WHO/UNICEF Review of National Immunization Coverage India

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WHO/UNICEF Review of National Immunization Coverage 1980-2002 India October, 2003

India Estimates, 1980-2002 80 66 68 73 73 60 40 30 20 10 0 1980 19 1982 1983 1984 1985 1986 1987 1988 1989 19 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 DHS/MICS CES RCH-RHS CES (24-35) Reported to UNICEF Reported to WHO Estimated Coverage Administrative data Trends in officially reported data show an increase in coverage beginning in the early to mid 1980s reflecting the phased geographic expansion of the EPI programme from 31 districts in 1985 to all 452 districts by 19. In 1985 the Universal Immunization Programme (UIP), the inclusion of immunization in India s Technology Mission (one of 5 missions reporting directly to the Prime Minister) and the infusion of resources associated with the global Universal Childhood Immunization (UCI) goal resulted in rapidly increasing coverage in the late 1980s.While official reports describe sustained high levels of coverage following 19, survey data suggests significantly lower coverage beginning in the late 1980s. Officially reported data may be over d due to methods for ascertaining the size of the target population. Coverage for 19 and 1991 was d to have been 66% and 62% respectively based on an extensive sub-national Immunization Coverage of 1991 and results from the 1992 National Family Health (NFHS). Estimates prior to 19 were established by calibrating the data reported to UNICEF by the 19 established by an evaluation of the 1991 and 1992 surveys. The marked increase to 19 and the subsequent decline are attributed to the extensive (but unsustained) efforts to reach UCI goals. Coverage prior to 19 is below that of, probably due to the number of home deliveries.the s for the periods following 1995 are based primarily on the Coverage Evaluation s (CES), MICSs, and a second National Family & Health (1997/98) and show a marked decline in coverage during this period. Estimates for 1993 through 1995 are interpolated between the levels established by the 1992 and 1996 surveys. The for 1995-1997 are based an evaluation of the survey data. The of 1997 is based the CES. The of 72% is supported by results from the 1997 Reproductive and Child Health and NFHS (1997/98). The 1995 peak was established from data in the 1996 CES that described coverage in a cohort 25-36 of age. The 1999 is based on the MICS. The recent increase is supported by the 2001 and 2002 CES surveys. WHO/UNICEF Review of National Immunization Coverage, June 2003

India Data presented in chart - WHO/ Year UNICEF WHO Reported to: UNICEF Government official Reported doses administered data * 12-23 <12 1980 19 4 12 12 1982 4 28 14 1983 6 30 20 1984 7 37 21 1985 8 47 24 1986 9 77 29 1987 23 95 72 1988 23 97 72 1989 28 89 19 66 97 1991 62 93 92 1992 65 96 96 62 59 1993 69 97 97 1994 71 96 1995 97 96 1996 79 98 96 1997 72 96 1998 91 91 72 69 1999 68 99 72 99 96 68 2000 73 99 103 103 2001 73 73 80 73 103 74 2002 97 *In case more than one survey was implemented in a certain year the highest value is presented. Details of all data are presented in second section of this report. WHO/UNICEF Review of National Immunization Coverage, as of June -2002 Draf

India Estimates, 1980-2000 80 60 55 64 64 40 30 20 10 0 1980 19 1982 1983 1984 1985 1986 1987 1988 1989 19 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 DHS/MICS CES RCH-RHS Adjusted DHS/MICS Adjusted CES Adjusted CES (24-35) Reported to UNICEF Reported to WHO Estimated Coverage Administrative Reports Trends in officially reported data show an increase in coverage beginning in the early to mid 1980s reflecting the phased geographic expansion of the EPI programme from 31 districts in 1985 to all 452 districts by 19. In 1985 the Universal Immunization Programme (UIP), the inclusion of immunization in India s Technology Mission (one of 5 missions reporting directly to the Prime Minister) and the infusion of resources associated with the global Universal Childhood Immunization (UCI) goal resulted in rapidly increasing coverage in the late 1980s. While official reports describe sustained high coverage following 19, survey data suggests significantly lower coverage beginning in the late 1980s. Officially reported data may be over d due to methods for ascertaining the size of the target population. Coverage for 19 & 1991 was d to have been % and 57% respectively based on an extensive sub-national Immunization Coverage of 1991 and results from the 1992 National Family Health (NFHS). Estimates prior to 19 were established by calibrating the data reported to UNICEF by the 19 established by an evaluation of the 1991 & 1992 surveys. The marked increase to 19 and the subsequent decline are attributed to the extensive (but unsustained) efforts to reach UCI goals. The s for the periods following 1995 are based on the Coverage Evaluation s (CES), MICSs, and a second NFHS (1997/98) and show a marked decline in coverage during this period. Estimates for 1993 through 1995 are interpolated between the levels established by the 1992 and 1996 surveys. The for 1995-1997 are based an evaluation of the survey data. Results from previous Demograhic and Health s (similar to the NFHS and MICS) suggest that coverage values based on mother s history are effected by a recall bias for the multi-antigen vaccines (i.e., OPV 1,2,3 and DPT 1,2,3.) and to most likely occur in longer surveys covering a variety of indicators. It does not appear to be a problem in surveys focused on immunization coverage such as the EPI 30 cluster surveys and the CES. To control for this bias we have adjusted the card or history value by calculating the dropout rate from to based on card results and applying this multiplier to the card or history value. This adjustment may result in an over since children without a card are less likely to be immunized than children with a card. The 1996 and 1997 results of the CES seem to the upper range of actual coverage. The dropout rate of 6% from to in the 1998/1999 CES is unusually low (dropout from the NFHS 98/99 is 13% based on card only data). The of 1997 is based on an adjustment of the NFHS (1997/98) results to account for recall bias and the CES. The of 62% is supported by results from the 1997 Reproductive and Child Health. The 1995 peak was established from data in the 1996 CES that described coverage in a cohort 25-36 of age. The 1999 is based on the MICS adjusted for recall bias. The recent increase is supported by the 2001 and 2002 CES surveys.

