PAIN MEDICINE FOR THE NON-PAIN SPECIALIST 2017

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PAIN MEDICINE FOR THE NON-PAIN SPECIALIST 2017 FEBRUARY 16-18, 2017 JW MARRIOTT DESERT SPRINGS RESORT & SPA PALM DESERT, CALIFORNIA Learn the latest treatment strategies and multidisciplinary management options for patients with acute and chronic pain. 2016 MFMER 3572499-1

Low Back Pain: A Practical Approach Richard H. Rho, M.D. Pain Medicine For The Non-Pain Specialist February 18, 2017 2016 MFMER 3572499-2

Disclosure Statement Nothing to disclose 2016 MFMER 3572499-3

Learning Objectives After completion of this activity the participants will be able to: Identify common sources of low back pain. Identify red flag sources low back pain. Identify a general clinical framework in the assessment and conservative treatment for low back pain. 2016 MFMER 3572499-4

Low Back Pain is a common problem Today, back pain is the third largest reason patients seek medical attention 1 (1. Skin Disorders 2. Osteoarthritis/Joint Problems) Sg2 (www.sg2.com), a national healthcare consulting firm, confirms that 80% of the US adult population will experience back pain at some point in their lifetimes and that it s the third most expensive health problem Lack of consensus in the medical community for evidence based care pathways 1. St. Sauver JL, et al. Why patients visit their doctors: assessing the most prevalent conditions in a defined american population. Mayo Clin Proc. 2013;88(1):56-67 2016 MFMER 3572499-5

Low Back Pain comes in different flavors Bone Axial Limb Spinal Stenosis Discogenic Sacroiliac Radiculopathy Facet Myofascial Cauda Equina Syndrome RED FLAGS: CANCER, INFECTION, CERVICAL MYELOPATHY, FRACTURE, AUTOIMMUNE DZ, RADICULOPATHY 2016 MFMER 3572499-6

Axial Low Back Pain Myofascial Facet Sacroiliac Discogenic Bone pain Cauda Equina Syndrome Spinal Stenosis An accurate diagnosis can be difficult Diagnosis Treatment Preserved Functioning + Reduced Pain 2016 MFMER 3572499-7

Axial Low Back Pain Which of these causes of low back pain have evidence based treatments available? Myofascial Facet Sacroiliac Discogenic Bone pain Cauda Equina Syndrome Spinal Stenosis 2016 MFMER 3572499-8

Limb Pain Radiculopathy Cauda Equina Syndrome Spinal Stenosis Diagnosis An accurate diagnosis can be difficult Treatment Preserved Functioning + Reduced Pain 2016 MFMER 3572499-9

Limb Pain Which of these causes of low back pain have evidence based treatments available? Radiculopathy Cauda Equina Syndrome Spinal Stenosis 2016 MFMER 3572499-10

Back pain is complicated Many Low Back Pain Treatment Guidelines refer to axial low back pain as non-specific mechanical low back pain Taken from La Plante, M, et al. Multivariable analysis of the relationship between pain referral patterns and the source of chronic low back pain. Pain Physician 2012; 15:171-178 ISSN 1533-3159 Image taken from Hall JA. The role of radiofrequency facet denervation in chronic low back pain. Jacksonville Medicine, Duval County Medical Society. October 1998. 2016 MFMER 3572499-11

Low Back Pain Red Flags Cancer Persistent/worsening pain > 1 month Unexplained weight loss Previous history of non-skin cancer (positive likelihood ratio 14.7) Age > 50 years No relief with bedrest Infection History of IV drug use, urinary tract infection or skin infection Cauda Equina Syndrome Urinary retention Fracture Corticosteroid use Age > 50 years Trauma Ankylosing Spondylitis Age < 40 years Chronic onset, duration > 3 months Morning stiffness > 30 minutes Improvement with exercise but not rest Awakening during second half of night only Alternating buttock pain Herniated Disc or Radiculopathy Positive straight leg test and crossed straight leg test Motor/sensory deficit, DTR changes Spinal Stenosis Radiating leg pain Changing symptoms with downhill treadmill test Age > 65 years 1. Chou R, Huffman, LH. Guideline for the evaluation and management of low back pain. Evidence review. American Pain Society. 2009 2. Deyo R, Diehl A. Cancer as a cause of back pain: frequency, clinical presentation, and diagnostic strategies. J Gen Intern Med. 1988;3(3):230-238. 3. Deyo RA, Rainville J, Kent DL. What can the history and physical examination tell us about low back pain? JAMA. 1992;268(6):760-765. 2016 MFMER 3572499-12

Reassure Educate Goertz M, Thorson D, Bonsell J, Bonte B, Campbell R, Haake B, Johnson K, Kramer C, Mueller B, Peterson S, Setterlund L, Timming R. Institute for Clinical Systems Improvement. Adult Acute and Subacute Low Back Pain. Updated November 2012. 2016 MFMER 3572499-13

