Roche A sustainable business model based on innovation and productivity gains Karl Mahler, Head of Investor Relations 1
This presentation contains certain forward-looking statements. These forward-looking statements may be identified by words such as believes, expects, anticipates, projects, intends, should, seeks, estimates, future or similar expressions or by discussion of, among other things, strategy, goals, plans or intentions. Various factors may cause actual results to differ materially in the future from those reflected in forward-looking statements contained in this document, including among others: (1) pricing and product initiatives of competitors; (2) legislative and regulatory developments and economic conditions; (3) delay or inability in obtaining regulatory approvals or bringing products to market; (4) developments in financial market conditions, including the market for acquisition financing and other capital markets and fluctuations in currency exchange rates; (5) uncertainties in the discovery, development or marketing of new products or new uses of existing products, including without limitation negative results of clinical trials or research projects and unexpected side-effects of pipeline or marketed products; (6) increased government pricing pressures or changes in third party reimbursement rates; (7) interruptions in production; (8) loss of or inability to obtain adequate protection for intellectual property rights; (9) Litigation; (10) the inherent uncertainties involved in negotiations with the special committee of Genentech and that there can be no assurances that a negotiated transaction will ultimately be agreed to or consummated; (11) potential difficulties in integrating the businesses of Genentech and Roche, and that some or all of the anticipated benefits of the proposed transaction may not be realized on the schedule contemplated or at all; (12) that future dividends are subject to the discretion of the board of directors of Roche and a number of other factors, some of which are beyond the control of Roche; (13) the ability of Roche to generate cash flow to, among other things, repay acquisition-related debt as currently contemplated; (14) loss of key executives or other employees; and (15) adverse publicity and news coverage. The directors of Genentech who are also employees of Roche will not take part in the consideration of the proposed transaction by the Genentech board and accordingly are not permitted to comment or respond to questions regarding the transaction as representatives of Genentech. For marketed products discussed in this presentation, please see full prescribing information on our website www.roche.com All mentioned trademarks are legally protected. 2
Performance up-date Strategy Main trends influencing long term value propositions Summary 3
Q1 2009: High single-digit growth for both divisions Well above world market CHF bn % change in Q1 08 Q1 09 CHF local Pharmaceuticals 8.6 9.2 8 8 Diagnostics 2.3 2.4 3 8 Roche Group 10.9 11.6 7 8 4
Performance up-date Our Strategy and the changing environment Main trends influencing long term value propositions Summary 5
Roche s unique window of opportunity Roche s unique position Stability of business model Peers Growth Roche Bridging the cliffs, Cost-cutting, Diversification 2007 2013-14 The industry Low replacement power of current earnings levels Poor pipelines Cost cutting Roche Extended stability Low generic exposure Investment into the future 6
Focus on our core businesses High Roche Focus Pharma Dia Medical Differentiation MedTech Generics OTC Low Premium for Innovation High 7
