Chapter 16: Ketogenic Diets

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Chapter 16: Ketogenic Diets 1. Wilder RM The effects of ketonuria on the course of epilepsy. Mayo Clin Bull, 1921, 2 307. 2. National Institute for Health and Clinical Excellence Clinical Guideline 20: The Epilepsies. London: NICE, 2012. 3. http://www.nice.org.uk/nicemedia/live/13635/57784/57784.pdf 4. Solomon NA Parent s Handbook Complex Childhood Epilepsy. National Centre for Young People with Epilepsy, 2010. 5. Dudley RW, Penney SJ, Buckley DJ First drug treatment failures in children newly diagnosed with epilepsy. Paediatr Neurol, 2009, 40 71 7. 6. Leen WG, Klepper J, Verbeek MM et al. Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder. Brain, 2010, 133 655 70. 7. Wexler ID, Hemalatha SG, Kerr DS et al. Outcome of pyruvate dehydrogenase deficiency treated with ketogenic diets. Studies in patients with identical mutations. Neurology, 1997, 49 1655 61. 8. Nabbout R, Mazzuca M, Hubert P Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES). Epilepsia, 2010, 51 2033 7.

9. Nordli DR, De Vivo DC Effects of the ketogenic diet on cerebral energy metabolism. In: Stafstrom CE, Rho JM (eds) Epilepsy and the Ketogenic Diet. Totowa, NJ: Humana Press, 2004. 10. Yudkoff M, Daikhin Y, Nissim I et al. Ketogenic diet, brain glutamate metabolism and seizure control. Prostagland, Leukotr Ess Fatty Acids, 2004, 70 277 85. 11. Weinshenker D Galanin and neuropeptide Y: orexigenic peptides link food intake, energy homeostasis, and seizure susceptibility. In: Stafstrom CE, Rho JM (eds) Epilepsy and the Ketogenic Diet. Totowa, NJ: Humana Press, 2004. 12. Tabb K, Szot P, White SS et al. The ketogenic diet does not alter brain expression of orexigenic neuropeptides. Epilepsy Res, 2004, 62 35 9. 13. Szot P The role of norepinephrine in the anticonvulsant mechanism of action of the ketogenic diet. In: Stafstrom CE, Rho JM (eds) Epilepsy and the Ketogenic Diet. Totowa, NJ: Humana Press, 2004. 14. Greene AE, Todorova MT, Seyfield TN Perspectives on metabolic management of epilepsy through dietary reduction of glucose and elevation of ketone bodies. J Neurochem, 2003, 86 529 37. 15. Huttenlocher PR, Wilbourn AJ, Signore JM Medium chain triglycerides as a therapy for intractable childhood epilepsy. Neurology, 1971, 21 1097 103. 16. Kossoff EH, McGrogan JR, Vining EP et al. A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy. Epilepsia, 2006, 47 421 4. 17. Kang HC, Lee HS, You SJ et al. Use of a modified Atkins diet in intractable childhood epilepsy. Epilepsia, 2007, 48 182 6. 18. Kossoff EH, Dorward JL The modified Atkins diet. Epilepsia. 2008, 49(Suppl 8) 37 41.

19. Pfeifer HH, Thiele EA Low glycaemic index treatment: liberalised ketogenic diet for treatment of intractable epilepsy. Neurology, 2005, 65 1810 12. 20. Muzykewicz DA, Lyczkowski DA, Thiele EA et al. Efficacy, safety and tolerability of the low glycaemic index treatment in pediatric epilepsy. Epilepsia, 2009, 50 1118 26. 21. Freeman JM, Vining EP, Pilas DJ et al. The efficacy of the ketogenic diet: a prospective evaluation of intervention in 150 children. Pediatrics, 1998, 102 1358 63. 22. Lefevre F, Aronson N Ketogenic diet for the treatment of refractory epilepsy in children. A systematic review of efficacy. Pediatrics, 2000, 105 E46 1 7. 23. Levy R, Cooper P Ketogenic diet for epilepsy. The Cochrane Library Issue 3. Chichester, UK: John Wiley, 2004. 24. Neal EG, Chaffe H, Schwartz RH et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol, 2008, 7 500 6. 25. Neal EG, Chaffe H, Schwartz RH et al. A randomized trial of classical and mediumchain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia, 2009, 50 1109 17. 26. Hong AM, Turner Z, Kossof EH et al. Infantile spasms treated with the ketogenic diet: prospective single-center experience in 104 consecutive infants. Epilepsia, 2010, 51 1403 7. 27. Eun SH, Kang HC, Kim HD et al. Ketogenic diet for treatment of infantile spasms. Brain Dev, 2006, 566 7. 28. Nordli DR Jr, Kuroda MM, De Vivo DC et al. Experience with the ketogenic diet in infants. Pediatrics, 2001, 108 129 33.

