In Ext2 these outcomes are only adjudicated for Medical Record Cohort (MRC) ppts. ID WHI Participant Common ID Col#1 ASCSOURCE Ascertainment Source Col#2 1 Local Form 121 1,112 14.4 2 Central Form 121 394 5.1 3 Central Form 132 6,219 80.5 CAROTID Carotid Artery Disease Col#3 1 Yes 1,610 20.8 Missing 6,115 79.2 Carotid Artery Disease was adjudicated for CT and OS participants through Ext1. In Ext2 It is only adjudicated for the Medical Record Cohort. Carotid Artery Disease occurring on or after a Stroke is not counted. STRKHEMO Hemorrhagic Stroke Col#4 1 Yes 1,001 13.0 Missing 6,724 87.0 Defined as a Stroke where the diagnosis question indicates a hemorrhagic stroke. Hemorrhagic Stroke was adjudicated for CT and OS participants through Ext1. In Ext2 it is only adjudicated for the Medical Record Cohort. Strokes from cause of death, Form 121 and early versions of 132 were not able to determine Hemorrhagic/Ischemic classification. Includes inpatient strokes for the core WHI study and inpatient and outpatient strokes after the core study closeout. STRKISCH Ischemic Stroke Col#5 1 Yes 5,084 65.8 Missing 2,641 34.2 Defined as a Stroke where the diagnosis question indicates an iscemic stroke. Ischemic Stroke was adjudicated for CT and OS participants through Ext1. In Ext2 it is only adjudicated for the Medical Record Cohort. Strokes from cause of death, Form 121 and early versions of 132 were not able to determine Hemorrhagic/Ischemic classification. Includes inpatient strokes for the core WHI study and inpatient and outpatient strokes after the core study closeout. STROKE Stroke Col#6 1 Yes 6,117 79.2 Missing 1,608 20.8 Defined as the first occurrence of Stroke or a Death due to Cerebrovascular. Stroke was adjudicated for CT and OS participants through Ext1. In Ext2 it is only adjudicated for the Medical Record Cohort. In order to be able to classify strokes, WHI uses central adjudications if possible, even though Strokes were only fully centrally adjudicated in HT participants. See the DEATH and DEATHSRC variables for details about the death adjudication process. Includes inpatient strokes for the core WHI study and inpatient and outpatient strokes after the core study closeout. Page 1 of 5
STROKEDX Stroke diagnosis Col#7 1 Subarachnoid hemorrhage 225 2.9 2 Intraparenchymal hemorrhage 753 9.7 3 Other or unspec intracranial hemorrhage 23 0.3 4 Occlusion of cerebral arteries w/infarction 5,084 65.8 5 Acute but ill-defined cerebrovascular 30 0.4 disease 6 Central nervous system complications 0 0.0 during/from procedure Missing 1,610 20.8 Value 6 was only on form 121 and early versions of form 132. Strokes with a diagnosis code of 6 were unable to be classified as Hemorrhagic or Ischemic. STROKEPROC Stroke occurred during or resulted from a procedure Col#8 0 No 5,471 70.8 1 Yes 333 4.3 9 Unknown 32 0.4 Missing 1,889 24.5 Not collected on early versions of F132. A stroke is defined as procedure-related if it occurs within 24 hours after any procedure or within 30 days after a cardioversion or invasive cardiovascular procedure. STROKEOUTPAT F132 Stroke diagnosed or managed as outpatient Col#9 Was the stroke diagnosed or managed as an outpatient?* *The outpatient setting includes any emergency department or observation unit, short hospital stays of less than 24 hours duration or a direct admission to a rehab facility without an associated admission to an acute care hospital. 0 No 3,881 50.2 1 Yes 165 2.1 Missing 3,679 47.6 Only collected after WHI closeout. STROKEOXFORD Oxfordshire Classification Col#10 1 Total Anterior Circulation Infarction (TACI ) 305 3.9 2 Partial Anterior Circulation Infarction (PACI) 2,464 31.9 3 Lacunar Infarction (LACI) 1,424 18.4 4 Posterior Circulation Infarction (POCI) 858 11.1 Missing 2,674 34.6 Page 2 of 5