Roche s strategy focuses along either dimension Proximity to Core (regarding products) Corixa BioVeris Domantis Chiron Vaccines Vaccines Hexal GlycArt Sirtris Pharma Pharma Lek Generics Generics Zentiva NimbleGen Sabex Proximity to Core (regarding business model) * Bubble size depicts value of acquisition Source: SDI Analysis 8
Not to invest in the future means being out of business in ten years Refill of top line Maturing portfolio Years 1 2 3 4 5 6 7 8 9 10 Drug development timeline* Pre-clinical R&D Clinical R&D NDA Review *Source: www.fda.gov/fdac/graphics/newdrugspecial/drugchart.pdf 9
A well risk balanced approach to investment Most projects in late stage de-risked New Molecular Entities % of Pharma Development spend NMEs in Phase III 40 NMEs in Phase I 16 NMEs in Phase II dalcetrapib (CETPi) *PPARαγ taspoglutide (GLP-1) TDM-1 ocrelizumab pertuzumab 1 LE in Phase I Proof of Concept Line Extensions 42% 40% 11 LEs in Phase II 36 LEs in Phase III 2007 2008 * Formal decision to move into phase III pending 10
Responsible management of R&D spend Higher attrition in early stage - higher success in late stage 100 90 100 80 60 40 Success Rate (%) 80 70 Preclinical, Phase I and II Phase III and Registration Industry Median Roche 20 Industry Median Roche Attrition Rate (%) 60 0 '95-'99 '96-'00 '97-'01 '98-'02 '99-'03 '00-'04 '01-'05 '02-'06 '95-'99 '96-'00 '97-'01 '98-'02 '99-'03 '00-'04 '01-'05 '02-'06 Source: R&D General Metrics Study, KMR GROUP, INC
Performance up-date Strategy Main trends influencing long term value propositions Personalized Healthcare- Roche best positioned Summary 12
Main trends influencing the long-term value propositions Personalised Healthcare Maximizing assets on hand 13
Personalised Healthcare Increasing demand by stakeholders Patients & Physicians Best treatment Regulators Better efficacy & safety profile Payers Better cost / benefit Industry More competitive 14
Scenarios for PHC Added Value Distribution Value captured by different stakeholders depending on IP and timing of diagnostic Breast Cancer Assay Rx Low IP for Diagnostic High Rx B-Raf inhibitor B-Raf mutant test Dx High High Dx Diagnostic after Drug Launch Payor Rx High Low Neutral High Payor Rx Diagnostic with Drug Launch Dx Medium Medium Dx K-Ras Test Payor High Neutral No IP for Diagnostic Payor Herceptin and Her2 test 15
Main trends influencing the long-term value propositions Personalised Healthcare Maximizing assets on hand 16
Key drivers for long term development in place Develop the short term drivers while not neglecting the long term opportunities Inherent development risk Low High ILLUSTRATIVE Oncology Inflammation existing Earlier Phases Maturity of portfolio Virology CNS Metabolic 17
Oncology franchise approaches CHF 20 billion in sales Oncology sales (CHF billion) 20.0 16.0 12.0 8.0 4.0 local growth +15 % 7% 40% 53% +27 % +9 % +20 % Double-digit growth continues Europe/RoW Continued strong increase in Avastin sales, driven by strong uptake in mcrc and mbc Emerging markets contributing to continued growth of MabThera, Herceptin and Tarceva Japan Strong launches of Avastin, Tarceva, and adjuvant Herceptin 0.0 2004 2005 2006 2007 2008 Europe/RoW US Japan 18
Major growth opportunities outside the US for key products % of sales 100 80 56 49 49 41 35 29 24 60 40 20 44 51 51 59 65 71 76 0 AVASTIN MABTHERA CELLCEPT TARCEVA XELODA HERCEPTIN PEGASYS Time on market EU / ROW (incl. Japan) Nth America 19
