Lower your costs. Save money with preferred generic and preferred brand-name drugs 2018 Aetna Rx Step Program Medicine List

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Call out bold Call out light Contact information, call X-XXX-XXX-XXXX or visit www.aetna.com Call to action small copy (especially related to mobile apps). Hendani adionse rferum faceatis incte voluptassi aut maximpe rumquid ebitatur? Ut labo. Mil mo blabore ssumque conet officim. Lower your costs Save money with preferred generic and preferred brand-name drugs 2018 Aetna Rx Step Program Medicine List Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. Disclaimer. www.aetna.com 2015 Aetna Inc. XX.XX.XXX.X (X/15) 05.03.392.1 G (8/17) aetna.com

You can save money when you make a preferred brand-name drug your first choice. This list shows the brand-name drugs that require. This means that you need to try the preferred brand drug first or your prescription may not be covered, and you may need to pay the full cost. So to save money, be sure to try the equivalent preferred generic drug or preferred brand-name drug first. Key UPPERCASE Brand-name medicine lowercase italics Generic medicine Drug class Acute bronchodilators Asthma PROVENTIL HFA XOPENEX HFA Try one week of each: PROAIR VENTOLIN HFA XOPENEX NEB Try one week of: levalbuterol inhalation solution BROVANA PERFOROMIST PULMICORT Antidepressants Depression APLENZIN nefazodone PEXEVA SEREVENT SEREVENT ASMANEX FLOVENT/HFA QVAR budeprion SR/XL bupropion SR/XL citalopram escitalopram fluoxetine fluvoxamine mirtazapine paroxetine/sr selfemra sertraline venlafaxine venlafaxine SR 2 Health benefits and insurance plans are offered, administered and/or underwritten by Aetna Health Inc., Aetna Health Insurance Company of New York, Aetna Health Insurance Company, Aetna HealthAssurance Pennsylvania Inc. and/or Aetna Life Insurance Company (Aetna). In Florida, by Aetna Health Inc. and/or Aetna Life Insurance Company. In Utah and Wyoming by Aetna Health of Utah Inc. and Aetna Life Insurance Company. In Maryland, by Aetna Health Inc., 151 Farmington Avenue, Hartford, CT 06156. Each insurer has sole financial responsibility for its own products. Aetna Pharmacy Management refers to an internal business unit of Aetna Health Management, LLC.

Drug class Antidepressants Depression FETZIMA KHEDEZLA PRISTIQ TRINTELLIX VIIBRYD VIIBRYD Kit from at least two different subclasses: For example: SSRIs citalopram, fluoxetine SNRIs duloxetine, venlafaxine TCAs amitriptyline, nortriptyline Heterocyclic antidepressants mirtazapine, trazodone Antimigraine agents Migraine headache AXERT CAMBIA RELPAX naratriptan rizatriptan sumatriptan zolmitriptan TREXIMET naratriptan rizatriptan sumatriptan zolmitriptan and concurrent use of prescription strength naproxen >/= 500 mg MIGRANAL Try one month of: dihydroergotamine nasal spray Two of the following naratriptan rizatriptan sumatriptan zolmitriptan Antispychotics/ bipolar disorder Behavioral ABILIFY CLOZARIL FANAPT REXULTI SAPHRIS VRAYLAR One atypical generic antipsychotic. For example: olanzapine, quetiapine, risperidone, ziprasidone or LATUDA GEODON INVEGA RISPERDAL RISPERDAL-M RISPERDAL solution SEROQUEL SEROQUEL XR ZYPREXA ZYPREXA ZYDIS Try one month of: LATUDA VERSACLOZ Try one month of: clozapine oral tablets FAZACLO One atypical generic antipsychotic (For example: olanzapine, quetiapine, risperidone, ziprasidone) or LATUDA 3