India Data presented in chart - DTP3 WHO/ Year UNICEF WHO Reported to: UNICEF Government official Reported doses administered data * 12-23 <12 1980 6 53 19 6 58 31 1982 12 74 37 1983 14 78 40 1984 16 87 41 1985 18 45 1986 20 85 53 1987 30 97 73 1988 40 93 73 1989 83 19 92 1991 57 89 1992 56 89 52 47 1993 61 93 93 1994 67 95 91 1995 71 91 89 1996 66 92 89 77 1997 62 93 77 1998 58 91 69 52 1999 55 93 69 93 47 2000 64 94 94 94 2001 64 64 76 64 64 2002 91 *In case more than one survey was implemented in a certain year the highest value is presented. Details of all data are presented in second section of this report. WHO/UNICEF Review of National Immunization Coverage, as of June -2002 Draf

India OPV3 Estimates, 1980-2002 80 60 66 61 40 30 20 10 0 1980 19 1982 1983 1984 1985 1986 1987 1988 1989 19 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 DHS/MICS CES RCH-RHS Adjusted DHS/MICS Adjusted CES Adjusted CES (24-35) Reported to UNICEF Reported to WHO Estimated Coverage Administrative Reports Trends in officially reported data show an increase in coverage beginning in the early to mid 1980s reflecting the phased geographic expansion of the EPI programme from 31 districts in 1985 to all 452 districts by 19. In 1985 the Universal Immunization Programme (UIP), the inclusion of immunization in India s Technology Mission (one of 5 missions reporting directly to the Prime Minister) and the infusion of resources associated with the global Universal Childhood Immunization (UCI) goal resulted in rapidly increasing coverage in the late 1980s. While official reports describe sustained high levels of coverage following 19, survey data suggests significantly lower coverage beginning in the late 1980s. Officially reported data may be over d due to methods for ascertaining the size of the target population. Coverage for 19 and 1991 was d to have been 66% and 58% respectively based on an extensive sub-national Immunization Coverage of 1991 and results from the 1992 National Family Health (NFHS). Estimates prior to 19 were established by calibrating the data reported to UNICEF by the 19 established by an evaluation of the 1991 & 1992 surveys. The marked increase to 19 and the subsequent decline are attributed to the extensive (but unsustained) efforts to reach UCI goals. The s for the periods following 1995 are based primarily on the Coverage Evaluation s (CES), MICSs, and a second National Family & Health (1997/98) and show a marked decline in coverage during this period. Estimates for 1993 through 1995 are interpolated between the levels established by the 1992 and 1996 surveys. The for 1995-1997 are based an evaluation of the survey data. Results from previous Demographic and Health s (similar to the NFHS and MICS) suggest that coverage values based on mother s history are effected by a recall bias for the multi-antigen vaccines (i.e., OPV 1,2,3 and DPT 1,2,3.) and to most likely occur in longer surveys covering a variety of indicators. It does not appear to be a problem in surveys focused on immunization coverage such as the EPI 30 cluster surveys and the CES. To control for this bias we have adjusted the OPV3 card or history value by calculating the dropout rate from OPV1 to OPV3 based on card results and applying this multiplier to the OPV1 card or history value. This adjustment may result in an over since children without a card are less likely to be immunized than children with a card.the 1996 and 1997 results of the CES surveys seem to the upper range of actual coverage. The dropout rate of 6% from OPV1 to OPV3 in the 1998/1999 CES is unusually low (dropout from the NFHS 98/99 is 13% based on card only data). The of 1997 is based on an adjustment of the NFHS (1997/98) results to account for recall bias and the CES. The of 63% is supported by results from the 1997 Reproductive and Child Health. The 1995 peak was established from data in the 1996 CES that described coverage in a cohort 25-36 of age. The 1999 is based on the MICS adjusted for recall bias. The recent coverage level at % is supported by the 2001 and 2002 CES surveys. WHO/UNICEF Review of National Immunization Coverage, June 2003

