HEALTHY REDUCTION-MCS TM

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HEALTHY REDUCTION-MCS TM Healthy Reduction-MCS Canine dry and wet diets are higher protein, lower energy, highly digestible, and provide a nutrient profile appropriate to support lean body mass in dogs that require calorie restriction for weight loss. Reduced caloric density allows for a more satisfying food volume 1 and along with high palatability improves owner compliance and success during a weight loss program. Overweight dogs are at higher risk of osteoarthritis 2,3,4 and weight loss can improve clinical signs 5,6. Supplementation with rich sources of omega 3 (EPA/DHA/DPA) provides an evidence-based method to help reduce joint inflammation in the management of dogs with osteoarthritis 7-10. Inclusion of prebiotics (FOS) helps maintain gastrointestinal health 11. Dry: 3 kg, 9.5 kg Wet: 400 g Maintenance Features: Higher protein levels to maintain lean 1, 12 body mass during weight loss Reduced caloric density 1 Rich levels of n-3 fatty acids (EPA/DHA/DPA) Increased levels of micronutrients to ensure adequate nutrient delivery during calorie restriction 13,14 Moderate to low sodium content Moderate Fat content (< 30% of ME from fat) Excellent palatability High digestibility Moderate fibre content with added prebiotics (fructooligosaccharides) maintains gastrointestinal health and normal stool volume. Complementary dry and wet diets provide an option of combination feeding (dry and wet), which may increase the success and compliance of weight loss, weight maintenance and/or joint health programs. Therapeutic Indications: Weight loss 1,15 Weight maintenance, and/or transition needs after successful weight loss programs Osteoarthritis 7,8,9 Inactive or sedentary lifestyle Risk of orthopedic disease and high physical demand activities Post orthopedic surgery Physical rehabilitation patients Acute and chronic pancreatitis -dependent 18, 19, 20, 21 on patient

INGREDIENTS (DRY): Turkey, dried peas, brown rice, fish meal, pea protein, turkey meal, tomato pomace, natural flavor, salmon oil (preserved with mixed tocopherols), fructooligosaccharides, calcium carbonate, sea salt, vitamins (vitamin E supplement, vitamin B12 supplement, niacin, d-calcium pantothenate, vitamin A acetate, biotin, riboflavin, thiamine mononitrate, vitamin D3 supplement, pyridoxine hydrochloride, folic acid), choline chloride, minerals (ferrous sulfate, zinc oxide, manganous oxide, copper sulfate, iron amino acid chelate, zinc amino acid chelate, manganese amino acid chelate, copper amino acid chelate, sodium selenite, cobalt carbonate, ethylenediamine dihydroiodine), rosemary extract. NUTRITIONAL DETAILS (Calculated **) & AMOUNT/CUP: Dry (3 kg, 9.5 kg) ME: 3359 kcal/kg as is; 3651 dry weight Approximate g/cup: 88 kcal/cup 297 Percentage of Metabolizable Energy from: Protein 37.2 % Fat 24.1 % CHO-NFE 38.6% Nutrient % As Is % Dry Matter (92%) G/1000 kcal Protein 35.78 38.90 115.79 Fat 9.53 10.36 30.84 Crude Fibre 4.49 4.88 14.52 CHO-NFE # 37.04 40.27 119.87 Calcium 0.97 1.05 3.14 Phosphorous 0.91 0.99 2.94 Potassium 0.81 0.88 2.62 Sodium 0.22 0.24 0.72 Magnesium 0.15 0.16 0.49 Copper (mg/kg) 17.21 mg/kg 18.71 mg/kg 5.57 mg EPA/DHA/DPA* 0.53 0.58 1.72 * Omega -3 fatty acids: eicosapentaenoic acid / docosahexaenoic acid / docosapentaenoic acid # Carbohydrate Nitrogen Free Extract = CHO-NFE **The values listed represent expected numbers and are based on thorough analysis of diet ingredients; some lot to lot variation due to ingredient related factors is expected. Strict attention to nutrients of clinical concern is upheld with quality assurance analyses prior to product release. INGREDIENTS (WET): Water, turkey, sweet potatoes, turkey liver, potato starch, potato protein, egg whites, pea fiber, guar gum, tricalcium phosphate, dried algae meal, vitamins and minerals (choline chloride, magnesium oxide, zinc amino acid complex, vitamin E supplement, iron amino acid complex, thiamine mononitrate, niacin, manganese amino acid complex, copper amino acid complex, vitamin A supplement, pyridoxine hydrochloride, d-calcium

