Houston Society of Clinical Pathologists and The Methodist Hospital Department of Pathology and Genomic Medicine combine to present

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Houston Society of Clinical Pathologists and The Methodist Hospital Department of Pathology and Genomic Medicine combine to present Houston lung symposium April 28-29, 2012 Program Director: Philip T. Cagle, M.D. The Methodist Hospital Research Institute, Texas Medical Center, Houston

Program Director Philip T. Cagle, M.D. The Methodist Hospital Research Institute Medical Director, Pulmonary Pathology Department of Pathology and Genomic Medicine Professor of Pathology and Laboratory Medicine Weill Medical College of Cornell University Needs Assessment: There have many advances and paradigm shifts in pulmonary pathology and medicine, especially lung cancer, over the past few years. These include: (1) New targeted therapies for lung cancer and associated biomarkers, including new lung cancer biomarker guidelines under development by the College of American Pathologists., The International Association for the Study of Lung Cancer and the Association for Molecular Pathology. (2) New pathologic classification for adenocarcinoma of the lung proposed by the International Association for the Study of Lung Cancer, the American Thoracic Society and the European Respiratory Society. (3) New staging protocol for lung cancer by the American Joint Committee on Cancer, the International Union for Cancer Control and the College of American Pathologists. (4) New guidelines for the diagnosis of diffuse malignant mesothelioma. (5) New guidelines for the pathologic and clinical diagnosis and management of idiopathic pulmonary fibrosis by the American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society, the Latin American Thoracic Society, the Society of Thoracic Radiology and the Pulmonary Pathology Society. (6) Development of new pathology imaging techniques for the in-vivo microscopic-level diagnosis of pulmonary diseases. Target Audience: This activity is directed towards practicing pathologists, pulmonologists and oncologists and trainees in the field of pathology, pulmonology and oncology. Educational Methods: The program format will consist of didactic lectures with Q&A and discussions. Handouts will be provided. Evaluation: Evaluation by questionnaire will address program content, presentation, and possible bias. Accreditation: This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Texas Medical Association (TMA) and the Houston Society of Clinical Pathologists. The TMA is accredited by the ACCME to provide continuing medical education for physicians. Credit Designation: The TMA designates this educational activity for a maximum of 15 AMA PRA Category 1 Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity. Policy on Disclosure: In order to meet the requirements of the ACCME it is the policy of The TMA that all individuals who are in a position to control the content of a CME activity (activity director, planning committee members, and faculty) disclose relevant financial relationships with commercial interests. All identified conflicts of interest are managed to help ensure that the educational material is scientifically based, accurate, and objectively presented. Faculty are also required to disclose any discussion of off-label or investigational uses of any commercial products or devices not yet approved in the United States. Specific disclosure will be made to the participants prior to the educational activity.

Faculty Yung-Jue Bang, M.D. Seoul National University Hospital Seoul, Korea Alain C. Borczuk, M.D. Columbia University Medical Center New York, New York Paul Bunn, M.D. University of Colorado Comprehensive Cancer Center Denver, Colorado Lucian Chirieac, M.D. Brigham & Women s Hospital Boston, Massachusetts Andrew Churg, M.D. University of British Columbia Vancouver, Canada Thomas Colby, M.D. Mayo Clinic Arizona Scottsdale, Arizona Sanja Dacic, M.D., Ph.D. University of Pittsburgh Pittsburgh, Pennsylvania Lida P. Hariri, M.D., Ph.D. Massachusetts General Hospital Boston, Massachusetts Juergen Hetzel, M.D. University of Tuebingen Tuebingen, Germany James R. Jett, M.D. Journal of Thoracic Oncology National Jewish Health Denver, Colorado Keith Kerr, M.D. Aberdeen Royal Infirmary Aberdeen University Medical School Scotland, United Kingdom Marc Ladanyi, M.D. Memorial Sloan-Kettering Cancer Center New York, New York Kevin O. Leslie, M.D. Mayo Clinic Arizona Scottsdale, Arizona Neal I. Lindeman, M.D. Brigham & Women s Hospital Boston, Massachusetts Laura MacConaill, Ph.D. Center for Cancer Genome Discovery Dana-Farber Cancer Institute Boston Massachusetts Jeffrey Myers, M.D. University of Michigan Ann Arbor, Michigan Geoffrey R. Oxnard, M.D. Dana-Farber Cancer Institute Boston, Massachusetts Ignacio Wistuba, M.D. The University of Texas MD Anderson Cancer Center Stephen T. C. Wong, Ph.D., P.E. The Methodist Hospital Houston, Texas Maureen F. Zakowski, M.D. Memorial Sloan Kettering Cancer Center New York, New York