Reassure and Educate Reassure The prognosis is excellent for acute low back pain. Most patients will get better within two weeks, and most experience a dramatic improvement within 1 month (Hayden, 2010; Kent, 2005; Atlas, 2001). About 2/3 of patients with acute low back pain will have another episode within the next year. Unless the presentation is dramatically different from the first episode or the patient has a new medical condition, recovery should be similar for each episode (Hestbaek, 2003; Pengel, 2003). Educate Remain active Normal light activity is the key to recovery, and the key to long term management of low back pain Goertz M, Thorson D, Bonsell J, Bonte B, Campbell R, Haake B, Johnson K, Kramer C, Mueller B, Peterson S, Setterlund L, Timming R. Institute for Clinical Systems Improvement. Adult Acute and Subacute Low Back Pain. Updated November 2012. 2016 MFMER 3572499-14

Facet Joint Pain Pearls More likely with increased age Physical Examination Lumbar extension and rotation Neuro WNL Testing Lumbar xray if pain > 6 wks or if red flags (+) Treatment Core treatment plan* PT: DLS, core strengthening Radiofrequency ablation Gofeld M, et al. Radiofrequency denervation of the lumbar zygapophysial joints: 10 year prospective clinical audit. Pain Physician 2007; 10:291-299. ISSN 1533-3159 2016 MFMER 3572499-15

Sacroiliac Joint Pain Pearls May be associated with HLA-B27 syndromes Ask about morning stiffness, nocturnal pain Physical Examination FABER (flexion abduction external rotation of ipsi hip) Neuro WNL Testing Lumbar/pelvic xray if pain > 6 wks or if red flags (+) Treatment Core treatment plan* PT: DLS, core strengthening, pelvis stretch/mobilization Cooled Radiofrequency ablation Patel, N. (2016), Twelve-Month Follow-Up of a Randomized Trial Assessing Cooled Radiofrequency Denervation as a Treatment for Sacroiliac Region Pain. Pain Pract, 16: 154 167. doi:10.1111/papr.12269 2016 MFMER 3572499-16

Myofascial Low Back Pain Pearls May have spasms or knots in tissue Physical Examination Pain distribution is along muscle/trigger point patterns* Neuro WNL Testing Lumbar xray if pain > 6 wks or if red flags (+) Treatment Core treatment plan* PT: DLS, core strengthening Trigger point injections *Travell J, et al. Myofascial pain and dysfunction: the trigger point manual (2 vol. set, 2nd Ed.). Lippincott Williams & Williams. 1999. ISBN 0-683-08363-5. 2016 MFMER 3572499-17

Discogenic Low Back Pain Pearls More likely with younger patients Physical Examination Patients may stand during office visit Pain reproduced with axial loading, lumbar flexion Neuro WNL Testing Lumbar xray/mri if pain > 6 wks or if red flags (+) Treatment Core treatment plan* PT: DLS, core strengthening Epidural steroid injections, provocative discography Spine surgery Manchikanti L, Staats PS, Nampiaparampil DE, Hirsch JA. What is the Role of Epidural Injections in the Treatment of Lumbar Discogenic Pain: A Systematic Review of Comparative Analysis with Fusion. Korean J Pain. 2015 Apr;28(2):75-87. http://dx.doi.org/10.3344/kjp.2015.28.2.75 2016 MFMER 3572499-18

Bone Pain Pearls More likely with osteoporosis, malignancy, steroid exposure, elderly Physical Examination Focal pain over spine Any movement of spine is severely painful Spasms may be significant Neuro WNL Testing Lumbar xray if pain > 6 wks or if red flags (+) Treatment Core treatment plan* PT: DLS, core strengthening, bracing Percutaneous Vertebral Augmentation (i.e. vertebroplasty, kyphoplasty) Hussain A, Erdek M. Vertebroplasty augmentation procedures: examining the controversy. Pain physician 2013; 16:E483-E490. 2016 MFMER 3572499-19

Radiculopathy Pearls Neuropathic descriptors: burning, tingly, electric shock Testing Lumbar MRI if pain > 6 wks or if red flags (+) Physical Examination Neuro may reveal changed motor/sensory/dtr to L4, L5, or S1 spinal segments, (+) SLR Treatment Core treatment plan* PT: DLS, core strengthening; strength maintenance in affected region Epidural steroid injection Spine surgery Manchikanti L, et al. Epidural injections for lumbar radiculopathy and spinal stenosis: a comparative systematic review and meta-analysis. Pain physician 2016; 19(3): E365-410. 2016 MFMER 3572499-20

Cauda Equina Syndrome Pearls May report saddle distribution numbness, loss of control of bowel/bladder function Physical Examination Neuro: perineal sensory deficit, loss of anal sphincter tone, may have weakness/numbness of legs Testing Emergent MRI Treatment Emergent consultation from Spine Surgeon McLain RF, et al. Acute cauda equina synddrome caused by a disk herniation is emergent surgery the correct option? Surgical decompression remains the standard of care. Spine. 40(9): 639-641, May 01, 2015. 2016 MFMER 3572499-21

