ATOMIC METALLOGRAMS OF BIOLOGICAL LIQUIDS:

ATOMIC METALLOGRAMS OF BIOLOGICAL LIQUIDS: SCIENTIFIC BASIS INDICATIONS AND JUSTIFICATIONS COMPARAISON BETWEEN VARIOUS METALLOGRAMS (URINE BLOOD SERUM HAIR SPERM) URINARY ATOMIC METALLOGRAM: MAU - BGU JUSTIFICATION AND METHODOLOGY Glycan Group Page 1

Numerous studies elaborated on biological liquids (blood, urine, sperm ) confirm the depletion from various types of metals (natural elements), along with heavy and toxic metals. The practice of Urinary Atomic Metallogram appears to be a medical and scientific way that proposes or states that resolute patients, require or not, the intake of metallic cations (trace elements). With regard to the clinician, the interest lays in the possibility to know whilst practicing of the totality of the real necessities of cations required by the patients. Thanks to the atomic metallograms of the biological liquids, carried out by the Medical Biological Laboratory, the clinician may suitably follow up the intake of the metallic cations or other medications (ponderal or homeopathic). Indeed, the atomic metallogram enables to create a specific metallotherapy for the considered individual, along with providing perfectly adapted personal formulas, which are very useful in the process of the patient s state of health improvement. Whilst it is a true fact that the association of oligo-metallic intake according to the method of diathesis is suitable to resolve defined disorders, it does not mean that this process is recognized as a complete method since it is not fully based on real studies of cations, and it does not quantify any excess or deficiencies. This is the reason why we notice that systematic empirical prescription of trace elements that meets defined pathological disorders, or suspected ones, may often be open to criticism. It seems indispensable to be biologically informed on the qualitative and quantitative dispatch of trace elements that are present in the biological liquids, since the metals and metalloids are compulsory catalysors. We can hardly see how they could be excluded from pathological and catabolic mechanisms, which use similar metals and move these in accordance. The use of trace element therapy in an empirical manner has often delayed the beneficial and curative effects of metallic cations (trace elements). With regard to a considerable amount of difficult cases, which were following a traceelements treatment, some of the patients state of health was not improving and therefore thanks to the strict and well knowledge procedure of biological liquids Atomic Metallogram (UAM) carried out by the clinician, they were able to undergo a thorough restructuration. Therefore, a metal such as Copper (molecularily linked to glucose molecule), which is being administered to patients with cancer, and most specifically concerning the cancerigenic pathology of the digestive tract, must be supervised by a Urinary Metallogram. Glycan Group Page 2

Some intensive chemotherapies cause important depletions of metallic cations (Magnesium, Zinc, Selenium, Boron or Molybdenum) that are found again in the biological liquids and in particular in urines. The same phenomenons are present in diabetology study and specifically in case of insulin-dependent patients, where the frequent insulin intake moves substantial quantities of indispensable metals in the body. This gives us more important insight as far as etiopathogenic factors in neuropathy, angiopathy and diabetic retinopathy are concerned. Finally, the Urinary Atomic Metallograms have permitted to establish and control the losses of Silicon within gerontology. Equally, it appears that the use of Metallogram remains indispensable at the beginning of a pregnancy, as well as during the breastfeeding period, in particular for the supervision of deficiencies in Zinc, Cobalt, Manganese, Selenium and Magnesium. It is well known that important deficiencies in Zinc at the beginning of a pregnancy can be responsible for genetic diseases, and even congenital malformations. One must not forget that all genetical information is linked to the quantified emission of cations in the cellular nucleus and that it is the D.N.A. that acts as nucleic support for the quantified stockage of genetical package. This is the reason why it is so important during the pregnancy to make sure that the D.N.A. structure is properly transmitted during the process of mitosis and the embryo s formation, along with verifying that there is an adequate proportion of metallic cations in the mother to avoid the deficiencies that may occur during the fetus formation. Indeed, the embryo followed by the fetus will take from the mother a great quantity of cations for his organism. Consequently, the mother can experience a situation of compromises, at the time when the labour hormonal mechanisms is imminent and during the retrieval of post-partum. Those endocrine modifications are frequent and they are intimately linked to cationic depletions suited to hormonological medium. The list on biological liquid Atomic Metallograms is not limited to the already mentioned cases, further studies are possible. The Metallogram may become an efficient mean for preventive medicine thanks to a better ground knowledge and when it finds its correct application within curative medicine as an additive determination to diagnostic. Before undertaking metallotherapy, it would be necessary and useful to rehearse a first Metallogram, then eventually to repeat the procedure on the second or third month of re-locating cationic treatment following the depletions seriousness that have been found in the analysis.. Glycan Group Page 3