Program Schedule Educational Objectives: Saturday, April 28, 2012 1. Understand and diagnose interstitial lung diseases in the context of updated concepts and classifications of these diseases 2. Differentiate benign from malignant neoplasms of the lung and pleura 3. Comprehend recently implemented and proposed changes to the pathology of lung cancer 7:45-8:00 am Welcome-Philip Cagle, M.D. 8:00-8:45 am Proposed New Classification of Lung Cancer Keith Kerr, M.D. 8:45-9:30 am Dilemmas in Lung Cancer Staging Sanja Dacic, M.D., Ph.D. 9:30-10:15 am Benign Tumors and Tumor-Like Conditions of the Lung Alain Borczuk, M.D. 10:15-10:45 am Break 10:45-11:30 am Update on Mesothelioma Lucian Chirieac, M.D. 11:30-12:00 pm Clinical Genotyping of Lung Cancer: Beyond EGFR and EML4-ALK, Beyond Adenocarcinoma Marc Ladanyi, M.D. 12:00-12:30 pm Role of Cytopathology in the Molecular Diagnostics and Targeted Therapy of Lung Cancer Maureen Zakowski, M.D. 12:30-1:00 pm Lunch 1:30-2:15 pm Separation of Benign versus Malignant Mesothelial Proliferations Andrew Churg, M.D. 2:15-3:00 pm Update on Idiopathic Interstitial Pnuemonias Thomas Colby, M.D. 3:00-3:30 pm Break 3:30-4:15 pm Pulmonary Pathology of the Rheumatic Diseases Kevin Leslie, M.D. 4:15-5:00 pm The Changing Role of Pathology in Managing Patients with Unexplained Diffuse Lung Disease Jeffrey Myers, M.D. 5:00-5:30 pm Panel Discussion 5:30 pm Adjournment-Philip T. Cagle, M.D.

7:45-8:00 am Welcome-Philip Cagle, M.D. 8:00-8::30 am Worldwide Overview of the Current Status of Lung Cancer Diagnosis and Treatment Paul Bunn, M.D. 8:30-9:00 am EGFR, ALK and KRAS Molecular Testing in Lung Adenocarcinoma: Why, When and How Neal I. Lindeman, M.D. 9:00-9:30 am Treatment of ALK-Positive NSCLC Yung-Jue Bang, M.D. 9:30-10:00 am Strategies to Overcome Resistance to EGFR Target Therapies Geoffrey R. Oxnard, M.D. 10:00-10:30 am Break 10:30-11:00 am Cryobiopsy in Pulmonary Diseases Jurgen Hetzel, M.D. 11:00-11:30 am Advancing Personalized Cancer Medicine in Lung Cancer Laura MacConaill, M.D. 11:30-12:30 pm Lunch 12:30-1:00 pm Volumetric Optical Frequency Domain Imaging of Lung Pathology: Improving Biopsy Sampling and Evaluation Lida P. Hariri, M.D., Ph.D. 1:00-1:30 pm Lung Cancer Differential Diagnosis by Label-Free, Molecular Vibrational Imaging Stephen T. C. Wong, Ph.D., P.E. 1:30-2:00 pm Screening for Lung Cancer: Who Should be Screened? James Jett, M.D. 2:00-2:30 pm Molecular Pathology of Lung Cancer: Changes in Prevention and Therapy Paradigms Ignacio Wistuba, M.D. 2:30-3:00 pm Panel Discussion Program Schedule Educational Objectives: Sunday, April 29, 2012 1. Be familiar with the role of current and future molecular targeted therapies, whole genome analysis and predictive biomarkers in the personalized health care of lung cancer patients 2. Appreciate advances in technology that impact the future early diagnosis and screening of lung cancer patients 3:00 pm Adjournment-Philip T. Cagle, M.D.

