1. Nutrition and Cancer 2. Strength of the Data Regarding Nutrition and Cancer Page - 1
3. Major Source of the DATA 4. Nutrition and Cancer Page - 2
5. Diets high in what dietary factors 6. Diets low in what dietary factors Page - 3
7. Foods and Risk of Cancer 8. Foods and Risk of Cancer Page - 4
9. Learning Objectives 10. Leading Causes of Death in US (1998) Page - 5
11. Cancer Mortality, 2002 (Females) 12. Cancer Mortality, 2002 (Males) Page - 6
13. Estimated Causes of Cancer in US, 1993 14. Causes of Cancer Page - 7
15. Cross-country Comparisons 16. Cancer: Definition Page - 8
17. Cancer Cells 18. 5 Themes: Role of Nutrition Page - 9
19. Nutrition and Cancer 20. Two Stages in Cancer Development Page - 10
21. Cancer Formation and Nutrition 22. Examples of ROS Page - 11
23. Theme 1: Antioxidants as Protectors of Initiation 24. Theme 1: Antioxidants as Protectors Against Initiation Page - 12
25. Cancer and Antioxidant Protection 26. Theme 2: Fat Intake as a Promoter of Cancer Page - 13
27. Theme 2: Fat Intake as a Promoter of Cancer 28. : Slide 28 Page - 14
29. Breast Cancer Incidence Rates in Migrant Pops. 30. Risk Factors for Breast Cancer Page - 15
31. Theme 2: Fat Intake 32. Case-Control Studies in Breast Cancer Page - 16
33. Dietary Fat and Breast Cancer (Nurse's Study) 34. Dietary Fat and Breast Cancer (Nurse s Study) Page - 17
35. Comparison of Estradiol Levels in British and Chinese Women... 36. Diet Intervention Study (N=55 pre-menopausal women) Page - 18
37. Nutrition Intervention Studies of Low Fat/High Fiber 38. Nutrition Intervention Trial: Women s Health Initiativ... Page - 19
39. Colon Cancer and Fat Intake: Promoter 40. Colon Cancer and Fat Intake Page - 20
41. Age-Adjusted Relative Risk of Colon Cancer 42. Intervention Studies in Colorectal Cancer (Fat and Fiber)... Page - 21
43. Intervention Trials on Fiber in Colorectal Cancer 44. Intervention Trials on Fiber in Colon Rectal Cancer Page - 22
45. Theme 3: Fiber Intake as an Anti-promoter 46. Quote Page - 23
47. Relative Risk of Colorectal Cancer 48. Relative Risk of Colorectal Cancer Page - 24
49. Theme 4: Differentiation and Vitamin A 50. Theme 4: Vitamin A and Differentiation Page - 25
51. Theme 4: Vitamin A and Differentiation 52. Theme 5: Phytochemicals Page - 26
53. Theme 5: Phytochemicals 54. : Slide 54 Page - 27
55. Theme 5: Phytochemicals Functions of Phytochemicals are Dive... 56. Theme 5: Phytochemicals Function of Phytochemicals, cont... Page - 28
57. : Slide 57 58. : Slide 58 Page - 29
59. : Slide 59 60. : Slide 60 Page - 30
61. Principles 62. Theme 5: Phytochemicals Page - 31
63. Summary: 5 Themes 64. Types of Studies on Nutrition and Cancer Page - 32
65. Challenges in Diet and Cancer 66. Bradford-Hill Criteria Page - 33
67. Cancers with the Strongest Links to Nutritional Factors 68. Current Dietary Recommendations to Decrease Risk of Cancer... Page - 34
69. Nutrition and Cancer Summary 70. Nutrigenomics Page - 35
71. Interaction Between Nutrition and the Human Genome 72. Direct and Indirect Effects of Nutrients on Gene Expression... Page - 36
73. Example: Type of Fat (n-3 fatty acids) 74. Concept Page - 37
75. Special Role of n-3 Fatty Acids Page - 38