29. Pulsifer MB, Gordon JM, Brandt J et al. Effects of the ketogenic diet on development and behaviour: preliminary report of a prospective study. Dev Med Child Neurol, 2001, 43, 301 6. 30. Dunlea O The cost benefit of the ketogenic diet in the treatment of epilepsy. King's College, University of London, 2003. 31. Chandratre SR, Davison J, Whitehouse WP Ketogenic diet therapy: is it cost effective. Poster presentation at International Ketogenic Symposium, Edinburgh, 2010. 32. Hallbook T, Lundgren J, Rosen I Ketogenic diet improves sleep quality in children with therapy resistant epilepsy. Epilepsia, 2007, 48 59 65. 33. Martinez CC, Pyzik PL, Kossoff EH Discontinuing the ketogenic diet in seizure free children: recurrence and risk factors. Epilepsia, 2007, 48 187 90. 34. Furth SL, Casey JC, Pyzik PL et al. Risk factors for urolithiasis in children on the ketogenic diet. Pediatr Nephrol, 2000, 15, 125 8. 35. Hertzberg GZ, Fivush BA, Kinsman SL et al. Urolithiaisis associated with the ketogenic diet. J Pediatr, 1990, 117 743 5. 36. Paul E, Conant KD, Dunne IE et al. Urolithiasis on the ketogenic diet with concurrent topiramate or zonisamide therapy. Epilepsy Res, 2010, 90 151 6. 37. Bergqvist AG, Schall JI, Zemel BS Progressive bone mineral content loss in children with intractable epilepsy treated with the ketogenic diet. Am J Clin Nutr, 2008, 88 1678 84. 38. Delgado MR, Mills J, Sparagana S Hypercholesterolemia associated with the ketogenic diet. Epilepsia, 1996, 37(Suppl 5) 108. 39. Kwiterovitch PO, Vining EP, Pyzik P et al. Effect of high fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children. J Am Med Assoc, 2003, 290 12 20. 40. Huttenlocher P Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res, 1976, 10 536 40.

41. Nizamuddin J, Turner Z, Rubenstein JE et al. Management and risk factors for dyslipidaemia with the ketogenic diet. J Child Neurol, 2008, 23 758 61. 42. Couch SC, Schwarzman F, Carroll J et al. Growth and nutritional outcomes of children treated with the ketogenic diet. J Am Diet Assoc, 1999, 99 1573 35. 43. Williams S, Basualdo-Hammond C, Curtis R et al. Growth retardation in children with epilepsy on the ketogenic diet: a retrospective chart review. J Am Diet Assoc, 2002, 102 405 7. 44. Vining EP, Pyzik P, McGrogan J et al. Growth of children on the ketogenic diet. Dev Med Child Neurol, 2002, 449 796 802. 45. Peterson SJ, Tangey CC, Pimentel-Zablah EM et al. Changes in growth and seizure reduction in children on the ketogenic diet as a treatment for intractable epilepsy. J Am Diet Assoc, 2005, 105 725 6. 46. Neal EG, Chaffe H, Edwards N et al. Growth of children on classical and medium chain triglyceride ketogenic diets. Pediatrics, 2008, 122 e334 40. 47. Best TH, Franz DN, Gilbert DL et al. Cardiac complications in pediatric patients on the ketogenic diet. Neurology, 2000, 54 2328 30. 48. Stewart WA, Gordon K, Camfield P Acute pancreatitis causing death in a child on the ketogenic diet. J Child Neurol, 2001, 16 633 5. 49. Ballaban-Gill K, Callahan C, O Dell C et al. Complications of the ketogenic diet. Epilepsia, 1998, 7 744 8. 50. Woody RC, Steele RW, Knapple WL et al. Impaired neutrophil function in children with seizures treated with the ketogenic diet. J Pediatr, 1989, 115 427 30.

