e-figure 1. The design of the study.

e-figure 1. The design of the study. NDM, no diabetes; DM, diabetes; TB, tuberculosis; SN, sputum smear negative; SP, sputum smear positive; AFB, acid fast bacilli.

e-figure 2. Representative H&E (A) and Masson s trichrome staining (B) sections of granulomas with differential degrees of fibrotic encapsulation. Class 1+, reduced perinecrotic fibrosis, more multinucleated giant cells ( <200 M thick ) MNGCs; >3 MNGCs per 10 high power fields, HP >3/10 HP), epithelioid cells and inflammatory cells; Class 2+, moderate perinecrotic fibrosis (200-500 M thick), fewer MNGCs (1 2/10 HP), epithelioid cells and inflammatory cells; Class 3+, severe perinecrotic fibrosis (>500 M thick), collagen hyperplasia, absence of MNGCs (0/10 HP), epithelioid cells and inflammatory cells. C. Representative computed tomography (CT) scans at the time of diagnosis.1. a thin-walled cavity (arrow); 2. a thick-walled cavity ; 3. a tree-in-bud appearance (TIB); 4. lobular consolidations (LC), and 5. a thick-walled cavity with a fibrotic band (FB).

e-figure 3. Changes in WBC and RBC indices between NDM-TB and DM-TB groups during TB progression. Horizontal lines represent median values. Gray areas represent normal ranges of the indices. SN, smear negative TB;SP, smear positive TB;WBC, white blood cell;rbc, red blood cell;hgb, hemoglobin;neu/lym, neutrophil to lymphocyte ratio; Mon/Lym, monocyte to lymphocyte ratio. Differences between groups were analyzed by Mann Whitney tests.

e-figure 4. Changes in antibody isotypes, complements and RBC indices between NDM-TB and DM-TB during TB progression. Horizontal lines represent median values. Gray areas represent the normal ranges of the indices. SN, smear negative TB;SP, smear positive TB; C3, complement component 3; MCV, erythrocyte mean corpuscular volume;hct, hematocrit; MCH, Mean corpuscular hemoglobin The differences between groups were analyzed by Mann Whitney tests.

e-table 1. CT findings of NDM-TB and DM-TB patients Prevalence of CT findings, No. (%) Prevalence of CT findings, No (%) CT findings SN-NDM-TB SN-DM-TB P-value* SP-NDM-TB SP-DM-TB P-value* (n=40) (n=40) (n=87) (n=92) Centrilobular nodule or 9 (22.50) 15(37.50) 0.143 50 (57.47) 68 (73.91) 0.020 a branching Tree-in-bud appearance 9 (22.50) 13 (32.50) 0.317 35 (40.23) 49 (53.26) 0.081 Poorly defined ( fuzzy ) 9 (22.50) 17 (42.50) 0.056 37 (42.53) 51 (55.43) 0.084 nodule Cavity 6 (15.00) 13 (32.50) 0.066 59 (67.82) 80 (86.96) 0.002 a Thin-walled cavity 0 (0.00 ) 2 (5.00) 0.152 9 (10.34) 6 (6.52) 0.356 Thick-walled cavity 5 (12.50 ) 8 (20.00) 0.363 38 (43.68) 64 (69.57) <0.001 a Lobular consolidations 34 (85.00) 33 (82.50) 0.762 68 (78.16) 80 (86.96) 0.120 Bronchovascular distortion 1 (2.50) 2 (5.00) 0.556 48 (55.17) 55 (59.78) 0.533 Fibrotic band 24 (60.00) 10 (25.00) 0.002 a 47 (54.02) 36 (39.13) 0.046 a Bronchiectasis 3 (7.50) 1 (2.50) 0.305 52 (59.77) 58 (63.04) 0.653 Miliary nodules 0 (0.00) 1 (2.50) 0.314 3 (0.03) 3 (3.26) 0.944 Hilar and mediastinal adenopathy 11 (27.50) 14 (35.00) 0.469 14 (16.09) 68 (73.91) <0.001 a Table notes: CT, computed tomography; DM, diabetes mellitus; DM-TB, TB patients with DM; NDM-TB, TB patients without DM; TB: tuberculosis; SN, smear negative; SP, smear positive. * 2 test a P <0.05.