The clinician can do a new control to check on therapeutic reaction and biological result. This way, we can biologically understand the evolution of the parameters, which are linked to the kinetic of the studied pathology. The Metallogram permits also to check the medicines intake, when these have been administered for several years or in the case of acute illnesses treatments that require very tough chemical medicine intake or in a large quantity. As a consequence, further than being able to detect the produced depletions, we can also correct its losses with the help of a defined and quantified contribution of metallic cations. COMPARAISON BETWEEN DIFFERENT METALLOGRAMS: BLOOD-URINE- SERUM-HAIR-SPERM The Hair Analysis has been the subject of many studies, most of them originating from hospital or researchers in private field. Once the sampling has been done from the Hair Analysis, it reveals that there are some discrepancies as far as the distribution of macro-elements (Na, K, Mg, P, Ca) are concerned so that when the deficiencies are serious, it is referred to as posteriori analysis. Still, the latter does not allow elaborating a suitable etiopathology, and therefore, does not present a major bio-medical interest. Although, thousands of test samples were established by specific pathologies and enumerated by numerous American studies published in the «MEDLINE», they do not grant any credibility to these exams. Furthermore, capillar tegument must not be considered as the main seating of a sufficient metabolic exchange that permits the attribution of a precise physiological, immunitary or hormonological origin to a deficiency or a noticed excess, due to the fact that both electrochemical and catalytical flows are not important enough. In addition, at an analytical level, the depletions variations comparing to the norm, are not scientifically significant for the trace-elements that are present in the liquids and biological substrats (0.05 to 0.10 mg/l). Besides, the induced environmental pollutions, such as heavy metals (Cd, Hg, Pb, Sn) or transition metals (V, Fe, Co, Ni) fake considerably the measures of these trace elements. The important trace elements such as «Lanthanides» or «Rare Earths» (14 elements) are not dispatched through the hair. Secondly, the SELENIUM evaluation (substantial metalloïd) is found to be controversial in the hair due to the industrial and urban pollutions, as well as shampoo. Glycan Group Page 4

As a consequence, the Hair Ionogram does not allow a complete multi-elementary analysis (55 oligos et 5 macro-elements) compared to Urinary Atomic Metallogram, neither permits the bio-supervising and therefore cannot deliver a pathologic image. As far as the therapist is concerned, there is a bio-medical interest when it is possible to check the medecine intake of his patients, with the help of several urinary metallograms, whether these medicines are chemical ones (homeopathy, phytotherapy, oligotherapy, etc ), physical (electrotherapy) or of energetic type (acupuncture, auriculomedicine ). The only serious indications related with the prescription of a Hair Metallogram or known dermoskeleton are linked to MENKES disease where depletions deficiencies of Zinc and Copper are equitably noticed. In severe professional intoxications due to heavy metals, the hair and dermoskeleton exam is scientifically founded. It has to be underlined that hospital analysis were carried out by non-professionals, with regard to medical and analytical plan. And that these analyses have greatly contributed to create «analytical mode» that has delayed numerous further serious studies on biological liquids (blood, urine, sperm). In conclusion, the interest does exist concerning the toxicological aspect once the Hair Analysis is coupled to heavy and toxic metals in other biological liquids (blood, sperm, urines, serum). The multi-elementary analysis conducted in total blood, plasma and other specialized fractionals, gives an interesting approach with regard to the amount of trace elements that are present in the circulatory. Blood offers the advantage to mix the extra cellular medium: red globules, leucocytes, blood platelets, erythrocytes. In fact, the produced image by a multi-elementary Metallogram within the blood is linked to kinetic distribution. It represents a constitutional image, which must be read with great bio-medical cautiousness. The variation of the plasmatic concentration of a given trace element, does not logically imply the same variation in other mediums. For instance, normal plasmatic Zinc does not always correspond to a normal erythrocytical Zinc. Some elements, such as RUBIDIUM (Rb), belong mainly to intra-cellular medium, the plasma therefore cannot be considered as the most significant medium to appreciate the concentration of variations for these elements. To conclude, blood analysis represents a constitutional image of medium circulation that must be correlated to urinary pathological image (depletion). Since the major concerns are being directed towards preventive medicine, this explains the choice of urinary depletion (One experiment out of several thousands of Metallograms). Glycan Group Page 5