Harlan J. Spjut Award Dinner The Board of Directors of the Houston Society of Clinical Pathologists established the Harlan J. Spjut Award in 1989, upon the announcement of Dr. Spjut s retirement, to recognize an individual who has demonstrated sustained and distinguished schoraly achievement in pathology or related disciplines. This year s recipient is Thomas Wheeler, MD, Professor and Chair of the Department of Pathology and Immunology at the Baylor College of Medicine. Spouses, guest of conference recipients and other persons not registered for the Symposium are welcome to attend. However, due to limited space, advanced reservations are required. Please call (713) 524-4267 ext. 223 for more information. POLICY OF DISCLOSURE It is the policy of the Texas Medical Association that all planners and faculty disclose real or apparent conflicts of interest relating to the topics of this educational activity. Detailed disclosure will be made in the syllabus of the course materials. ACCOMMODATIONS A block of rooms has been set up at the Houston Marriott Hotel at the Texas Medical Center under the name of The Methodist Hospital at a discounted rate of $179 for Singles and doubles. Code: MEP, Rate Program: MEPA. For reservations call: 1-800-465-4213. HOUSTON Houston is the fourth-largest city in the U.S. and more than 90 languages are spoken throughout the Houston area. Houston s George Bush Intercontinental Airport (a Continental Airlines hub) is located 23 miles north of the Texas Medical Center and Hobby Airport (a Southwest Airlines hub) is located 12 miles southeast of the Texas Medical Center. The Texas Medical Center is the world s largest medical complex, situated on 675 acres and housing 42 institutions and 13 patient care facilities. PARKING Parking is $12 for 7 hours or more. Walking distance to MITIE: Garage 7 (off of John Freeman Blvd.) Garage 1 (off of Bertner Ave.) Garage 3 (corner of E. Cullen St. And Ross Sterling Ave.) Commons Garage (John P. McGovern Commons-Water Wall) Near Houston Marriott Hotel: Smith Garage (Smith Tower) Scurlock Garage (Scurlock Tower)

Registration Houston Society of Clinical Pathologists 53 Annual Symposium & The Methodist Hospital Lung Seminar Saturday, April 28-29, 2012 Name: Degree: Address: City: State: Zip: Ph: ( ) - Fax: ( ) - Institution/Affiliation: Email: @ Specialty: Designation: Student Res/Fellow Faculty Alumni Other Prior to 3/30/12 After 3/30/12 Reg Type: 1 Day 2 Day Reg Type: 1 Day 2 Day HSCP Member $275 $450 Phys. Non-Mem $300 $475 Res/Fellow $90 $150 Non-Physician $115 $175 HSCP Member $300 $475 Phys. Non-Mem $325 $500 Res/Fellow $115 $175 Non-Physician $175 $200 Your registration must be prepaid. NO REFUNDS AFTER March 20, 2012 Online registration: www.houstonpathologists.org OR fax attention to Stefanie Cunanan at (713) 528-0951 Payment Type: Check(payable to HSCP) Amex DC MC VISA Name on Card: Account #: Exp. Date: Spjut: ($100/person) Auth. Total Amt: - - - / (# of tickets) X $100= Total: $ Special Assistance: In compliance with the Americans with Disibilities Act, the Houston Society of Clinical Pathologists will make reasonable efforts to accomdate persons with disabilities at this meeting. Please call (713) 524-4267 ext. 223

Houston Society of Clinical Pathologists John P. McGovern Bldg. 1515 Hermann Drive Houston, TX 77004 53 Annual Spring Symposium And the The Methodist Hospital Lung Seminar Saturday, April 28-29, 2012 For more information log on to www.houstonpathologists.org OR call (713) 524-4267 ext. 223