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The 16 th Biennial Congress of the Metastasis Research Society & The 12 th National Congress of the Chinese Society of Tumor Metastasis September 16-20, 2016 Venue: Chengdu JinJiang Hotel, Chengdu, Sichuan Province, China Co- Chairs: Qinghua Zhou (West China Hospital, Sichuan University, China) Yibin Kang (Princeton University, USA) Scientific Committee: Jonathan Sleeman (University of Heidelberg, Germany), President, MRS Lalita Shevde- Samant (University of Alabama at Birmingham, USA), MRS Robin Anderson (Peter MacCallum Cancer Centre, Australia), MRS Douglas R Hurst (University of Alabama at Birmingham, USA), MRS Barbara Fingleton (Vanderbilt University, USA), MRS Kazuyuki Itoh (Osaka Medical Center of Cancer and Cardiovascular Diseases, Japan), MRS Conor C Lynch (H. Lee Moffitt Cancer Center, USA), MRS Klaus Pantel (University Cancer Center Hamburg, Germany), MRS Rajeev S Samant (University of Alabama at Birmingham, USA), MRS Andries Zijlstra (Vanderbilt University, USA), MRS Lunxiu Qin (Fudan University Huashan Hospital, China), ChMRS Weigang Fang (Peking University, China), ChMRS Xiuwu Bian (Third Military University, China), ChMRS Jian Zhang (Guangxi Medical University, China), ChMRS Xiaohong Helena Yang, Cell Press Friday, September 16 th 8:00-13:00 10:00-11:00 11:00-13:00 12:00-18:30 14:00-14:15 ECAM Satellite Symposium CEM Editorial Board Meeting MRS Executive Board Meeting Registration Opening Remarks Jonathan Sleeman, University of Heidelberg, Germany, President, MRS Qinghua Zhou (West China Hospital, China), President, ChMRS Yibin Kang (Princeton University), President- Elect, MRS

14:15-15:15 Keynote Lecture Chairperson: Yibin Kang (Princeton University) Joan Massagué, Sloan- Kettering Institute, New York, US 15:15-16:15 Topic 1: Heterogeneity and metastatic evolution Chairperson: Douglas Hurst (University of Alabama, USA) Vito Quaranta, Vanderbilt University, US Devon Lawson, University of California- Irvine, US 16:15-16:45 16:45-18:45 Group picture and Topic 2: EMT, CSC and plasticity Chairperson: Andries Zijlstra (Vanderbilt University, US) Jean Paul Thiery, National University of Singapore, Singapore Hideyuki Saya, Keio University, Japan Xiuwu Bian, Third Military Medical University, China (ChMRS) Hongquan Zhang, Peking University, China (ChMRS) 19:00 Conference Reception dinner Saturday, September 17 th 8:00-10:00 Topic 3: Metastasis organotropism Chairperson: Conor Lynch (H. Lee Moffitt Cancer Center, US) Theresa Guise, Indiana University, US Peter Siegel, McGill University, Canada Xiang H.- F. Zhang, Baylor College of Medicine, US Lunxiu Qin, Fudan University, China (ChMRS)

10:00-10:30 10:30-11:30 Topic 4: Dormancy and DTCs Chairperson: Klaus Pantel (University Medical Center, Germany) Cyrus Ghajar, Fred Hutchinson Cancer Research Center, Seattle, US Dario Marchetti, Baylor College of Medicine, US 11:45-12:45 Lunch Session: Meet the Journal Editors Chairperson: Yibin Kang and Jonathan Sleeman Gemma Alderton (Nature Reviews Cancer) Victoria Aranda (Nature Medicine) Xiaohong Helena Yang (Cancer Cell) Alexia- Ileana Zaromytidou (Nature Cell Biology) 13:00-17:00 13:00-17:00 17:00-19:00 Concurrent Symposium I (Short talks) Concurrent Symposium II (Short talks) Poster Session I Sunday September 18 th (Clinical- focus day) 8:00-9:30 Topic 5: Liquid Biopsy: Circulating tumor cells vs. ctdna Chairperson: Klaus Pantel (University Medical Center, Germany) Klaus Pantel, University Medical Center, Germany Catherine Alix- Panabieres; University Institute of Clinical Research, France Michael Speicher, Medical University of Graz, Austria 9:30-10:00 10:00-10:45 Kurt Hellmann Award Lecture Chairperson: Qinghua Zhou (West China Hospital, China) Patricia Steeg, National Cancer Institute, USA

11:45-11:45 Topic 6: Aging and therapy induced metastasis Chairperson: Robin Anderson (Peter MacCallum Cancer Centre, Australia) Judith Campisi, Buck Institute for Research in Aging, US Suzanne Fuqua, Baylor College of Medicine, US 12:00-13:00 Lunch Session: Patient Advocates Round- Table Forum (tentative) Chairperson: Irwin Gelman (Rosewell Park Cancer Institute, US) 13:00-14:00 Topic 7: Stress, inflammation, and immune regulation of metastasis Chairperson: Robin Anderson (Peter MacCallum Cancer Centre, Australia) Karin de Visser, Netherlands Cancer Institute, Netherlands Xuetao Cao, Chinese Academy of Medical Sciences, China 14:00-15:00 Topic 8: Advanced imaging in metastasis research and treatment Chairperson: Rajeev Samant (University of Alabama, US) David Piwnica- Worms, M.D. Anderson Cancer Center Peter Friedl, M.D. Anderson, US 15:00-15:30 15:30-17:00 Topic 9: Immunotherapy, targeted therapies and drug development Chairperson: Kazuyuki Itoh (Osaka Medical Center, Japan) Andy Minn, University of Pennsylvania, US Phil Darcy, Peter MacCallum Cancer Centre, Australia Qinghua Zhou, West China Hospital, Sichuan University, China, ChMRS 17:00-19:00 Poster Session II 19:00 Invited Speaker Dinner

Monday September 19 th 8:00-10:30 Topic 10: Exosomes and other vesicles in metastasis Chairperson: Janine Erler (University of Copenhagen, Denmark) David Lyden, Weil Cornell Medical College, US Emily Wang, City of Hope, US Delores Di Vizio, Cedars- Sinai, US Alissa Weaver, Vanderbilt University, US Jian Zhang, Guangxi Medical University, China, ChMRS 10:30-11:00 11:00-12:30 Topic 11: Non- coding RNAs in metastasis Chairperson: Barbara Fingleton (Vanderbilt University, US) Li Ma, M.D. Anderson Cancer Center, US Erwei Song, Sun Yat- sen Memorial Hospital, China (ChMRS) Tianhua Zhou, Zhejiang University, China 12:30-14:30 14:30-15:10 Lunch Session: MRS Annual General Membership Meeting ECAM- selected speaker Chairperson: Lalita Shevde- Samant (University of Alabama, USA) Alana Welm, Huntsman Cancer Institute, US 15:10-15:55 Fidler Innovation Award Lecture Chairperson: Yibin Kang (Princeton University, US) Dihua Yu, M.D. Anderson Cancer Center, US

15:55-16:25 16:25-17:10 MRS Young Investigator Award Chairperson: Jonathan Sleeman (University of Heidelberg, Germany) Jing Yang, University of California, San Diego, US 17:10-17:25 17:25-17:40 Poster Awards Qinghua Zhou, West China Hospital, Sichuan University Closing Remarks Yibin Kang, Princeton University, US Qinghua Zhou, West China Hospital, Sichuan University 18:30 Conference Banquet