Wednesday, August 15, 2018 IASLC School of Thoracic Oncology Program Agenda Chairs: Luis E. Raez (USA), Luis Corrales-Rodriguez (Costa Rica) 7:30 a.m. Breakfast and Registration 8:15 a.m. 8:20 a.m. 8:45-9:15 a.m. 9:15-9:45 a.m. 9:45-10:15 a.m. 10:15-10:30 a.m. 10:30-11:00 a.m. 11:00-11:30 a.m. 11:30-11:45 a.m. 11:45 a.m. - 12:45 p.m. Welcome and Introductions Luis E. Raez (USA), Eduardo Richardet (Argentina) Pre-meeting Test Pulmonary Medicine Miriam Lasanosky (Argentina) Pathology Fred Hirsch (USA), Marileila Varella-Garcia (USA) Thoracic Surgery Francisco Tarrazzi (USA) Break Radiation Oncology Ana Botero (USA), Berta Roth (Argentina) Medical Oncology Christian Rolfo (USA) Question and Answers Norma Pilnik (Argentina) Working Lunch: Biostatistics Eduardo Cuestas (Argentina) 1
Wednesday, August 15, 2018 Participants will be divided into five groups and each group will rotate through each working station 12:45-1:15 p.m. 1:15-1:45 p.m. 1:45-2:15 p.m. 2:15-2:30 p.m. Workstation 1, Pulmonary Miriam Lasanosky (Argentina) Workstation 2 (Pathology) Ignacio Wistuba (USA) Workstation 3 (Thoracic Surgery) Daniel Maldonado (Argentina) Break 2:30-3:00 p.m. 3:00-3:30 p.m. 3:30-4:00 p.m. 4:00 p.m. TO BE ANNOUNCED Workstation 4 (Radiation Oncology) Ana Botero (USA), Gustavo Ferraris (Argentina) Workstation 5 (Medical Oncology) Luis E. Raez (USA), Eduardo Richardet (Argentina) Post-meeting Test Wrap up and Adjourn Workshop LATM Molecular Pathology Working Group 2
Thursday, August 16, 2018 10:15-11:40 a.m. Patient Advocacy 1 Location: To Be Announced Chairs: Nise Yamaguchi (Brazil), Eduardo Cazap (Argentina) 10:15 a.m. 10:20 a.m. 10:30 a.m. 10:40 a.m. 10:50 a.m. 11:00 a.m. 11:10 a.m. 11:20 a.m. Welcome Nise Yamaguchi (Brazil) Tumor Molecular Profile: A New Challenge Luis Mas (Peru) Learning from Patients: The Story of LALCEC To Be Announced Our Body Helping to Cure Cancer: Immunotherapy Diego Kaen (Argentina) Celebrating the Survivors: The Story of To Be Announced Communication Skills Martin Richardet (Argentina) Is it Easy to Get New Drugs in Latin America? Open Discussion Lucia Delgado (Uruguay) Round Table Nise Yamagushi (Brazil), Guadalupe Pallotta (Argentina), Eduardo Cazap (Argentina) Noon - 1:00 p.m. OPENING CEREMONY Location: TBA Chairs: Eduardo Richardet (Argentina), Norma Pilnik (Argentina), Christian Rolfo (USA) Welcome and Introduction to LALCA 2018, Eduardo Richardet (Argentina) The future of lung cancer management in Latinoamerica, Norma Pilnik (Argentina) Welcome from IASLC CEO, Fred R. Hirsch (USA) 3
Thursday, August 16, 2018 1:00-2:00 p.m. 1:00 p.m. 1:15 p.m. 1:30 p.m. 1:45 p.m. CANCER CONTROL PROGRAM AND TOBACCO FORUM 1 (4th Floor) Chairs: Nise Yamaguchi (Brazil), Lucia Delgado (Uruguay) Early Detection in Heavy Smoker Lucia Llambi (Uruguay) Importance of Smoking Cessation in the Treatment of Lung Cancer Patient Raquel Pendito (Argentina) Framework convention in WHO in LATA Nise Yamaguchi (Brazil) Panel Discussion Eduardo Cazap (Argentina), Jaime de la Garza (Mexico) Concurrent Industry Supported Symposia 2:15-3:15 p.m. Location: Lugones 1 Industry Symposium Supported by To Be Announced Location: Lugones 2 Industry Symposium Supported by To Be Announced LUNG CANCER SCREENING 3:30-4:30 p.m. 3:30-3:50 p.m. 3:50-4:10 p.m. 4:10-4:30 p.m. Location: To Be Announced Chairs: Edgardo S. Santos (USA), Luis Corrales-Rodriguez (Costa Rica) Lung Cancer screening in clinical practice & guidelines Luis Corrales-Rodriguez (Costa Rica) Lung Cancer Screening: Impact in Survival and Economics Monica Campos (Argentina) Lung Cancer Screening in Latin America: Challenges and Progress Carlos Barrios (Brazil) 4
