Alameda Alliance for Health Pharmacy & Therapeutics (P&T) Committee Decisions

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Alameda Alliance for Health FORMULARY UPDATE Effective: October 27, 2017. Drugs notated with an * have an undetermined implementation date Alameda Alliance for Health Pharmacy & Therapeutics (P&T) Committee Decisions The P&T Committee reviewed the efficacy, safety, cost, and utilization profiles of the following therapeutic categories and drug monographs at the September 14, 2017 meeting: Therapeutic Class Reviews Chelating Agents ADHD Treatment Agents Opioid Dependency Agents Atypical Antipsychotics Alzheimer s Disease Agents Parkinson s Disease Agents Hepatitis C Movement Disorders Agents for Atopic Dermatitis Insulins Insomnia Agents Pediculicides Methotrexate Injections The P&T Committee approved the following modifications to the formulary for the Alliance s Medi-Cal, and Alliance Group Care programs: Generic Name & Deferasirox Jadenu Granule Packet Add to formulary and add prior authorization Penicillamine Depen Add prior authorization Penicillamine Cuprimine Remove from formulary Trientine Syprine Add prior authorization Dimercaptosuccinic acid Chemet Remove fill limit of #105/fill Dexmethylphenidate 2.5, 5, 10 mg Rivaroxaban Focalin 2.5, 5, 10 mg Xarelto 15 mg Add age restriction 6-18 years Remove prior authorization, add quantity limit # 2/day - 1 -

Dextroamphetamine and Amphetamine 5, 7.5, 10, 12.5, 15, 20, 30 mg Methylphenidate HCl 40, 50, 60 mg Capsule ER Methylphenidate HCl ER 10 mg ER Methylphenidate HCl ER 20 mg ER Methylphenidate HCl 5, 10, 20 mg quinidine gluconate 324 mg SR tab Methylphenidate 10 mg/9, 15 mg/9, 20 mg/9, 30 mg/9 hr transdermal patch Atomoxetine 10, 18, 25, 40, 60, 80, 100 mg Guanfacine ER 1, 2, 3, 4 mg Tablet ER (24 hours) Methylphenidate HCl 20, 30, 40 mg Capsule ER (24 hours) Methylphenidate HCl 10 mg Capsule ER (24 hours) Dextroamphetamine 5, 10 mg Dextroamphetamine 5, 10, 15mg Lisdexamfetamine 10, 20, 30, 40, 50, 60 mg chewable Eszopiclone 1 mg, 2 mg, 3 mg Flurazepam 15 mg, 30mg Temazepam 15, 30 mg Adderall 5, 7.5, 10, 12.5, 15, 20, 30 mg Metadate CD 40, 50, 60 mg Capsule ER Metadate 10 mg ER Metadate 20 mg ER Ritalin 5, 10, 20 mg Quinidine Gluconate 324 mg SR tab Daytrana Strattera 10, 18, 25, 40, 60, 80, 100 mg Intuniv 1, 2, 3, 4 mg Tablet ER (24 hours) Ritalin LA 20, 30, 40 mg Capsule ER (24 hours) Ritalin LA 10 mg Capsule ER (24 hours) Dexedrine 5, 10 mg Dexedrine 5, 10, 15mg Vyvanse 10, 20, 30, 40, 50, 60 mg chewable Lunesta 1 mg, 2 mg, 3 mg Dalmane Restoril 15, 30 mg Add age restriction 3-18 years Add age restriction max 18 years; change age minimum from 3 years to 6 years Add age restriction 6-18 years, increase quantity to #3/day to allow for three times daily dosing Add age restriction 6-18 years #3/day Remove from formulary (no grandfather, no utilization) Add age restriction 6-18 years and quantity limit # 1 patch/day Remove step therapy and add quantity limit #1/1 day Add quantity limit #1 per day #1 per day #1 per day Add age restriction 3 18 years and add quantity limit #4 per day Remove from formulary (grandfather current users) Add to formulary with quantity limit #1/1 day Doxepin 3, 6 mg Silenor 3, 6 mg Add POS message "Use doxepin concentrate" Memantine 5, 10 mg and 5/10 mg dose pack Namenda 5, 10 mg and 5/10 mg dose pack Remove step therapy (maintain as formulary) - 2 -

Memantine 2 mg/ml oral Memantine XR Bromocriptine 5 mg Amantadine 50 mg/ml syrup Namenda 2 mg/ml oral Namenda XR Cycloset 5 mg Symmetrel 50 mg/ml syrup Remove from formulary and remove step therapy Update step therapy to include prior use of memantine (in addition to donepezil) Remove from formulary and remove prior authorization Remove from formulary Glecaprevir/Pibrentasvir Mavyret Add to formulary and add prior authorization Insulin Glargine Insulin Glargine Insulin Glulisine Insulin Glulisine Insulin Aspart Insulin Isophane Protamine/ Protamine/ Insulin Aspart Protamine and Insulin Aspart Insulin Isophane and Insulin Regular Natroba Malathion Benzyl Alcohol Lotion Lantus vial Lantus Solostar Apidra Apidra Solostar Humalog Kwikpen 100 unit/ml Novolog Flexpen Humulin N Kwikpen Humalog Mix 50-50 Kwikpen Humalog Mix 75-25 Kwikpen Novolog Mix 70-30 Flexpen Humulin 70-30 Kwikpen Spinosad Ovide Ulesfia Term grandfathering and remove from formulary Term grandfathering and remove from formulary Add to formulary and add QL #30 ml per 30 days Add to formulary and add QL #30 ml per 30 days failure of permethrin OTC or failure of permethrin OTC or Add to formulary and add step therapy (trail and failure of permethrin OTC or - 3 -

Ivermectin Piperonyl butoxide/pyrethrins/permet hrin kit Sklice Add to formulary and add step therapy (trail and failure of permethrin OTC or Add to formulary Permethrin 1% liquid Elimite 1% liquid Add to formulary Piperonyl/pyrethrins liquid Medi-Lice Remove from formulary (obsolete) Methotrexate 25 mg/ml vial Methotrexate Trexall Add to formulary Remove from formulary, grandfather current users Methotrexate Otrexup Add to formulary and add prior authorization Methotrexate Rasuvo Add to formulary and add prior authorization Tolterodine Tolterodine ER Lifitegrast Ophthalmic Detrol Detrol LA Xiidra failure of oxybutynin or oxybutynin ER) failure of oxybutynin or oxybutynin ER) Add to formulary and add prior authorization - 4 -

PRIOR AUTHORIZATION GUIDELINE UPDATES Urinary Incontinence Agents PA Criteria Testosterone agents Lipotropics Cyclosporine Ophthalmic (Restasis) Multaq (dronedarone) Malaria Entresto (sacubitril/valsartan) Anti-emetics PRIOR AUTHORIZATION GUIDELINES REVIEWED (NO UPDATES) Solaraze (diclofenac sodium) 3% DPP4 Inhibitors Incretin Mimetics/GLP-1 Agonists Inhaler Assistant Devices Niaspan (niacin) Cystic Fibrosis Agents Relistor (methylnaltrexone) Anti-Obesity SGLT2 inhibitors Flector (diclofenac epolamine) and Pennsaid (diclofenac) Xolair Pristiq (desvenlafaxine) For questions, please contact the Alliance s Pharmacy Services department at: 510.747.4541-5 -