e-table 2. Association of immune, biochemical indices with granuloma caseous necrosis in 67 TB (34NDM, 33DM) patients. Parameters Area of caseous necrosis Odd Ratio (95% CI) P Odd Ratio1 (95% CI) P Odd Ratio 2 (95% CI) P Demographic indices Age (year) 0.926 (0.860, 0.997) 0.041 0.962 (0.885, 1.046) 0.367 0.955 (0.872, 1.046) 0.322 Height (cm) 1.085 (1.000, 1.177) 0.049 0.976 (0.854, 1.114) 0.715 0.964 (0.832, 1.117) 0.628 Weight (Kg) 1.061 (1.001, 1.124) 0.045 0.970 (0.818, 1.151) 0.731 0.956 (0.796, 1.150) 0.634 BMI 1.123 (0.928, 1.358) 0.233 1.084 (0.889, 1.322) 0.425 1.014 (0.819, 1.254) 0.900 Immune cells and inflammatory indices WBC ( 10 9 / L) 1.052 (0.770, 1.437) 0.750 0.975 (0.686, 1.387) 0.890 0.917 (0.619, 1.359) 0.666 Neu (%) 0.971 (0.902, 1.046) 0.439 0.996 (0.915, 1.085) 0.935 0.996 (0.907, 1.093) 0.929 Neu ( 10 9 /L) 1.004 (0.649, 1.554) 0.984 0.973 (0.590, 1.605) 0.914 0.912 (0.520, 1.600) 0.749 Mon (%) 1.166 (0.862, 1.577) 0.319 1.147 (0.793, 1.660) 0.466 1.028 (0.703, 1.504) 0.885 Mon ( 10 9 /L) 7.687 (0.159, 372.376) 0.303 2.940 (0.042, 204.954) 0.618 0.640 (0.006, 70.411) 0.853 Lym (%) 1.015 (0.927, 1.111) 0.746 0.976 (0.876, 1.088) 0.666 0.973 (0.864, 1.096) 0.651 Lym ( 10 9 /L) 1.146 (0.496, 2.645) 0.750 0.794 (0.317, 1.991) 0.623 0.679 (0.246, 1.877) 0.456 Eo (%) 1.045 (0.851, 1.283) 0.675 1.044 (0.860, 1.245) 0.665 1.080 (0.881, 1.324) 0.458 Baso (%) 6.579 (1.003, 43.153) 0.050 7.253 (0.692, 76.060) 0.098 8.468 (0.554, 129.552) 0.125 Eo ( 10 9 /L) 3.446 (0.102, 116.917) 0.491 2.328 (0.075, 72.649) 0.630 3.500 (0.108, 113.247) 0.480 Baso ( 10 9 /L) 0.414 (0.000, 736.456) 0.817 0.225 (0.000, 1029.395) 0.729 1.499 (0.000, 0.928 10122.018) Neu/Lym 0.864 (0.420, 1.778) 0.692 1.166 (0.481, 2.828) 0.734 1.152 (0.440, 3.015) 0.773 Mon/Lym 12.206 (0.011, 13767.318) 0.485 29.837 (0.004, 232549.928) 0.458 2.768 (0.000, 0.825 22939.028) PLT/Neu 0.997 (0.974, 1.020) 0.780 1.000 (0.977, 1.024) 0.979 1.002 (0.976, 1.028) 0.897 PLT/Lym 0.997 (0.987, 1.008) 0.589 1.001 (0.988, 1.014) 0.852 1.003 (0.989, 1.016) 0.707 Platelet and coagulation indices PLT ( 10 9 /L) 0.997 (0.990, 1.005) 0.483 0.997 (0.988, 1.005) 0.463 0.997 (0.989, 1.006) 0.566 PCT (%) 0.001 (0.000, 6.366) 0.125 0.002 (0.000, 38.353) 0.213 0.012 (0.000, 445.629) 0.412 MPV (fl) 0.861 (0.604, 1.228) 0.409 0.942 (0.619, 1.433) 0.780 1.144 (0.661, 1.977) 0.631 INR 0.001 (0.000, 3.406) 0.093 0.000 (0.000, 5.343) 0.100 0.000 (0.000, 4.415) 0.090 Fibrinogen (g/l) 1.245 (0.704, 2.200) 0.452 1.488 (0.755, 2.931) 0.251 0.995 (0.443, 2.235) 0.990 D-Dimer (ng/ml) 0.998 (0.996, 1.001) 0.189 0.999 (0.996, 1.002) 0.344 0.999 (0.996, 1.003) 0.722 Glucose and lipid-associated indices TCH (mmol/l) 0.712 (0.408, 1.243) 0.232 0.668 (0.352, 1.267) 0.217 0.707 (0.363, 1.379) 0.309 TG (mmol/l) 1.197 (0.726, 1.975) 0.481 0.926 (0.436, 1.965) 0.841 0.708 (0.301, 1.664) 0.428 HDL-C (mmol/l) 0.734( 0.217, 2.483) 0.619 2.256 (0.388, 13.128) 0.365 6.435 (0.693, 59.741) 0.102 ApoA (mmol/l) 0.427 (0.073, 2.512) 0.347 1.465 (0.165, 13.033) 0.732 4.950 (0.352, 69.606) 0.236 ApoB (mmol/l) 0.315 (0.038, 2.625) 0.286 0.170 (0.015, 1.942) 0.154 0.186 (0.013, 2.617) 0.213 ApoE (mmol/l) 0.980 (0.946, 1.014) 0.251 0.987 (0.946, 1.028) 0.523 0.988 (0.946, 1.032) 0.588 LPA (mmol/l) 0.998 (0.996, 1.001) 0.130 0.999 (0.996, 1.001) 0.328 0.998 (0.995, 1.001) 0.204 GLU (mmol/l) 1.266 (0.934, 1.717) 0.129 1.144 (0.828, 1.579) 0.415 0.833 (0.555, 1.250) 0.378

Red blood cell-associated indices RBC ( 10 12 / L) 1.474 (0.414, 5.246) 0.549 0.256 (0.041, 1.587) 0.143 0.247 (0.031, 1.977) 0.188 HGB (g/l) 1.008 (0.971, 1.046) 0.672 0.955 (0.902, 1.011) 0.117 0.962 (0.904, 1.024) 0.223 HCT (%) 14.776 (0.000, 10047137.413) 0.694 0.000 (0.000, 95.782) 0.134 0.000 (0.000, 735.983) 0.169 MCV (fl) 0.956 (0.829, 1.101) 0.531 0.951 (0.794, 1.140) 0.589 0.956 (0.794, 1.151) 0.634 MCH (pg) 0.943 (0.652, 1.366) 0.757 0.821 (0.532, 1.289) 0.391 0.935 (0.577, 1.513) 0.783 MCHC (g/l) 0.998 (0.969, 1.028) 0.908 0.986 (0.941, 1.034) 0.560 1.002 (0.956, 1.051) 0.928 Table notes: BMI, body mass index; WBC, white blood cell; Neu (%), percentage of neutrophil; Neu ( 10 9 /L), counts of neutrophil; Mon (%), percentage of monocyte; Mon ( 10 9 /L), counts of monocyte; Lym (%), percentage of lymphocyte; Lym ( 10 9 /L), counts of lymphocyte; Eo (%), percentage of eosinophil; Baso (%), percentage of basophil; Eo ( 10 9 /L), counts of eosinophil; Baso ( 10 9 /L), counts of basophil; Neu/Lym, neutrophil to lymphocyte ratio; Mon/Lym, monocyte to lymphocyte ratio; PLT/Neu, platelet to neutrophil ratio; PLT/Lym, platelet to lymphocyte ratio; PLT, counts of platelets; PCT, plateletcrit; MPV, Mean platelet volume; INR, international normalized ratio; TCH, total cholesterol; TG, triglyceride; HDL-C, high density lipoprotein cholesterol; ApoA, apolipoprotein A; ApoB, apolipoprotein B; ApoE, apolipoprotein E; LPA, lipoprotein A; GLU, fasting glucose level; RBC, red blood cell; HGB, hemoglobin; HCT, red blood cell specific volume; MCV, erythrocyte mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration. Odd ratios are calculated from binary logistic analysis. Patients were divided into two groups according to the 15.2 mm 2 or >15.2 mm 2 caseous necrotic areas of the granuloma under 5 microscope observation. aor1, odd ratios after adjusted for gender, age and BMI; aor2, odd ratios after adjusted for gender, age, BMI and NDM/DM status. Bold numbers indicate a P value of < 0.05.

