Egg donation resort: the Spanish position? Valérie Vernaeve, MD PhD

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Egg donation resort: the Spanish position? Valérie Vernaeve, MD PhD vvernaeve@eugin.es

Outline of the presentation Cross border reproductive care in Europe Spain as an egg donation destination: quality of care legal situation organ donation experience profile of recipients and donors Experience of a large Spanish fertility clinic

Fertility treatments around the globe ±1.5 million IVF treatments/year worldwide Europe currently carries out 1/3 of them Spain in the top 3: 11% of Europe s (55.000 IVF trts/year) ESHRE 2012

Do patients travel? About 25.000 women/year perform a fertility treatment outside their own country Shenfield et al., Human Reprod 2010

Why do patients travel? Shenfield et al., Human Reprod 2010

Oocyte donation in Europe: Legal aspects? Differences between countries Non - regulated Egg donation Anonymous Egg donation Non-anonymous Egg donation Forbidden Egg donation

What about Spain and CBRC? 40% Cross-Border Reproductive Care in Europe is performed in Spain (± 10,000-15,000 treatments/year) 60% using donated sperm or oocytes

Egg donation in Spain 50% of egg donation treatments reported in Europe are performed in Spain on local and overseas patients Kupka et al. Hum. Reprod., 2014

Evolution of oocyte donation cycles in Spain 12000 OD cycles in Cataluña 10000 10146 8506 8000 7602 6000 5075 6285 4000 3026 3989 2000 613 701 1340 2012 0 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 SOURCE: FIVCAT

Why Spain? Spanish Clinics have an excellent reputation: For the quality of their assistance For their success rates - above the European average Kupka et al. Hum. Reprod., 2014

Why Spain? Assisted Reproduction Techniques (ART) and access to egg donation in Spain is protected by a very clear and rigorous law

Legal situation in Spain Egg donation: voluntary, anonymous and altruistic ART accessible to any woman, regardless of her marital status or sexual choice Double donation (sperm + egg donation allowed)

Legal situation in Spain Patients Minimum age: 18 Maximum age: adequate age - EUGIN 50 years Without medical contra indications for pregnancy

Legal situation in Spain Donors Age: 18 et 35 years Good physical and mental health Without infectious or hereditary/congenital diseases Maximum 6 children

Recommendations bioethical committee Information, inclusion criteria, practical aspects, informed consents, compensation, etc. Maximum 6 stimulations

Why Spain? Spain, world leader in organ donation for last 20 consecutive years

Why Spain? Families accepting organ donation at the moment of death: France: 70% Spain: 85% Now: anonymous kidney donation from a living donor allowed

Why Spain?

Why Barcelona? First Spanish ART baby was born in Barcelona Strict regulatory body ( FIVCAT Catalan Register for Assisted Reproduction) Cosmopolitan: easy to find suitable donors with varied characteristics

What about the donors in Spain and Europe? Human Reprod, mars 2014 1423 questionnaires in 11 European countries (60 centres) late 2011 mid 2012

Country of origin and of residence? Pennings et al., HR 2014

Motives for donation Pennings et al., HR 2014

Patient and donor characteristics of a large Spanish centre?

Oocyte donation activity at Eugin 2014: > 11.000 treatments 6.5000 IVF > 3.500 oocyte donation cycles Oocyte donation: Oocyte donation: ± 10% of the oocyte donation cycles in Europe are performed at clinical Eugin (Probably world leading clinic)

Who are Eugin s patients? 70% foreign patients Nationalities of foreign patients: 78 different countries 40% French main others: Italy, Swiss, MENA region, UK, German Profile of French oocyte recipient: mean age: 41 88% heterosexual couples 11% singles 1% homosexual couples

Who are Eugin s donors? Medium age: 26,8 years 42%: with partner 45,5%: with own children 60%: working 24%: unemployed 10%: student 4%: housewife 3%: others

Who are Eugin s donors? 71,5%: at least secondary school 100% live in Barcelona 84% Spanish Average number of cycles per donor in our clinic: 2,6

How donors know us? Word of mouth: 40% Internet: 37% Other: 23%

Motivation of our donors? 30% altruism 50% altruism + financial 20% financial

Conclusions Lots of patients cross their border in order to get a fertility treatment Reasons for travelling are: legal reasons, access difficulty, better quality, previous failures Spain is European top country for gamete donation: high quality of care pregnancy rates above European average very clear and rigorous law altruistic population with large history of organ transplantation Spanish donors are typical: highly educated, 27 years, living close by, working, altruistic

vvernaeve@eugin.es