Urinary Incontinence and Overactive Bladder Update NICE Guidelines on UI for women - GP Perspectives Arun Sahai PhD, FRCS (Urol) Consultant Urological Surgeon & Honorary Senior Lecturer Guy s Hospital King s Health Partners
COI Allergan unrestricted educational grant, advisor Astellas, Pfizer - Honoraria for lectures, advisory boards
Objectives NICE Update on UI Important aspects related to primary care Mirabegron data Cases Discussion / Question Time
NICE Guideline Development Group 2 Uro-gynaecologists 1 Urologist 1 GP 1 Geriatrician 1 nurse specialist 1 physiotherapist 1 continence advisor 2 patients
What it covers Stress Urinary incontinence (UI) Urgency Urinary Incontinence Mixed Urinary incontinence Overactive Bladder (OAB)
Primary Care Assessment Decide which is the predominant type of UI If SUI predominant symptom in MUI, discuss OAB drugs before offering surgery [new 2013] Screen for predisposing Conditions Identify possible lifestyle modifications
Primary care Assessment 2 Questionnaires - ICIQ, BFLUTS, I-QOL, SUIQQ, UISS, SEAPI-QMM, ISI and KHQ 3 day voiding diary Per vaginal examination Masses Prolapse Finger squeeze - to assess whether PFE will be of benefit [amended 2013] PVR measurements (scan better than catheter) Voiding dysfunction Recurrent UTI
No longer recommended Pad tests Q tip test / Bonney / Marshall tests Imaging except bladder scan
To Culture or not to culture? UTI Symptoms No UTI Symptoms +ve urine dip MSU -ve Urine dip MSU Empirical antibiotics Empirical antibiotics if clinical concern MSU Antibiotics only if positive culture No MSU
Red Flags urgent referral Non-visible haematuria 50yrs+ Visible haematuria Recurrent/persisting UTI with haematuria 40yrs+ Suspected malignancy
Immediate specialist referral Persisting bladder/urethral pain Benign pelvic masses Associated faecal incontinence Neurological disease Voiding dysfunction Suspected Fistulae Previous pelvic surgery/radiation Palpable bladder on bimanual or abdo examination
Stress UI treatment Pelvic floor exercises Supervised tuition 3 months duration At least 8 repetitions three times per day No routine use of biofeedback Mixed UI also do Bladder training
Urge UI & OAB initial treatment Lifestyle modifications Lose weight Offer intravaginal oestrogens in postmenopausal women with vaginal atrophy Bladder training 6 weeks If no improvement at 6 weeks move to medication
Medical management of OAB & UUI Consider voiding dysfunction, anticholinergic load, AEs
Medical Management OAB & UUI First line anti-cholinergics Immediate release oxybutinin (not in frail or elderly) Immediate release tolterodine Darifenacin Face to face or telephone review at 4 weeks Starting a medication Changing medication Changing dose of a medication
Medical Management OAB & UUI 2 Second line treatments Transdermal oxybutinin if can t tolerate tablets Another drug with the lowest acquisition cost Third line treatment Mirabegron Can refer to secondary care if patient wants an alternative treatment to medication at any point
Follow up of patients on medical management Annual review if younger than 75 years Six monthly review if older than 75 years
Nocturia avoid in > 65 in those with CV disease or HT, caution in cystisc fibrosis In women who prefer drugs vs surgery for SUI
Catheters Indications for Indwelling urethral catheters chronic urinary retention in women who are unable to manage intermittent self- catheterisation skin wounds, pressure ulcers or irritations that are being contaminated by urine distress or disruption caused by bed and clothing changes Pt preference Indwelling suprapubic catheters may be associated with lower rates of symptomatic UTI, 'bypassing', and urethral complications than indwelling urethral catheters.
OAB patient demographics (UK) 1 Consulted GP Currently on OAB drug 22% Adult population With OAB 15% Without OAB 46% Never Consulted GP 54% Not currently on OAB drug 78% 85% Data presented is from 2010/2011. Astellas, Data on File VES12228UK. July 2012. Data is sourced from Lightspeed Consumer Panels (with Millward Brown, survey conducted by Millward Brown and CSD Patient Data).
