The EU Early Warning System: 20 years of monitoring New Psychoactive Substances in Europe Rachel Christie, PhD NDEWS webinar: Examining Global Drug Early Warning Systems, Part 4: Monitoring Drug Trends in Europe 29 November 2017
20 years of monitoring NPS holistic approach variety of information sources triangulation of information +660 NPS monitored ~150 public health alerts 30 risk assessments..since 2014 ~300 NPS newly detected + 50 public health alerts 17 risk assessments Europol and EMA 2
The EU EWS: who we are 1997: New drugs monitored under Joint Action 97/396/JHA Until 2005: EMCDDA mainly collects data on a small number of drugs most of which controlled by the UN drug conventions risk communication formal notification alerts advisories briefings Future: new legislation shorter deadlines 3
What we monitor 2 types of drugs 4
The EU EWS: definition and scope New narcotic or psychotropic drug, in pure form or in preparation, that is not controlled by the 1961 or the 1971 UN Conventions, but which may pose a public health threat comparable to that posed by substances listed in Schedule I or II or IV of the former and in Schedule I or II or III or IV of the latter convention (CD 2005/387/JHA) New psychoactive substances i.e. New to the drug market or newly misused Scope of the EU-EWS: Changes in purity of established (controlled) drugs Established (controlled) drugs adulterated with unusual and/or harmful cutting agents Substances sold as others e.g. heroin sold as cocaine New patterns (forms) of use e.g. injection of cathinones Fatal and non-fatal intoxications Large seizures, seizures that show evidence of international trafficking and/or involvement of organised crime 5
What should be reported? Substances which are: - Potentially psychoactive - New (not listed in the UN conventions) But also: - Precursors - Medicines In case of doubt, please report!!! 6
What should be reported? First detection in Europe formal notification - EMCDDA-Europol Reporting Form - Complete analytical report First detection in the country event-based data - EMCDDA-Europol Reporting Form Subsequent detections aggregated data - EWS Progress Reports (January June) - EWS Final Reports (July December) 7
Event-based seizures EMCDDA-Europol Reporting Forms (RFs) 8
EU EWS Formal Notification 9
Aggregated seizures EWS Progress/Final Reports Aggregated data is reported through: EWS Progress Reports (January June) EWS Final Reports (July December) 10
First detections of NPS in Europe Case-level data 11
First detections of NPS in Europe 12
Seizures of new psychoactive substances in Europe 13
Increasing seizures of synthetic cannabinoids and cathinones 14
Responding to NPS causing concerns Toxicovigilance system Signal Management system Risk Communication system Risk Assessments 15
Toxicovigilance The active process of detecting, reporting, evaluating, understanding, monitoring and responding to adverse events associated with new psychoactive substances In the context of early warning it focuses on serious adverse events Prioritisation: which substances should we react to? 16
Signal management system Signal management is a stepwise process covering six steps; it begins with the detection of a signal and ends with a recommendation for action that details how we should react to the signal. 1. detection 2. validation 3. analysis 4. Prioritisation which substances should we react to? 5. assessment 6. recommendation for action 17
Signal Management System a systematic, reproducible, and transparent approach to detect, validate, understand, prioritise, and react to signals, according to the type of risk that they pose, the seriousness of the risk, the urgency of the risk 1. Detection 2. Validation 3. Analysis 4. Prioritisation 6. Response/Action 5. Assessment 18
Everything begins with a signal A signal is the information arising from one or more sources which suggests either a new association or a new aspect of a known association between a substance, and an event or set of related events that is judged to be of sufficient likelihood to justify verificatory action, and, where necessary remedial action. 19
Recommendations for action Awareness Intensive monitoring (solicited reporting) Risk communication (push and pull of information) Formal notifications Alerts Advisories Briefings Joint Report 20
Substances of Concern monitoring and responding to harms Public health alerts issued by the EMCDDA in 2015: Deaths associated with the use of potent opioids Clusters and outbreaks of intoxications associated with cannabinoids Seizures of ecstasy tablets containing 4-CMA Deaths associated with PMMA sold as ecstasy and heroin sold as cocaine Public health alerts issued in 2016 included: Serious adverse events associated with the use of cannabinoids Deaths associated with the use of potent opioids Superman logo ecstasy tablets containing PMMA Public health-related advisories were also issued in 2016: Fatty acid amide hydrolase (FAAH) inhibitors; Ocfentanil sold as heroin Cocaine containing scopolamine and associated intoxications 21
