Modena International Breast Cancer Conference

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Modena International Breast Cancer Conference 7 th meet the professor Modena, 5-6-7 October 2011 Section of Oncology University of Modena and Reggio Emilia

Aims The breast cancer meeting in Modena started seven years ago as a Meet the Professor initiative to facilitate the discussion among recognized Experts and physicians involved in breast cancer management. Over the years, the number and the expertise of the attendees has increased as has the scientific content of the meeting. This seventh edition is now an international conference that will gather some of the top scientists and clinicians from all over the word. The Programme of the Conference includes lectures, round tables on topics that require a multifaceted approach, highlights from international meetings, debates on controversial items and clinical case discussions. Even though the Conference has increased the number of the participants and the international inspiration, this 7 th Modena International Breast Cancer Conference will maintain its characteristics of a friendly forum where internationally recognized experts and attendees can exchange experiences and comment on the most exiting advances in breast cancer biology and therapy. In order to reward scientific excellence and facilitate international cooperation, the International Scientific Committee of MIBCC 7 th, will award the Second International Unimore Prize for Breast Cancer Research to a young scientist who has published a breakthrough paper in the previous year and the Monica Boscolo Research Grant to an Italian scientist willing to pursue a research project in a foreign institution. Medical oncologists, breast surgeons, radiologists, pathologists and basic scientists interested in translational research are welcome to Modena to listen to breast cancer leaders and exchange experience in a friendly atmosphere. PierFranco Conte, Gabriel N. Hortobagyi Addressed to Oncologists, radiologists, breast surgeons ECM Based on the in force Italian regulations, Accademia Nazionale di Medicina (provider n. 31, accreditation valid through July 13 th, 2012) will propose 3,5 ECM points. The Meeting is addressed to physicians specialized in oncology, radiology, breast surgery The credit certification is subject to: - attendance of at least 80% of the meeting - the completion of the meeting evaluation form - a signed declaration of attendance of the meeting We would like to remind to participants that only 1/3 of the MCE Credits acquired during the years 2011-2013 can come from a sponsorship Official Language The official language of the Meeting is English. No simultaneous translation will be provided. Registration The registration fee is 250,00 tax free. It includes the conference bag, the conference book and all coffee breaks and lunches. It does not include hotel accomodation, dinners and travel expenses. To register, please send: registration form duly filled out (even when sponsored by a Pharmaceutical Company) privacy statement and consent to the use of personal data (as in the back of the form) payment to Accademia Nazionale di Medicina Palazzina CUP II Piano, Via Massarenti 9, 40138 Bologna fax 0039 051 6364605 e-mail: infobologna@forumservice.net, within september 29 th. Online registration is possible on the website http://meettheprofessor.accmed.org By submitting the form and the payment, your registration is completed with the exception of specific decisions of the Meeting Secretariat. Incomplete registration will NOT be admitted. Cancellation If the participants minimum number is not reached, Accademia Nazionale di Medicina will advise by a written communication and proceed with the total refund of the fee. In order to cancel please give advise with a written communication to Accademia Nazionale di Medicina within October 25 th. A 70% of the registration fee will be returned. Any cancellation after that deadline will not be reimbursed. ESMO-MORA CREDITS The course has been accredited with 15 ESMO Mora points.

