CURRICULUM VITAE Liviu Paul LEFTER General Surgeon, MD, PhD Date and place of Birth: 13 th of September 1970, Romania Nationality: Romanian Current Position General Surgeon Assistant Professor Gr.T. Popa University of Medicine and Pharmacy Department of Surgery, Saint Spiridon Hospital, Iasi, Romania Funcţia in cadrul Proiectului: PI-Director 1. Nume: LEFTER 2. Prenume: LIVIU PAUL 3. Data şi locul naşterii: 13/09/1970 4. Cetăţenie: ROMAN 5. Stare civilă: CASATORIT 6. Studii: Instituţia Perioada: de la (luna, anul) până la (luna, anul) Grade sau diplome obţinute UMF Gr.T.Popa Iaşi oct 1989 - sept 1995 Diplomă de doctor, medic Tohoku University School of Medicine, Sendai, Japan UMF Gr.T.Popa Iaşi sept 2003 2005 Doctor în Ştiinţe Medicale - Chirurgie Oncologică şi Biologie Moleculară Medic primar chirurg, chirurgie general 7. Titlul ştiinţific: MD, PhD, Medic primar chirurgie generala 8. Experienţa profesională: Perioada: Nov 2001- April Iun 2001-Sept de la..(luna, anul) 2002 2003 Oct 2000-2004 Ian 2005
până la..(luna, anul) Locul: Instituţia: Funcţia: Descriere: Department of Surgery, Supervisor Prof. C. Partensky Edouard Herriot Hospital Lyon, France Fellow in General Surgery and Liver Transplantation Activitate de cercetare şi chirurgicală în chirurgie generală şi chirurgie de transplant hepatic Department of Gastroenterolog ical Surgery, Supervisor: Prof. S. Matsuno Tohoku University School of Medicine, Sendai, Japan Fellow in Hepato-Billiary- Pancreatic Surgery Cercetare şi training în chirurgia hepato-biliopancreatică Department of Gastroenterological Surgery, Supervisor: Prof. S. Matsuno Tohoku University School of Medicine, Sendai, Japan PhD Fellow in Clinical-Research Cercetare, studii doctorale, teza Functional evidences of TSGs on chromosome 18 in pancreatic cancer Clinica a III a Chirurgie Sp. Sf. Spiridon, Iaşi Medic primar chirurg, chirurgie generală Cercetare şi activitate chirurgicală în chirurgia generală 9. Locul de muncă actual şi funcţia: UMF Gr.T.Popa Iaşi, Clinica a IIIa Chirurgie, Centrul de cercetare in Chirurgia Oncologică şi Training în Chirurgia Generală, Iaşi, medic primar chirurg, asistent universitar 10. Vechime la locul de muncă actual: 13 ani 11. Brevete de invenţii: - 12. Lucrări elaborate şi / sau publicate (se anexează lista lucrarilor elaborate/publicate trebuie sa contina maxim 5 (cinci) lucrari in domeniul proiectului, relevante pentru activitatile ce urmeaza a fi desfasurate in cadrul proiectului): 1. LP Lefter, S Dima, M Sunamura, T Furukawa, Y Sato, M Abe, M Chivu, I Popescu and A Horii. Transcriptional silencing of ETS-1 efficiently suppresses angiogenesis of pancreatic cancer. Cancer Gene Ther. 2009 Feb;16(2):137-48. 2. L.P. Lefter, Walker S., Dewhurst F., Turner W. Operative Notes Audit - facts and ways to improve. ANZ Surgery, 78:9, 2008. 3. Masaharu Ishida, Makoto Sunamura, Toru Furukawa, L.P. Lefter, Rina Morita, Masanori Akada, Shinichi Egawa, Michiaki Unno, Akira Horii. The PMAIP1 Gene on Chromosome 18 is a Candidate Tumor Suppressor Gene in Human Pancreatic Cancer. Dig Dis Sci., 53(9):2576-82, 2008. 4. Scripcariu V, Dajbog E, Lefter L, Ferariu D, Pricop A, Grigoras M, Dragomir C. Malignant peritoneal mesothelioma. Chirurgia (Bucur). 2006 Nov-Dec; 101(6):641-6.