e-table 3. Association analysis of immune and biochemical indices with extent of peri-necrosis fibro-encapsulation of granuloma in 67 TB (34NDM, 33DM) patients. Parameters Fibro-encapsulation Odd Ratio (95% CI) P Odd Ratio1 (95%CI) P Odd Ratio 2 (95%CI) P Demographic indices Male a 3.273 (1.082, 9.895) 0.036 2.371 (0.747, 7.526) 0.143 2.581 (0.727, 9.159) 0.142 Weight (kg) 0.977 (0.932, 1.024) 0.334 0.963(0.833, 1.115) 0.617 0.949 (0.806, 1.118) 0.534 Height (cm) 0.968 (0.902, 1.039) 0.368 0.963 (0.858, 1.080) 0.518 0.946 (0.828, 1.080) 0.411 Age (year) 1.016 (0.951, 1.086) 0.631 0.978 (0.908, 1.053) 0.554 0.975 (0.897, 1.059) 0.544 BMI 1.036 (0.883, 1.215) 0.664 1.016 (0.864, 1.195) 0.848 0.934 (0.777, 1.122) 0.465 Immune cell and inflammatory indices WBC ( 10 9 / L) 1.017 (0.769, 1.346) 0.904 1.005 (0.747, 1.351) 0.975 0.921 ( 0.654, 1.296) 0.637 Neu (%) 1.006 (0.939, 1.078) 0.866 1.018 (0.943, 1.099) 0.641 1.021 (0.936, 1.113) 0.646 Neu ( 10 9 /L) 0.979 (0.654, 1.464) 0.916 1.054 (0.685, 1.621) 0.811 0.964 (0.588, 1.579) 0.884 Lym (%) 0.997 (0.917, 1.085) 0.949 0.962 (0.874, 1.059) 0.424 0.956 (0.857, 1.066) 0.416 Lym ( 10 9 /L) 0.946 (0.453, 1.978) 0.883 0.787 (0.360, 1.719) 0.548 0.626 (0.256, 1.533) 0.306 Mon (%) 1.000 (0.775, 1.290) 0.999 0.942 (0.710, 1.250) 0.678 0.820 (0.592, 1.134) 0.230 Mon ( 10 9 /L) 0.817 (0.037, 18.166) 0.898 0.698 ( 0.025, 19.193) 0.831 0.078 (0.001, 4.019) 0.204 Eo (%) 0.954 (0.791, 1.149) 0.618 1.058 (0.876, 1.278) 0.558 1.107 (0.918, 1.336) 0.288 Baso (%) 2.523 (0.557, 11.428) 0.230 1.971 (0.368, 10.554) 0.428 1.509 (0.209, 10.888) 0.683 Eo ( 10 9 /L) 0.340 (0.015, 7.588) 0.496 0.387 (0.019, 7.779) 0.464 5.241 (0.220, 124.697) 0.306 Baso ( 10 9 /L) 2.165 (0.002, 2563.059) 0.831 0.379 (0.000, 665.711) 0.799 3.274 (0.001, 7672.588) 0.765 Neu/Lym 0.926 (0.457, 1.874) 0.831 1.411 (0.622, 3.198) 0.410 1.414 (0.572, 3.493) 0.453 Mon/Lym 0.754 (0.002, 280.650) 0.926 1.185 (0.001, 948.519) 0.960 0.072 (0.000, 134.456) 0.494 PLT/Neu 0.995 (0.974, 1.016) 0.616 0.998 (0.976, 1.020) 0.847 1.001 (0.977, 1.027) 0.916 PLT/Lym 0.996 (0.986, 1.006) 0.406 0.999 (0.988, 1.010) 0.936 1.001 (0.989, 1.012) 0.916 Platelet and coagulation indices PLT ( 10 9 /L) 0.997 (0.990, 1.004) 0.377 0.998 (0.990, 1.005) 0.549 0.998 (0.990, 1.007) 0.703 PCT (%) 0.001 (0.000, 6.366) 0.125 0.043 (0.000, 244.169) 0.476 0.717 (0.000, 8249.061) 0.944 MPV (fl) 1.160 (0.845, 1.591) 0.359 0.945 (0.661, 1.350) 0.755 1.149 (0.726, 1.820) 0.552 PT (seconds) 0.641 (0.333, 1.233) 0.183 0.668 (0.308, 1.449) 0.307 0.657 (0.283, 1.527) 0.329 INR 0.044 (0.000,74.194) 0.410 0.094 (0.000, 483.530) 0.588 0.047 (0.000, 505.134) 0.519 Fibrinogen (g/l) 1.488 (0.863, 2.566) 0.153 1.771 (0.959, 3.272) 0.068 1.187 (0.575, 2.450) 0.642 D-Dimmer (ng/ml) b 0.997 (0.994, 1.000) 