Natural Approaches to Supporting Healthy Mood

Natural Approaches to Supporting Healthy Mood

Integria Healthcare and Standard Process sponsor these webinars to provide health care information to practitioners and to provide them the opportunity to hear about the views, recommendations and experiences of other practitioners. Health related information provided here is not a substitute of medical advice. Integria, Standard Process and the speaker, Kerry Bone, have not evaluated the legal status of any products (except for Standard Process and MediHerb products), services or recommendations with respect to state or federal laws, including scope of practice. Integria, Standard Process and Kerry Bone do not and cannot accept responsibility for errors or omissions or for any consequences from applications of the information provided and makes no warranty, expressed or implied, with respect to the information provided. Audience members are reminded to be aware of and comply with their scope of practice at all times. Forms of mental illness can be very serious conditions and should be treated only by properly trained and licensed professionals. Nothing herein recommends, nor should any of this content be interpreted as recommending, that a person without proper training and licensure should treat mental illness or any other condition. The products discussed in this webinar are not intended to diagnose, treat, cure or prevent any disease. Kerry s recommendations for Standard Process and MediHerb product dosages are sometimes different than the doses that appear on the product labels. Please refer to the product labels or to the product descriptions found in the product catalogs or on the website for Standard Process and MediHerb dosage recommendations. 2

Our Topics Lifestyle Herbs and nutrients Supporting healthy sleep in mood challenges Addressing mood through healthy inflammatory response function, including mitochondrial support 3

Lifestyle and Mood Neuroprogression Poor Diet Impaired Sleep Reduced Physical Activity Immunoinflammation Neurotransmitter Imbalances Oxidative & Nitrosative Stress HPA Imbalances Mitochondrial Disturbances Depressive Disorder Lopresti AL, Hood SD, Drummond PD. J Affect Disord 2013; 148(1): 12-27 PMID 23415826 4

Healthy Mood: Key Herbs Gold standard evidence for St John s Wort Saffron Rhodiola Kava Address NI drivers Nrf2 Sleep quality Additional mitochondrial support as per the case https://en.wikipedia.org/wiki/kava#/media/file:starr_070515-7054_piper_methysticum.jpg Bone KM, Mills SY. Principles and Practice of Phytotherapy: Modern Herbal Medicine. 2nd Edition, Elsevier, UK, 2013 5

Molendijk ML et al. Molecular Psychiatry 2011; 16: 1088-1095. PMID: 20856249 6

Saffron and Mood Systematic review of Saffron (30 mg/day extract) in mood: 6 studies, concluded evidence was positive 1 Since then, Saffron (30 mg/day extract) and fluoxetine (40 mg/day) were equivalent in 6- week RCT of 40 patients with mood issues, recently undergone a coronary procedure 2 1. Lopresti AL, Drummond PD. Hum Psychopharmacol 2014; 29(6): 517-527 PMID 25384672 2. Shahmansouri N, Farokhnia M, Abbasi SH et al. J Affect Disord 2014; 155: 216-222 PMID 24289892 7

Saffron Mechanisms in Mood NMDA-R antagonism Antioxidant activity and healthy inflammation support Neuroprotective activity Monoamine neurotransmission probably negligible effects Bone K, MediHerb e-monitor No.42, July 2012, P1 Lopresti AL, Drummond PD. Hum Psychopharmacol 2014; 29(6): 517-527 PMID 25384672 8

Saffron and Age-related Memory Loss Saffron (30 mg/day stigma extract) versus donepezil (10 mg/day) in 54 patients with moderate memory loss equal efficacy after 22 weeks 1 More effective than placebo (same dose) in 46 patients over 16 weeks 2 Recently, saffron (same dose) versus memantine (20 mg/day) in 68 patients with moderate to severe memory loss equal efficacy after 12 months 3 1. Akhondzadeh S, Shafiee Sabet M, Harirchian MH et al. Psychopharmacology (Berl) 2010; 207(4) :637-643 2. Akhondzadeh S, Sabet MS, Harirchian MH et al. J Clin Pharm Ther 2010; 35(5): 581-588 3. Farokhnia M, Shafiee Sabet M, Iranpour N et al. Hum Psychopharmacol 2014; 29(4): 351-359 9