Each cancer type is different And needs a specific treatment approach Incidence 100% 80% 60% 40% 3rd line 2nd line 1st line adjuvant 20% Survival 0% CRC BC NSCLC Adjuvant DFS at 3 years* 72 % 81 % 50 % Metastatic median OS * 25 months 36 months 11 months * Assuming best current care, Incidence: GLOBOCAN 2002 and Roche market research 20
First in class mechanisms establishing new standards of care Rank Drug Sales ($m) MAT 3Q08 1 MabThera 4,189 2 Herceptin 4,129 3 Avastin 4,052 4 Glivec 3,491 5 Taxotere 2745 6 Eloxatine 2,236 First in class 7 Arimidex 1,944 8 Gemzar 1,601 9 Erbitux 1,412 10 Casodex 1,343 Successful products need to be first class entrants the race begins early in R&D 21
Paradigm change: Development of all main cancer types in parallel Example of Avastin 3 rd line 2 nd line 1 st line Adjuvant 3 rd line 2 nd line 3 rd line 2 nd line 1 st line 1 st line Adjuvant Adjuvant RCC BC NSCLC CRC Gastric Ovarian Prostate Completed Ongoing GIST 22
Avastin: significant potential for additional indications in the metastatic setting Important Phase III newsflow over next 2 years Indication Study name Start Status* Filing* Previously-treated glioblastoma BRAIN 2007 May 5, 2009 US FDA granted accelerated approval 2008 1st line metastatic ovarian cancer GOG-0218 ICON-7 Q3 05 Q4 06 Interim analysis H2 09 Expect data 2010 2010 Relapsed Platinum sensitive ovarian cancer OCEANS GOG-0213 Q2 07 Q4 07 Expect data 2010 Expect data 2013 2010-2013 1st line hormonerefractory prostate cancer CALGB 90401 Q4 07 Interim analyses Q2 09 and Q4 09 2011 1st line advanced gastric cancer AVAGAST Q3 07 Interim analysis H2 09 2010 *Projected timelines for positive results 23
Exciting mid / early-stage opportunities in oncology 3rd generation anti-cd20- potential for improvement over MabThera based on Glycart technology Improved product features Increased direct cell death Increased ADCC Lower CDC Phase I in NHL Extended patent life for many other monocloncal antibodies? MabThera Herceptin Pertuzumab. GA101: Phase II ongoing Phase I data presented at ASH 2009 ADCC= (antibody dependent cell-mediated cytotoxicity); CDC= (complement dependent cytotoxicity) 24
ASCO 2009 Highlights Avastin NSABP C-08: Adjuvant colon cancer efficacy results late-breaker abstract RIBBON-1: 1 st line HER2-negative metastatic breast cancer oral presentation Tarceva ATLAS: 1 st line maintenance therapy for advanced non-small cell lung cancer late-breaker oral presentation SATURN: 1 st line maintenance therapy for advanced non-small cell lung cancer oral presentation SATURN: 1 st line maintenance therapy for advanced non-small cell lung cancer biomarker data Herceptin ToGA: 1 st line HER2-positive advanced gastric cancer oral presentation T-DM1 Phase II second-line+ HER2-positive mbc final results Joint Roche-Genentech Investor Science Events Sunday May 31st NSABP = National Surgical Adjuvant Breast and Bowel Project Monday June 1st 25
Key drivers for long term development in place Develop the short term drivers while not neglecting the long term opportunities Inherent development risk Low High ILLUSTRATIVE existing Oncology Inflammation Maturity of portfolio Virology Metabolic CNS Earlier Phases 26
Rheumatoid Arthritis: Not all patients respond to current therapy Gold standard therapy anti-tnf + MTX % ACR70 Responders Unmet Medical Need Only 1 of 3 patients receives significant benefit anti-tnf + MTX anti-tnf alone ACR 70 70 Improvement in: MTX alone Disease activity patient Disease activity physician Patient assessment of Pain Physical disability Acute phase reactants CRP,ESR 27