0.022 0.997 (0.994, 1.000) 0.046 0.998 (0.994, 1.001) 0.155 Glucose and lipid-associated indices TCH (mmol/l) 0.807 (0.483, 1.349) 0.413 0.844 (0.485, 1.466) 0.547 0.924 (0.508, 1.678) 0.795 TG (mmol/l) 1.362 (0.810, 2.289) 0.245 1.355 (0.674, 2.725) 0.394 1.166 (0.529, 2.568) 0.703 LDL-C (mmol/l) 0.617(0.328, 1.159) 0.133 0.660 (0.342, 1.273) 0.215 0.795 (0.396, 1.597) 0.520 ApoB (mmol/l) 0.499 (0.070, 3.570) 0.489 0.503 (0.060, 4.193) 0.525 0.794 (0.075, 8.345) 0.847 ApoE (mmol/l) 1.025 (0.992, 1.059) 0.143 0.980 (0.944, 1.018) 0.296 0.980 (0.940, 1.021) 0.334 LPA (mmol/l) 1.001 (0.999, 1.003) 0.422 0.999 (0.997, 1.002) 0.659 0.999 (0.996, 1.002) 0.459 GLU (mmol/l) 1.221 (0.946, 1.577) 0.125 1.139 (0.879, 1.475) 0.325 0.775 (0.541, 1.111) 0.165

Red blood cell-associated indices RBC ( 10 12 / L) b 0.722 (0.221, 2.364) 0.590 0.192 (0.037, 1.004) 0.051 0.140 (0.020, 0.998) 0.050 HGB (g/l) 0.995 (0.961, 1.029) 0.758 0.966 (0.921, 1.013) 0.155 0.973 (0.923, 1.025) 0.304 HCT (%) 0.559 (0.000, 133477.645) 0.927 0.000 (0.000, 38.365) 0.129 0.000 (0.000, 50.973) 0.122 MCV (fl) 0.918 (0.806, 1.047) 0.202 1.064 (0.907, 1.249) 0.444 1.068 (0.899, 1.267) 0.454 MCH (pg) 1.303 (0.922, 1.842) 0.133 1.120 (0.747, 1.681) 0.583 1.404 (0.878, 2.243) 0.156 MCHC (g/l) 1.000 (0.974, 1.027) 0.973 0.994 (0.961, 1.027) 0.700 1.011 (0.979, 1.045) 0.507 Table notes: BMI, body mass index; WBC, white blood cell; Neu (%), percentage of neutrophil; Neu ( 10 9 /L), counts of neutrophil; Mon (%), percentage of monocyte; Mon ( 10 9 /L), counts of monocyte; Lym (%), percentage of lymphocyte; Lym ( 10 9 /L), counts of lymphocyte; Eo (%), percentage of eosinophil; Baso (%), percentage of basophil; Eo ( 10 9 /L), counts of eosinophil; Baso ( 10 9 /L), counts of basophil; Neu/Lym, neutrophil to lymphocyte ratio; Mon/ Lym, monocyte to lymphocyte ratio; PLT/Neu, platelet to neutrophil ratio; PLT/Lym, platelet to lymphocyte ratio; PLT, counts of platelets; PCT, plateletcrit; MPV, Mean platelet volume; INR, international normalized ratio; TCH, total cholesterol; TG, triglyceride; ApoA, apolipoprotein A; ApoB, apolipoprotein B; ApoE, apolipoprotein E; LPA, lipoprotein A; GLU, fasting glucose level; RBC, red blood cell; HGB, hemoglobin; HCT, red blood cell specific volume; MCV, erythrocyte mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration. Odd ratios are calculated from binary logistic analysis. Patients were divided into two groups with slight (1+) and moderate plus severe (2+ plus 3+ ) fibro-encapsulation. aor1, odd ratios after adjusted for gender, age and BMI; aor2, odd ratios after adjusted for gender, age, BMI and NDM/DM status. Bold numbers indicate a P value of < 0.05. a female as reference. b indice with P<0.05, but the value of aor ratio (95% CI) includes /close to 1.000.

