San Giovanni Addolorata Hospital - Rome, Italy

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- Rome, Italy General Information New breast cancer cases treated per year 411 Breast multidisciplinarity team members 19 Radiologists, surgeons, pathologists, medical oncologists, radiotherapists and nurses Clinical Director: Lucio Fortunato, MD At San Giovanni-Addolorata Hospital, we offer a dedicated, comprehensive facility, with specialized personnel devoted to the management of breast cancer patients. The Center received the European Certification ItalCert in May 2017. Our aim is to provide an up-to-date multidisciplinary service, with a constant attention to human touch and psychological needs of our patients. Our patients are accompanied through all steps of breast cancer management, including diagnosis, surgery, medical oncology, radiation oncology, rehabilitation, psyco-oncology and genetic counseling. In addition, through non-profit organizations, we promote meetings for breast cancer patients, including non-conventional topics as diet, acupunture, omeopathy, and a laboratory of make up for those patients undergoing chemotherapy. Every patient is encouraged to participate to a 'Pre-Abilitation' program, a pre-operative course where all the steps of treatment are discussed and detailed. Clinical research is available, and several scientific meetings have been organized by the Unit in the last few years. San Giovanni Addolorata Hospital Via Amba Aradam 8 00184 Rome, Italy Phone: +390677056762 Fax: +390677055112 E-mail: lfortunato@hsangiovanni.roma.it Web-site: www.hsangiovanni.roma.it 1/7

CERTIFICATION(S) ACCREDITATION(S) San Giovanni Addolorata Hospital BCCERT - Breast Centres Certification Expiration date: 20 May 2017 Certification document (original lang.) Regione Lazio - Accreditamento Regionale Expiration date: 03 December 2017 Regione Lazio This Centre has notified to be certified and, as such, been requested to upload the certification document for further information. When the certification document/s is/are provided, it is/they are made available hereafter. 2/7

Available services Reconstructive/Plastic Surgery Nuclear Medicine Rehabilitation Genetic Counselling Data Management Psycho-oncology Breast Nurses Social Workers Nutritional Counselling Survivorship Groups Sexual Health Counselling Supportive and Palliative Care Integrative Medicine Dedicated Radiologists 4 Mammograms per year 8000 Breast radiographers Screening program Verification for non-palpable breast lesions on specimen Axillary US/US-guided FNAB Available imaging equipment Mammography Ultrasound Magnetic Resonance Imaging (MRI) Available work-up imaging equipment Computer Tomography Ultrasound Magnetic Resonance Imaging (MRI) PET/CT scan Primary technique for localizing non-palpable lesions Hook-wire (or needle localization) Charcoal marking/tattooing ROLL: radio-guided occult lesion localization Available breast tissue sampling equipment Stereotactic Biopsy (Mammography guided) Core Biopsy (Tru-cut) Vacuum assisted biopsy Ultrasound-guided biopsy Fine-needle aspiration biopsy (FNAB, cytology) Core Biopsy Vacuum assisted biopsy MRI-guided biopsy Core Biopsy Vacuum assisted biopsy New operated cases per year (benign and malignant) 561 Dedicated Breast Surgeons 5 Surgeons with more than 50 surgeries per year 5 beds 4 Breast Nurse specialists 4 Outpatient surgery Intra-operative evaluation of sentinel node Reconstruction performed by Breast Surgeons Primary technique for staging the axilla Axillary lymph node dissection Sentinel lymph node biopsy: Blue dye technique Radio-tracer technique Blue dye + Radio-tracer Axillary sampling 3/7