Thursday, August 16, 2018 4:45-6:45 p.m. DIAGNOSTIC IMAGING INNOVATION Chairs: Luis Fein (Argentina), Jorge Alatorre (Mexico) 4:45 p.m. PET CT scan as a tool for lung cancer management: Utility Marcelo Claria (Argentina) YOUNG INVESTIGATOR S SESSION Location: Salon Champaqui Chairs: Christian Caglevic (Chile), Martin Richardet (Argentina) 4:45 p.m. How to write a manuscript and a research grant? Gilberto Lopes (USA) 5:00 p.m. EBUS and Navigation system to yield a diagnosis. Francisco Tarrazzi (USA) 5:05 p.m. How to incorporate research in Latin America? Roberto I. Lopez (Panama) 5:15 p.m. Stereotactic Body Radiotherapy in NSCLC with oligometastic Disease. Ana Botero (USA) 5:25 p.m. The role of medical school to promote basic and clinical research obstacles, resources and policies Gabriel Rabinovich (Argentina) 5:30 p.m. Role of Interventional Radiology in the modern era of lung cancer. Carlos Rojas (Peru) 6:00-7:00 p.m. OPPOSED INDUSTRY SUPPORTED SYMPOSIUM Location: Room 1 (TBA) OPPOSED INDUSTRY SUPPORTED SYMPOSIUM Location: Room 2 (TBA) 7:00-9:00 p.m. WELCOME RECEPTION Location: TBA Palacio Ferreira 5
Friday, August 17, 2018 7:00-9:00 a.m. 8:00-9:30 a.m. IASLC Business Meeting (By Invitation Only) Location: Salon Las Sierras PRESIDENTIAL SYMPOSIUM Presentation & Discussion of Top Rated Abstracts Chairs: Eduardo Richardet (Argentina), Norma Pilnik (Argentina), Giorgio Scagliotti (Italy) 8:00 a.m. TBD 8:15 a.m. TBD 8:30 a.m. TBD 8:45 a.m. TBD 9:00 a.m. TBD 9:15 a.m. TBD 9:00 a.m. - 6:00 p.m. EXHIBITION OPEN Location: TBA 9:30-10:30 a.m. GENERAL SESSION 1: INNOVATIVE CLINICAL TRIAL DESIGN FOR NSCLC. Chairs: Carlos Vallejos (Peru), Christian Rolfo (USA) 9:30 a.m. 9:45 a.m. 10:00 a.m. 10:15 a.m. Bringing Opportunities in Clinical Research for Latin America. Denisse Bretel (Peru) Master Protocols David Gandara (USA) Lung MAP Roy Herbst (USA) Bringing Research to the Patient: Remote Consenting for a Novel trial: Genomics of Young Lung Cancer. Ezequiel Klimosky (Argentina) 6
Friday, August 17, 2018 NETWORKING BREAK AND POSTER VIEWING [Poster Session 1] 10:30-11:00 a.m. Location: Exhibit Hall, Sheraton Hotel Snacks and refreshments provided 11:00 a.m. - noon GENERAL SESSION 2: Lung Cancer Pathology in The Era of Targeted Therapy Chairs: Marileila Varella-Garcia (USA), Liliana Darluzo (Argentina) GENERAL SESSION 3: Diagnostic and Staging Issues in the Contemporary Pulmonary Medicine Chairs: David Smith (Argentina), Claudia Poleri (Argentina) 11:00 a.m. The importance of Histologic Diagnosis in Lung: Clinical Implications Martin Paradelo (Argentina) 11:00 a.m. Assessment of the Pulmonary Nodule Sergio Luchino (Argentina) 11:15 a.m. Tissue Quality Control for Molecular Testing Ignacio I. Wistuba (USA) 11:15 a.m. Potential and Limitations of EBUS for Diagnosis and Staging Francisco Tarrazzi (USA) 11:30 a.m. Gene expression profile for role in the era of targeted Therapy Luis E. Raez (USA) 11:30 a.m. Optimization of Bronchoscopic Samples in the Era of Molecular Pathology Mark Block (USA) 11:45 a.m. Questions and Answers 11:45 a.m. Roadmap for Liquid Biopsy in Lung Cancer. Christian Rolfo (USA) 7
