Index Note: Page numbers of article titles are in boldface type. A Abuse substance. See Substance abuse Acquired disorders presenting as psychosis in children and young adults, 581 608. See also specific disorders and Psychosis(es), congenital and acquired disorders presenting as, in children and young adults Adolescent(s) co-occurring trauma and psychosis in manifestation of, 633 637 clinical and diagnostic presentation, 633 634 diagnostic comorbidities, 634 evidence-based assessment procedures, 634 637 treatments for, 637 638 psychosis in psychopharmacologic treatment of, 727 744. See also Psychosis(es), in children and adolescents, psychopharmacologic treatment of Adult-onset schizophrenia (AOS) genome-wide association studies of, 680 Affective disorders, 569 580 history of, 569 570 psychotic symptoms in, 572 574 study of issues complicating, 570 571 Antipsychotic(s) for EOS, 721 722 AOS. See Adult-onset schizophrenia (AOS) ASDs. See Autism spectrum disorders (ASDs) Ataxia congenital and acquired disorders associated by, 589 Attention in cognitive profile of syndromal EOS, 719 Auditory problems congenital and acquired disorders associated by, 592 Autism COS and, 682 Autism-plus spectrum disorders, 609 627 nature of problem, 609 616 overview of, 609 616 Autism spectrum disorders (ASDs) defined, 609 610 Child Adolesc Psychiatric Clin N Am 22 (2013) 759 768 http://dx.doi.org/10.1016/s1056-4993(13)00069-2 childpsych.theclinics.com 1056-4993/13/$ see front matter ª 2013 Elsevier Inc. All rights reserved.
760 Index Autism (continued ) psychosis with comorbidity of, 612 613, 616 619 difficulties associated with, 610 616 genetics in, 619 imaging in, 618 mental status examination findings in, 617 618 patient history in, 616 617 ratings scales and standardized assessments in, 618 B Biological stress response psychotic disorders and, 562 Body size abnormal congenital and acquired disorders associated by, 589 Bone abnormalities congenital and acquired disorders associated by, 589 C Cannabis for SIPD, 648 649 Cardiovascular system abnormalities congenital and acquired disorders associated by, 590 Child PTSD Symptom Scale (CPSS) for co-occurring trauma and psychosis in adolescents, 636 Childhood-onset schizophrenia (COS), 539 555 autism and, 682 clinical findings in, 542 544 comorbidities, 548 549 defined, 541 diagnostic dilemmas, 547 548 diagnostic modalities for, 542 differential diagnosis of, 544 genetics of, 675 687 common alleles studies in, 678 680 familial aggregation studies in, 676 678 gene environment interaction in, 682 genome-wide association studies of AOS in, 680 overview of, 675 676 pleiotropy, 682 rare alleles studies in, 680 682 gray matter alterations in in high-risk youth, 702 703 imaging of, 542, 544 implications for clinical practice, 549 incidence of, 539 540 introduction, 539 541 MDI group, 548
Index 761 overview of, 675 676 pathology of, 544 547 physical examination in, 542 premorbid phenotype of, 540 542 rating scales for, 542 symptoms of, 541 Childhood trauma psychosis and, 629 641 described, 630 631 introduction, 629 manifestation of in adolescents, 633 637. See also Adolescent(s), co-occurring trauma and psychosis in, manifestation of specific types of traumatic events, 631 633 Children psychosis in psychopharmacologic treatment of, 727 744. See also Psychosis(es), in children and adolescents, psychopharmacologic treatment of CHR syndromes. See Clinical high-risk (CHR) syndromes Clinical high-risk (CHR) syndromes, 557 567 Clinician-administered PTSD Scale for Children and Adolescents for co-occurring trauma and psychosis in adolescents, 634 Clozapine for psychosis in children and adolescents, 738 739 Cognitive impairment congenital and acquired disorders associated by, 590 591 in EOS after psychosis onset evolution of, 719 721 psychotic disorders related to, 559 Community rehabilitation for psychotic disorders in youth, 745 758 employment and education in, 747 750 introduction, 745 747 physical health in, 750 753 Complex neurodevelopmental disorders with multiple domains of dysfunction, 613 616 Congenital disorders presenting as psychosis in children and young adults, 581 608. See also specific disorders and Psychosis(es), congenital and acquired disorders presenting as Connective tissue abnormalities congenital and acquired disorders associated by, 589 COS. See Childhood-onset schizophrenia (COS) D Delusion(s) characteristics of in youth, 656 defined, 573 grandiose
