabetes: casual or causal associations? G.B. Desideri Uric Acid and renal damage F. Viazzi Asymptomatic hyperuricemia and CV risk: is it time to act? C. Borghi Uric Acid as a target of treatment: a lesson in pharmacoeconomy L. Degli Esposti

SCIENTIFIC PROGRAM SCIENTIFIC PROGRAM FRIDAY, MAY 20, 2016 SATURDAY, MAY 21, 2016 14.15 SESSION 3 The kidney, diabetes and cardiovascular disease Chairmen: R. Cordera, G. Garibotto Metabolic syndrome, obesity and renal damage L. Del Vecchio Glucose lowering treatment in Diabetic Kidney Disease R. Trevisan Antihypertensive treatment in Chronic Kidney Disease R. Pontremoli 16.00 Coffee Break 16.30 SESSION 4 Assessing global risk profile for optimal management of the hypertensive patient Chairmen: G. Grassi, G. Murialdo Ambulatory Blood Pressure Monitoring G.F. Parati Left ventricular hypertrophy M.L. Muiesan Vascular Stiffness G. Schillaci Microalbuminuria L.M. Ruilope 18.30 Open Discussion with the Opinion Leader 19.30 End of session 08.30 SESSION 5 Strategies to reduce CV risk and progression of renal damage in CKD Chairmen: F. Dallegri, A. Morganti Fibromuscular dysplasia revisited: from clinical description to genetic dissection A. Persu RAAS inhibition: monotherapy vs combination S. Bianchi Hypertension in CKD: a diagnostic and therapeutic challenge L. De Nicola 10.30 Coffee Break 11.00 SESSION 6 The high-risk comorbid patient Chairmen: E. Paoletti, F. Viazzi Atrial Fibrillation in CKD: a therapeutic challenge S. Genovesi Onco-Cardiology: the time has come C. Giannatasio, P. Vallerio New developments in atherosclerosis: from pathogenetic mechanisms to therapeutic innovations F. Cipollone 13.30 Open Discussion with the Opinion Leader 14.30 Closing Remarks and Take home Message R. Pontremoli 15.00 Farewell cocktail

FACULTY GENERAL INFORMATION G. Bellelli Milano S. Bianchi Livorno C. Borghi Bologna F. Cipollone Chieti R. Cordera Genova F. Dallegri Genova G. Deferrari Genova L. Degli Esposti Ravenna L. Del Vecchio Lecco L. De Nicola Napoli G.B. Desideri L Aquila C. Ferri L Aquila G. Garibotto Genova S. Genovesi Milano C. Giannatasio Milano G. Grassi Milano A. Morganti Milano M.L. Muiesan Brescia G. Murialdo Genova M. Muscaritoli Roma P. Odetti Genova E. Paoletti Genova G.F. Parati Milano A. Pende Genova A. Persu Brussels, Belgium R. Pontremoli Genova L.M. Ruilope Madrid, Spain G. Schillaci Perugia A. Stella Milano S. Taddei Pisa G. Tocci Roma R. Trevisan Bergamo P. Vallerio Milano F. Viazzi Genova M. Volpe Roma CONGRESS VENUE Palazzo Ducale Piazza Giacomo Matteotti, 9 16123 Genova Italy Ph. +39 010 8171614 Fax +39 010 8171601 Web www.palazzoducale.genova.it UEMS CREDITS The The Kidney, Hypertension and Cardiovascular Risk is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. The EACCME is an institution of the European Union of Medical Specialists (UEMS), www.uems.net The The Kidney, Hypertension and Cardiovascular Risk is designated for a maximum of 9 hours of European external CME credits. Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. Through an agreement between the European Union of Medical Specialists and the American Medical Association, physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits. Information on the process to convert EACCME credit to AMA credit can be found at www.ama-assn.org/go/internationalcme Live educational activities, occurring outside of Canada, recognized by the UEMS-EACCME for ECMEC credits are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of The Royal College of Physicians and Surgeons of Canada.

GENERAL INFORMATION C.M.E. - CONTINUING MEDICAL EDUCATION (For Italian Physicians only) Aristea Education (Provider n. 500) has inncluded the Meeting in the Educational Plan 2016. The Congress will be suited for Physicians (Nephrologists, Cardiologists, Internal Medicine Physicians, General Practioners, Diabetologists, Endocrinologists, Geriatricians) and provides 9,5 C.M.E. credits. In order to obtain C.M.E. credits, participants must attend the 100% of the Meeting and submit the filled in evaluation questionnaire and C.M.E.: Verification Form. The certificate of attendance with the number of C.M.E. assigned credits can be downloaded after 60 days from the date of the Congress directly through the website www.aristea.com/ecm REGISTRATION The registration is free. To register please visit the website www.aristea.com/cardiorenalrisk2016 TRAINING OBJECTIVES Clinical research. Clinical care and rehabilitation programs. Patient management and care profiles.