Lumbar Spinal Stenosis Pearls Intolerance to standing, walking; + shopping cart sign May involve axial limb pain distributions Due to facet joint arthritis, bulging discs, thickened ligamentum flavum all are potential sources of pain in their own right Physical Examination Neuro exam may be normal; little pain while sitting or with lumbar flexion Testing Lumbar MRI if pain > 6 wks or if red flags (+) Treatment Core treatment plan* PT: DLS, core strengthening; strength maintenance in affected region Epidural steroid injection Spine surgery?mild Lurie, Jon D. et al. Long-Term Outcomes of Lumbar Spinal Stenosis: Eight-Year Results of the Spine Patient Outcomes Research Trial (SPORT). Spine 40.2 (2015): 63 76. PMC. Web. 19 Sept. 2016. 2016 MFMER 3572499-22

2016 MFMER 3572499-23

Summary: Low Back Pain Bone Axial Limb Spinal Stenosis Discogenic Sacroiliac Radiculopathy Facet Myofascial Cauda Equina Syndrome RED FLAGS: CANCER, INFECTION, CERVICAL MYELOPATHY, FRACTURE, AUTOIMMUNE DZ, RADICULOPATHY 2016 MFMER 3572499-24

References 1. St. Sauver JL, et al. Why patients visit their doctors: assessing the most prevalent conditions in a defined american population. Mayo Clin Proc. 2013;88(1):56-67 2. Hall JA. The role of radiofrequency facet denervation in chronic low back pain. Jacksonville Medicine, Duval County Medical Society. October 1998. 3. La Plante, M, et al. Multivariable analysis of the relationship between pain referral patterns and the source of chronic low back pain. Pain Physician 2012; 15:171-178 ISSN 1533-3159 4. Chou R, Huffman, LH. Guideline for the evaluation and management of low back pain. Evidence review. American Pain Society. 2009 5. Deyo R, Diehl A. Cancer as a cause of back pain: frequency, clinical presentation, and diagnostic strategies. J Gen Intern Med. 1988;3(3):230-238. 6. Deyo RA, Rainville J, Kent DL. What can the history and physical examination tell us about low back pain? JAMA. 1992;268(6):760-765. 2016 MFMER 3572499-25

References continued 7. Goertz M, et al. Institute for Clinical Systems Improvement. Adult Acute and Subacute Low Back Pain. Updated November 2012. Travell J, et al. Myofascial pain and dysfunction: the trigger point manual (2 vol. set, 2nd Ed.). Lippincott Williams & Williams. 1999. ISBN 0-683-08363-5. 8. Gofeld M, et al. Radiofrequency denervation of the lumbar zygapophysial joints: 10 year prospective clinical audit. Pain Physician 2007; 10:291-299. ISSN 1533-3159 9. Patel, N. (2016), Twelve-Month Follow-Up of a Randomized Trial Assessing Cooled Radiofrequency Denervation as a Treatment for Sacroiliac Region Pain. Pain Pract, 16: 154 167. doi:10.1111/papr.12269 10. Travell J, et al. Myofascial pain and dysfunction: the trigger point manual (2 vol. set, 2nd Ed.). Lippincott Williams & Williams. 1999. ISBN 0-683-08363-5. 11. Manchikanti L, Staats PS, Nampiaparampil DE, Hirsch JA. What is the Role of Epidural Injections in the Treatment of Lumbar Discogenic Pain: A Systematic Review of Comparative Analysis with Fusion. Korean J Pain. 2015 Apr;28(2):75-87. http://dx.doi.org/10.3344/kjp.2015.28.2.75 2016 MFMER 3572499-26

References continued 12. Hussain A, Erdek M. Vertebroplasty augmentation procedures: examining the controversy. Pain physician 2013; 16:E483-E490. 13. Manchikanti L, et al. Epidural injections for lumbar radiculopathy and spinal stenosis: a comparative systematic review and meta-analysis. Pain physician 2016; 19(3): E365-410. 14. McLain RF, et al. Acute cauda equina synddrome caused by a disk herniation is emergent surgery the correct option? Surgical decompression remains the standard of care. Spine. 40(9): 639-641, May 01, 2015. 15. Lurie, Jon D. et al. Long-Term Outcomes of Lumbar Spinal Stenosis: Eight-Year Results of the Spine Patient Outcomes Research Trial (SPORT). Spine 40.2 (2015): 63 76. PMC. Web. 19 Sept. 2016. 16. Chou R, et al. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society. Ann Intern Med. 2007: 147:478-491. 2016 MFMER 3572499-27

Questions & Discussion 2016 MFMER 3572499-28