51. Berry-Kravis E, Booth G, Taylor A et al. Bruising and the ketogenic diet: evidence for diet-induced changes in platelet function. Ann Neurol, 2001, 49 98 103. 52. Kossoff EH, Zupec-Kania BA, Vining EP et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia, 2009, 50 304 17. 53. Vaisleib II, Buchalter JR, Zupanc ML Ketogenic diet: outpatient initiation, without fluid or caloric restrictions. Paed Neurol, 2004, 31 198 202. 54. Bergqvist AG, Schall JI, Stallings VA et al. Fasting versus gradual introduction of the ketogenic diet: a prospective, randomised clinical trial of efficacy. Epilepsia, 2005, 46 1810 19. 55. Department of Health Report on Health and Social Subjects No. 41. Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. London: TSO, 1991. 56. World Health Organization. Energy and Protein Requirements. Reports of the Joint FAO/WHO/ UNU Meeting. Geneva: World Health Organization, 2007 (WHO Technical Report Series 724). 57. Dewy KG, Beaton G, Fjeld C et al. Protein requirements of infants and children. Eur J Clin Nutr, 1996, Suppl 1 S119 50. 58. Kossoff EH, Freeman J, Turner Z et al. Ketogenic Diets Treatment for Epilepsy and Other Disorders, 5th edn. New York: Demos Health, 2010. 59. Holland B, Welch AA, Unwin ID et al. McCance and Widdowson s Composition of Foods, 6th edn. Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food. London: TSO, 1991. 60. Huttenlocher, P Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res, 1976, 10 536 40.

61. Schwartz RH, Eaton J, Bowyer BD et al. Ketogenic diets in the treatment of epilepsy: short-term clinical effects. Dev Med Child Neurol, 1989, 31 145 51. 62. Ranhotra GS, Gelroth JA, Glaser BK Levels of medium-chain triglycerides and their energy value. Cereal Chem, 1995, 72 365 7. 63. European Council Directive on Food Labelling (1990). Official Journal of the European Communities, No. L276/41, pp. 27 31. 64. Kossoff EH, Turner Z, Vining EP et al. A randomized, crossover comparison of daily carbohydrate limits using the modified Atkins diet. Epilepsy Behav, 2007, 10 432 6. 65. Vaisleib LL, Buchalter JR, Zupanc ML Ketogenic diet: outpatient initiation, without fluid or caloric restrictions. Paed Neurol, 2004, 31 198 202. 66. McNally MA, Pyzik PL, Kossoff EH et al. Empiric use of potassium citrate reduces kidney-stone incidence with the ketogenic diet. Pediatrics, 2009, 124 e300 4. 67. DeVivo DC, Bohan TP, Coulter DL et al. L-carnitine supplementation in childhood epilepsy: current perspectives. Epilepsia, 1998, 39 1216 25. 68. Berry-Kravis E, Booth G, Sanchez AC et al. Carnitine levels and the ketogenic diet. Epilepsia, 2001, 42 1445 51. 69. Gilbert D, Pyzik P, Freeman JM The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketone levels. J Child Neurol, 2000, 15 787 90. 70. Eltze C, Fitzsimmons GJ, Sewell M et al. Great Ormond Street Hospital Clinical Guidelines for the Ketogenic Diet, 2010. http://www.gosh.nhs.uk/health-

professionals/clinical-guidelines/the-ketogenic-diet-in-the-management-of-epilepsy. Accessed 31 October 2012. 71. Worden LT, Turner Z, Kossoff EH et al. Is there an ideal way to discontinue the ketogenic diet? 72. Epilepsy Res, 2011, 95 232 6. 73. Patel A, Pyzik PL, Kossoff EH et al. Long-term outcomes of children treated with the ketogenic diet in the past. Epilepsia, 2010, 51 1277 82.