Drug class Angiotensin II receptor blocker High blood pressure BENICAR TEVETEN alone or with a hydrochlorothiazide (HCTZ) combination product for one month: candesartan eprosartan irbesartan losartan telmisartan valsartan BENICAR HCT Try any three of the following for one month each: candesartan/hctz eprosartan/hctz irbesartan/hctz losartan/hctz telmisartan/hctz valsartan/hctz TRIBENZOR Try any two of the following for one month each: candesartan/hctz + amlodipine eprosartan/hctz + amlodipine irbesartan/hctz + amlodipine losartan/hctz + amlodipine telmisartan/hctz + amlodipine telmisartan/amlodipine + HCTZ EXFORGE HCT AZOR Try any two of the following for one month each: candesartan + amlodipine eprosartan + amlodipine irbesartan + amlodipine losartan + amlodipine telmisartan + amlodipine telmisartan/amlodipine valsartan + amlodipine EXFORGE Attention deficit hyperactivity disorder (ADHD) Behavioral ADDERALL ADDERALL XR APTENSIO XR CONCERTA DAYTRANA DESOXYN DEXEDRINE FOCALIN FOCALIN XR METADATE CD METHYLIN chewable METHYLIN solution PROCENTRA QUILLIVANT XR RITALIN (brand only) RITALIN LA RITALIN SR ZENZEDI 2.5 mg ZENZEDI 5 mg for 14 days each: amphetamine/ dextroamphetamine SR dexmethylphenidate SR dextroamphetamine methamphetamine methylphenidate ER/SR STRATTERA VYVANSE 4

Drug class Attention deficit hyperactivity disorder (ADHD) Behavioral INTUNIV KAPVAY KAPVAY pack for 14 days each: amphetamine/ dextroamphetamine SR clonidine SR dexmethylphenidate SR dextroamphetamine guanfacine methamphetamine methylphenidate ER/SR STRATTERA VYVANSE Bisphosphonates Osteoporosis or bone BINOSTO for one month each: alendronate and ACTONEL ACTONEL with CALCIUM ATELVIA, or ibandronate HMG-CoA reductase inhibitors High cholesterol LIVALO atorvastatin fluvastatin lovastatin pravastatin simvastatin H. pylori agents Stomach ulcer HELIDAC Try all of the following in combination for 14 days: metronidazole tetracycline over-the-counter bismuth subsalicylate Nasal spray Allergy BECONASE AQ ZETONNA for two weeks each: NASONEX or VERAMYST or budesonide, fluticasone propionate or triamcinolone Nonsteroidal anti-inflammatory agents Inflammation or pain PENNSAID VIMOVO TIVORBEX ZORVOLEX for two weeks: for one month each: Any generic NSAID ibuprofen diclofenac etodolac fenoprofen flurbiprofen indomethacin ketoprofen ketorolac meclofenamate mefenamic acid meloxicam nabumetone naproxen oxaprozin piroxicam sulindac tolmetin Sedative and hypnotics Sleep EDLUAR INTERMEZZO SILENOR for one week: zolpidem zolpidem ER 5

This list indicates the common uses for which the drug is prescribed. Some drugs are prescribed for more than one. Brand-name drugs not listed here may be covered by your plan without the use of a generic first. Information provided here is not a substitute for medical advice or treatment. Step therapy does not apply to fully insured members in New Jersey. However, these programs are available to self-funded plans. Discuss this information with your doctor or care provider. Aetna assumes no liability for the information provided or for any diagnosis or treatment made in reliance thereon, nor is it responsible for the reliability of the content. Subject to state law restrictions. This document contains references to brand-name prescription drugs that are trademarks or registered trademarks of pharmaceutical manufacturers that are not affiliated with Aetna. Listed products are for informational purposes only and are not intended to replace the clinical judgment of the prescriber. Targeted therapeutic classes, specific drugs and criteria are subject to change. Aetna Pharmacy Management refers to an internal business unit of Aetna Health Management, LLC. This document may not be used after December 31, 2018. Policy forms issued in Oklahoma include: HMO OK COC-5 09/07, HMO/OK GA-3 11/01, HMO OK POS RIDER 08/07, GR-23, GR-29/GR-29N. Policy forms issued in Missouri include: AL HGrpPol 01R5, HI GrpAg 01, HO HGrpPol 01. 2017 Aetna Inc. 05.03.392.1 G (8/17) aetna.com