e-table 4. Association of immune and biochemical indices with sputum bacteria counts in 139 SP-TB (67NDM, 72DM) patients. Parameters Sputum bacteria counts Odd Ratio (95% CI) P Odd Ratio 1 (95%CI) P Odd Ratio 2 (95%CI) P Demographic indices Male a 0.454 (0.184, 1.117) 0.086 0.475 (0.188, 1.205) 0.117 0.407 (0.154, 1.075) 0.070 Age (year) 1.002 (0.975, 1.029) 0.904 0.997 (0.969, 1.026) 0.841 0.995 (0.966, 1.025) 0.741 Height (cm) 0.999 (0.955, 1.044) 0.957 1.067 (0.992, 1.148) 0.079 1.070 (0.993, 1.154) 0.075 Weight (Kg) 0.979 (0.946, 1.014) 0.239 1.081 (0.975, 1.199) 0.140 1.081 (0.971, 1.204) 0.153 BMI b 0.926 (0.825, 1.040) 0.195 0.931 (0.827, 1.049) 0.240 0.873 (0.767, 0.995) 0.041 Immune cell and inflammatory indices Neu (%) 1.027 (0.991, 1.064) 0.149 1.027 (0.987, 1.068) 0.186 1.022 (0.982, 1.064) 0.277 Lym (%) 0.972 (0.933, 1.013) 0.179 0.972 (0.929, 1.016) 0.213 0.973 (0.929, 1.018) 0.235 Lym ( 10 9 /L) 1.156 (0.670, 1.993) 0.603 1.460 (0.784, 2.719) 0.233 1.356 (0.707, 2.600) 0.359 Mon (%) 1.076 (0.941, 1.231) 0.284 1.103 (0.956, 1.273) 0.179 1.125 (0.967, 1.310) 0.128 Eo ( 10 9 /L) 0.034 (0.001, 1.004) 0.050 0.046 (0.002, 1.409) 0.078 0.052 (0.002, 1.512) 0.082 Baso ( 10 9 /L) 0.000 (0.000, 1.020) 0.050 0.000 (0.000, 197.356) 0.125 0.000 (0.000, 1435.196) 0.162 Neu/Lym 1.057 (0.975, 1.145) 0.178 1.045 (0.955, 1.144) 0.340 1.045 (0.955, 1.143) 0.339 PLT/Lym 1.002 (1.000, 1.004) 0.091 1.002 (0.999, 1.004) 0.206 1.002 (0.999, 1.005) 0.118 PLT/Neu 0.998 (0.986, 1.010) 0.748 0.995 (0.982, 1.008) 0.453 0.999 (0.985, 1.014) 0.936 CRP (mg/l) b 1.009 (1.001, 1.018) 0.027 1.012 (1.002, 1.021) 0.013 1.010 (1.001, 1.020) 0.030 ESR (mm/h) b 1.017 (1.006, 1.029) 0.003 1.020 (1.007, 1.032) 0.002 1.018 (1.005, 1.031) 0.006 Immune globins and complements IGG (g/l) 1.080 (0.988, 1.181) 0.091 1.090 (0.994, 1.197) 0.068 1.072 (0.971, 1.182) 0.169 IGA (g/l) 1.143 (0.897, 1.457) 0.281 1.206 (0.928, 1.567) 0.161 1.152 (0.877, 1.513) 0.309 IGM (g/l) 0.794 (0.472, 1.337) 0.386 0.752 (0.443, 1.277) 0.292 0.679 (0.382, 1.204) 0.185 C3 (g/l) 1.700 (0.579, 4.995) 0.334 2.359 (0.716, 7.769) 0.158 1.325 (0.362, 4.854) 0.671 C4 (g/l 0.517 (0.015, 18.018) 0.716 0.560 (0.014, 22.339) 0.758 0.123 (0.002, 6.252) 0.296 TRF (g/l) 0.715 (0.403, 1.269) 0.251 0.781 (0.427, 1.428) 0.422 0.592 (0.305, 1.146) 0.120 Platelet and coagulation indices PLT ( 10 9 /L) b 1.005 (1.001, 1.009) 0.010 1.006 (1.002, 1.010) 0.008 1.006 (1.002, 1.010) 0.005 PT (seconds) 0.981 (0.703, 1.369) 0.910 0.974 (0.685, 1.385) 0.884 1.032 (0.715, 1.488) 0.868 INR 9.541 (0.250, 364.633) 0.225 9.117 (0.200, 415.934) 0.257 24.611 (0.436, 1390.314) 0.120 Fibrinogen (g/l) 1.114 (0.844, 1.472) 0.446 1.173 (0.872, 1.577) 0.293 1.128 (0.826, 1.541) 0.448 D-Dimmer (ng/ml) 1.000 (1.000, 1.000) 0.284 1.000 (1.000, 1.000) 