21 Antimuscarinics Currently the most widely used therapy for OAB 1 with a long history of use Evidence to date suggests they are an efficacious therapeutic option for OAB, which also improves quality of life 2 Around 70-90% of patients stop their treatment within 1 year, 3,4 this may be due to: 5-7 Adverse effects of medication Low sensitivity to beneficial effects (poor efficacy) Inadequate follow-up after instigating therapy Drug drug interactions Lack of efficacy 1.Chapple CR, et al. Urology. 2002;60(Suppl 5A):82 9. 2.Chapple CR, et al. Eur Urol. 2008;54:543 62. 3.Basra RK, et al. BJU Int 2008;102:774 9. 4.D'Souza AO, et al. J Manag Care Pharm 2008;14:291 301 5.Thüroff JW, et al. Eur Urol 2011;59:387 400. 6.Kelleher CJ, et al. Br J Obstet Gynaecol 1997;104:988 93. 7.Andersson KE, et al. Pharmacological treatment of urinary incontinence. 3rd International Consultation on Incontinence. Monaco, June 26 29, 2004. 21
Muscarinic Receptors in Organs of the Parasympathetic Nervous System & CNS M1: CNS Dizziness Somnolence Impaired memory & Impaired cognition M2, M3, M5: Iris / Ciliary Body = Blurred Vision M2, M3: Lacrimal Gland = Dry Eyes M2, M3: Salivary Glands = Dry Mouth (parotid, sublingual, submaxillary) M2: Heart = Tachycardia M2: Gall Bladder M3: Stomach = Dyspepsia M2, M3: Colon/ Small Intestine = Constipation M3, M2: Bladder (detrusor muscle) M2 : M3 receptors = 80% : 20%, but M3 is more involved in detrusor contraction
The challenge of persistence with antimuscarinics Patients remaining on antimuscarinic treatments over one year 1 A 12-month retrospective analysis of prescription data from 4833 OAB patients, prescribed antimuscarinic treatment between January December 2007 1 ER, extended release; IR, immediate release Adapted from Wagg et al., 2012. 1 1.Wagg A et al. BJU Int 2012;110(11):1767 1774.
Mirabegron is a first in class, selective β 3 -adrenoceptor (AR) agonist 1 Both efficacy and side effects (including dry mouth) of antimuscarinic therapy are related to their specific interaction at the muscarinic receptor 2,3 97% of bladder ß-ARs are of the ß 3 -AR subtype 4 1. Gras J. Drugs of Today 2012;48(1):25-32. 2. Hegde SS. Br J Pharmacol 2006;147(Suppl 2):S80 S87. 3. Staskin DR, Zoltan E. Rev Urol 2007;9(4):191 196. 4. Yamaguchi O. Urology 2002;59:(Suppl: 5A)25 29. Date of preparation: February 2013. BET13018UK
Mirabegron is a novel treatment for OAB that works differently to antimuscarinics 1,2 Mode of action of OAB treatments 1,3 Adapted from Betmiga Summary of Product Characteristics, December 2012 1 and Chu et al., 2006. 3 1.Betmiga Summary of Product Characteristics, December 2012. 2.Gras J. Drugs of Today 2012;48(1):25-32. 3.Chu F, Dmochowski R. Am J Med 2006;119(3A):3S 8S. Date of preparation: February 2013. BET13018UK
SCORPIO: A key European-Australian, 12-week, Phase III trial in patients with OAB 1 SCORPIO trial design 1 A randomised, double-blind, placebo- and active-controlled, 12-week Phase III trial of 1978 patients with OAB 1 Mirabegron 50mg (n=493) Adapted from Khullar et al., 2013. 1 *Evaluation of adverse events and concomitant medication by telephone or visit for a period of 30 days. Tolterodine ER (extended-release) 4mg was included as an active control in this study. 1.Khullar V et al. Eur Urol 2013;63(2):283 295. Date of preparation: February 2013. BET13018UK
SCORPIO: Improvements in incontinence episodes/24h (co-primary endpoint) 1 Incontinence episodes/24h (FAS-I) Adapted from Khullar et al., 2013. 1 Tolterodine ER (extended-release) 4mg was included as an active control in this study. FAS-I = all full analysis set patients who had 1 incontinence episode at baseline. ns = no statistically significant difference vs. placebo. *Statistically significant improvement vs. placebo (p<0.05). Mean difference vs. placebo (95% two-sided CI: -0.72, -0.09). 1. Khullar V et al. Eur Urol 2013;63(2):283 295. Date of preparation: February 2013. BET13018UK
SCORPIO: Improvements in micturitions/24h (co-primary endpoint) 1 Micturitions/24h (FAS) Adapted from Khullar et al., 2013. 1 Tolterodine ER (extended-release) 4mg was included as an active control in this study. FAS = full analysis set ns = no statistically significant difference vs. placebo. *Statistically significant improvement vs. placebo (p<0.05). Mean difference vs. placebo (95% two-sided CI: -0.90, -0.29). 1. Khullar V et al. Eur Urol 2013;63(2):283 295. Date of preparation: February 2013. BET13018UK