pantothenate, riboflavin, sodium selenite, folic acid, vitamin B12 supplement, calcium iodate, vitamin D3 supplement, biotin), fructooligosaccharides, potassium chloride NUTRITIONAL DETAILS (Calculated **) & AMOUNT/CAN: Wet (400g) ME: 768 kcal/kg as is; 3,729 kcal/kg dry weight Approximate kcal/can = 307 Percentage of Metabolizable Energy from: Protein 40.2 % Fat 25.5 % CHO-NFE 34.3 % Nutrient % As Is % Dry Matter (20.61%) G/1000 kcal Protein 8.82 42.80 114.78 Fat 2.31 11.18 29.99 Crude Fibre 0.74 3.58 9.60 CHO-NFE # 7.54 36.58 98.10 Calcium 0.22 1.04 2.80 Phosphorous 0.17 0.82 2.20 Potassium 0.16 0.77 2.05 Sodium 0.07 0.34 0.90 Magnesium 0.02 0.09 0.23 Copper (mg/kg) 3.29 mg/kg 15.94 mg/kg 4.27 mg EPA/DHA/DPA* 0.14 0.66 1.77 FEEDING GUIDELINES Always follow your veterinarian s instructions, as feeding amounts can vary by as much 22, 23 as 30 % between dogs. Avoid free feeding (unless there is a specific medical reason); it may promote obesity over time, especially in spayed or neutered dogs. 24 The tables below can be used to estimate the amount to feed using the dog s optimum weight. Always introduce new foods gradually over 5-7 days by substituting larger amounts of the new food in place of the old diet. Please see our website to locate our handy Feeding Calculator under the heading Diets. The calculator can assist you with the caloric requirements,feeding volumes and includes combinations of wet and dry diet.

DRY (WEIGHT MAINTENANCE) Cups to Feed Per Day Grams to Feed Per Day 5-10 2.3 4.6 ⅔ - 1 54 91 10-20 4.6 9.1 1 1 ¾ 91 152 20-30 9.1-13.6 1 ¾ - 2 ⅓ 152 207 30-40 13.6-18.2 2 ⅓ - 3 207 256 40-50 18.2-22.7 3 3 ½ 256 304 50-60 22.7-27.3 3 ½ - 4 304 347 60-70 27.3-31.8 4 4 ½ 347 390 70-80 31.8-36.4 4 ½ - 5 390 432 80-90 36.4-40.9 5-5⅓ 432 472 90-100 40.9-45.5 5 ⅓ - 5 ¾ 472 510 WET (WEIGHT MAINTENANCE) Cans to Feed Per Day 5-10 2.3 4.6 ⅔ - 1 10-20 4.6 9.1 1 1 ⅔ 20-30 9.1-13.6 1 ⅔ - 2 ¼ 30-40 13.6-18.2 2 ¼ - 2 ¾ 40-50 18.2-22.7 2 ¾ - 3 ⅓ 50-60 22.7-27.3 3 ⅓ - 3 ¾ 60-70 27.3-31.8 3 ¾ - 4 ¼ 70-80 31.8-36.4 4 ¼ - 4 ⅔ 80-90 36.4-40.9 4 ⅔ - 5 ¼ 90-100 40.9-45.5 5 ¼ - 5 ½

