Antiviral Library. HBV Subset. Focus on non-nucleoside compounds

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Antiviral Library BV ubset ocus on non-nucleoside compounds YAI, eb, 2015

Isosteric transformations eference Compounds examples W 2014106019 BV replication inhibition in immortalized murine hepatocyte (AML12)-derived stable cell line (AML12BV10) and liver ep DE19 cells (EC 50 < 1 M) in MTT assays. Baruch Blumberg Institute Me high diversity :C,, W 2014184350 spiro analogues BV replication inhibition in human hepatoma epg2.2.15 and epg2.117 cells (EC 50 <0.005 and 0.005 M, respectively). It showed no cytotoxicity against epg2 cells (CC 50 >100 M upon 4 days incubation), in resazurin assays. Janssen &D Ireland C 103664897 (2014) BV DA replication inhibition (98% at 500 nm) in human hepatoma epg2.2.15 cells in a qpc-based assay. EC Pharm W 2015011281 BV replication inhibition in human hepatoma epg2.2.15 (EC 50 < 0.004 M) and epg2.117 (EC 50 = 0.002 M) cells in in vitro assays without cytotoxicity against epg2 cells (CC 50 > 100 M) in resazurin assays Janssen &D Ireland Compound extracted from Lllicium henryi C 103864699 (2014) everse transcriptase inhibitors inhibit IV-1 reverse transcriptase BV with an IC 50 =0.41 M (in human liver epg2 2.2.15 cancer cell) Peking University antiviral activity against BsAg and BeAg antigens (IC 50 = 0.43 and 0.5 M; in ELIA assays) and it also showed significant cytotoxicity (TC 50 = 3.28 M; using MTT method) in human hepatoma ep G2 2.2.15 cells with therapeutic index values of 7.6 and 6.6, respectively. Zhengzhou University C 103304528 (2013) W 2014033167 :, BV replication inhibition EC 50 = 0.21 and 0.62 M, in epg2.2.15 and epg2.117 cells, respectively Antivir es 2014, 107: 6 BM601, a novel inhibitor of BV W 1999058526 C 103739597 (2014) W 2014161888 significant antiviral activity against BsAg, BeAg antigens and inhibited BV DA replication (IC 50 =121.49, 19.73 and 23.51 mcm, respectively) in human hepatoma ep G2.2.15 cells without showing any significant cytotoxicity (CC50 = 2466.06 mcm) in MTT assays. Kunming Institute of Botany activity against human hepatoma ep G2.2.15 (stably transfected with BV genome) and ep G2.117 (stably inducible BV producing cell line) cells (EC 50 = 0.065 and 0.091 M, respectively). Janssen &D Ireland Me + W 2001038308 sanguinarine derivatives C 103360402 (2014)

University of Maryland Bioorg Med Chem Lett 2005, 15(24): 5397 U 2013059895 compound inhibited BV-DA (IC 50 =5.4 M and CC 50 >100 M) U 2014316132 Toll-like receptor TL7 ligand that stimulated I-alpha production in human peripheral blood mononuclear cells (MEC = 0.03 M). eported to be useful for the treatment of BV al these compounds dose-dependently inhibit activity of BV polymerase (by 42% at 1 mcg/ml) and also CV A-dependent A-polymerase (5B, by 75% at 10 mcg/ml) in vitro W 1998033501 Gilead ciences W 2011061590 W 2007014023 (C)n antiviral activity in lymphoid MT2 cells infected with 92T599-MT2 IV-1 strain with 104.5 and 80.45% inhibition at 1 and 0.1 M, respectively, and IC 50 values of 0.0117 and 0.0242 M, in p24 estimation assays. It also showed cell viabilities of 99.97 and 89.93% at 1 and 0.1 mcm, respectively, against MT2 cells (CC 50 >1 M), in MTT cytotoxicity assays Bioorg Med Chem 2010, 18(14): 5048 n:1-3 W 2002079187 U 2015038515 CCC-0975, dose-dependently reduced cccda (10, 20 and 70% reduction at 1, 3 and 10 mcm, respectively) and DP-rcDA levels in epde19 cells. compound inhibited BV proliferation in epg2 cellular assays (EC 50 =0.01 M). IC 50 <1.1 µm and I>90.9 ch Pharm 2011, 344(2): 78 U 2009324544 Enanta Pharmaceuticals, Inc. W 2005095376 compound inhibited BV replication in 2.2.15 human hepatoma cells with respective EC 50 and EC 90 values of 0.6 M and 3.4 M. 42nd Intersci Conf Antimicrob Agents Chemother (ICAAC) (eptember 27-30, an Diego) 2002, Abst -1697 C-04522, inhibited BV DA replication in epg2 2.2.15 cells with IC 50 and CC 50 values of 1.46 and 221.11 M (I=151.06) respectively, in MTT assays C 102584690 (2012) EC 50 =4 M,BV-transfected human ep G2 cells C 102690262 (2012) J Med Chem 2011, 54(16): 5660

Topological analogues ChemDiv Compounds (examples) W 2014106019 C448-0243 3019-0256 G211-0001 J030-0938 template W 2014161888 K205-1685 G631-0128 321-1357 T787-2497 T865-2312 Et 2 Et Et C 103664897 (2014) 7430-0485 D188-0088 D481-0749 1502-1501 E543-0004 C202-2756 C 103864699 (2014) 3455-0488 K781-0122 K286-0076 8011-2020 C200-3043

Topological analogues ChemDiv Compounds (examples) template Me Antivir es 2014, 107: 6 W 1999058526 W 2001038308 7282-5623 0504-0688 K606-0071 K976-0383 K784-2343 G542-0710 P055-0019 P803-1103 V020-5138 V001-2303 V017-3870 G542-0089 J057-1068 027-0125 8017-0343 Me D314-0432

Topological analogues ChemDiv Compounds (examples) template Br 254-0033 022-1697 517-1123 721-0476 D289-0082 G839-0146 Br 8563-1215 4617-1526 C893-0478 Me T853-0551 D322-0036