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Name and address of Centre CERTIFIED TRAINING CENTER OF THE EUROPEAN ACADEMY OF ANDROLOGY, BUDAPEST A. 1082 BUDAPEST, ULLOI UT 78/B. B. 1062 BUDAPEST, PODMANICZKY UTCA 109-111. Type of Centre University University Hospital Private Centre Other (please specify) x x 1. Director Dr. Zsolt Kopa Ph.D, EAA member 2010 Clinical Andrologist, Hung. Androl. Spec.. 2. Director (if more Institutions in the Centre) Prof. Gyorgy Papp Ph.D., EAA member 1997 Clinical Andrologist, Hung. Androl. Spec 3. Present Staff (Senior Scientists) 1) Name Prof. Peter Nyirady Degree M.D., D.Sci. Speciality Urologist, Andrologist 2) Name Edit Erdei Degree M.D., Ph. D. Speciality Urologist, Andrologist Academician x Affiliated Member Hung. Androl. Spec. x 2) Name Peter Riesz Degree M.D., Ph. D. Speciality Urologist, Andrologist, Med. Oncologist 3) Name Gyorgy Bogyi Degree M.D. M.S.C. Speciality Urologist, Andrologist 4) Name Istvan Albert Degree M.D. Speciality Urologist, Andrologist, Oncologist 1

5) Name Robert Kovács Degree M.D. Speciality Urologist, Andrologist Insert any additional staff below (if required) MD/Biologists/Chemists 1) Name Katalin Szabo Degree Speciality Biologist Full time/part time Academician Affiliated Member Clinical Andrologist 2) Name Degree Speciality Full time/part time Academician Affiliated Member Clinical Andrologist 3) Name Degree Speciality Full time/part time Academician Affiliated Member Clinical Andrologist 4) Name Degree Speciality Full time/part time Academician Affiliated Member Clinical Andrologist Insert any additional staff below (if required) PhD Students Nurses 1) Name Tamas Takacs M.D. 2) Name 3) Name 1) Name Jozsefne Kautzky Androl. Assistant 2) Name Ildiko Kedves Androl. Assitstant 3) Name Melinda Bozsanyi Androl. Assistant Laboratory Technicians 1) Name Janosne Rakita 2) Name Nikolett Bozso 2

3) Name Administrative Personnel 1) Name 2) Name 3) Name Insert any additional staff below (if required) For each staff category please specify changes (increased or decreased since last EAA site visit Physicians Nurses Unchanged Increased X Decreased Unchanged x Increased Decreased Laboratory Technicians Unchanged x Increased Decreased 3 Administrative Personnel Unchanged x Increased Decreased Overall comment is personnel staff enough for centres activities? Yes x No Further comment 4. Clinical Activity A. Outpatients: Consultations per year in the last 3 years Center A: Üllői street New patients 805 987 1111 Controls 1856 1770 1564 Type of patients in the last years (%) (2011) (2012) (2013) Infertility 40 41 39 Erectile dysfunction 31 27 29 Hypogonadotropic Hypogonadism 1,5 2 1,5 Klinefelter 0,001 0,001 0,002 Gynaecomastia 0,5 0,5 0,5 Varicocele 14 15 13

Cryptorchidism 0,5 0,6 0,6 Male sex accessory gland infections 12 14 12 Testicular tumours 1 1 1 Disorders of gender identity 0,1 0,05 0,1 Other 1 1 1 Center B/ Podmaniczky Street New patients 5644 5219 5944 Controls 1130 1160 1190 Type of patients in the last years (%) (2011) (2012) (2013) Infertility 50% 56,5% 54,5% Erectile dysfunction 15% 15% 15% Hypogonadotropic Hypogonadism 2% 2% 2% Klinefelter 0,0004% 0,0002% 0,0002% Gynaecomastia 0,4% 2% 2% Varicocele 25,5% 23% 25% Cryptorchidism 0,5% 0,2% 0,4% Male sex accessory gland infections 5% 0,8% 0,6% Testicular tumours 0,5% 0,2% 0,2% Disorders of gender identity 0,2% 0,3% 0,3% Other 0,3% 0% 0% B. Ultrasound (testis, penile, prostate) Center A (Üllői Street) Scrotal Duplex/ 1341/888 1392/942 598/422 Patient No. Small pelvis/ 2557/1317 2589/1340 2149/1172 Patient No. Center B (Podmaniczky Street) New patients 5190 4905 5760 Controls 1000 980 833 Unknown Formatted: English (UK) 4

C. Andrological surgery procedures Center A (Üllői street) Testicular biopsies - 30 62 72 multifocal random TESE+ microtese 2 13 34 Varicocele ligation microsurgical 1 5 5 Varicocele ligation laparoscopic 38 42 42 Prostate biopsies 59 57 77 BPH /PCA 18 28 43 Vasectomy 4 5 14 Vaso-vasostomy 1 2 1 microsurgical microsurgical tubulo-vasostomy. 4 2 4 MESA - 2 11 Microsurgery all 8 23 56 Center B (Podmaniczky Street) Testicular biopsies 62 62 80 Varicocele ligation 51 60 70 Prostate biopsies 3 2 2 BPH 1 0 0 Prostate cancer 0 0 0 Vasectomy 3 10 4 Vaso-vasostomy 0 0 0 Other 0 0 0 5. A. Andrology laboratory activity Center A (Üllői Street) 5