0.291 1.000 (1.000, 1.000) 0.177 FDP (mg/l) 1.035 (0.984, 1.089) 0.179 1.039 (0.985, 1.095) 0.161 1.050 (0.990, 1.114) 0.101 Glucose and lipid-associated indices TCH (mmol/l) 0.958 (0.676, 1.359) 0.812 1.017 ( 0.695, 1.486) 0.932 0.949 (0.632, 1.425) 0.801 TG (mmol/l) 1.549 (0.755, 3.179) 0.232 1.847 (0.839, 4.064) 0.127 2.111 (0.920, 4.845) 0.078 HDL-C (mmol/l) 0.477 (0.163, 1.399) 0.178 0.353 (0.113, 1.107) 0.074 0.356 (0.112, 1.137) 0.081 LDL-C (mmol/l) 1.090 (0.730, 1.630) 0.673 1.205 (0.774, 1.875) 0.409 1.058 (0.659, 1.698) 0.817 ApoB (mmol/l) 1.795 (0.465, 6.929) 0.396 2.732 (0.593, 12.582) 0.197 2.151 (0.429, 10.780) 0.352 ApoE (mmol/l) 1.011 (0.986, 1.036) 0.407 1.005 (0.979, 1.032) 0.709 1.010 (0.983, 1.038) 0.464 LPA (mmol/l) 1.000 (0.999, 1.001) 0.608 1.000 (0.999, 1.001) 0.605 1.000 (0.998, 1.001) 0.562

GLU (mmol/l) 1.040 (0.956, 1.132) 0.360 1.076 (0.976, 1.187) 0.141 0.981 (0.871, 1.105) 0.755 GA-L (%) 1.040 (0.995, 1.086) 0.082 1.055 (1.005, 1.107) 0.030 1.008 (0.944, 1.077) 0.807 Red blood cell-associated indices RBC ( 10 12 / L) 0.924 (0.560, 1.526) 0.759 1.118 (0.612, 2.041) 0.717 0.938 (0.498, 1.767) 0.843 HGB (g/l) b 0.976 (0.958, 0.995) 0.013 0.977 (0.955, 1.000) 0.045 0.972 (0.949, 0.996) 0.023 MCHC (g/l) 0.999 (0.971, 1.027) 0.932 1.006 (0.976, 1.037) 0.990 0.999 (0.968, 1.031) 0.945 Table notes: BMI, body mass index; Neu (%), percentage of neutrophil; Lym (%), percentage of lymphocyte; Lym ( 10 9 /L), counts of lymphocyte; Mon (%), percentage of monocyte; Eo ( 10 9 /L), counts of eosinophil; Baso ( 10 9 /L), counts of basophil; Neu/Lym, neutrophil to lymphocyte ratio; PLT/Lym, platelet to lymphocyte ratio; PLT/Neu, platelet to neutrophil ratio; CRP, C- reactionprotein; ESR, erythrocyte sedimentation rate; IGG, Immunoglobulin G; IGA, Immunoglobulin A; IGM, Immunoglobulin M; C3, complement component 3; C4, complement component 4; TRF, transferrin; PLT, counts of platelets; PT, prothrombin time; INR, international normalized ratio; FDP, Fibrinogen degradation product; TCH, total cholesterol; TG, triglyceride; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; ApoB, apolipoprotein B; ApoE, apolipoprotein E; GLU, fasting glucose level; GA-L (%), percentage of glycosylated hemoglobin; RBC, red blood cell; HGB, hemoglobin; MCHC, mean corpuscular hemoglobin concentration. Odd ratios are calculated from binary logistic analysis. Patients were divided into two groups according to less (class 1 and 2) and more (class 3 and 4 ) sputum bacteria amounts. aor1, odd ratios after adjusted for gender, age and BMI; aor2, odd ratios after adjusted for gender, age, BMI and NDM/DM status. Bold numbers indicate a P value of < 0.05. a female as reference; b indice with P<0.05, but the value of aor ratio (95% CI) includes /close to 1.000. 171706