India Data presented in chart - WHO/ Year UNICEF WHO Reported to: UNICEF Government official Reported doses administered data * 12-23 <12 1980 2 42 19 2 7 1982 8 87 12 1983 10 18 1984 12 82 28 1985 14 94 35 1986 16 73 45 1987 27 83 64 1988 37 88 64 1989 55 82 19 66 93 1991 58 91 89 1992 56 91 89 53 48 1993 61 94 93 1994 67 95 91 1995 71 92 1996 67 93 77 1997 63 94 91 77 1998 62 91 69 60 1999 61 93 69 93 59 2000 95 95 95 2001 77 68 2002 96 *In case more than one survey was implemented in a certain year the highest value is presented. Details of all data are presented in second section of this report. WHO/UNICEF Review of National Immunization Coverage, as of June -2002 Draf

India Measles Vaccine Estimates, 1980-2002 80 60 40 30 20 10 56 56 56 67 0 1980 19 1982 1983 1984 1985 1986 1987 1988 1989 19 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 DHS/MICS CES RCH-RHS CES (24-35) Reported to UNICEF Reported to WHO Estimated Coverage Administrative Reports Measles vaccine was in 1985. Trends in officially reported data show a rapid increase in coverage reflecting the phased geographic expansion of the EPI programme from 31 districts in 1985 to all 452 districts by 19. In 1985 the Universal Immunization Programme (UIP), the inclusion of immunization in India s Technology Mission (one of 5 missions reporting directly to the Prime Minister) and the infusion of resources associated with the global Universal Childhood Immunization (UCI) goal resulted in rapidly increasing coverage in the late 1980s. While official reports describe sustained high levels of coverage following 19, survey data suggests significantly lower coverage beginning in the late 1980s. Officially reported data may be over d due to methods for ascertaining the size of the target population. Coverage for 19 and 1991 was d to have been 56% and 43% respectively based on an extensive sub-national Immunization Coverage of 1991 and results from the 1992 National Family Health (NFHS). Estimates prior to 19 were established by calibrating the data reported to UNICEF by the 19 established by an evaluation of the 1991 and 1992 surveys. The marked increase to 19 and the subsequent decline are attributed to the extensive (but unsustained) efforts to reach UCI goals. The s for the periods following 1995 are based primarily on the Coverage Evaluation s (CES), MICSs, and a second National Family & Health (1997/98) and show a marked decline in coverage during this period. Estimates for 1993 through 1995 are interpolated between the levels established by the 1992 and 1996 surveys. The for 1995-1997 are based an evaluation of the survey data. The of 1997 is based the CES. The of 55% is supported by results from the 1997 Reproductive and Child Health and NFHS (1997/98). The 1995 peak was established from data in the 1996 CES that described coverage in a cohort 25-36 of age. The 1999 is based on the MICS. The recent increase is supported by the 2001 and 2002 CES surveys. WHO/UNICEF Review of National Immunization Coverage, June 2003

India Data presented in chart - MCV WHO/ Year UNICEF 1980 19 1982 1983 WHO Reported to: UNICEF Government official Reported doses administered data * 12-23 <12 1984 1985 1 1 1986 10 16 1 1987 24 44 44 1988 32 55 44 1989 42 69 69 19 56 91 87 1991 43 85 86 1992 51 86 85 42 33 1993 59 89 88 1994 67 87 86 1995 72 1996 66 1997 55 72 1998 51 66 85 55 42 1999 60 55 87 2000 56 89 88 88 2001 56 56 76 56 92 61 2002 67 67 67 67 85 *In case more than one survey was implemented in a certain year the highest value is presented. Details of all data are presented in second section of this report. WHO/UNICEF Review of National Immunization Coverage, as of June -2002 Draf