Semen analyses 629 652 666 Sperm antibodies collaboration collaboration collaboration Seminal markers collaboration collaboration collaboration Center B (Podmaniczky Street) Semen analyses 6209 5868 6586 Sperm antibodies 10 15 15 Seminal markers 22 20 20 5. B. Andrology laboratory activity Sperm banking donors Yes x No Sperm banking cancer patients Yes x No If yes: Number of samples 28 18 25 5. C. Hystopathologial evaluation of biopsies Yes x No 5. D. Reproductive Hormones Assays Yes x No If yes please specify type of assays and number of samples in the last year FSH, LH, Prolaktin, Testosteron, Inhibin B, Estradiol, AMH 5. E. Y chromosome microdeletions according to EAA/EMQN guidelines If yes number of tests in the past year Yes x No 60 Center A (Podmaniczky) Participation to the EAA quality control scheme? Yes x No If no, specify if available in another lab of the same hospital Yes No Blood karyotyping Yes x No If no, specify if available in another lab of the same hospital Yes No Other genetic tests (please specify) Center B (Üllői street) 6. Collaborations with other Clinical Units of the University/Hospital 6

IVF Unit Yes x No If yes please specify: Urology Clinic Yes x No Endocrine Clinic Yes x No Genetics Lab/Unit Yes x No Paediatric Unit Yes x No Central Hospital Laboratory Yes x No Private Centres Yes x No If yes please specify: 7. Clinical teaching activity Duration of training (years): 2 FLUENTLY Center A (Üllői Street) Number A: Trainees in the last five years 10 B: Trainees who passed EAA-ESAU\exam for Clinical Andrologist in the last 5yrs - C: Trainees working in the centre preparing to pass the EAA-ESAU examination 1 D: Ph D Students 1 E: Medical Students 8 F: Other students Center B (Podmaniczky Street) Number A: Trainees in the last five years 2 B: Trainees who passed EAA-ESAU\exam for Clinical Andrologist in the last 5yrs 2 C: Trainees working in the centre preparing to pass the EAA-ESAU examination D: Ph D Students E: Medical Students F: Other students 8. Formal Andrology teaching program 8. Center A Yes x No If yes: specify duration (years/months): Years Months Hours of formal teaching per year Medical Students Hungarian/ English/ German language Ph D Students Post Graduate students 48 Trainees 7 Professional training (weeks/months) 2/2/2 8 hours/week 12 month 24 month

Other degrees (please specify) nurses 168 8. Formal Andrology teaching program Center B: Yes x No If yes: specify duration (years/months): Years Months Medical Students Ph D Students Post Graduate students Trainees Other degrees (please specify) Hours of formal teaching per year 2 + 2 hours 4 hours per year Professional training (weeks/months) 9. Research Activity Please list the main papers in peer review journals in the last 3 years with I.F. in a separate file. See separate file 10. Research Funding the amount of available funds in the last 3 years and their source (Government, European Union, University, Local Government, Pharmaceutical Industries, Banks, Foundations.) Year 0 Total amount ( ) Funding Source(s) Year Total amount ( ) Funding Source(s) Year Total amount ( ) Funding Source(s) Insert any additional funding below if required 11. Please report the main improvements of the Centre following the (last) EAA site visit Clinical Activity HIGHER Laboratory Activity HIGHER BUT MAINLY COLLABORATION 8

Research Activity LESS BECAUSE OF SPECIAL POLITICAL SITUATION (REDUCED NUMBER OF CALLS FOR GRANTS, REDUCED POSSIBILITY TO PAY FOR RESEARCH FELLOWS Teaching MORE 12. Overall considerations by the Centre Director A. The centre is growing x Is stable Has problems If has problems, please specify PERIOD OF TRANSITION B. Other Comments by the Centre Director IN THE LAST ONE YEAR TWO CLINICAL ANDROLOGISTS MOVED TO AN OTHER COUNTRY. NEW COLLEAGUES STARTED WITH ANDROL. ACTIVITY. 13. Anticipated future changes in the Centre - IMPROVE SCIENTIFIC ACTIVITY - IMPROVE MICROSURGICAL ACTIVITY - STAFF STABILIZATION Date Director s signature P.S. In 2014. two different Andrological Institutes in our capital will find a new form of collaboration: they will start to work as a new EAA Center of Budapest. (Center A new Center, University Clinic of Semmelweis Budapest, Üllői Street, Center B previously established EAA Center Budapest, University Hospital, Podmaniczky street). The new Center has two Directors, Dr. Kopa Member of EAA and Prof. Papp Member of EAA. In January 2016. Prof. Papp will retire. 9