Timo Siepmann, M.D. Biographical sketch. Academic and clinical appointments Beth Israel Deaconess Medical Center

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Timo Siepmann, M.D. Biographical sketch Department of Neurology, Institute of Clinical Pharmacology University Hospital Carl Gustav Carus Dresden University of Technology 01307 Dresden, Saxony Germany I Phone: +49-351-458-18578 I Fax: +49-351-458-4365 timo.siepmann@uniklinikum-dresden.de I siepmann@ppcr.hms.harvard.edu As a clinical neuroscientist who received training in clinical neurology and neurological research in leading international universities such as Harvard Medical School and Charité University Medicine Dr. Siepmann is dedicated to patient care and advancing clinical and basic neuroscience with a focus on the development of novel techniques to diagnose and treat disorders of the autonomic nervous system. Motivating his work is a passion for discovery and international collaboration in research to elucidate new insights in neuroscience and connect neuroscience with complementary disciplines in an international collaborative approach to illuminate our understanding of the autonomic nervous system and build bridges between scientists of different countries and cultures. Academic and clinical appointments 2011-present University Hospital Carl Gustav Carus Resident and, since 2012, stroke fellow, Department of Neurology; Instructor in clinical pharmacology, Institute of Clinical Pharmacology, Dresden University of Technology, Dresden, Germany 2010-2011 Beth Israel Deaconess Medical Center Clinical research fellow, Center for Autonomic and Peripheral Nerve Disorders, Harvard Medical School, Boston, MA 2009-2011 MediClin Klinikum- Rostock Medical Faculty Teaching Hospital, Resident and director of the Laboratory for Autonomic Functions and Biofeedback, at the Department of Neurology, University of Rostock, Plau, Germany

Scientific leadership positions 2014-present Dresden International University Program director, Master s Degree Program in Clinical Research (M.Sc.) Dresden, Germany Harvard Medical School Site director, Carl Gustav Carus Site Center, Principles and Practice of Clinical Research, Department of Continuing Education, Harvard Medical School, Boston, MA 2009-2012 Medical Council Mecklenburg-Vorpommern Course director, Academia neurologica, Plau, Germany Education and doctoral thesis 2008 University Hospital Carl Gustav Carus Thesis:The effects of venlafaxine on autonomic and cognitive functions, thesis with distinction, Institute of Clinical Pharmacology, Dresden University of Technology, Dresden, Germany 2002-2008 Charité University Medicine Berlin, Germany Teaching Medical Faculty Carl Gustav Carus Lecturer, Autonomic Disorders in the Elderly (geriatrics main course lectures); seminar facilitator, Antibiotics (clinical pharmacology main seminar); lecturer, Clinical Neurology (practical bedside seminar) Dresden University of Technology, Dresden Germany 2014- present Dresden International University Seminar facilitator, Neurological Emergencies, Economic Aspects of Clinical Research, Scientific Presentation (postgraduate seminars), Division of Medical Sciences Honors and awards 2013 International Society for Autonomic Neuroscience and European Federation of Autonomic Societies Travel Award 2012 American Academy of Neurology International Scholarship Award 2011 International Society for Autonomic Neuroscience and American Autonomic Society Travel Award

2011 American Academy of Neurology International Scholarship Award 2010 German Society of Clinical Pharmacology Rudolf Buchheim Award 2010 German Research Foundation Fellowship 2010 American Autonomic Society Fellowship Award 2009 Medical Faculty Carl Gustav Carus Carl Gustav Carus Award for Outstanding Dissertation Review and advisory panels 2014-present New England Journal of Medicine Peer reviewer Neuropsychiatric Disease and Treatment Editorial Board Journal of Contemporary Medical Education Associate Editor American Journal of Pharmacological Sciences Editorial Board Member 2012 Academy of Neurology Abstract Reviewer, AAN-autonomic disorders section, 64th Annual Meeting Peer reviewer for several international journals including Nutrition and Dietary Supplements, Degenerative Neurological and Neuromuscular Disease, Journal of Clinical Immunology, Autonomic Neuroscience: Basic and Clinical, Journal of Public Health, Journal of Surgery, Deutsche Medizinische Wochenschrift Membership in professional societies : 2010-present: 2009-present German Neurological Society Harvard University Alumni Club of Berlin German Society of Clinical Pharmacology Hartmann Bund (German Medical Society)