5. Dajbog, E., Lefter, L.P., Scripcariu, V., Ferariu, D., Dragomir, C. Diagnostic Features of Benign Pancreatic Insulinomas. An Analysis of Three Cases. J Gastrointestinal and Liver Diseases, 2006, 15(1):59-64. 6. Lefter, L.P., Dajbog, E., Scripcariu, V., Dragomir, C. Safety and Efficacy of Conservative Management in Acute Severe Pancreatitis. Chirurgia, 2006; 101(2):67-74. 7. Pricop, C., Lefter, L.P., Scripcariu, V., Danciu, M., Buleu, D., Dragomir, C. Metachronous primary cancers of the colon and stomach. Rev Med Chir Soc Med Nat Iasi, 2005, 109(4): 817-821. 8. Lefter, L.P., Dajbog, E., Scripcariu, V., Dragomir, C. Current Strategy in Colorectal Cancer Screening. Rev Med Chir Soc Med Nat Iasi, 2005, 109(4): 753-759. 9. R. Dãnilã, L. Andriescu, C. Dascalescu, Lefter, L.P., R. Popovici, B. Galusca, C. Vulpoi, C. Ungureanu, V. Mogoş, Dragomir, C. Peculiar morphological and clinical forms. Rev Med Chir Soc Med Nat Iasi, 2005, 109(4): 746-752. 10.Dragomir C, Lefter, L.P. Recommendations of the Consensus Conference about diagnosis and treatment of acute pancreatitis, Iasi-2005, Chirurgia 2005; 100(4):402-406. 11.Dajbog, E., Lefter, L.P., Scripcariu, V., Dãnilã, R., Dragomir, C. Evidence-Based Colorectal Cancer Screening. Rev Med Chir Soc Med Nat Iasi, 2005, 109(2): 324-331. 12.Scripcariu V, Timofeiov S, Dragomir R, Lefter, L.P., Radu I, Dragomir C. Use of polypropylene mesh for incisional hernia repair. Rev Med Chir Soc Med Nat Iasi. 2004; 108(4):800-804. 13.Yamanaka, S., Sunamura, M., Furukawa, T., Sun, L., Lefter, L.P., Abe, T., Yatsuoka, T., Fujimura, H., Shibuya, E., Kotobuki, N., Oshimura, M., Sakurada, A., Sato, M., Kondo, T., Matsuno, S., Horii, A. Chromosome 12, Frequently Deleted in Human Pancreatic Cancer, May Encode a Tumor Suppressor Gene that Suppresses Angiogenesis. Lab Invest., 2004; 84:(9):1098-1107. 14.Lefter, L.P., Scripcariu, V., Sunamura, M., Furukawa, T., Matsuno, S., Oshimura, M., Drug, V., Dragomir, C., Horii, A. Screening for Functional Tumor Suppressor Activity in Pancreatic Cancer. Rom J Gastroenterol, 2004; 99(5):305-310. 15.Scripcariu, V., Lungu, M., Dragomir, R., Lefter, L.P., Radu, I., Dragomir, C. Anterior resection of the rectum for rectal cancer - options, limits, immediate complications. Chirurgia, September, 2004, 99(5):305-310. 16. Sunamura, M., Lefter, L.P., Duda, D.G., Morita, R., Inoue, H., Yokoyama, T., Yatsuoka, T., Abe, T., Egawa, S., Furukawa, T., Fukushige, S., Oshimura, M., Horii, A., Matsuno, S. The Role of Chromosome 18 Abnormalities in Progression of Pancreatic Adenocarcinoma. Pancreas, 2004; 28(3):311-316. 17. L. P. Lefter, Sunamura, M., Furukawa, T., Yastsuoka, T., Abe, H., Inoue, H., Abe, T., Egawa, S., Miura, K., Morita, R., Horii, A., Matsuno, S. Functional Analysis of Chromosome 18 in Pancreatic Cancer:
Strong Evidence for New Tumour Suppressor Genes. Asian J Surg, 2004; 27(2):85 92. 18.Lefter, L.P., Sunamura, M., Furukawa, T., Takeda, K., Kotobuki, N., Oshimura, M., Matsuno, S., Horii, A. Inserting Chromosome 18 into Pancreatic Cancer Cells Switches Them to a Dormant Metastatic Phenotype. Clin Cancer Res. 2003; 9:5044-5052. 19.Duda DG, Sunamura M, Lefter LP, Furukawa T, Yokoyama T, Yatsuoka T, Abe T, Inoue H, Motoi F, Egawa S, Matsuno S, Horii A. Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. Oncogene, 2003, 22:6857-6864. 20.Lefter, L.P., Furukawa, T., Sunamura, M., Duda, D., Takeda, K., Kotobuki, N., Oshimura M., Matsuno, S., Horii, A. Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines. Genes Chromosomes Cancer. 2002; 34:234-242. 21. Lefter, L.P., Duda, D., Sunamura, M., Lozonschi, L., Furukawa, T., Sunamura, D., Takeda, K., Matsuno, S., Horii, A. Brain Angiogenesis Inhibitor 1 (BAI1) inhibits the tumor neovascularization in pancreatic cancer. Proceeding of Balkanic Society of Oncology Meeting, Monduzzi Editore: 2001: 133-139, ISBN 88-323-0911-4. Monographs 1. In quest for tumour suppressor genes. Lefter, L.P. 2006, Ed. Demiurg, Iaşi, ISBN 973-7603-22-2. 2. Lectures in General Surgery - Andriescu, L., Dãnilã, R., Lefter, L.P. 2006, Ed. Demiurg, Iaşi, ISBN 973-7603-22-2. 3. Evidence Based Colorectal Cancer Screening - Lefter, L.P., Dajbog, E., Scripcariu, V. 2005, Ed. Tehnopress, Iaşi, ISBN 973-702-274-2. 4. A guide to Surgical Examination - Scripcariu, V., Lefter, L.P., Dajbog, E. 2005, Ed. Tehnopress, Iaşi, ISBN 973-702-274-2. Communications 1. L.P. Lefter, Walker S., Dewhurst F., Turner W. Operative Notes Audit - facts and ways to improve. RACS Annual Meeting, Hong-Kong, 2008. 2. Lefter, L.P., Furukawa T., Sato, Y., Dima, S., Popescu, I., A. Horii - Ets-1 dominant negative molecule inhibits angiogenesis in pancreatic (Hepatology 53-Suppl 8:A69). The 17 th International Association of gastroenterologists and Oncologists, Bucharest, Sept, 2007. 3. Lefter, L.P., Dima, S., Popescu, I. Romanian Pancreatic Cancer Registry. First Romanian Pancreas Club, Cluj-Napoca, 2007. 4. Lefter, L.P., Sunamura, M., Scripcariu, V., Horii, A. A magic bullet? Ets- 1 gene therapy in pancreatic cancer. (Gut 54-Suppl 9:A12). The 13 th United European Gastroenterology Week, Copenhagen, 2005, ISSN 0017-5749.
5. Dajbog E, Scripcariu V, Lefter LP, Dragomir C, Combined Management of Radiotherapy and Total Mesorectal Exicision in Rectal Cancerretrospective study,18 th APCC, 2005, Seoul, Korea, 7-9, 2005. 6. Lefter, L.P., et al. The dominant negative form of Ets-1 efficiently suppreses angiogenesis and induces specific gene profiles in pancreatic cancer cells (Pancreatology Suppl 4:388, 2004), and Moderator of the Pancreatic Cancer - Molecular Targeting P03 Session, Joint Meeting of IAP-JPS, June, Sendai, Japan, 2004, ISSN 1424-3903. 7. Lefter, L.P. "Current perspectives on antiangiogenesis strategies in pancreatic cancer, invited speaker, Evidence Based Medicine Digestive Cancer Seminar, June, Sendai, Japan, 2004. 8. Lefter, L.P. et al. Ets-1 dominant-negative molecule induces a dormant angiogenetic phenotype in pancreatic cancer. (Eur J Can 40:11, 168). The 18 th Meeting of EACR, Innsbruck, June, 2004. 9. Sunamura, M., Lefter, L.P., Rina Morita, et al. Implication of Chromosome 18 Abnormalities in the Progress of Pancreatic cancer. (Gastroenterology 125: Suppl. S - A803), Digestive Disease Week 2004 Meeting, Orlando, Florida, USA, May, 2004. 10.Radulescu, C., Lefter, L.P., Scripcariu, V., Negru, D., Andriescu, L., Necroziting Pancreatitis Being Surgical or Conservative? (Chirurgia 99:330), The 22 nd Romanian Surgical Society Meeting, 2004, May, Tg. Mures, ISSN 1221-9118. 11.Scripcariu, V., Lungu, M., Dragomir, R., Lefter, L.P., et al. Anterior resection of the rectum for rectal cancer - options, limits, immediate complications. (Chirurgia 99:348), The 22 nd Romanian Surgical Society Meeting, 2004, May, Tg. Mures, ISSN 1221-9118. 