Reconstructive/Plastic Surgery Reconstructive/Plastic surgeons 3 Immediate Reconstruction available Type of breast reconstructive surgery available Remodelling after breast-conserving surgery Reconstruction after mastectomy: Two-stage reconstruction (tissue expander followed by implant) One-stage reconstruction Autogenous tissue flap Latissimus dorsi flap Transverse rectus abdominis (TRAM) Free-flaps (free TRAM, DIEP, SIEA, gluteal, etc.) Surgery on the contralateral breast for symmetry Dedicated Breast Pathologists 2 Available studies Cytology Haematoxylin & eosin section (H&E) Surgical specimen Sentinel node Core biopsy Frozen section (FS) Surgical specimen Sentinel node Immunohistochemistry stain (IHC) Estrogen receptors Progesterone receptors HER-2 Ki-67 Other special studies available Fluorescence in-situ Hybridization for HER-2 gene (FISH) Oncotype Dx (21-gene assay) MammaPrint (70-gene microarray) Prediction Analysis of Microarray 50-gene set (PAM 50) Parameters included in the final pathology report stage (pt and pn) Tumour size (invasive component in mm) Histologic type Tumor grade ER/PR receptor status HER-2/neu receptor status Peritumoural/Lymphovascular invasion Margin status Dedicated Breast Medical Oncologists 3 Outpatient systemic therapy 4/7

Dedicated Radiation Oncologists Available techniques after breast-conserving surgery (including experimental) Whole-Breast RT (WBRT) Partial breast irradiation (PBI): External beam PBI Interstitial brachytherapy Targeted brachytherapy (MammoSite, SAVI applicator, other devices) Intra-operative RT (IORT) Tomotherapy Multidisciplinary Meeting (MDM) / Tumour Board (TB) Regular MDM/TB for case management discussion Twice a week Weekly Every two weeks Other Schedule Cases discussed at MDM/TB Preoperative cases Postoperative cases Specialties/services participating in MDM/TB Reconstructive/Plastic Surgery Genetic Counselling Breast Nurse Service Psycho-oncology Dietician Further Services and Facilities Nuclear Medicine Lymphoscintigraphy Bone scan Positron Emission Tomography (PET) PET/CT scan Rehabilitation Prosthesis service Physiotherapy Lymph-oedema treatment Genetic Counselling Specialist Providing Genetic Counselling/Risk assessment service: Dedicated Clinical Geneticist Medical Oncologist Breast Surgeon General Surgeon Gynaecologist Genetic Testing available Surveillance program for high-risk women Data Management Database used for clinical information Data manager available 5/7

Contact details Clinical Director Lucio Fortunato, MD Clinical Director of the Breast Unit lfortunato@hsangiovanni.roma.it +390677056832 Laura Broglia, MD Responsible, Breast Imaging Unit lbroglia@hsangiovanni.roma.it Lucio Fortunato, MD Head of the Breast Unit lfortunato@hsangiovanni.roma.it +390677056762 Reconstructive Surgery Andrea Loreti, MD Director, Plastic Surgeon aloreti@hsangiovanni.roma.it +390677056762 Leopoldo Costarelli, MD Responsible, Breast Pathologist lcostarelli@hsangiovanni.roma.it +390677055341 Maria Mauri, MD Responsible, Breast Medical Oncologist mmauri@hsangiovanni.roma.it +390677052943 Ugo De Paula, MD Chief of Dpt. udepaula@hsangiovanni.roma.it +390677054295 6/7

How to reach us San Giovanni Addolorata Hospital Via Amba Aradam 8 00184 Rome, Italy Phone: +390677056762 Fax: +390677055112 E-mail: lfortunato@hsangiovanni.roma.it Web-site: www.hsangiovanni.roma.it From airport: Train to Termini Station. Then bus line 714 to P.za S. Giovanni in Laterano stop (1 min. walk to the hospital). By train: Train to Termini Station. Then bus line 714 to P.za S. Giovanni in Laterano stop (1 min. walk to the hospital). By bus or sub-way/underground: Bus line 714 to P.za S. Giovanni in Laterano stop (1 min. walk to the hospital). By car: From EUR take Via Cristoforo Colombo. From Termini Station take Via Merulana. Otherwise Tangenziale EST to Piazza San Giovanni. Last modified: 14 November 2017 7/7