Estimated Immunization Coverage, 1980-2000 80 60 40 30 20 10 0 1980 19 1982 1983 1984 1985 1986 1987 1988 1989 19 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 Year OPV3 MCV Year OPV3 MCV 1980 6 2 19 4 6 2 1982 4 12 8 1983 6 14 10 1984 7 16 12 1985 8 18 14 1 1986 9 20 16 10 1987 23 30 27 24 1988 23 40 37 32 1989 28 55 42 19 66 66 56 1991 62 57 58 43 1992 65 56 56 51 1993 69 61 61 59 1994 71 67 67 67 1995 71 71 72 1996 79 66 67 66 1997 72 62 63 55 1998 58 62 51 1999 68 55 61 2000 73 64 56 2001 73 64 56 2002 67 WHO/UNICEF Review of National Immunization Coverage, June 2003

India Details Data Year Source Antigen Confirmation method Compliance % with coverage schedule Age group Sample size % cards seen year Comments 2001 Routine Immunization and Maternal Care, CES, 2002 C or H <12 74 12-23 m 53.8 2002 C or H <12.6 12-23 m 53.8 2002 C or H <12 63.8 12-23 m 53.8 2002 C or H <12 68.3 12-23 m 53.8 2002 C or H <12 61.4 12-23 m 53.8 2002 2000 Routine Immunization and Maternal Care, CES, 2001 Card or History 72.8 12-23 m 57.2 2001 Card or History 71.1 12-23 m 57.2 2001 Card or History 63.6 12-23 m 57.2 2001 Card or History.4 12-23 m 57.2 2001 Card or History 55.6 12-23 m 57.2 2001 1999 India, Multiple Indicator Cluster India (MICS-II) 2000 Card or History 67.7 12-23 m 2000 Card or History 64.4 12-23 m 2000 Card or History 46.6 12-23 m 2000 Card or History 58.9 12-23 m 2000 Card or History.4 12-23 m 2000 1997 Evaluation of Routine Immunization 1998-99 Card or History 72.3 12-23 m 7855 48.5 1998/99 Confirmation Method assumed Card or History 72.8 12-23 m 7855 48.5 1998/99 Confirmation Method assumed Card or History 68.6 12-23 m 7855 48.5 1998/99 Confirmation Method assumed Card or History 68.6 12-23 m 7855 48.5 1998/99 Confirmation Method assumed Card or History 55.2 12-23 m 7855 48.5 1998/99 Confirmation Method assumed 1997 National Family Health, India 1998-99 Card or History 71.6 C or H <12 69.1 Card or History 71.4 C or H <12 68.8 Card or History 55.1 C or H <12 52.1 Card or History 62.8 C or H <12 59.2 Card or History.7 C or H <12 41.7 1996 Evaluation of Routine Immunization 1997-98 Card or History 79 12-23 m 7295 56 1997/98 Confirmation Method assumed Card or History n.a. 12-23 m 7295 56 1997/98 Confirmation Method assumed Card or History 73 12-23 m 7295 56 1997/98 Confirmation Method assumed Card or History 73 12-23 m 7295 56 1997/98 Confirmation Method assumed Card or History 66 12-23 m 7295 56 1997/98 Confirmation Method assumed 1996 Evaluation of Routine Immunization 1998-99 WHO/UNICEF Review of National Immunization Coverage, as of June -2002 Draf

India Details Data Year 1991 Source Antigen Confirmation method Compliance % with coverage schedule Age group Sample size % cards seen year Comments Card or History 77 12-23 m 1996/97 as /OPV3 is the same in 1998/1999, it is assumed to be the same for 1997 too Card or History 77 12-23 m 1996/97 Confirmation Method assumed India, National Family Health (MCH and Family Planning) 1992-93, 1995 Card or History 62.2 C or H <12 58.7 Card or History 66.3 C or H <12 62.4 Card or History 51.7 C or H <12 46.9 Card or History 53.4 C or H <12 48.3 Card or History 42.2 C or H <12 32.7 WHO/UNICEF Review of National Immunization Coverage, as of June -2002 Draf

INDIA WHO/UNICEF s of the percent of children born in 2000-2002 protected against tetanus by vaccination of their mothers with tetanus toxoid (PAB) In most instances PAB reflects the number of mothers receiving two doses of tetanus toxoid during pregnancy. In some cases the mother may have received an adequate number of doses of tetanus toxoid prior to the pregnancy, protecting the child even though no doses were received during the current pregnancy. These s are based on data provided through the WHO/UNICEF Joint Reporting Form on Vaccine Preventable Diseases and have been supplemented by information from national household surveys conducted under the auspices of the National government and from data available in the published literature. Year WHO and UNICEF's Data source of the percent of newborn infants protected against neonatal tetanus through maternal immunization with tetanus toxoid 2000 74 Administrative Coverage and Maternal Care Coverage 1999 2001 75.5 Administrative Coverage and Maternal Care Coverage 2001 2002 78.3 Administrative Coverage and Maternal Care Coverage 2002 WHO/UNICEF Review of National Immunization Coverage, as of June 2003 - Draft