Fig. 59 Malignant phaeochromocytoma, hepatic metastasis.

Fig. 59 Malignant phaeochromocytoma, hepatic metastasis. X 120 Hyperte nsion Fig. 60 Malignant sympathetic paraganglioma, lymph node metastasis Primary in bladder. x 1 20 Hypertension

Fig. 61 Malignant parasympathetic paraganglioma, carotid body local invasion and lymph node metastasis occurred. x 75 Fig. 62 Neuroblastoma, adrenal medulla X 120

Fig. 63 Neuroblastoma, adrenal medulla Neurofibrillary area. x 300 Fig. 64 Mixed neuroendocrine-neural tumour, adrenal medulla Ganglioneuromatous area. Fig. 64 to 66 are from same case. X 120 Hypertension

Fig. 65 Mixed neuroendocrine-neural tumour, adrenal medulla Partly ganglioneuromatous, partly diffuse phaeochromocytoma (centre of field). x 120 Hypertension Fig. 66 Mixed neuroendocrine-neural tumour, adrenal medulla Area of malignant phaeochromocytoma with mitotic activity. X 300 Hypertension

Fig. 67 Adenoma, parathyroid Adenoma with attached normal gland and thyroid. x 5 Hyperparathyroidism.,.,, ~""' :~.. "":': ~, 1",} ' -,, ~::\ 't~~ ~- - f't;t~"l: Fig. 68 Chief cell adenoma, parathyroid Rim of suppressed gland. x 120 Hyperparathyroidism

Fig. 69 Chief cell adenoma, parathyroid Nuclear pleomorphism. X 120 Hyperparathyroidism Fig. 7Q Chief cell adenoma, parathyroid Follicular architecture simulates thyroid. x 120 Hyperparathyroidism

Fig. 71 Chief cell adenoma, parathyroid Portion of fibrous wall of cystic tumour. x 50 Hyperparathyroidism Fig. 72 Water-clear cell adenoma, parathyroid Rim of inactive chief cells with some oxyphils. x 30 Hyperparathyroidism

Fig. 73 Oxyphil cell adenoma, parathyroid Abundant granular eosinophilic cytoplasm. x 300 Fig. 74 Inactive parathyroid gland Small chief cells, fat. Same case as Fig. 70. x 300 Hyperparathyroidism

Fig. 75 Carcinoma, parathyroid Broad trabecular pattern, fibrous bands. X 50 Hyperparathyroidism Fig. 76 Carcinoma, parathyroid Invasion of muscle and vessels at edge of tumour. X 50 Hyperparathyroidism

,, ~ '- # ~ if~... ' ' '._.}._-.,... ~~-... ' ~' ' ' Fig. 77 Carcinoma, parathyroid Vascular invasion. X 120 Hyperparathyroidism Fig. 78 Carcinoma, parathyroid Uniform cells, mitotic activity. x 75 Hyperparathyroidism

~ '-. ''. -;_;>'- ~ -. ~ \~ Fig. 79 Lipoadenoma, parathyroid Section of 5 cm tumour. x 50 Hyperparathyroidism Fig. 80 Primary nodular hyperplasia, parathyroids Large upper, small lower glands. x 3 Hyperparathyroidism, MEN I

Fig. 81 Primary nodular hyperplasia, parathyroid Chief and oxyphil cell nodules. x 50 Hyperparathyroidism. MEN I Fig. 82 Primary nodular hyperplasia, parathyroid Multiple ill-defined oxyphil cell nodules. x 50 Hyperparathyroidism. MEN I

Fig. 83 Primary nodular hyperplasia, parathyroid Nodules of differing architecture and cell type. X 120 Hyperparathyroidism : ~... ~.... :...,..,... --,... :. k..,....,,.,,...,.... ~. :-., J..~.. ~-; :.. ~..!.' ~; :............ :. :. ~... ~."-. r............ '.-.':--.. ~...! ~ il, ~tl...,.._.. - : : : --:: ~ -.,. -. ~ -~ ",-... ~"' "' ~,.. "4:.~ "' ~ Jl -._ 11. : "' :!t:" I,....,.., ".:-..,~~..,., :.:... ;..... ~.. '. ~... :.'.... Fig. 84 Primary water-clear cell hyperplasia, parathyroid. X 120 Hyperparathyroidism