Friday, August 17, 2018 12:15-1:15 p.m. GENERAL SESSION 4 Molecular Markers in Lung Cancer Chairs: Rafael Rosell (Spain), Mario Varangot (Uruguay) 12:15 p.m. 12:30 p.m. 12:45 p.m. 1:00 p.m. Molecular Markers in Lung Adenocarcinomas Marileila Varella-Garcia (USA) Molecular Markers in Squamous cell carcinoma Rafael Rosell (Spain) Molecular Diagnosis Guidelines Recommended Internationally Fred R. Hirsch (USA) Molecular Testing in Lung Cancer: Efforts and Perspectives in Latin America Oscar Arrieta (Mexico) GENERAL SESSION 5: New Developments in Surgery Location: Salon Champaqui Chairs: Ricardo Terra (Brazil), Nestor Bustamante (Argentina) 12:15 p.m. 12:30 p.m. 12:45 p.m. 1:00 p.m. Invasive Mediastinal Staging: Mediastinoscopy, EBUS and EUS Francisco Tarrazzi (USA) VATS, Robot-Assisted or Thoracotomy for Lung Cancer Surgery Ricardo Terra (Brazil) Sublobar Resection for Stage I NSCLC Mark Block (USA) Navigation system to secure tissue diagnosis To Be Announced (Argentina) Thoracic Society-PRES 1:30-2:30 pm. Industry Symposium Supported By: TBA Location: Salon Las Sierras 8
Friday, August 17, 2018 2:45-4:00 p.m. GENERAL SESSION 6: Adjuvant Therapy in the Molecular Era Location: TBA Chairs: Gonzalo Recondo (Argentina), Clarissa Mathias (Brazil) 2:45 p.m. 3:00 p.m. 3:15 p.m. 3:30 p.m. 3:45 p.m. Adjuvant Chemotherapy for NSCLC: Where are we now? Norma Pilnik (Argentina) Role of Targeted Agents in the Adjuvant Setting Clarissa Mathias (Brazil) Is there a role for immunotherapy in Lung Cancer Adjuvant Setting? Edgardo S. Santos (USA) Prognostic and Predictive Makers for Adjuvant Therapy NSCLC Osvaldo Aren (Chile) Question and Answers 4:00-4:30 p.m. NETWORKING BREAK AND POSTER VIEWING [Poster Session 1] Location: Exhibit Hall 9
Friday, August 17, 2018 4:30-5:30 p.m. GENERAL SESSION 7: Stage IIIA/B Non-Small Cell Lung Cancer Chairs: Santiago Bella (Argentina), Jorge Gallardo (Chile) 4:30 p.m. 4:45 p.m. 5:00 p.m. 5:15 p.m. Optimal Radiation Dose and Schedule Gustavo Ferraris (Argentina) Optimal Combined Modality Therapy for LA-NSCLC Alberto Chiappori (USA) Is there a role of Neoadjuvant Therapy for N2 disease Edgardo S. Santos (USA) Integration of Molecular Imaging and Agents in LA- NSCLC Luis Mas (Peru) GENERAL SESSION 8: Squamous Cell Carcinoma Chairs: Claudio Martin (Argentina), Luis Ubillos (Uruguay) 4:30 p.m. 4:45 p.m. 5:00 p.m. 5:15 p.m. Biological insights of Squamous Cell Carcinoma Novel Targets Jorge Gomez (USA) Maintenance therapy in Squamous cell carcinoma Gilberto Castro (Brazil) Checkpoint inhibitors and vaccines in Squamous cell carcinoma Martin Dietrich (USA) How to approach second-line in Squamous Cell Carcinoma David Gandara (USA) Industry Supported Symposium 5:45-6:45 p.m. Location: TBA (TWO ROOMS; 1 SYMPOSIA) 8:15-11:00 p.m. Faculty Dinner - By Invitation Only Location: TBA 10