12.Liviu P. Lefter, Sunamura M., Furukawa T., Sato, Y., Takeda, K., Seiki Matsuno, A. Horii - Ets-1 dominant negative molecule inhibits angiogenesis in pancreatic (Gut 52-Suppl 6:A48). The 11 th United Gastroenterology Week, Madrid, Nov., 2003, ISSN 0017-5749. Grants and Awards Merit Award, 13 th United European Gastroenterology Week, Copenhagen, 2005. Merit Award, 12 th United European Gastroenterology Week, Praga, September, 2004. Travel Award, International Association of Pancreatology Meeting, Sendai, Japan, June, 2004. Merit Award, the 18 th Meeting of EACR, Innsbruck, Austria, June, 2004. "IN HOC SIGNO VINCES - Magna cum Laude" Award, National University Council, Romania, 2004. Merit Award, 11 th United European, Gastroenterology Week, Madrid, November 2003. Merit Award, 39th Annual Meeting of ASCO, Chicago, May 2003. Merit Award, Joint Meeting IAP-EPC, Heidelberg, Germany, June, 2002. EAES Advanced Laparoscopic GI Surgery Course, Dundee, June, 2002.
Travel Grant, the 17 th Meeting of EACR, Granada, Spain, 2002. Travel Award, the 93rd Annual Meeting of AACR, San Francisco, April 2002. 13. Membru al asociaţiilor profesionale: Professional Memberships and Affiliations Peer-reviewer, National University Council, Romania (NURC, 2005-). Member of Executive Committee, National University Council, Romania (2005-2006). Peer-reviewer, United European Gastroenterology Federation (UEGF 2004-2008). Peer-reviewer, Medical Surgical Journal, Surgical Section, ISSN: ISSN 0048-7848. Peer-reviewer, Journal of Surgery, ISSN: 1584-9341. Associate Member of EACR (2002). Associate Member of AACR (ID: 78848, 2000). Associate Member of ASCO (ID: 37586, 2000). Japanese Association of Cancer (2001). Associate Member of Society of Physicians Naturalists, Romania (1998). Romanian Society of Surgery (1996). 14. Limbi straine cunoscute: engleză (IELTS band 8/2008), franceză, japoneză 15. Alte competenţe: Cell culture, cloning, site directed mutagenesis, gene transfer using viruses, bacterial and physical methods, proliferation and invasion assays. Microarray analysis: spotting, hybridization, data analysis (Amersham and Hitachi platforms). Molecular biology techniques (RT-PCR, Southern, Northern, Western Blotting). 16. Specializări şi calificări: Medic specialist, Doctor in medicina, primar în chirurgie generală. Courses Advanced Wound Care Theory-VAC Therapy Aug 11 2007, Workshop 3 rd Congress on negative pressure wound therapy, Sydney, Australia Basic Course in Laparoscopic Gastric Banding August 2006, Monash University, Melbourne, Australia Master class in Upper GI Surgery
May 14-17, 2006, RACS Annual Meeting, Sydney, Australia Workshop of the AIDPIT (Artificial Insulin Delivery, Pancreas and Islet Transplantation) Study Group February 2-6, 2006, Pisa (Italy). Oncoplastic Breast Surgery May 5-9, 2005, Royal College of Surgeons of England. EAES Laparoscopic GI Surgery Course June 12-18, 2002, Scotland (Professor Sir Alfred Cuschieri FRCS, sponsorized by KARL STORZ GmbH & Co). Grant Writing Course April 4, 2002, American Association for Cancer, San Francisco. The STEP Course June 23-26, 1999, 3-rd Surgical Unit, Iasi, Romania (under tuition of the Royal College of Surgeons of England). Basic Surgical Skills Course Jan, 11-19, 1998, 3-rd Surgical Unit, Iasi, Romania Postgraduate Course Elements of Laparoscopic Surgery June, 15-21, 1997, University of Medicine, Iasi, Romania. Peripheral Vascular Surgery Course St. Elisabeth Clinic Brussels, Iasi, 15-18 Oct. 1996. Teaching Experience Tohoku University School of Medicine, Sendai, Japan. Directing the work of medical students and junior medical staff. 2001-2003. Department of Surgery, University of Medicine and Pharmacy, Iasi, Romania. Assistant Professor in General Surgery. 1998-2000, 2003-present. Department of Surgery, University of Tasmania, Clinical Lecturer in Surgery 17. Experienţa acumulată (inclusiv experienta manageriala) în alte programe/proiecte naţionale/internaţionale: Programul/Proiectul 1. Grant CNCSIS-IDEI 1435 2009 Defining of Genetic profiles induced by transcriptional suppression of ETS-1 in Funcţia Perioada: de la... până la... Director 2009-2011