Saffron and Retinal Flicker Retinal flicker sensitivity (RFS) dynamic retinal vascular diameter change in response to flickering light endothelial/microvascular function 1 RFS in memory loss subjects 2 Saffron (20 mg/day) improved RFS in an RCT of 25 patients with age-related vision changes 3 1. Chang LY, Lowe J, Ardiles A et al. Alzheimers Dement 2014; 10(2): 251-261 2. http://www.abc.net.au/worldtoday/content/2015/s4217520.htm 3. Falsini B, Piccardi M, Minnella A et al. Invest Ophthalmol Vis Sci 2010; 51(12): 6118-6124 10

Rhodiola and Mood 6-week RCT (n=99): two doses (340 or 680 mg/day extract) versus placebo mood, sleep and emotions all improved in both Rhodiola groups 1 12-week RCT (n=57): Rhodiola extract (340 mg/day) versus sertraline (50 mg/day) versus placebo Rhodiola active but less than drug, but fewer side effects 2 1. Darbinyan V, Aslanyan G, Amroyan E et al. Nord J Psychiatry 2007; 61(5): 343-348. PMID: 17990195 2. Mao JJ, Xie SX, Zee et al. J Phytomedicine 2015; 22(3): 394-399 PMID 25837277 11

Rhodiola and Mood Postulated mechanism via animal models improved sensitivity of GR via downregulation of stress-activated protein kinases (SAPK) Image: Opiola Jerzy CC by 2.5 taken 24 June 2006 Bone K Mediherb e-monitor no. 19, 2007, p1 12

Kava Anxiety Mood Spectrum Study Anxiety Outcome Mood Outcome Sarris J, Kavanagh DJ, Byrne G, Bone KM etal. Psychopharmacology (Berl) 2009; 205(3):399-407 13

Key Herbs for Sleep Onset Valerian Passion Flower Zizyphus Kava Corydalis California Poppy Chaste Tree Chamomile 14

Key Herbs for Sleep Maintenance St John s Wort Chaste Tree Valerian Kava Licorice and/or Rehmannia Image: H Zell GNU Free Documentation License taken 12 August 2009 15

Key Herbs for Restorative Sleep Withania Rhodiola Korean Ginseng or Schisandra Licorice Rehmannia Image: VoDeTan2 GNU Free Documentation License 16

Addressing Healthy Mood as NI Downregulate Neuroinflammation Brain Mitochondrial Function Mood as NI Neuroprotection/ Cytoprotection Antioxidant Protection 17

Addressing Healthy Mood as NI O&NS MtD AOx Conventional Treatments NP Inflam CMI Maes M, Fišar Z, Medina M et al. Inflammopharmacology 2012; 20(3): 127-150 PMID 22271002 18

Addressing Healthy Mood as NI Key abbbreviations O & NS = oxidative and nitrosative stress AOx = lower levels of antioxidants Inflam = inflammation CMI = cell-mediated immune responses MtD = mitochondrial dysfunction NP = neuroprogression 19

Addressing Healthy Mood as NI O&NS MtD AOx Novel Therapy: Nrf2 activators NP Inflam CMI Maes M, Fišar Z, Medina M et al. Inflammopharmacology 2012; 20(3): 127-150 PMID 22271002 20

Turmeric Rosemary Green tea Key Nrf2 Activators Grape Seed Garlic Ginkgo Resveratrol (Polygonum) 21

Switching off NI Systemic inflammation and its drivers Brain inflammation: Boswellia Turmeric Omega-3 fatty acids Image: J.M. Garg GNU Free Documentation License taken 14/02/09 22

Support Mitochondrial Function Omega-3 fatty acids Medium chain fatty acids (MCFA), eg coconut oil Key herbs: Hawthorn Resveratrol (Polygonum) Ginkgo Magnesium Other Nrf2 herbs 23

Key Nrf2 Herbs Turmeric/curcumin Rosemary/carnosol and carnosic acid Green Tea Polygonum/resveratrol Garlic Ginkgo Schisandra 24

Herb Summary Saffron/St John s Wort Rhodiola Kava Sleep herbs as needed Boswellia/Turmeric Hawthorn Ginkgo Other Nrf2 herbs 25

Thank You and Questions 26