Feeding guidelines are from the AAHA 2010 Nutritional Assessment Guidelines for Dogs and Cats 23.The above tables should be used as a starting guideline and the actual amounts fed may need to be increased or decreased based on each dog s individual energy requirements. Energy requirements will vary depending upon such factors as age, breed, gender and neuter status, activity level, and underlying disease state. After completion of a weight loss program dogs have a lower energy requirement and an individual pet may only require 10% more calories than needed to lose weight to maintain ideal body weight. 16,17 DRY (WEIGHT LOSS) Cups to Feed Per Day Grams to Feed Per Day 5-10 2.3 4.6 ½ - ¾ 39 65 10-20 4.6 9.1 ¾ - 1 ¼ 65 109 20-30 9.1-13.6 1 ¼ - 1 ⅔ 109 148 30-40 13.6-18.2 1 ⅔ - 2 148 184 40-50 18.2-22.7 2 2 ½ 184 217 50-60 22.7-27.3 2 ½ - 2 ¾ 217 249 60-70 27.3-31.8 2 ¾ - 3 ¼ 249 279 70-80 31.8-36.4 3 ¼ - 3 ½ 279 309 80-90 36.4-40.9 3 ½ - 3 ¾ 309 337 90-100 40.9-45.5 3 ¾ - 4 337 364 WET (WEIGHT LOSS) Cans to Feed Per Day 5-10 2.3 4.6 ½ - ¾ 10-20 4.6 9.1 ¾ - 1 ¼ 20-30 9.1-13.6 1 ¼ - 1 ⅔ 30-40 13.6-18.2 1 ⅔ - 2 40-50 18.2-22.7 2-2 ⅓ 50-60 22.7-27.3 2 ⅓ - 2 ¾ 60-70 27.3-31.8 2 ¾ - 3 70-80 31.8-36.4 3-3 ⅓ 80-90 36.4-40.9 3 ⅓ - 3 ⅔ 90-100 40.9-45.5 3 ⅔ - 4

Feeding guidelines are from the AAHA 2014 Weight Management Guidelines for Dogs and Cats 1.The above tables should be used as a starting guideline and the actual amounts needed to safely lose weight may need to be increased or decreased based on each dog s individual energy requirements. Some patients may require as much as 20% less calories than what is listed in the above table to successfully lose weight. 1 The target rate for safe weight loss in dogs is 1-2% weight loss/week. 1,12 Body condition score, muscle condition score and weight should be evaluated every 2-4 weeks during a weight loss program and feeding amounts adjusted to achieve an ideal rate of weight loss. An individualized weight loss program for each patient is necessary for successful weight loss and owner compliance. Using a gram scale to measure the amount of dry food to be fed is recommended, as it is more accurate than the use of a measuring cup. The use of a measuring cup leads to overfeeding especially when small volumes of food are required. 25 COMPATIBLE TREATS Rayne Rewards S.I.T. Every Dog Apple and Pumpkin biscuits (20 kcal/biscuit). Ensure that energy intake from treats does not exceed 10 % of daily kcal intake, and that the total kcal from treats is subtracted from the calculated daily kcal requirement when determining the volume of diet to be fed. 26 NUTRITIONAL ADEQUACY STATEMENT FOR DIFFERENCE LIFE STAGES Both diets have been formulated to meet the Association of American Feed Control (AAFCO) nutrient requirements for maintenance of adult dogs. HELP For veterinarians or clinic staff wanting to discuss individualized patient recommendations, obtain additional diet information, access the veterinary login, or any other questions, please call or email for a consult. One of the Rayne clinical consult team members will be pleased to communicate with you: consults@raynecanada.ca or 1-855-850-1410. Please see our website under Veterinary Team Resource Login for detailed weight/joint care information provided in our Rayne Proofs Healthy Reduction & Healthy Reduction Toolkit. References to support the above clinical indications and aid client discussions about the benefits of the above veterinary exclusive diets include: 1. Brooks D, Churchill J, Fein K, Linder D, Michel KE, Tudor K, Ward E, Witzel A. 2014 AAHA weight management guidelines for dogs and cats. JAAHA 2014; 50 (1): 1-10. 2. Kealy RD, Lawler DF, Ballam JM, Mantz SL, Biery DN, Greeley EH, Lust G, Segre M, Smith GK, Stowe HD. Effects of diet restriction on life span and age-related changes in dogs. J Am Vet Med Assoc 2002; 220: 1315-1320. 3. Kealy RD, Lawler DF, Ballam JM, Lust G, Biery DN, Smith GK, Mantz SL. Evaluation of the effect of limited food consumption on radiographic evidence of osteoarthritis in dogs. J Am Vet Med Assoc 2000; 217: 1678-1680.

