SA COLD AND FLU REMEDY INDUSTRY LANDSCAPE REPORT

SA COLD AND FLU REMEDY INDUSTRY LANDSCAPE REPORT COMPILED: FEBRUARY 2017

REPORT OVERVIEW The South African Cold and Flu Remedy Industry Landscape Report (105 pages) provides a dynamic synthesis of industry research, examining the local and global Cold and Flu Remedy industry from a uniquely holistic perspective, with detailed insights into the entire value chain from manufacturing to retail, pricing analysis and consumption trends.. SOME KEY QUESTIONS THE REPORT WILL HELP YOU TO ANSWER: For the Global Cold and Flu Remedy Industry Section: What are the current market dynamics of the Global Cold and Flu Remedy industry? What are the Global Cold and Flu Remedy industry trends, drivers, and restraints? For the South African Cold and Flu Remedy Industry Section: What are the current market dynamics of the SA Cold and Flu Remedy industry? Who are the key manufacturing players in the SA Cold and Flu Remedy industry? What are the South African industry trends, drivers and challenges? For the South African Retail and Pricing Analysis Section: Who are the key retail players (retail outlets and independent pharmacies) in the SA Cold and Flu Remedy industry? What are the prices of Cold and Flu Remedy across SA retail outlets? In terms of South African Consumer Insights and Trends: How many people in South Africa are using Cold and Flu Remedies (2011-2015)? What are the statistics regarding volume usage among Cold and Flu Remedies (2011-2015)? 2

SCREENSHOTS FROM REPORT 105 page report filled with detailed charts, graphs, tables and insights 3

Million US Dollars SAMPLE FROM REPORT: GLOBAL KEY MARKETS OVERVIEW Globally the largest OTC markets were China and the USA which accounted for 44.6% of the global OTC market in 2016 (as illustrated in the graph). TOP 10 BEST PERFORMING OTC MARKETS BY NET CONTRIBUTION IN Q1 2016 (IN MILLION US$) 1,600 1,400 1,200 1,000 800 600 400 200 0 These countries were responsible for a slightly higher proportion of global OTC growth of 46.6% in the first quarter of 2016. Slower growth was observed in Europe and North America due to the decrease in cold and flu remedies growth while Japan showed renewed life. 1356 1029 262 233 175 114 62 58 51 1 Europe and North America are the most important markets within the global Cold and Flu Remedy industry. Based on geography, the global Cold and Flu Remedy market is segmented into seven key regions: North America, South America, Eastern Europe, Western Europe, Asia Pacific (excluding Japan), and the Middle East and Africa. North America is the largest revenue generating segment in the global Cold and Flu Remedy market, followed by Europe. The increasing prevalence of viral infections and rapid economic developments benefiting healthcare sectors in Asian countries are projected to drive the growth of the Cold and Flu Remedy market in Asia. Source: Futuremarketinsights; Nicholashallcompany Image Source: Freepik 4

SAMPLE FROM REPORT: SOUTH AFRICAN INDUSTRY TRENDS South African consumers have become more health conscious. Increase of generic medication in South Africa. The demand for health and wellness products, including herbal medicines, have seen strong growth as South African consumers become increasingly health conscious. Many companies are thus focusing on providing products made from natural herbs rather than chemicals. Better quality products. Instead of manufacturers only improving the strength of their products, they are improving the taste especially for children s products - as well as making products more specialized for specific ailments, but that also covers more than one symptom. The popularity of generic medication has been on the rise in South Africa for several years. The opinion of generic medications is changing in South Africa, even if many doctors and patients perceive generics to be inferior to brand name medication. According to Vivian Fritelli, CEO of the National Association of Pharmaceutical Manufacturers, it is important to change this perception of generic products to help consumers realize the important savings they can get from generics. The IMS Health estimates that every 1% increase in generic utilization translates into a saving of R270 million for the consumer. Manufacturers are also trying to differentiate their products by providing products better suited to daytime and a different one suited to night time. Source: How we made it in Africa, Health24 Image source: Integrative; Freepik 5