Programme Wednesday, October 5 th Thursday, October 6 th Chairman: Pietro Torricelli 9.30 Lecture 1 Screening programmes: evidence, limits, perspectives Carlo Naldoni 10.00 Lecture 2 Management of high-risk women: BRCA and beyond Laura Cortesi 10.30 Coffee break 11.00 Round Table 1. Breast Cancer Prevention Chairman: Alberto Costa - Lifestyle - Massimo Federico - Chemoprevention - Andrea De Censi - Surgery - Emiel J. Rutgers Chairmen: Filippo Bertoni, Giovanni Tazzioli 12.15 Highlights on Surgery Sentinel node biopsy and axillary node dissection: what is new Kelly Hunt 12.45 Highlights on Partial Breast Irradiation New techniques, new data, ASTRO consensus statement Philip Poortmans 13.15 Lunch break 14.15 Round Table 2. Innovation in Reconstructive Surgery Chairman: Giorgio De Santis - Reconstruction with perforator flaps Aldona J. Spiegel - Autologous fat transplantation and external vacuumassisted therapy Roger Kouri - Oncoplastic surgery Remy Salmon - Reconstructive surgery and radiation therapy Giorgio De Santis 15.40 Discussion and coffee break 16.10 Clinical Case Discussion 1. Surgical Challenges Chairman: Emiel J. Rutgers Presenters: Alberto Bottini, Maria Grazia Lazzaretti, Emanuela Roncella, Giovanni Tazzioli Panelists: Alberto Costa, Kelly Hunt, Philip Poortmans, Remy Salmon Clinical cases of breast cancers with difficult/ controversial characteristics will be presented. The audience will vote a list of options and the panelists will discuss the votes and express their opinion. 17.40 Adjourn Chairmen: Pier Franco Conte, Gabriel N. Hortobagyi 8.30 Highlights on Molecular Pathology Gene Expression Profiles as prognosticators and predictors of treatment efficacy Christos Sotiriou 9.00 Round Table 3. Which information pathology reports should provide? Luca Gianni, Giuseppe Viale - Focal HER2 amplification - Rare histologies - Discrepancy between primary and metastases 10.00 Clinical Case Discussion 2. Clinicians-Pathologists crosstalk (Part 1) Chairman: Gabriel N. Hortobagyi Presenters: Alessandra Gennari, Anna Maria Molino, Fabio Puglisi Cases of early breast cancers with clinical or pathological controversial characteristics will be presented. The audience will vote a list of options. 11.00 Coffee break 11.30 Clinical Case Discussion 2. Clinicians-Pathologists crosstalk (Part 2) Chairman: Gabriel N. Hortobagyi Discussant: Valentina Guarneri Panelists: Pier Franco Conte, Luca Gianni, Sibylle Loibl, Antonio Maiorana, Miguel Martin, Anna Sapino, Christos Sotiriou, Giuseppe Viale, Christoph Zielinski On the basis of the clinical cases presented and the audience choices, the discussant will ask the panelists to discuss the role of genomic classifiers and molecular markers in treatment decision. 12.30 Lecture 3 Breast cancer stem cells Maria Grazia Daidone 13.00 Lunch break Chairmen: Pier Franco Conte, Gabriel N. Hortobagyi 14.00 Lecture 4 Adjuvant treatment of EBC 2011 Gabriel N. Hortobagyi 14.30 Highlights on Bisphosphonates as adjuvant treatment for early breast cancer Robert Coleman 15.00 Debate 1. Closing credits for chemotherapy in HR+ EBC? Pro chemotherapy - Miguel Martin Contra chemotherapy Christoph Zielinski 16.00 Coffee break 16.20 Highlights on Primary Systemic Therapy for OBC Sibylle Loibl

16.50 Ceremony for the presentation of the UniMore Award for advances in breast cancer research, the Monica Boscolo Research Grant and Patrizia Rossi merit award. 17.10 Lecture of the Unimore awardee 17.40 Adjourn Friday, October 7 th Chairmen: Pier Franco Conte, Steven Johnston 8.30 Lecture 5 Inflammatory breast cancer Hussein Khaled 9.00 Debate 2. Closing credits for chemotherapy in HER2+ disease? Pro chemotherapy David Khayat Contra chemotherapy Steven Johnston 10.00 Coffee break 10.30 Lecture 6 Triple negative breast cancer: how many diseases, how many therapies? Marjorie C. Green Panelists: Filippo Bertoni, Pier Franco Conte, Marjorie C. Green, Gabriel N. Hortobagyi, Fikri Icli, Stephen Johnston Cases of advanced breast cancers with limited tumor burden or metastatic sites eligible for a multidisciplinary treatment will be presented and the panelists will discuss the audience choices and express their opinion. 12.30 Highlights on advanced HR+ disease Paolo Pronzato 12.50 Highlights on Metastatic Bone Disease Antonio Frassoldati 13.10 Update on ongoing adjuvant trials in HER2+ EBC Valentina Guarneri 13.30 Adjourn and final evaluation questionnaire Directors Pier Franco Conte Gabriel N. Hortobagyi Department of Breast Medical Oncology University of Texas - MD Anderson Cancer Center Houston (USA) Scientific Committee Fikri Içli Oncology Research and Treatment Center Ankara University (TR) Jacek Jassem Department of Oncology and Radiotherapy Medical University of Gdansk (PL) Stephen Johnston NIHR Biomedical Research Centre for Cancer Royal Marsden NHS Foundation Trust & Institute of Cancer Research London (UK) David Khayat Salpetriere Hospital Paris, France Sibylle Loibl German Breast Group University Frankfurt (D) Miguel Martin Medical Oncology Service Hospital Universitario Gregorio Maranon Madrid (E) Christoph Zielinski Clinical Medical University - General Hospital Vienna (A) 11.00 Clinical Case Discussion 3. Multidisciplinary approach to metastatic breast cancer Chairman: Jacek Jassem Presenters: Carmelo Bengala, Roberto Sabbatini, Claudio Zamagni Hussein Khaled Cairo University (ET)

