Pharmacy Program Updates: Quarterly Pharmacy Changes Effective July 1, 2017

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Pharmacy Program Updates: Quarterly Pharmacy Changes Effective July 1, 2017 DRUG LIST CHANGES Based on the availability of new prescription medications and Prime s National Pharmacy and Therapeutics Committee s review of changes in the pharmaceuticals market, some additions, revisions (drugs still covered but moved to a higher out-of-pocket payment level) and/or exclusions were made to the Blue Cross and Blue Shield of Montana (BCBSMT) drug lists. Changes that will be effective as of July 1, 2017 are outlined below. Drug List Updates (Coverage Additions) As of July 1, 2017 Preferred Brand 1 Drug Class/Condition Used For Basic (formerly known as Standard) Drug List Eloctate Hemophilia Entresto Heart Failure Humulin R U-500 Humulin R U-500 KWIKPEN Kisqali Linzess Irritable Bowel Syndrome Vyvanse ADHD Xtandi Enhanced (formerly known as Generics Plus) Drug List Eloctate Hemophilia Entresto Heart Failure Humulin R U-500 Humulin R U-500 KWIKPEN Invokamet Invokamet XR Invokana Kisqali Welchol High Cholesterol Xtandi Performance Drug List armodafinil tab 50 mg, 150 mg, 200 mg, 250 mg Narcolepsy clindamycin phosph-benzoyl peroxide (refrig) gel 1.2 (1)-5% XIGDUO XR XTAMPZA ER Pain ZERIT Antiviral Performance Select Drug List armodafinil tab 50 mg, 150 mg, 200 mg, 250 mg Narcolepsy BELSOMRA Insomnia BYSTOLIC Hypertension clindamycin phosph-benzoyl peroxide (refrig) gel 1.2 (1)-5% olmesartan medoxomil tab 5 mg, 20 mg, 40 mg Hypertension A Division of Health Care Service Corporation, a Mutual Legal Reserve Company, an Independent Licensee of the Blue Cross and Blue Shield Association

olmesartan medoxomil-hydrochlorothiazide tab 20-12.5 mg, 40-12.5 mg, 40-25 mg XIGDUO XR XTAMPZA ER ZERIT Hypertension Pain Antiviral Drug List Updates (Revisions/Exclusions) As of July 1, 2017 Non-Preferred Brand 1 Drug Class/Condition Used For Generic Preferred Alternative(s) 2 Basic (formerly known as Standard) Drug List Revisions Atrovent Asthma/COPD Ipratropium Bromide Preferred Brand Alternative(s) 1,2 Spiriva, Incruse, Ellipta Adapalene cream 0.1%, gel 0.1%, gel 0.3% Butalbital/Acetaminophen/Caffeine with Codeine capsule 50-300-40-30 mg Calcipotriene/Betamethasone Dipropionate Ointment 0.005-0.064% Epi-Pen and Epi-Pen Jr. Performance Drug List Exclusions Headaches Topical Steroid Anaphylaxis Members should talk to their pharmacist or doctor for over-thecounter options or other covered therapeutic alternatives butalbitalacetaminophencaff W/ cod cap 50-325-40-30 mg Karbinal ER Allergies carbinoxamine maleate soln 4 mg/5 ml Paroxetine ER 25 mg Antidepressant paroxetine tablets (immediate Enstilar epinephrine autoinjector 0.15 mg/0.3 ml (EPIPEN JR authorized generic) Taclonex Topical Steroid Enstilar Taytulla Birth Control junel fe 1/20 tab, Tretinoin microsphere gel 0.04%, 0.1% gildess fe 1/20 tab, larin fe 1/20 tab, microgestin fe tab tretinoin creeam cream 0.05%, tretinoin cream 0.1%, tretinoin gel 0.01%, tretinoin gel gel 0.05%

Chloroquine phosphate tab 250 mg Performance Drug List Revisions Malaria chloroquine phosphate tablet 500 mg, hydroxychloroquine sulfate tablet Clemastine fumarate tab 2.68 mg Allergic Rhinitis Members should talk to their Coditussin AC Cough/Cold cheratussin ac Lindane Shampoo Lice permethrin cream, malathion lotion Methergine Postpartum bleeding Members should talk to their Metoclopramide ODT 5 mg Nausea/vomiting metoclopramide tablet (non-orally disintegrating), metoclopramide Ninjacof-XG Cough/Cold cheratussin ac Oxymorphone Hcl SR tab Pain oxycodone tablets,, oxymorphone tablets (immediate Tolmetin sodium 400 mg Arthritis ibuprofen tablet, meloxicam tablet, naproxen tablet Adapalene cream 0.1%, gel 0.1%, gel 0.3% Butalbital/Acetaminophen/Caffeine with Codeine capsule 50-300-40-30 mg Calcipotriene/Betamethasone Dipropionate Ointment 0.005-0.064% Performance Select Drug List Exclusions Headaches Oxycontin tablets Members should talk to their pharmacist or doctor for over-thecounter options or other covered therapeutic alternatives butalbitalacetaminophencaff W/ cod cap 50-325-40-30 mg Topical Steroid Enstilar Karbinal ER Allergies carbinoxamine maleate soln 4 mg/5 ml Paroxetine ER 25 mg Antidepressant paroxetine tablets (immediate Taytulla Birth Control junel fe 1/20 tab, gildess fe 1/20 tab, larin fe 1/20 tab, microgestin fe tab