pancreatic cancer, University of Medicine Gr. T. Popa Iasi, Center of Research in Oncological Surgery, St. Spiridon Hospital Iasi, Romania. Director: Dr. Liviu P Lefter. 2009-2011, Email: lilefter@gmail.com, valoare 1.000.000 RON. 2. Grant CEEX-ET 97-2006 The Evaluation of Maspin protein as marker for early diagnosis and prediction of pancreatic cancer survival, University of Medicine Gr. T. Popa Iasi, Center of Research in Oncological Surgery, St. Spiridon Hospital Iasi, Romania. Director: Dr. Liviu P Lefter. 2006-2007, Email: lilefter@gmail.com, valoare 100.000 RON. 3. Research Grant CEEX-ET-117 (Ministry of Education, Romania). Consolidarea si Cresterea Vizibilitatii Internationale a Romaniei privind Metodologia de Terapie Multidisciplinara a Cancerului Pancreatic, Director: Liviu Lefter, Email: lilefter@gmail.com (2006-2007), VALOARE 200.000 RON. 4. Research Grant CEEX-ET-195 (Ministry of Education, Romania). Terapie Genica in Cancerul Pancreatic prin Manipularea Translationala a Ets1, Director: Liviu Lefter, Email: lilefter@gmail.com (2006-2007), valoare 150.000 RON. 5. Research Grant CEEX-M1-62 (Ministry of Education, Romania). Biological features of transcriptional suppression of ETS-1 in pancreatic cancer. Director: Prof. Irinel Popescu, Email: irinel.popescu@icfundeni.ro, valoare 1.000.000 RON (2006-2009). 6. Research Grant CEEX-M1-121 (Ministry of Education, Romania). Expresia Caveolinelor 1, 2 si 3 in Cancerele Pancreatice; Tinte Moleculare in Diagnostic si Terapie. Director: Prof. Irinel Popescu, Email: irinel.popescu@icfundeni.ro (2006-2009). 7. Grant CEEX-M1-449. Study of the genomic expression profile and biomarkers correlated with clinical and pathological parameters in pancreatic cancer. Fundeni Clinical Institute, Bucharest, Centre of General Surgery and Hepatic Transplantation. Director: Irinel Popescu, Director 2006-2007 Director 2006-2008 Director 2006-2007 Responsabil Stiintific 2006-2008 Executant 2006-2009 Executant 2005 2008
Email: irinel.popescu@icfundeni.ro 8. Ph.D. Student Monbusho Grant (Ministry of Education, Culture, Sports, Science and Technology, Japan, No: 87542), Department of Gastroenterogical Surgery, Tohoku University, Sendai, Japan, Grant Administrator: Prof. Seiki Matsuno. 9. Research Grant (Foundation for Promotion of Cancer Research in Japan), Department of Molecular Pathology, Tohoku University, Sendai, Japan, Grant Administrator: Prof. Akira Horii 10. Research Grant (Vehicle Racing Commemorative Foundation), Department of Molecular Pathology, Tohoku University, Sendai, Japan, Grant Administrator: Prof. Akira Horii 11.Research Grant (No: 14657277 - Japanese Ministry of Health, Labour and Welfare), Department of Molecular Pathology, Tohoku University, Sendai, Japan, Grant Administrator: Prof. Akira Horii. 18. Alte menţiuni: Responsabil Stiintific Executant Executant Executant 2000 2004 2002 2001 2000 Declar pe propria răspundere că datele prezentate sunt în conformitate cu realitatea. Data completării: 09.02.2009 Semnătura