SCORPIO: Additional secondary endpoints and other measures 1,2 Statistically significant improvements were seen with mirabegron 50mg vs. placebo (p<0.05) in secondary endpoints: 1,2 Urgency episodes/24h (grade 3 or 4 using the PPIUS*) 1 Nocturia episodes/24h 2 Other measures: Additionally, in a responder analysis, nearly half of patients who were incontinent at baseline were dry (based on a 3-day micturition diary) at the end of the study with mirabegron 50mg (45% of patients; n=132/293). The improvements over placebo were not statistically significant 1 *PPIUS = Patient Perception of Intensity of Urgency Scale. 1.Khullar V et al. Eur Urol 2013;63(2):283 295; 2.Astellas, data on file MIR/12/001/EU, 2012. Date of preparation: February 2013. BET13018UK
SCORPIO: Most common AEs ( 2% in any treatment group) 1 In the three, 12-week Phase III studies, the most common adverse reactions reported for mirabegron 50mg were tachycardia and urinary tract infections (1.2% and 2.9% respectively). Serious adverse reactions included atrial fibrillation (0.2%) 2 In SCORPIO, rates of drug discontinuation due to AEs were low and comparable in the active groups (<5%) 1 Adverse events % Incidence of most common ( 2%) AEs 1 Placebo (n=494) Mirabegron 50mg (n=493) Tolterodine ER 4mg active control (n=495) Dry mouth 2.6% 2.8% 10.1% Constipation 1.4% 1.6% 2.0% Hypertension 7.7% 5.9% 8.1% Nasopharyngitis 1.6% 2.8% 2.8% Headache 2.8% 3.7% 3.6% Urinary tract infection 1.4% 1.4% 2.0% For the full list of adverse events refer to the SmPC. 2 Tolterodine ER 4mg was included as an active control therefore direct statistical comparisons cannot be made between mirabegron and tolterodine ER 4mg. Table adapted from Khullar et al., 2013. 1 Data not shown for the unlicensed 100mg dose of Mirabegron. TEAEs, treatment-emergent adverse events. 1.Khullar V et al. Eur Urol 2013;63(2):283 295. 2.Betmiga Summary of Product Characteristics, December 2012. Date of preparation: February 2013. BET13018UK
TAURUS: 12-month extension study looking at the safety and efficacy of mirabegron 1 TAURUS trial design: long-term safety and efficacy of mirabegron A multi-centre, 12-month, double-blind study of 2444 patients with OAB 1 Tolterodine ER 4mg was an active control Mirabegron 50mg (n=812) Adapted from Chapple et al., 2013. 1 Eligible patients who completed Phase III, 12-week mirabegron studies could be enrolled, but required a minimum 30-day drug washout. The study was not designed to demonstrate a statistically significant difference in efficacy between treatment groups. Tolterodine ER 4mg was an active control. No direct statistical comparisons can be made between tolterodine ER 4mg and mirabegron 50mg. 1.Chapple CR et al. Eur Urol 2013;63(2):296 305. Date of preparation: February 2013. BET13018UK
TAURUS: Efficacy variables over 52 weeks (secondary endpoint) Mean number of incontinence episodes/24h (FAS-I) 1 Adapted from Chapple CR et al., 2013. 1 Tolterodine ER (extended-release) 4mg was included as an active control in this study. FAS-I = all full analysis set patients who had 1 incontinence episode at baseline. 1.Chapple CR et al. Eur Urol 2013;63(2):296 305. Date of preparation: February 2013. BET13018UK
TAURUS: Efficacy variables over 52 weeks (secondary endpoint) Mean number of micturitions/24h (FAS) 1 Adapted from Chapple CR et al., 2013. 1 Tolterodine ER (extended-release) 4mg was included as an active control in this study. FAS = full analysis set. 1.Chapple CR et al. Eur Urol 2013;63(2):296 305. Date of preparation: February 2013. BET13018UK
Contraindications Mirabegron 50mg Administration considerations 1 Patients with any hypersensitivity to the active substance or its excipients. Dose adjustments Dose adjustment to 25mg is recommended in patients with; mild/moderate renal and/or mild hepatic impairment receiving strong CYP3A inhibitor concomitantly and in patients with severe renal and/or moderate hepatic impairment. Special populations Should not be used in patients with: End stage renal disease or requiring haemodialysis Severe hepatic impairment Severe uncontrolled hypertension (SBP 180mmHg and/or DBP 110mmHg) Not recommended in patients with severe renal impairment and/or moderate hepatic impairment concomitantly receiving strong CYP3A inhibitors SBP, systolic blood pressure; DBP, diastolic blood pressure. 1.Betmiga Summary of Product Characteristics, December 2012. Date of preparation: February 2013. BET13018UK
NICE Technology Appraisal 290 (June 13)
Mirabegron: Summary of key clinical data In clinical trials, mirabegron (50 mg) significantly reduced the number of daily micturitions and incontinence episodes compared with placebo 1 3 The efficacy of mirabegron was similar to tolterodine 4 Overall, mirabegron was well-tolerated, with a lower incidence of the well-known side effects of anticholinergics, such as dry mouth 1-4 1. NCT00912964 http://clinicaltrials.gov/ct2/show/results/nct00912964?sect=x430125#othr. Last accessed July 2013. 2. Nitti VW, et al. J Urol 2013;189:1388 95. 3. Khullar V, et al. Eur Urol 2013;63:283 95. 4. Chapple C, et al. Eur Urol 2013;63:296 305.
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