Report to the IAC WHO meeting June 13-14, 2005 Kjell Hansson Mild Nat l Inst Working Life Umeå, Sweden

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INTERNATIONAL EMF PROJECT Workshop on Electrical Hypersensitivity Location: Prague, Czech Republic Monday 25 October & Tuesday 26 October 2004 Report to the IAC WHO meeting June 13-14, 2005 Kjell Hansson Mild Nat l Inst Working Life Umeå, Sweden

The WHO workshop on "Electrical hypersensitivity" in Prague, Oct 25-26, 2004, over 150 participants. 18 invited talks, and over 40 abstract were submitted, of which 14 were presented in short oral presentations and another 15 presented as posters. Speakers power point presentations can be found on the WHO EMF project home page. The third day working groups were organized: (i) Report on CHARACTERIZATION, DIAGNOSIS AND TREATMENT Rapporteur: Lena Hillert (ii) Report on RESEARCH NEEDS Rapporteur: N. Leitgeb (iii) Report on POLICY OPTIONS, COMMUNICATIONS WITH IEI INDIVIDUALS AND RECOMMENDATIONS TO NATIONAL AUTHORITIES Rapporteur: Jill Meara

Monday 25 October 09.00 Tutorial - Characterizing EHS Prof B Stenberg - Idiopathic Environmental Intolerance (IEI): a causation analysis Dr H Staudenmayer 10.30 EHS and the electromagnetic environment - Prevalence of EHS in Populations of Different Countries Dr P Levallois - Electromagnetic environment in EHS homes and workplaces Prof K Hansson Mild 11.30 Physiological Studies - EMF Hypersensitivity and tissues generating electric current Dr J Bures - Sensor reactivity and autonomic regulation in persons with perceived electrical hypersensitivity Prof E Lyskov 14.00 Physiological Studies (cont'd) - Electrohypersensitivity: Observations in the Human Skin of a Physical Impairment Prof O Johansson 15.30 Provocation and Epidemiological Studies - A review of EHS provocation and epidemiological studies Prof A Ahlbom - Provocation study on subjects with self reported EHS: The NEMESIS Project Dr C Müller - Provocation studies in electromagnetically hypersensitive persons Dr E David

Tuesday 26 October 8.30 Upcoming Research - Planned studies on EHS in the UK Prof L Challis - Ongoing and planned EHS research Prof N Leitgeb 9.30 Clinical Studies / Treatment - A Physician s Approach to EMF Sensitive Patients Dr B Hocking 10.00 Coffee Break (Poster display in coffee area) 10.30 Clinical Studies / Treatment (cont'd) - RF/ELF Human Studies in the UK Dr R Cox - Cognitive therapy for patients who report electromagnetic hypersensitivity Dr L Hillert - Discussion AFTERNOON SESSION CHAIR: Dr E van Rongen 13.30 Discussion (short contributions from the floor) 14.30 Policy Options - Review of current governmental responses Dr E van Deventer - Possible policy options Dr J Meara

Characterizing EHS Prof B Stenberg He has experience of over 350 patients. Makes a distinction between two groups of patients in this area; 1. those that experience facial skin symptoms in connection with work near a VDT display unit, has typically sensory sensation as stinging, itching, burning erythema, exzema, rosacea. 2. those that besides skin symptoms also had general nervous system response when exposed to EMF from different electrical appliances, has the above symptom as well as fatigue, headache, sleep, dizziness, cardiac, cognitive. Prognosis for group 1 is generally good and they improve over time and most can still be at work. Group 2 with more general symptom have much in common with other environmental illnesses such as dental filling problems, MCS. The prognosis for this group is not as favourable as the other, and they do not generally heal over time as the VSS group.

Idiopathic Environmental Intolerance (IEI): a causation analysis Dr H Staudenmayer Argued that the name EHS would be changed to IEI. The term EHS is misleading both in implying a causal relationship to EMF and the term hyper has no medical support. At a WHO meeting in 1996 in Berlin the IEI was defined as: An acquired disorder with multiple recurrent symptoms. Associated with diverse environmental factors tolerated by the majority of people. Not explained by any know psychiatric or psychological disorder.

Sensor reactivity and autonomic regulation in persons with perceived electrical hypersensitivity. Prof E Lyskov Reported on neurophysiological studies on EHS patients. The patients had a higher critical flicker frequency than normal, and the visual evoked potential, VEP, was significantly higher than in controls, increased heart rate and decreased HRV (heart rate variability), increased electrodermal reaction to sound stimuli. Provocation 60 Hz, 10 T magnetic field had no effect on any of the physiological parameters, in either group. 24 h ECG recording in EHS patients showed night time decrease in the ratio of the low frequency/high frequency components of HRV, indicating an autonomic imbalance and lack of normal circardian rhymes in EHS patients. The findings of an hyperreactivity in the central nervous system and an imbalance in the autonomic nervous system has been known under the name vasoregulatory asthenia or neurocirculatory asthenia, and in the 50-ies and the 60-ies many patients were seeking for the same symptom as we now have in the EHS groups, but today no one is coming to the clinical physiology departments with these symptoms. Is EHS just another name for the neurocirculatory asthenia?

Conclusions from the workshop EHS is characterized by a variety of non-specific symptoms that differ from individual to individual. The symptoms are certainly real and can vary widely in their severity. For some individuals the symptoms can change their lifestyle. The term "Idiopathic Environmental Intolerance (IEI) with attribution to EMF" was proposed by the working group to replace EHS since the latter implies that a causal relationship has been established between the reported symptoms and EMF. The majority of studies indicate that IEI individuals cannot detect EMF exposure any more accurately than non-iei individuals. By and large well controlled and conducted double-blind studies have shown that symptoms do not seem to be correlated with EMF exposure.

Recommendations for medical evaluation Whatever its cause, IEI can be disabling for the affected individual. Treatment should focus on the health symptoms and the clinical picture by performing: a medical evaluation to identify and treat any specific conditions that may be responsible for the symptoms, an assessment of the workplace and home for factors that might contribute to the presented symptoms. These could include indoor air pollution, excessive noise, poor lighting (flickering light) or ergonomic factors. A reduction of stress and other improvements in the work situation might be appropriate. EMF might be assessed to ensure that levels of exposure meet existing standards and recommendations. a psychological evaluation to identify alternative psychiatric/psychological conditions that may be responsible for the symptoms. Some studies suggest that certain physiological responses of IEI individuals tend to be outside the normal range. In particular, the findings of hyper reactivity in the central nervous system and misbalance in the autonomic nervous system need to be followed up in clinical investigations and the results for the individuals taken as input for possible treatment.

Research recommendations Because EMF has not been established as a causative factor for symptoms of IEI individuals, the focus of research should be on characterizing their physiological responses.

Advice to national authorities Governments should also note that IEI patients have real symptoms, but that there is no scientific evidence of causal link with EMF exposure, and therefore no grounds to use IEI as a diagnostic classification.