Fig. 85 Secondary hyperplasia, parathyroid Uniform appearance found in all glands. Renal failure. X 30 Secondary hyperparathyroidism Fig. 86 Secondary hyperplasia, parathyroids Long-standing renal failure. Early nodularity in one gland. X 3 Secondary hyperparathyroidism

Fig. 87 Nodular hyperplasia, parathyroids Nodularity in all glands. Hypercalcaemia and long-standing renal failure. x 3 Tertiary hyperparathyroidism Fig. 88 Adenomas, parathyroids Two adenomas and two suppressed glands. Hypercalcaemia and long-standing renal failure. x 3 Tertiary hyperparathyroidism

Fig. 89 Nodular hyperplasia, parathyroid Hypercalcaemia and renal failure. x 12 Tertiary hyperparathyroidism Fig. 90 Nodular hyperplasia, parathyroid Oxyphil and chief cell nodules. x 50 Tertiary hyperparathyroidism

Fig. 91 EC-cell carcinoid, ileum Mainly submucosal tumour extending through thickened muscle to serosa. x 5 Fig. 92 EC-cell carcinoid, ileum Solid islands of cells in a fibrous stroma. X 50

Fig. 93 EC-cell carcinoid, ileum Submucosal tumour. Islands of cells with glandular differentiation. x 50 I. Fig. 94 EC-cell carcinoid, appendix Islands and strands of tumour in fibrous stroma. x 120

Fig. 95 EC-cell carcinoid, appendix Oiazo-positivity most marked in basigranular peripheral cells. Alkaline diazonium. X 120 Fig. 96 EC-cell carcinoid, ileum Carcinoid invading mucosa. Note distinction between normal Paneth cells and eosinophilic granular tumour cells. x 300

Fig. 97 EC-cell carcinoid, ileum Same case and area as Fig. 96. Masson-Fontana. X 300 \.. I ' "' -~. '."'...., Fig. 98 EC-cell carcinoid, ileum Same case and area as Fig. 96. Bodian. x 300

Fig. 99 EC-cell carcinoid, ileum Hepatic metastasis, partial cystic change. Grimelius x 120 Carcinoid syndrome Fig. 100 G-cell tumour, pancreas Trabecular pattern. Tumour metastasized. MEN I. x 120 Zollinger-EIIison syndrome

Fig. 101 G-cell tumour, pancreas Mitotic activity. X 300 Zollinger-EIIison syndrome Fig. 1 02 G-cell tumour, pancreas Argyrophilic cells. Small tumour in MEN I. Grimelius. X 120 Zollinger-EIIison syndrome

Fig. 103 G-cell tumour, pancreas Argyrophilic cells. Grimelius. x 300 Zollinger-EIIison syndrome Fig. 1 04 Bronchial carcinoid Regular cells, granular cytoplasm. x 300

Fig. 1 05 Bronchial carcinoid Solid islands of cells. Resemblance to classic carcinoid pattern. Same case as Fig. 1 07 and 1 OB. x 120 Fig. 1 06 Bronchial carcinoid Ribbon pattern, same case as Fig. 1 04. x 300

Fig. 107 Bronchial carcinoid Encroaching on bronchial lumen. Diffuse pattern. x 120 ~ :,;'."':'"! -... ; Fig. 1 08 Bronchial carcinoid Scattered argyrophilic cells. Same case and area as Fig. 1 07. Grimelius. X 120

Fig. 109 Bronchial carcinoid Strongly argyrophilic tumour. Bodian. x 120 Fig. 11 0 Thymic carcinoid X 120 Cushing"s syndrome (ectopic ACTH)

