THINK TANK MEETING ON RESEARCH CHALLENGES IN BREAST CANCER 1-3 March 2018 Palazzo Bernabei, Assisi - Italy Under the patronage
AIMS - to identify grey zones in daily clinical practice in breast cancer treatment by detecting where the evidence is not so firm, - to brainstorm on issues in combined treatment modalities, - to identify affordable trial proposals to address the issues and put them forward to the scientific community, public and private sponsors - to promote cure and enhance patients quality of life.
METHOD To achieve these aims the Meeting will take the following steps: 1. The Scientific Organizers (SO) nominated an international Expert Board (EB) and identified the main clinical situations demanding investigation; 2. The SO chose the Chairs and Speakers for each topic; 3. Clinical cases with questions on treatment options were prepared; 4. The EB voted on different clinical choices in a monkey questionnaire before the meeting; 5. At the meeting, on Day 1 (Thursday afternoon, 1 March 2018), the EB will: a) discuss the monkey survey results and the outstanding clinical issues b) select the trial proposals to be debated on the following days 6. On Day 2 (Friday, 2 March 2018), trial proposals will be presented and debated by the EB. Meeting attendees, who will act as the first validation group, will comment on the proposals from their perspective. Moreover, potential public and private research sponsors will attend and decide whether they are interested in funding the research proposals. 7. On Day 3 (Saturday, 3 March 2018), the EB will a) review protocol drafts to outline the final proposals b) deliver a set of trial proposals for each topic, each of which will include: 1. Aim 2. Primary and secondary endpoints 3. Patient selection 4. Treatment modalities to be tested 5. Research method: prospective study (expected benefit should be defined so as to set the accrual number and timing) or large data base collection c) plan the outline of the white paper to be written about ATTM and trial proposals d) set topics for future meetings. TOPICS 1. Primary systemic therapy, mastectomy and breast reconstruction, post mastectomy radiation therapy 2. Therapeutic options in ductal carcinoma in situ 3. De-escalated therapies in early breast cancer
PROGRAM Thursday, 1 March 2018 Participants: Expert Board Morning: arrival; welcome lunch 14.00-14.30 Meeting aims and methodology: Why this meeting? Why this methodology? What follow-up? Philip Poortmans, Cynthia Aristei, Vincenzo Valentini 14.30 15.30 Report the results of the clinical case monkey questionnaire - Topics 1,2 and 3 Room A: 15.30-19.00 Topic 1 : Primary systemic therapy, mastectomy and breast reconstruction, post mastectomy radiation therapy Team Chairs: Bruno Cutuli, Lurdes Trigo Secretary: Elisabetta Perrucci 15.30-15.35 Monkey-survey results and on-site tele-voting Elisabetta Perrucci 15.35-15.55 Review the main evidence Icro Meattini 15.55-16.15 Review ongoing clinical trials Liesbeth Boersma 16.15-16.30 Discussion 16.30-17.00 Coffee Break 17.00-19.00 Scouting for trial proposal: which goal? All Expert Board Group Room B : 15.30-19.00 Topic 2 : Therapeutic options in ductal carcinoma in situ Team Chairs: Meritxell Arenas, Céline Bourgier Secretary: Fabio Marazzi 15.30-15.35 Monkey-survey results and on-site tele-voting Fabio Marazzi 15.35-15.55 Review the main evidence Angel Montero Luis 15.55 16.15 Review ongoing clinical trials Cristina Leonardi 16.15-16.30 Discussion 16.30-17.00 Coffee Break
17.00-19.00 Scouting for trial proposal: which goal? All Expert Board Group Room C : 15.30-19.00 Topic 3: De-escalated therapies in early breast cancer Team Chairs: Ugur Selek, Raphael Pfeffer Secretary: Valeria Masiello 15.30-15.35 Monkey-survey results and on-site tele-voting Valeria Masiello 15.35-15.55 Review the main evidence Pierfrancesco Franco 15.55-16.15 Review ongoing clinical trials Vassilis Kouloulias 16.15-16.30 Discussion 16.30-17.00 Coffee Break 17.00-19.00 Scouting for trial proposal: which goal? All Expert Board Group 19.00-20.00 Presentations of working group proposals
