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Infectious Diseases Weekly Report TOKYOIDWR Tokyo Metropolitan Infectious Disease Surveillance Center 12 January / Number 1 Surveillance System in Tokyo, Japan The infectious diseases which all physicians must report All physicians must report to health centers the incidence of the diseases which are shown at page one. Health centers electronically report the individual cases to Tokyo Metropolitan Infectious Disease Surveillance Center. The infectious diseases required to be reported by the sentinels The numbers of patients who visit the sentinel clinics or hospitals during a week are reported to health centers in Tokyo. And they electronically report the numbers to Tokyo Metropolitan Infectious Disease Surveillance Center. We have about 500 sentinel clinics and hospitals in Tokyo. Tokyo Metropolitan Institute of Public Health TEL:81-3-3363-3213 FAX:81-3-5332-7365 e-mail:www@tokyo-eiken.go.jp URL:idsc.tokyo-eiken.go.jp/

Number of patients with the diseases which all physicians must report Category I II III IV Diseases Tokyo 50th 51st 52nd 1st 1st Japan Ebola hemorrhagic fever Crimean-Congo hemorrhagic fever Smallpox South American hemorrhagic fever Plague Marburg disease Lassa fever Acute poliomyelitis Tuberculosis 61 62 81 14 14 132 132 Diphtheria Severe Acute Respiratory Syndrome(SARS) Middle East Respiratory Syndrome (MERS) Avian influenza H5N1 Avian influenza H7N9 Cholera Shigellosis 1 1 1 Enterohemorrhagic Escherichia coli infection 1 2 2 2 5 5 Typhoid fever Paratyphoid fever Hepatitis E 3 West Nile fever Hepatitis A 3 1 1 1 Echinococcosis Yellow fever Psittacosis Omsk hemorrhagic fever Relapsing fever Kyasanur forest disease Q fever Rabies Coccidioidomycosis Monkeypox Zika virus infection Severe Fever with Thrombocytopenia Syndrome Hemorrhagic fever with renal syndrome Western equine encephalitis Tick-borne encephalitis Anthrax Chikungunya fever 1 Scrub typhus(tsutsugamushi disease) 2 1 3 6 6 Dengue fever 2 2 2 2 Eastern equine encephalitis Avian influenza (excluding H5N1 and H7N9) Nipah virus infection Japanese spotted fever Japanese encephalitis Hantavirus pulmonary syndrome Herpes B virus infection Glanders Brucellosis Venezuelan equine encephalitis Hendra virus infection Epidemic typhus Botulism 1 1 1 1 Malaria Tularemia Lyme disease Lyssavirus infection(excluding rabies) Rift valley fever Melioidosis Legionellosis 5 1 2 8 8 Leptospirosis Rocky mountain spotted fever 1

Category V Diseases Tokyo 50th 51st 52nd 1st 1st Japan Amebiasis 4 4 4 1 1 1 1 Viral hepatitis(excluding hepatitis A and E) 1 2 1 2 2 CRE infection 1 5 3 3 9 9 Acute encephalitis(excluding JE and WNE) 3 2 4 2 2 11 11 Cryptosporidiosis Creutzfeldt-Jakob disease 2 2 Severe invasive streptococcal infections(tsls) 2 3 3 3 13 13 Acquired immunodeficiency syndrome (AIDS) 6 9 7 1 1 3 3 Giardiasis 1 Invasive Haemophilus influenzae disease 1 2 2 1 1 3 3 Invasive meningococcal disease 2 2 Invasive pneumococcal disease 7 5 6 7 7 54 54 Varicella (limited to hospitalized case) 1 1 1 1 4 4 Congenital rubella syndrome Syphilis 39 27 37 7 7 21 21 Disseminated cryptococcosis 1 Tetanus 1 Vancomycin-resistant S. aureus infection Vancomycin-resistant Enterococcus infection 1 Pertussis 8 8 Rubella Measles MDRA infection Number of patients with the diseases to be reported by the designated clinics and hospitals Diseases Tokyo 50th 51st 52nd 1st /sentinel Respiratory syncytial virus infection 88 103 96 54 0.22 Pharyngoconjunctival fever 197 184 141 46 0.18 Group A streptococcal pharyngitis 1,064 974 601 227 0.90 Infectious gastroenteritis 3,374 3,324 2,510 760 3.03 Chickenpox 205 145 124 108 0.43 Hand, foot, and mouth disease 153 97 59 10 4 Erythema infectiosum 30 33 18 19 8 Exanthem subitum 130 115 90 52 0.21 Herpangina 14 10 2 Mumps 31 16 28 16 6 Kawasaki disease 4 9 6 Cold with exanthems 14 10 21 3 1 Influenza 3,756 5,821 6,721 4,335 10.84 Acute hemorrhagic conjunctivitis 1 Epidemic keratoconjunctivitis 27 32 21 16 0.42 Bacterial meningitis 1 2 2 8 Aseptic meningitis 1 Mycoplasma pneumonia 4 2 6 1 4 Chlamydial pneumonia (excluding psittacosis) 2 1 4 Infectious gastroenteritis (only by Rotavirus) 1 1 4 Influenza-Associated Hospitalizations 21 41 51 86 3.44 ( Blank means 0. ) 2

Disease Trend Graph (weekly reported cases per sentinel in comparison) (Cases/sentinel) Respiratory syncytial virus infection Pharyngoconjunctival fever 5.00 Group A streptococcal pharyngitis 35.0 Infectious gastroenteritis 3 25.0 2 15.0 1 5.0 5.00 Chickenpox 2 Hand, foot, and mouth disease 15.0 1 5.0 3

(Cases/sentinel) 2.50 Erythema infectiosum Exanthem subitum 12.0 Herpangina Mumps 1 8.0 6.0 4.0 2.0 0 Kawasaki disease Cold with exanthems 75 50 25 0 4

(Cases/sentinel) 5 4 Influenza 3 2 1 Acute haemorrhagic conjunctivitis Epidemic keratoconjuncitivitis Bacterial meningitis Aseptic meningitis 5

(Cases/sentinel) 2.50 Mycoplasma pneumonia Chlamydia Pneumonia Infectious gastroenteritis (only by Rotavirus) 5.00 Influenza-Associated Hospitalizations 1.20 0.90 0.60 Number of sentinel facilities for weekly reporting Types of sentinels Number of sentinels Sentinels having reported Pediatric 264 251 Influenza 419 400 Ophthalmic 39 38 Speciallydesignated 25 25 6