Joint Report the next stage of early warning 1. Evidence of intoxication or fatalities = serious adverse events 2. Toxicopharmacological properties of the new psychoactive substance or analogy with better-studied compounds 3. Amount of seized material 4. Evidence of the potential for further (rapid) spread 5. Evidence of international trafficking 6. Evidence of organised crime involvement Based on the Joint Report the Council may request a risk assessment of the health and social risks 22
Risk assessment domains A) Physical, chemical, pharmaceutical and pharmacological information B) Dependence and abuse potential D) Health risks E) Social risks F) Involvement of organised crime C) Prevalence level 23
Risk assessments 1998 1999 2000 2001 2003 2007 2010 2012 2013 2014 2015 2016 4-MTA PMMA Mephedrone 5-IT α-pvp MDMB- CHMICA MBDB Ketamine GHB 2C-I 2C-T-2 2C-T-7 TMA-2 BZP 4-MA Methoxetamine MDPV 25I-NBOMe AH-7921 4,4 -DMAR MT-45 24
Risk assessments 2017 Completed in 2017: Acryloylfentanyl 2017 Furanylfentanyl (May) 2017 AB-CHMINACA ADB-CHMINACA 5F-MDMB-PINACA CUMYL-4CN-BINACA 4-Fluoro-isobutyrylfentanyl (4F-IBF) Tetrohydrofuranylfentanyl (THF-F) Carfentanil 25
Synthetic Cannabinoids Replacement Forms 26
""What's in a name? That which we call a rose By any other name would smell as sweet." Synthetic cannabinoids are structurally very diverse Some maintain names from original patents Unequivocal naming is vital for good monitoring Linked Group-Tail-Core-Linker Linked Group: methyl dimethyl butanoate (MDMB) Tail: cyclohexylmethyl (CHM) Core: indole (I) Linker: carboxamide (CA) When a tail substituent is present i.e.5f, this would be displayed at the front of the name: 5F-LinkedGroup - TailCoreLinker). 27
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MDMB-CHMICA timeline Hungary Police seizure 1 g herbal material Austria Bonzai 7 NFIs Sweden 4 deaths 6 NFIs Germany 2 deaths 3 NFIs UK 1 NFI Poland Mocarz EU wide 13 deaths 23 NFIs August 2014 15 Dec 2014 19 Dec 2014 25 Apr 2015 July 2015 08 Feb 2016 Reported to EMCDDA Sept 2014 EWS alert 27 Feb 2017 EWS alert 31 Aug 2016 EWS alert External alerts 22 July 2016 EWS alert Formal request Joint Report Questionnaire 18 April 2016 Formal notification to EWS Council implementing decision for control Proposal for EU control Risk Assessment meeting Joint Report submission The biggest single seizure on MDMB-CHMICA was reported in December 2014 by Luxembourg: 40 kg of white powder packed in 1 kg packages were seized in Dec 2014 by the Customs at Luxembourg Airport (Cargo). The product was on transit: the origin of the 2 barrels was China ( Shanghai) and the destination was Spain (Madrid). 31
Emergence of fentanyls in the EU market Formal notifications 2012-2017 cpentyl-f Benzodioxole-F Benzoylfentanyl 3-phenylpropanoylfentanyl Tetramethylcyclopropanefentanyl Cyclopropylfentanyl Thiophenefentanyl Benzylfentanyl ibf- benzyl fentanyl ib-α-methyl fentanyl carfentanil ocfentanil 4F-BF BF AcF Despropionyl 2F-F 4-MeO-BF FuF Valerylfentanyl Acryloylfentanyl 2F-fentanyl 4Cl-iBF 4F-iBF 3F-fentanyl MeOAcetyl fentanyl THF-F 2012 2013 2014 2015 2016 2017 32
Availability, supply, price Sold as drugs in their own right, but also as other substances on the surface web typically as research chemicals in powders but also in novel dosage forms (nasal sprays, liquids for electronic smoking devices, blotters) on the illicit market detected in mixtures with heroin and with cutting agents typically used for opioids (caffeine, paracetamol, etc) detected in mixtures with cocaine on other markets darkweb used to distribute carfentanil (UK and internationally) Produced in China and Hong Kong (wholesale and retail amounts) indications that Russia may also be a source (reported by 1 country) and then sold and distributed in the EU as received or mixed with other drugs (including illicit drugs)
Challenges Number, diversity and availability of NPS law enforcement seizures NPS data Complexity of NPS market Serious adverse events Outbreaks of infections and mass poisonings Lack of data on pharmacology, toxicology and epidemiology 38
Acknowledgment and thanks to the Reitox network and the national early warning system correspondents Email: Rachel.Christie@emcdda.europa.eu http://www.emcdda.europa.eu/activities/action-on-new-drugs @toxicovigilance emcdda.europa.eu twitter.com/emcdda facebook.com/emcdda youtube.com/emcddatube flickr.com/photos/emcdda