SAMPLE FROM REPORT: ADCOCK INGRAM OVERVIEW Adcock s Cold and Flu OTC division had a market share value of 29.7% and a 43% volume share in the pharmacy sector. In the fast moving consumer goods (FMCG) space, the coughs, colds and flu division had a market share of around 9%. In this mature cough and cold market, the portfolio continues to grow ahead of the market, maintaining and stretching its leadership position in the pharmaceutical industry. Sales and marketing activities are conducted in Midrand. Adcock Ingram Vitamin Brands: Adcock Ingram is able to distribute 1 736 units per minute to customers. In 2016, Adcock Ingram signed definitive pacts to sell its India business for $22 million to Samara, a private equity firm. CUSTOMERS* 2016 Adcock Ingram brands have strong representation across all indicators, including antitussives, expectorants, decongestants and analgesic combinations. 17% Public sector sales Private sector sales Adcock Ingram have expanded their brands, portfolios and businesses, with a primary focus on nonregulated portfolios in home care, personal care and baby care. 83% For future growth, the group is further seeking to search for acquisitions of brands for the OTC Division in the core categories of analgesia, colds & flu and anti-histamines. Source: Adcock Ingram Integrated Report 2016 *Governments, wholesalers, pharmacies, hospitals, doctors, insourcing customers, FMCG retailers Image Source: Adcock Ingram 6

SAMPLE FROM REPORT: ADCOCK INGRAM COLD & FLU REMEDY BRANDS Leading Adcock Ingram Brands: Adcock Ingram s Cold and Flu Remedy portfolio continues to grow in market share, maintaining its leadership position in the pharmacy sector. LCC continued to show strong growth (12.6%), well ahead of the market. Corenza Para-C, Adco-Napamol and Dilinct are part of the top 10 OTC brands which reached a turnover of R922 million. With its OTC products, Adcock Ingram is committed to supporting the responsible use of the medicines that they manufacture. Adcock Ingram had to improve the formulation of Broncleer Codeine as it was a very attractive product for potential Codeine abusers. Medi-Keel A throat lozenges are suggested for the relief of sore throats and offers soothing relief by numbing the pain of an inflamed throat. Cepacol's anti-bacterial formulations offer soothing relief from sore throats caused by the onset of colds or flu. 7 Source: Adcock Ingram Integrated Report 2016 ; Adcock Website Image Source: Adcock

SAMPLE FROM REPORT: COLD AND FLU REMEDY PRICING ANALYSIS BRANDS QUANTITY Efferflu C Expigen 20 tab R60.95 R60.95 R53.00 R64.95 R87.55 5 patches R37.95 R46.95 (Special Offer) N/A R69.95 N/A 100ml N/A R43.95 R39.99 R41.95 R41.49 200ml R79.95 R78.95 R76.99 N/A R78.99 Flutex 100 ml R43.95 R50.95 R49.99 R47.99 R48.99 Flugon 50 caps R104.95 R99.95 R95.95 R96.90 R96.90 10 sachets R81.95 R79.95 R72.99 R79.95 R79.80 Grippon 24 tab R68.95 R54.95 R53.99 R49.95 R56.90 Hot Toddy 200ml 8 sachets R78.36 (Special Offer) R22.36 (Special Offer) R92.95 R89.95 N/A R83.90 R23.95 R26.99 R29.95 R24.99 8 This pricing analysis was conducted at retail stores and supermarkets during w/c 13 February 2017

TABLE OF CONTENTS 1. Executive Summary (3 pages): 1.1 Global Industry Snapshot 1.2 South African Industry Snapshot 1.3 Industry Drivers and Restraints 2. Global Cold and Flu Remedy Industry (13 pages): 2.1 Global Cold and Flu Remedy Industry Overview 2.2 Global Cold and Flu Remedy Industry Market Environment 2.3 Global Cold and Flu Remedy Key Markets Overview: Regional: TOP 10 BEST PERFORMING OTC MARKETS BY NET CONTRIBUTION IN Q1 2016 (IN MILLION US DOLLARS) (Graph) 2.4 Global Cold and Flu Remedy Key Markets Overview: North America: SHARES OF U.S. OTC AND NATURAL SUPPLEMENTS MARKET BY SEGMENT (2016) 2.5 Global Cold and Flu Remedy Key Markets Overview: Europe 2.6 Global Cold and Flu Remedy Key Markets Overview: Asia-Pacific and Mexico 2.7 Global Cold and Flu Remedy Industry Trends 2.8 Global Cold and Flu Remedy Industry Drivers 2.9 Global Cold and Flu Remedy Industry Challenges 9

TABLE OF CONTENTS 3. South African Cold and Flu Remedy Industry (52 pages): 3.1 South African Cold and Flu Remedy Industry Overview (12 pages) 3.1.1 South African Cold and Flu Remedy Industry Overview 3.1.2 South African Cold and Flu Remedy Industry Overview: Pharmaceutical Market: SOUTH AFRICAN PHARMACEUTICAL MARKET: CATEGORISED BY SECTORS: 2015 (Graph) 3.1.3 South African Cold and Flu Remedy Industry Overview: Over-The-Counter Market: SOUTH AFRICAN OTC MARKET BREAKDOWN: MEDICATION SECTORS: 2015 (Graph) 3.1.4 South African Cold and Flu Remedy Industry Overview: Cold and Flu Remedy Market 3.1.5 South African Cold and Flu Remedy Market Environment 3.1.6 South African Cold and Flu Remedy Industry Trends 3.1.7 South African Cold and Flu Remedy Industry Drivers 3.1.8 South African Cold and Flu Remedy Industry Restraints 10