STROKETOAST TOAST Classification Col#11 Trial of Org 10172 in Acute Stroke Treatment (TOAST) Classification 1 Probable large artery atherosclerosis 262 3.4 2 Probable cardioembolism 1,183 15.3 3 Probable small vessel occlusion (lacune) 666 8.6 4 Probable stroke of other determined 122 1.6 etiology 5 Possible large artery atherosclerosis 109 1.4 6 Possible cardioembolism 300 3.9 7 Possible small vessel occlusion (lacune) 311 4.0 10 Possible Stroke of other determined 57 0.7 etiology 11 Stroke undetermined two or more causes 412 5.3 identified 12 Stroke undetermind negative evaluation 879 11.4 13 Stroke undetermined incomplete evaluation 750 9.7 Missing 2,674 34.6 A "probable" diagnosis is made if the clinical findings, neuroimaging data, and results of diagnostic studies are consistent with one subtype and other etiologies have been excluded. A "possible" diagnosis is made when the clinical findings and neuroimaging data suggest a specific subtype but other studies are not done. STROKEBASE Stroke diagnosis based on Col#12 1 Rapid neuro deficit & CT/MRI lesion & w/o 3,959 51.2 evid. of blood 2 Rapid neuro deficit duration >= 24 hrs & 58 0.8 rad n/a 3 Rapid neuro deficit duration >= 24hrs & rad 793 10.3 early no acute 4 Surgical evidence of ischemic infarction 1 0.0 5 CT or MRI blood hemor. in subarachnoid or 951 12.3 intra-parenchymal 6 Positive lumbar puncture 4 0.1 7 Surgical evidence of hemorrhage 2 0.0 8 None of the above 345 4.5 Missing 1,612 20.9 STROKE28DEATH Hospitalized stroke within 28 days of death Col#13 If stroke fatal: Hospitalized stroke within 28 days of death 0 No 38 0.5 1 Yes 653 8.5 STROKEPREV Previous stroke and no other lethal disease Col#14 If stroke fatal: Previous stroke and no known potentially lethal non-cerebrovascular disease process 0 No 671 8.7 1 Yes 20 0.3 Page 3 of 5
STROKEPOSTMORT Stroke diagnosed at post-mortem Col#15 If stroke fatal: Stroke diagnosed as cause of death at post-mortem examination 0 No 640 8.3 1 Yes 51 0.7 STROKEDEATHCERT Stroke listed on death certificate Col#16 If stroke fatal: Stroke listed as underlying cause of death on death certificate 0 No 160 2.1 1 Yes 530 6.9 Missing 7,035 91.1 STROKEGLASGOW Glascow stroke outcome scale Col#17 Participant s functional status at the time of discharge (Glasgow Outcome Scale) 1 Good recovery 2,136 27.7 2 Moderately disabled 1,548 20.0 3 Severely disabled 1,523 19.7 4 Vegetative survival 42 0.5 5 Deceased 660 8.5 6 Unable to assign category 182 2.4 Missing 1,634 21.2 CARDX Carotid artery disease diagnosis Col#18 1 Occlusion/stenosis w/o documentation of 1,500 19.4 cerebral infarction 2 Occlusion/stenosis w documentation of 88 1.1 cerebral infarcation CARBHOSP Carotid artery disease based on hosp discharge Col#19 Carotid artery disease based on: Symptomatic disease with carotid artery disease listed on the hospital discharge summary 0 No 1,009 13.1 1 Yes 579 7.5 Page 4 of 5
CARBABNORMAL Carotid artery disease based on abnormal findings Col#20 Carotid artery disease based on: Symptomatic disease with abnormal findings (>= 50% stenosis) on carotid angiogram, MRA, or Doppler flow study 0 No 871 11.3 1 Yes 717 9.3 CARBPROC Carotid artery disease based on vasc/surg proc. Col#21 Carotid artery disease based on: Vascular or surgical procedure to improve flow to the ipsilateral brain. 0 No 245 3.2 1 Yes 1,343 17.4 Page 5 of 5