762 Index Delusion(s) (continued) mood-incongruent 574 persecutory/paranoid of reference somatic mood-incongruent, 574 types of, 573 574 Dementia congenital and acquired disorders associated by, 590 591 Depression manic history of, 569 570 psychotic symptoms in, 574 575 Dermatologic abnormalities congenital and acquired disorders associated by, 591 Dysmorphic features congenital and acquired disorders associated by, 591 E Early-onset schizophrenia (EOS) after psychosis onset cognitive impairment in evolution of, 719 721 gray matter alterations in in high-risk youth, 702 703 neurocognition in, 715 726 antipsychotic treatment for, 721 722 introduction, 715 716 tests in, 716 717 in cognitive profile, 717 719 in premorbid phase, 717 in transition to syndromal disorder, 717 syndromal cognitive profile of, 717 719 Early-onset schizophrenia (EOS) spectrum disorders, 539 555 Education as factor in community rehabilitation for psychotic disorders in youth, 747 750 Employment as factor in community rehabilitation for psychotic disorders in youth, 747 750 Endocrine abnormalities congenital and acquired disorders associated by, 591 592 EOS. See Early-onset schizophrenia (EOS) F Familial aggregation studies in COS, 676 678
Index 763 Formal thought disorder described, 574 G Gene environment interaction in COS, 682 General intellectual ability in cognitive profile of syndromal EOS, 717 718 Genetics of COS, 675 687. See also Childhood-onset schizophrenia (COS), genetics of in psychosis with ASDs, 619 Genitourinary abnormalities congenital and acquired disorders associated by, 593 594 Grandiose delusions Gray matter alterations in schizophrenia in high-risk youth, 689 714 H Hallucination(s), 655 673 characteristics of in youth, 656 defined, 572 described, 572 573 overview of, 656 Hematologic abnormalities congenital and acquired disorders associated by, 592 Hepatic abnormalities congenital and acquired disorders associated by, 595 Hypothalamic-pituitary-adrenal axis psychotic disorders and, 562 I Intellectual disability congenital and acquired disorders associated by, 592 593 L Learning memory and in cognitive profile of syndromal EOS, 718 719 M Magnetic resonance imaging (MRI) in clinical high risk youth for schizophrenia
764 Index Magnetic (continued) structural findings, 693 699 meta-analyses of, 699 702 in genetic high risk youth for schizophrenia structural findings, 691 693 Mania defined, 572 574 prevalence of, 572 574 Manic depression history of, 569 570 MDI group. See Multidimensionally impaired (MDI) group Memory learning and in cognitive profile of syndromal EOS, 718 719 working in cognitive profile of syndromal EOS, 718 Mental health defined, 746 Mood disorders psychosis in assessment of, 575 576 Movement disorder congenital and acquired disorders associated by, 593 MRI. See Magnetic resonance imaging (MRI) Multidimensionally impaired (MDI) group in COS, 548 N Neurobiological abnormalities familial aggregation of, 677 678 Neurocognition in EOS, 715 726. See also Early-onset schizophrenia (EOS), neurocognition in Neurotransmitter(s) psychotic disorders and, 561 562 P Peripheral neuropathy congenital and acquired disorders associated by, 593 Persecutory/paranoid delusions Physical health as factor in community rehabilitation for psychotic disorders in youth, 750 753 Planning and problem solving in cognitive profile of syndrome EOS, 719 Pleiotrophy in COS genetics, 682
Positive and Negative Syndrome Scale (PANSS) for co-occurring trauma and psychosis in adolescents, 636 Processing speed in cognitive profile of syndromal EOS, 718 Prodromal syndrome criteria, 558 559 Prodrome clinical risk for psychotic disorders and, 557 567 defined, 557 Psychiatric disorders in youth prevalence of, 659 Psychosis(es) affective study of issues complicating, 570 571 ASDs and, 616 619. See also Autism spectrum disorders (ASDs), psychosis with, autistic symptoms as misdiagnosis of, 610 612 childhood trauma and, 629 641. See also Childhood trauma, psychosis and in children and adolescents affective disorders and, 569 580 in clinical samples rates of, 571 572 psychopharmacologic