Understanding the Mechanism and Chemical Properties of Tranexamic Acid and Its Applications in Orthopedics, Specifically Trauma Patients Temple University Hospital Anastassia Newbury M.D. Christopher Haydel M.D. Chava Blivaiss B.A.
<Understanding the Mechanism and Chemical Properties of Tranexamic Acid and Its Applications in Orthopedics, Specifically Trauma Patients > <Anastassia Newbury> My disclosure is in the Final AOFAS Mobile App. I have no potential conflicts with this presentation.
Background Tranexamic acid (TXA) is a safe and cost effective antifibrinolytic agent Utilized for decades during surgical procedures to minimize blood loss Early administration of TXA in trauma patients have decreased mortality rates and need for blood product transfusion No increase in thrombolytic events TXA well documented in the orthopaedic literature as being efficacious in decreasing blood loss during total knee arthroplasty.
Mechanism
Materials + Methods: CRASH-2
Materials + Methods: MATTERs
Materials + Methods: Meta-analysis review reduction in blood loss w/ TXA
Results TXA is most efficacious when given within an hour of injury and to those patients with more severe injuries with the highest concern for hemorrhage and hyperfibrinolysis
Conclusion XA leads to statistically significant decrease in blood loss in both trauma and orthopedic settings and could be beneficial in the field of trauma orthopedic
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