Friday, 2 March 2018 9.00-9.15 Aims and methodology of the day Philip Poortmans, Cynthia Aristei, Vincenzo Valentini 9.15-9.35 Lecture: Epidemiology of breast cancer Philip Poortmans 9.35-9.55 Lecture: Biological subtypes and their impact on survival Cynthia Aristei 9.55-10.15 Lecture: Learning from large data base in breast cancer: state of the art Vincenzo Valentini 9.55-10.15 Question time All participants 10.20-10.35 Primary systemic therapy, mastectomy and breast reconstruction, post mastectomy radiation therapy Team Chairs: Bruno Cutuli, Lurdes Trigo Secretary: Elisabetta Perrucci 10.20-10.15 Case presentation (on-site televoting) Elisabetta Perrucci 10.35-10.55 Review the main evidence Icro Meattini 10.55-11.15 Coffee Break 11.15-11.35 Review ongoing clinical trials Liesbeth Boersma 11.35-12.30 Trial proposal presentation by working group delegates 12.30-13.00 Voting to rank trial proposals All participants 13.00-13.15 Therapeutic options in ductal carcinoma in situ Team Chairs: Meritxell Arenas, Céline Bourgier Secretary: Fabio Marazzi 13.00-13.15 Case presentation (on-site televoting) Fabio Marazzi 13.15-13.35 Review the main evidence Angel Montero Luis 13.35-14.30 Lunch 14.30-14.50 Review ongoing clinical trials Cristina Leonardi 14.50-15.45 Trial proposal presentation by working group delegates 15.45-16.15 Voting to rank trial proposals All participants
16.15-16.30 De-escalated therapies in early breast cancer Team Chairs: Ugur Selek, Raphael Pfeffer Secretary: Valeria Masiello 16.15-16.30 Case presentation (on-site televoting) Valeria Masiello 16.30-16.50 Review the main evidence Pierfrancesco Franco 16.50-17.10 Coffee Break 17.10-17.30 Review ongoing clinical trials Vassilis Kouloulias 17.30-18.15 Trial proposal presentation by working group delegates 18.15-18.30 Voting to rank trial proposals All participants 18.30-18.45 Closing Remarks Philip Poortmans, Cynthia Aristei, Vincenzo Valentini Saturday, 3 March 2018 Participants: Expert Board 9.00-9.45 Finalize Trial Proposals for Topic 1 9.45-10.30 Finalize Trial Proposals for Topic 2 10.30-11.00 Coffee Break 11.00-12.45 Finalize Trial Proposals for Topic 3 11.45-12.15 Plan outline of white paper and propose topics for next meeting 12.15-12.30 Closing remarks
Scientific Organizers: Philip Poortmans, Cynthia Aristei, Vincenzo Valentini Executive Committee: Scientific organisers, Meritxell Arenas, Céline Bourgier, Orit Kaidar-Person, Icro Meattini Advisory members from Northern Europe: Liesbeth Boersma (NL), Charlotte Coles (UK), Birgitte Offersen (DK) Expert Board (apart from the executive Ctee): France: Bruno Cutuli (Reims), Sofia Rivera (Villejuif) Spain: Angel Montero Luis (Madrid) Portugal: Lurdes Trigo (Oporto) Greece: Vassilis Kouloulias (Athens) Turkey: Ugur Selek (MD Anderson, Istanbul) Israel: Raphael Pfeffer (Ramat-Gan) Italy: Antonella Ciabattoni, Lorenzo Falcinelli, Pierfrancesco Franco, Giovanni Frezza, Domenico Genovesi, Marco Krengli, Valentina Lancellotta, Cristina Leonardi, Fabio Marazzi, Valeria Masiello, Nadia Pasinetti, Elisabetta Perrucci, Luigi Pirtoli, Riccardo Santoni, Daniela Smaniotto, Vincenzo Tombolini, Cristiana Vidali Local Organizers: Lorenzo Falcinelli, Valentina Lancellotta, Fabio Marazzi, Valeria Masiello, Elisabetta Perrucci, Daniela Smaniotto
Expert Board Group 1 Liesbeth Boersma Bruno Cutuli Domenico Genovesi Marco Krengli Valentina Lancellotta Icro Meattini Birgitte Offersen Elisabetta Perrucci Riccardo Santoni Lurdes Trigo Expert Board Group 2 Meritxell Arenas Céline Bourgier Lorenzo Falcinelli Cristina Leonardi Fabio Marazzi Angel Montero Luis Sofia Rivera Daniela Smaniotto Vincenzo Tombolini Cristiana Vidali Expert Board Group 3 Antonella Ciabattoni Charlotte Coles Pierfrancesco Franco Giovanni Frezza Vassilis Kouloulias Valeria Masiello Nadia Pasinetti Raphael Pfeffer Luigi Pirtoli Ugur Selek ORGANIZING SECRETARIAT CONSULTA UMBRIA SRL Tel. +39 075 5000066 fax +39 075 5153466 E-mail : info@consultaumbria.com
NOTE
Sponsored by:
ULTIMATE GOAL: TO BE BACK HOME WITH A TRIAL PROPOSAL IN YOUR POCKET!