treatment of, 727 744 augmentation strategies, 737 738 clozapine, 738 739 efficacy of, 728 future directions in, 740 introduction, 727 728 side effects of, 728 732 management of, 732 733 treatment strategies, 733 737 symptoms of, 572 574 congenital and acquired disorders presenting as in children and young adults, 581 608 chart of diseases, 584 588 clinical approach to, 582 583 limitations of, 583, 596 disorders by associated signs, 589 596 introduction, 581 582 with doorway diagnoses, 597 easily missed diagnoses, 598 prevalence data, 597 in mood disorders assessment of, 575 576 risk factors for childhood adversities, 630 631 substance abuse and, 643 654. See also Substance abuse, psychosis and Index 765
766 Index Psychosocial stress and trauma psychotic disorders related to, 560 Psychotic disorders biological stress response and, 562 clinical risk for, 557 567 clinical findings associated with, 559 560 defined, 558 introduction, 557 559 diagnostic dilemmas associated with, 562 563 hypothalamic-pituitary-adrenal axis and, 562 imaging modalities for, 560 561 neuroanatomy of, 560 neurophysiology of, 560 561 neurotransmitters and, 561 562 pathology of, 561 562 substance-induced. See Substance-induced psychotic disorder (SIPD) in youth community rehabilitation and psychosocial interventions for, 745 758. See also Community rehabilitation, for psychotic disorders in youth Psychotic symptoms in youth assessment of, 662 664 differential diagnosis of, 664 668 epidemiology of, 656 658 medical conditions associated with, 659 662 in psychiatric care, 658 659 rating scales for, 663 664 R Rehabilitation community for psychotic disorders in youth, 745 758. See also Community rehabilitation, for psychotic disorders in youth Renal abnormalities congenital and acquired disorders associated by, 593 594 Response inhibition in cognitive profile of syndromal EOS, 719 Rule discovery and perseveration in cognitive profile of syndromal EOS, 719 S Schizophrenia adult-onset genome-wide association studies of, 680 childhood onset, 539 555. See also Childhood-onset schizophrenia (COS) DSM IV-TR criteria for, 543 familial aggregation of, 676
Index 767 genetic high risk for structural MRI findings in, 691 693 gray matter alterations in in high-risk youth, 689 714 Schizophrenia spectrum disorders familial aggregation of, 677 Seizure(s) congenital and acquired disorders associated by, 594 SIPD. See Substance-induced psychotic disorder (SIPD) Smoking as factor in community rehabilitation for psychotic disorders in youth, 751 752 Somatic delusions described, 574 Spasticity congenital and acquired disorders associated by, 594 595 Speech problems congenital and acquired disorders associated by, 595 Splenic abnormalities congenital and acquired disorders associated by, 595 Stress psychosocial psychotic disorders related to, 560 Substance abuse psychosis and, 643 654. See also Substance-induced psychotic disorder (SIPD) initial evaluation for, 645 646 introduction, 643 645 treatment of, 646 649 psychotic disorders related to, 560 Substance-induced psychotic disorder (SIPD) clinical example, 644 645 described, 644 645 initial evaluation for, 645 646 treatment of, 646 649 T Trauma childhood psychosis and, 629 641. See also Childhood trauma, psychosis and psychotic disorders related to, 560 Trauma Symptom Checklist for Children (TSCC) for co-occurring trauma and psychosis in adolescents, 636 U UCLA PTSD Index for Adolescents for co-occurring trauma and psychosis in adolescents, 634 636 V Visual system abnormalities congenital and acquired disorders associated by, 595 596
768 Index W Working memory in cognitive profile of syndromal EOS, 718 Y Youth. See also Adolescent(s); Children delusions in characteristics of, 656 hallucinations in characteristics of, 656 high-risk gray matter alterations in schizophrenia in, 689 714. See also Schizophrenia, gray matter alterations in, in high-risk youth in psychiatric care psychotic symptoms in, 658 659 psychiatric disorders in prevalence of, 659 psychosis in affective disorders and, 569 580 psychotic disorders in community rehabilitation and psychosocial interventions for, 745 758. See also Community rehabilitation, for psychotic disorders in youth psychotic symptoms in, 656 668. See also Psychotic symptoms, in youth