Tretinoin microsphere gel 0.04%, 0.1% tretinoin creeam cream 0.05%, tretinoin cream 0.1%, tretinoin gel 0.01%, tretinoin gel gel 0.05% Chloroquine phosphate tab 250 mg Performance Select Drug List Revisions Malaria chloroquine phosphate tablet 500 mg, hydroxychloroquine sulfate tablet Clemastine fumarate tab 2.68 mg Allergic Rhinitis Members should talk to their Coditussin AC Cough/Cold cheratussin ac Lindane Shampoo Lice permethrin cream, malathion lotion Methergine Postpartum bleeding Members should talk to their Metoclopramide ODT 5 mg Nausea/vomiting metoclopramide tablet (non-orally disintegrating), metoclopramide Oxymorphone Hcl SR tab Pain oxycodone tablets,, oxymorphone tablets (immediate Tolmetin sodium 400 mg Arthritis ibuprofen tablet, meloxicam tablet, naproxen tablet Oxycontin tablets DISPENSING LIMIT CHANGES The BCBSMT prescription drug benefit program includes coverage limits on certain medications and drug categories. Dispensing limits are based on U.S. Food and Drug Administration (FDA) approved dosage regimens and product labeling. Effective July 1, 2017: Drug Class and Medication(s) 1 Dispensing Limit(s) Basic (formerly known as Standard), Performance and Performance Select Drug List Changes Antibiotics Sivextro tablet 6 tablets per 180 days Opioid Dependence (cumulative across agents and strengths) Bunavail 2.1/0.3 mg, 4.2/0.7 mg, 6.3/1 mg films 60 films per 30 days

buprenorphine-naloxone 2/0.5 mg, 8/2 mg tablets 60 tablets per 30 days Suboxone 2/0.5 mg, 4/1 mg, 8/2 mg, 12/3 mg films 60 films per 30 days Zubsolv 0.7/0.18 mg, 1.4/0.36 mg, 2.9/0.71 mg, 60 tablets per 30 days 5.7/1.4 mg, 8.6/2.1 mg, 11.4/2.9 mg tablets Neuromuscular Agent (cumulative across strengths) Lyrica 25, 50, 75, 100, 150, 200, 225, 300 90 capsules per 30 days capsules UTILIZATION MANAGEMENT PROGRAM CHANGES Effective July 1, 2017, the following changes will be applied: o Injectable Atopic Dermatitis and Emflaza will be added to the standard Prior Authorization (PA) programs for standard pharmacy benefit plans. The Injectable Atopic Dermatitis PA program includes the target drug Dupixent. The Emflaza PA program includes the target drug Emflaza. o Several targeted medications will be added to the current PA programs for standard pharmacy benefit plans. As a reminder, please review your patient s drug list for the indicator listed in the Prior Authorization or Step Therapy column, as not all programs may apply. Also, please be sure to submit the specific prior authorization form for the medication being prescribed to your patient. Targeted drugs added to current pharmacy PA standard programs, effective July 1, 2017 Drug Category Targeted Medication(s) 1 Basic (Standard) and Performance Drug Lists Therapeutic Alternatives Auvi-Q, generic metformin ER (Fortamet) Per our usual process of member notification prior to implementation, targeted mailings were sent to members affected by drug list revisions and/or exclusions, dispensing limit and prior authorization program changes. For the most up-to-date drug list and list of drug dispensing limits, visit the Pharmacy Program section of our Provider website. 1 Third party brand names are the property of their respective owners 2 These lists are not all inclusive. Other medications may be available in this drug class. Prime Therapeutics LLC is a pharmacy benefit management company. BCBSMT contracts with Prime to provide pharmacy benefit management, prescription home delivery and specialty pharmacy services. BCBSMT, as well as several independent Blue Cross and Blue Shield Plans, has an ownership interest in Prime. The information mentioned here is for informational purposes only and is not a substitute for the independent medical judgment of a physician. Physicians are to exercise their own medical judgment. Pharmacy benefits and limits are subject to the terms set forth in the member s certificate of coverage which may vary from the limits set forth above. The listing of any particular drug or classification of drugs is not a guarantee of benefits. Members should refer to their certificate of coverage for more details, including benefits, limitations and exclusions. Regardless of benefits, the final decision about any medication is between the member and their health care provider.