Comprehensive development program in RA Covers all treatment stages MabThera IMAGE** (MTX naive, X-ray study) SERENE* (MTX IR) MIRROR* (MTX IR, dose escalation) REFLEX (Anti-TNF IR) SCORE** (DMARDs IR) current Tx paradigm NSAIDs or Cox-2 DMARDs TNF inhibitors 2 nd biologic (+/- MTX) (+/- MTX) OPTION* (MTX IR) Actemra AMBITION* (6 mnth MTX free/ MTX naive, monotherapy) TOWARD* (DMARDs IR) LITHE** (MTX IR, X-ray study) RADIATE* (Anti-TNF IR) * Indication not yet approved, awaiting regulatory approval ** Phase III trial in progress 28
Performance up-date Strategy Main trends influencing long term value propositions Summary 29
Roche Pharma pipeline overview Focused on five Disease Biology Areas Oncology Xeloda MabThera Herceptin Avastin Tarceva Pertuzumab T-DM1 R7159 3 rd gen anti-cd20 R1507 (IGF-1R mab) Apomab Apo2L/TRAIL Anti-CD40 mab Hedgehog inhibitor 16 ph. I compounds On Hand RA/Inflammation MabThera Actemra R1594 ocrelizumab R667 RARγ 9 ph. I compounds Metabolic/CV R1658 CETP Inh. R1583 GLP-1 R1439 dual PPAR 9 ph. I compounds Promising Late Stage Virology Pegasys Tamiflu R3484 HPV16 R7128 HCV pol. Inh. R7227 HCV prot. inh. Emerging Mid-Term CNS ocrelizumab RRMS R1678 Schizophrenia R3487 Alzheimer s 4 ph. I compounds Early Stage 30
Profitability measures Operating cash flow per employee CHF 000 s 250 Operative Cash Flow per employee 200 Roche 150 100 GSK Sanofi-Aventis Novartis 50 0 2003 2004 2005 2006 2007 SDI Analysis; Source: Annual Reports of corresponding companies, datastream, currency rates (average 365 days) 31
Roche: M&D and G&A % to sales Freeing up resources for innovation 40% Roche (Prescription) GSK 35% Sanofi-Aventis 30% Eli Lilly AstraZeneca 25% Merck & Co. Novartis 20% 2002 2003 2004 2005 2006 2007 32
Patent expiry 2008-2012 Roche short-/medium-term has the strongest patent protected portfolio and highest share of biotech products 100 Top 10 Corporations Protected Sales Expiring to 2012 & Beyond (US$ Const) SHARE OF PROTECTED SALES EXPIRING % US$ 80 60 40 20 0 42 Total Market 69 GSK 62 Pfizer 54 51 48 48 AZ S-A J&J MSD 41 Lilly 36 Novartis 24 Abbott 14 Roche 2008-2012 2013 & beyond Source: IMS Health MIDAS Market Segmentation MAT June 2008, Ethical protected brand sales only. 33
Roche: A unique investment case Clear and focused strategy Medically differentiated products Poised to become leader in Personalised Healthcare Attractive risk profile Low generic risk; lowest among European large-cap players Assets in place for sustained success World market leader in Oncology Emerging Rheumatology & Autoimmune, and Metabolic franchises Industry-leading organic growth Unique high-tech healthcare investment 34
We Innovate Healthcare 35
Avastin in mcrc: Strong uptake continues First line Second line Patient share Patient share 35% 35% 30% 30% 25% 25% 20% Avastin 20% Avastin 15% 15% 10% 10% 5% 5% 0% Q4 05 Q1 06 Q2 06 Q3 06 Q4 06 Q1 07 Q2 07 Q3 07 Q4 07 Q1 08 Q2 08 Q3 08 Q4 08 0% Q4 05 Q1 06 Q2 06 Q3 06 Q4 06 Q1 07 Q2 07 Q3 07 Q4 07 Q1 08 Q2 08 Q3 08 Q4 08 Source: Synovate Patient Monitor and Top-Up, Top-5 EU 36
Top 10 Oncology Products Sales and market shares in seven major markets in 2007 50% 40% Avastin $2,651m CAGR, 2006-07 30% 20% 10% 0% Herceptin $2,653m Erbitux Taxotere $1,040m Arimidex $1,837m $1,364m Gleevec $1,990m Gemzar Lupron Rituxan $1,156m $1,411m Eloxatin $3,216m $1,964m 0% 2% 4% 6% 8% 10% 12% -10% Bubble size represents 2007 sales Market share, 2007 Source: Datamonitor, MIDAS Sales Data, IMS Health, April 2008, Copyright, reprinted with permission Roche/Genetech s MabThera, Herceptin and Avastin DMHC2416: Commercial Insight: Top 20 Therapy Cancer Brands (08/2008) dominate the current cancer brands market 37