4. Smith GK, Paster ER, Powers MY, Laler DF, Biery DN, Shofer FS, McKelvie PJ, Kealy RD. Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs. J Am Vet Med Assoc 2006; 229:690-693. 5. German AJ, Holden SL, Wiseman-Orr ML, Reid J, Nolan AM, Biourge V, Morris PJ. Quality of life is reduced in obese dogs but improves after successful weight loss. The Veterinary Journal 2012b; 192: 428-434. 6. Impellizeri JA, Tetrick MA, Muir P. Effect of weight reduction on clinical signs of lameness in dogs with hip osteoarthritis. J Am Vet Med Assoc 2000;216: 1089-1091. 7. Fritsch D, Allen TA, Dodd CE, et al. Dose-Titration Effects of Fish Oil in Osteoarthritic Dogs. J Vet Intern Med 2010; 24:1020-1026. 8. Roush JK, Cross AR, Renberg WC, et al. Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis. J Am Vet Med Assoc 2010; 236: 67-73 9. Roush JK, Dodd CE, Fritsch DA, et al. Multicenter veterinary practice assessement of the effects of omega-3 fatty acids on osteoarthritis in dogs. J Am Vet Med Assoc 2010; 236: 59-66. 10. Vandeweerd JM, Coisnon C, Clegg P, Cambier C, Pierson A, Hontoir F, Saegerman C, Gustin P, Buczinski S. Systematic review of efficacy of nutraceutical to alleviate clinical signs of osteoarthritis. J Vet Intern Med 2012; 26:448-456. 11. Cave N. Nutritional management of gastrointestinal diseases. In: Delaney SJ, Fascetti A (eds). Applied Veterinary Clinical Nutrition. Chichester,UK: Wiley-Blackwell,2012:175-219. 12. Michel, K. Nutritional Management of Body Weight. In: Fascetti A and Delaney SJ (eds). Applied Veterinary Clinical Nutrition. 1st Edition. Chichester, UK: Wiley-Blackwell 2012. pp. 109-124. 13. Linder DE, Freeman LM, Morris P, German AJ, Biourge V, Heinze C, Alexander L. Theoretical evaluation of risk for nutritional deficiency with caloric restriction in dogs. Veterinary Quarterly 2012; 23: 123-129. 14. Nguyen P, Diez M. Nutritional aspects of obesity. Waltham Focus 2006; 16: 33-38. 15. Roudebush P, Schoenherr WD, Delany SJ. An evidence based review of the use of therapeutic foods, owner education, exercise, and drugs of the management of obese and overweight pets. J Am Vet Med Assoc 2008b; 233: 717-725. 16. German AJ, Holden, S.L, Morris P.J., Biourge V. Long-term follow-up after weight management in obese dogs: The role of diet in preventing weight gain. Vet J 2012a; 192: 65-70. 17. German AJ, Holden SL, Mather NJ, Morris PJ, Biourge V. Low-maintenance energy requirements of obese dogs after weight loss. Br J Nutr 2011a; 106: S93-S96. 18. Villaverde C. Nutritional management of exocrine pancreatic diseases. In: Delaney SJ, Fascetti A (eds). Applied Veterinary Clinical Nutrition. Chichester, UK: Wiley-Blackwell, 2012:221-233. 19. Mansfield, C. Acute Pancreatitis in dogs: Advances in understanding diagnostics, and treatment. Top Companion Anim Med 2012; 27 (3): 123-32. 20. Watson PJ, Archer J, Roulois AJ, et al. Observational study of 14 cases of chronic pancreatitis in dogs. Vet Rec 2010; 167 925): 968-76 21. Watson P. Chronic pancreatitis in dogs. Top Companion Anim Med. 2012; 27 (3): 133-9 22. Subcommittee on Dog and Cat Nutrition, Committee on Animal Nutrition, National Research Council. Nutrient requirements of dogs and cats, 2006. 23. Baldwin K, Bartges J, Buffington T, et al. AAHA nutritional assessment guidelines for dogs and cats. J Am Anim Hosp Assoc 2010;46(4):285-96. 24. Jeusette I, Detilleux J, Cuvelier C, et al. Ad libitum feeding following ovariectomy in female Beagle dogs: effect on maintenance energy requirement and on blood metabolites. J Anim Physiol Anim Nutr (Berl) 2004;88(3-4):117-21. 25. German AJ, Holden SL, Mason SL, Bryner C, Bouldoires C, Morris PJ, Deboise M, Biourge V. Imprecision when using measuring cups to weigh out extruded dry kibble food. J Anim Physiol Anim Nutr (Berl) 2011b; 95: 368-373. 26. Fascetti AJ and Delaney SJ. Feeding the healthy dog and cat. In: Delaney SJ, Fascetti A (eds). Applied Veterinary Clinical Nutrition. Chichester,UK: Wiley-Blackwell,2012:75-94. Last updated: June 2, 2017 (9807, 700)