Community services 2006-2013 Charité University Medicine Berlin Student Council Co-Chairman, Actions No Words Germany Selected Publications 1. Siepmann T, Heinke D, Kepplinger J, Barlinn K, Gehrisch S, Grählert X, Schwanebeck U, Reichmann H, Puetz V, Bodechtel U, Gahn G. Interaction of clopidogrel and statins in secondary prevention after cerebral ischemia a randomized, double-blind, double-dummy crossover-study. Br J Clin Pharmacol 2014; doi: 10.1111/bcp.12416. [Epub ahead of print] 2. Siepmann M, Hennig UD, Siepmann T, Nitzsche K, Mück-Weymann M, Petrowski K, Weidner K. The Effects of Heart Rate Variability Biofeedback in Patients with Preterm Labour. Appl Psychophysiol Biofeedback 2014; Mar;39:27-35 3. Siepmann T, Bodechtel U. Teaching NeuroImage: Macaroni Sign; Neurology 2014 Jul 1;83:e11 4. Siepmann T, Tesch M, Krause F, Illigens BM, Stoltenburg-Didinger G. Polymyositis with cytochrome C oxidase negative fibers - a pathological and clinical challenge. Ann Diagn Pathol 2013;17:183-6 5. Illigens BM*, Siepmann T*, Roofeh J, Gibbons C. Laser-Doppler Imaging in the Detection of Peripheral Neuropathy. Auton Neurosci 2013;177:286-90 * authors contributed equally 6. Siepmann T, Penzlin AI, Illigens BMW. Autonomic neuropathies. Dtsch Med Wochenschr 2013; 138:1465-9 7. Siepmann T, Penzlin AI, Illigens BMW. Autonomic neuropathy diagnosis and evidence based treatment. Dtsch Med Wochenschr 2013 ;138:1529-32 8. Goltz L, Bodechtel U, Siepmann T. Statins and ASA for primary prevention of cardiovascular and cerebrovascular disease. Dtsch Med Wochenschr 2013;139:283-6 9. Siepmann T, Yazar F, Illigens BM. A new journal of medical education: opportunities in an evolving field of science. J Contemp Med Edu 2013;1:67-8 10. Siepmann T, Gibbons C, Lafo J, Brown C, Freeman R. Quantitative Pilomotor Axon-Reflex Test A Novel Test of Pilomotor Function. Arch Neurol. 2012;6:1-5 11. Siepmann T, Roofeh J, Kiefer FW, Edelson DG. Hypogonadism and Erectile Dysfunction Associated With Soy Product Consumption. Nutrition 2011;27:859-62 12. Lindauer A, Siepmann T, Oertel R, Jung A, Ziemssen T, Jaehde U, Kirch W, Siepmann M. Pharmacokinetic/pharmacodynamic modeling of venlafaxine: pupillary light reflex as test system for noradrenergic effects. Clin Pharmacokinet 2008;47:721-31 13. Siepmann T, Mück-Weymann M, Oertel, R, Pittrow D, Kirch W, Siepmann M. The effects of venlafaxine on cognitive functions and quantitative EEG in healthy volunteers. Pharmacopsychiatry 2008;41:146-50 14. Siepmann T, Ziemssen T, Mueck-Weymann M, Kirch W, Siepmann M. The effects of venlafaxine on autonomic functions in healthy volunteers. J Clin Psychopharm 2007;27:687-91

Textbook 1. Kirch W, Siepmann T, Kullak-Ublick GA (Editors). Arzneimitteltherapie (Drug therapy). Thieme, Stuttgart, 2012 Abstract publications Over 25 abstract publications and congress presentations on international scientific meetings including annual meetings of the American Academy of Neurology, the American College of Clinical Pharmacology, and the American Autonomic Society