Local Scientific and Organizing Committee Giorgio De Santis Department of head-neck surgery Antonio Frassoldati Department of Oncology University Hospital of Ferrara (I) Valentina Guarneri Antonino Maiorana Department of Laboratories Pathology and Forensic Medicine Giovanni Tazzioli Department of General Surgery and Surgical Specialities Pietro Torricelli Department of Diagnostic services and imaging Speakers Carmelo Bengala Filippo Bertoni Department of Radiotherapy Alberto Bottini A.O. Istituti Ospedalieri di Cremona (I) Robert Coleman Weston Park Hospital / University of Sheffield Sheffield (UK) Laura Cortesi Alberto Costa European School of Oncology Milan (I) Maria Grazia Daidone Department of Experimental Oncology and Molecular Medicine Milan (I) Andrea De Censi Division of Medical Oncology EO Ospedali Galliera Genoa (I) Giorgio De Santis Department of head-neck surgery Massimo Federico Antonio Frassoldati Department of Oncology University Hospital of Ferrara (I) Alessandra Gennari Division of Medical Oncology EO Ospedali Galliera Genoa (I) Luca Gianni Department of Medical Oncology 1Q-A S. Raffaele Institute Milan (I) Marjorie C. Green Department of Breast Medical Oncology Division of Cancer Medicine University of Texas - MD Anderson Cancer Center Houston (USA) Valentina Guarneri Kelly Hunt Department of Surgical Oncology University of Texas MD Anderson Cancer Center Houston, Texas (USA) Fikri Içli Oncology Research and Treatment Center Ankara University (TR) Jacek Jassem Department of Oncology and Radiotherapy Medical University of Gdansk (PL) Stephen Johnston NIHR Biomedical Research Centre for Cancer Royal Marsden NHS Foundation Trust & Institute of Cancer Research London (UK)

Hussein Khaled Cairo University (Et) Miguel Martin Medical Oncology Service Hospital Universitario Gregorio Maranon Madrid (E) Emiel Rutgers The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Amsterdam (NL) Giovanni Tazzioli Department of General Surgery and Surgical Specialities David Khayat Salpetriere Hospital Paris, France Anna Maria Molino University Hospital Verona (I) Roberto Sabbatini Pietro Torricelli Department of Diagnostic services and imaging Roger K.Khouri Miami Breast Center Breast Surgery & Reconstruction Key Biscayne, FL (USA) Carlo Naldoni Emilia-Romagna Local Governement Health Policies Bologna (I) Remy Salmon Department of Surgery Institut Curie Paris (F) Giuseppe Viale Department of Pathology European Institute of Oncology University of Milan (I) Maria Grazia Lazzaretti Ramazzini Hospital Carpi, Modena (I) Philip Poortmans Department of Radiation Oncology Dr. Verbeeten Instituut Tilburg (NL) Anna Sapino Department of Biomedical Sciences and Human Oncology University of Turin Turin (I) Claudio Zamagni Medical Oncology Unit Policlinico S.Orsola-Malpighi Hospital Bologna (I) Sibylle Loibl German Breast Group University Frankfurt (D) Paolo Pronzato Department of Medical Oncology Genoa (I) Christos Sotiriou Unitè de Oncologie Istitut Jules Bordet Brussels (B) Christoph Zielinski Clinical Medical University - General Hospital Vienna (A) Antonino Maiorana Department of Laboratories, Pathology and Forensic Medicine Fabio Puglisi Department of Oncology University Hospital of Udine (I) Manuela Roncella University Hospital S. Chiara Pisa (I) Aldona J.Spiegel The Center for Breast Restoration The Methodist Hospital Houston, Texas (USA)

Meeting VENUE Aula Magna Centro Didattico Policlinico di Modena Via del Pozzo, 71 Modena How to reach the meeting venue By car arriving from the North: exit Modena North, follow the signs to City Center-Bologna Strada Statale, then follow directions to the Hospital Policlinico of Modena. By car arriving from the South: exit Modena South, turn right then keep going for 10 Km, at the mandatory turn sign, turn right and follow the street to the end. By train: Modena train station, bus n. 7. By plane: Bologna Aeroport 40 Km. Sponsored by ACCADEMIA NAZIONALE DI MEDICINA www.accmed.org General Manager: Stefania Ledda In a joint collaboration with: Integrated Department of Oncology and Haematology University of Modena and Reggio Emilia ORGANIZING PARTNER Forum Service Via Martin Piaggio 17/6 16122 Genova Information: http://meettheprofessor.accmed.org Ph. 0039 051 6364898-6360080 Fax 0039 051 6364605 info.bologna@forumservice.net Hotel booking: Ph. 0039 010 83794235 Fax 0039 010 83794261 booking@forumservice.net Scholarship Fondazione Federico Calabresi The Scholarship includes a reward of 1000,00, the registration fee, travel and accommodation in Modena for the Meeting. It will be assigned to the best publication on International press during the current year or "in press" to the date July 20th, 2011. The main author must be a clinical oncologist younger than 45 years old. Please send the request together with two copies of the work within July 15 th to Accademia Nazionale di Medicina, Via Martin Piaggio 17/6, 16122 Genova Subject: MIBCC Monica Boscolo Research Grant The Scientific Committee will select the winner of the Monica Boscolo Research Grant. This Research Award is restricted to young Italian researchers (<40 years) who will carry out a research project at a foreign institution. The award is made for an amount up to 24.000. Unimore Award The Scientific Committee will select young researchers (<40 years from any country) who have published in an international peer-reviewed journal, as the principal author, a manuscript reporting important clinical or biological advances in breast cancer. Prof. Conte and Prof. Hortobagyi will select the final winner which will be invited to present his/her study during the annual Conference. The Unimore Award consists of 6.000. Patrizia Rossi Merit Award This award is rescricted to students of the University of Modena and Reggio Emilia who have graduated in 2010/2011 with a graduation thesis on biological or clinical aspects of breast cancer. The award consists of 1.000.