TABLE OF CONTENTS 3.2 South African Cold and Flu Remedy Manufacturer/Distributor Overview (40 pages) 3.2.1 SA Cold and Flu Remedy: Actor Pharma 3.2.2 SA Cold and Flu Remedy: Adcock Ingram 3.2.3 SA Cold and Flu Remedy: Ascendis Health 3.2.4 SA Cold and Flu Remedy: Aspen Pharmacare 3.2.5 SA Cold and Flu Remedy: Austell (Bionorica) 3.2.6 SA Cold and Flu Remedy: Bayer 3.2.7 SA Cold and Flu Remedy: Brunel Laboratoria 3.2.8 SA Cold and Flu Remedy: Cipla 3.2.9 SA Cold and Flu Remedy: GSK (Aspen) 3.2.10 SA Cold and Flu Remedy: Johnson & Johnson 3.2.11 SA Cold and Flu Remedy: Kalbe Farma 3.2.12 SA Cold and Flu Remedy: Lebron Health (Boiron) 3.2.13 SA Cold and Flu Remedy: Nativa 3.2.14 SA Cold and Flu Remedy: Pfizer 3.2.15 SA Cold and Flu Remedy: Pharma Dynamics 3.2.16 SA Cold and Flu Remedy: Procter & Gamble 3.2.17 SA Cold and Flu Remedy: Reckitt Benckiser 3.2.18 SA Cold and Flu Remedy: Reitzer Pharmaceuticals 3.2.19 SA Cold and Flu Remedy: SA Natural Products 3.2.20 SA Cold and Flu Remedy: Tara Pharmaceuticals 11

TABLE OF CONTENTS 4. South African Cold and Flu Remedy Industry Retail Analysis (18 pages): 4.1 SA Retail Overview (10 pages) 4.1.1 SA Retail Overview: NUMBER OF STORES PER PHARMACY; 2016 SA COLDS AND FLU PRODUCT PRICE ANALYSIS (Graph & Table) 4.1.2 SA Retail: Clicks: RETAIL PHARMACY % OF CLICKS REVENUE 2016 (Graph) 4.1.3 SA Retail: Dis-Chem 4.1.4 SA Retail: In-Store Retail Pharmacies: MediRite, Pick n Pay Pharmacy, Spar Pharmacy 4.1.5 SA Retail: Hospital-based Pharmacies: Mediclinic Pharmacy, Netcare Pharmacy 4.1.6 SA Retail: Independent Pharmacies: Alpha Pharm, Durbell Pharmacies, Link 12

TABLE OF CONTENTS 4.2 Cold and Flu Remedy Pricing Analysis (8 pages) (conducted w/c 13 February 2017) 4.2.1 Cold and Flu Remedy Brands: Advil CS, Airborne, Airmune, Alcophyllex, Aspen, Benylin, Betta Immune, Bionorica- Sinupret: Forte Capsules and Syrup, Borstol, Bronchoped, Cal-C-Vita, Cepacol, Corenza C, Demazin, Dilinct, Echinaforce: Drops and Tablets, Efferflu C: Cold & Flu Tablets and Nazo Vapour Patches, Expigen, Flutex, Flugon, Grippon, Hot Toddy, L.C.C, Lennon, Linctagon, Med-Lemon, Medi-Keel A, Oscillococcinum, Prospan, Salex Pediatric, Sinucon C, Sinutab, Solal Immufend Syrup, Solphyllex, Strepsils, Vicks: Syrup and Vaporub, Vitaforce Ultra Immune, Viral Guard, Woods, Zam-Buk. Comparative Pricing at Retail Outlets: Dis-Chem, Clicks, MediRite, Durbell Pharmacies, and Pick n Pay Pharmacy 4.2.2 Cold and Flu Remedy Promotions on selected Cold and Flu Remedies: Clicks 4.2.3 Cold and Flu Remedy Promotions on selected Cold and Flu Remedies: Dis-Chem 5. South African Consumer Trends (5 pages): 5.1 AMPS Survey Methodology & Sample Design 5.2 AMPS Survey Questions Asked 5.3 Cold and Flu Remedy Purchasing Trends: 2011-2015 (Graph & Table) 5.4 Cold and Flu Remedy Volume Trends (Past 4 Weeks): 2011-2015 (Graph & Table) 13

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