Fig. 111 Gastric carcinoid X 120 Cushing"s syndrome (ectopic ACTH) Fig. 112 Gastric carcinoid Argyrophil cells and glandular structures. Bielschowsky. X 120

Fig. 113 Pancreatic carcinoid X 75 Verner-Morrison syndrome Fig. 114 Pancreatic carcinoid Grimelius-neutral red. x 190 Verner-Morrison syndrome

Fig. 115 Duodenal carcinoid X 30 Fig. 11 6 Duodenal carcinoid Trabecular pattern. X 120

Fig. 117 Duodenal carcinoid Arg yrophilia. Grimelius. X 120 Fig. 118 Rectal carcinoid Small submucosal tumour. Trabecular pattern. x 30

Fig. 119 Rectal carcinoid Mixed pattern. x 50 Fig. 120 Rectal carcinoid Ribbon pattern. x 120

Fig. 121 Gall bladder carcinoid X 120 Fig. 122 Mucocarcinoid, appendix Well-differentiated goblet cells invading muscle. X 120

Fig. 123 Mucocarcinoid, appendix Isolated argentaffin cells. Masson-Fontana-Mucicarmine. X 120 Fig. 124 Mucocarcinoid, appendix Perineural invasion in appendiceal muscle. Argentaffin cells. Masson-Fontana-Mucicarmine. x 300

Fig. 125 Mixed carcinoid-adenocarcinoma, rectum Carcinoid component. X 120 Fig. 126 Mixed carcinoid-adenocarcinoma, rectum Carcinoma with signet-ring cells. Same tumour as Fig. 1 25. X 120

Fig. 127 Mixed carcinoid-adenocarcinoma, rectum Both patterns of growth. Argyrophil cells. Bodian-mucicarmine x 120 Fig. 128 Adenocarcinoma, rectum Scattered EC-cells present. See Fig. 129. x 120

Fig. 129 Adenocarcinoma, rectum EC-cells. Same case and area as Fig. 128. Masson Hamperl. x 120 Fig. 130 Mucinous carcinoma, ovary Numerous very prominent EC-cells seen in haematoxylin eosin section. x 300

Fig. 131 Normal islets of Langerhans B cells (purple). Aldehyde fuchsin. x 300 Fig. 1 32 Normal islets of Langerhans A cells (argyrophilic). Grimelius. X 1 20

Fig. 133 Islet cell adenoma 8 -cell adenoma, trabecular pattern. X 120 Hypoglycaemia Fig. 134 Islet cell adenoma Stromal amyloid. x 120

Fig. 135 Islet cell adenoma B-cell adenoma. x 300 Hypoglycaemia Fig. 136 Islet cell adenoma B-cell adenoma. x 190 Hypoglycaemia

Fig. 137 Islet cell adenoma Capsule. hyperplastic islets. x 50 MEN I...., '..... '.... Fig. 138 Islet cell adenoma Clear cells, resemblance to adrenal cortex. x 120 MEN I

Fig. 139 Islet cell adenoma B-cell adenoma. Aldehyde fuchsin-positive cells. Aldehyde fuchsin. x 300 Fig. 140 Islet cell carcinoma B-cell tumour. Stromal fibrosis, calcification and amyloid. X 75 Hypoglycaemia

Fig. 141 Islet cell carcinoma B-cell tu mour. Hepatic metastases occurred. x 190 Hypoglycaemia Fig. 142 Islet cell carcinoma Liver metastasis. Regular cells, mi totic activity. x 480 Hypoglycaemia

.-..... -;. ~.. t l ' '.... ~ Fig. 143 Poorly differentiated endocrine carcinoma, pancreas Liver metastasis. x 120 Cushing's syndrome (ectopic ACTH) Fig. 144 Poorly differentiated endocrine carcinoma, pancreas X 300 Hyperglycaemia

Fig. 145 Islet cell hyperplasia Large numerous islets in normal exocrine pancreas. x 50 MEN I Fig. 146 Islet cell hyperplasia Chronic pancreatitis. Crowded islets, destroyed exocrine pancreas. x 50