Saturday, August 18, 2018 Registration Open 8:00 a.m. - 5:00 p.m. Location: Sheraton Hotel 8:00-9:15 a.m. Poster Discussion Session 1 1 Chairs: Giorgio Scagliotti (Italy), Eduardo Richardet (Argentina) Poster Discussion Session 2 2 Chairs: Fred R. Hirsch (USA), Norma Pilnik (Argentina) 8:00 a.m. PD.1.01 8:00 a.m. PD.2.01 8:05 a.m. PD.1.02 8:05 a.m. PD.2.02 8:10 a.m. PD.1.03 8:10 a.m. PD.2.03 8:15 a.m. Discussant: TBA 8:15 a.m. Discussant: TBA 8:30 a.m. Question & Answer Period 8:30 a.m. Question & Answer Period 8:35 a.m. PD.1.04 8:35 a.m. PD.2.04 8:40 a.m. PD.1.05 8:40 a.m. PD.2.05 8:45 a.m. PD.1.06 8:45 a.m. PD.2.06 8:50 a.m. Discussant: TBA 8:50 a.m. Discussant: TBA 9:05 a.m. Question and Answers 9:05 a.m. Question and Answers 11
Saturday, August 18, 2018 9:30-10:30 a.m. GENERAL SESSION 9: Management of Advanced Stage Non- Squamous-NSCLC Chairs: Christian Rolfo (USA), Norma Pilnik (Argentina) 9:30 a.m. 9:45 a.m. 10:00 a.m. 10:15 a.m. Front Line Therapy for EGFR/ALK/ROS-1 Genomic Aberrations Rafael Rosell (Spain) How to deal with ALK resistance- How far to go? Christian Rolfo (USA) Selecting Patients for Maintenance Therapy Giorgio Scagliotti (Italy) Molecular Targeted Therapy for Brain Metastases and Leptomeningeal Disease Ignatious Ou (USA) 10:20 a.m. Questions and Answers GENERAL SESSION 10: Immunotherapy in Non-Small Cell Lung Cancer Chairs: Ana Oton (USA), Eduardo Richardet (Argentina) 9:30 a.m. 9:40 a.m. 9:50 a.m. 10:00 a.m. 10:10 a.m. Immunotherapy: Making it in a Simple Language Gabriel Rabinovich (Argentina) Predictive Assays for Immunotherapy Fred R. Hirsch (USA) Clinical Trials with Anti-PD-1 inhibitors Luis E. Raez (USA) Clinical Trials with Anti-PDL-1 inhibitors Clarissa Mathias (Brazil) Other immunotherapy pathways CTL4 and others David Carbone (USA) 10:30-11:00 a.m. Networking Break and Poster Viewing (Poster Session 2) Location: Exhibit Hall 12
Saturday, August 18, 2018 11:00 a.m. - 12:30 p.m. ROUND TABLE DISCUSSIONS Location: TBD Chairs: Diego Kaen (Argentina), Martin Richardet (Argentina) Novel approaches in surgery: Robotic Surgery, VATS, Navigation System. Palliative Care in Lung Cancer. Treatment of Wild Type Lung Cancer Tumours First and Second Line. Therapy of Tumours Carrying EGFR Mutations or ALK Translocations. How to Study Molecular Biology and Tumour Markers. Radiation Therapy in Lung Cancer. New Molecules and Therapies for Lung Cancer. Diagnosis and Staging in Lung Cancer. Locally Advanced Non-Small Cell Lung Cancer. 13
Saturday, August 18, 2018 Therapy of EGFR/ALK Resistant Lung Cancer Tumours. Management of Toxicities from Immunotherapies in Lung Cancer Adjuvant therapy in Non-Small Cell Lung Cancer Management of Limited and Extensive Small Cell Lung Cancer Liquid Biopsy in Lung Cancer Chair Christian Rolfo (USA), David Gandara (USA) 14
Saturday, August 18, 2018 12:45-1:45 p.m. GENERAL SESSION 11: Small Cell Lung Cancer & Neuroendocrine Tumor (Net) Chairs: Oscar Arrieta (Mexico), Nise Yamaguchi (Brazil) 12:45 p.m. 1:00 p.m. 1:15 p.m. 1:30 p.m. Small Cell Cancer Biology: Are there new targets? Ruben Salanova (Argentina) Systemic therapy for SCLC Brian Hunis (USA) Success and Challenges of Radiation Therapy for SCLC Berta Roth (Argentina) Management of Well- Differentiated NET. Andres Cardona / Luis Mas GENERAL SESSION 12: Advanced Radiation Technology Chairs: Silvia Zunino (Argentina), Jorge Gonzalez (Chile) 12:45 p.m. 1:00 p.m. 1:15 p.m. 1:30 p.m. Radiation Oncology Challenges in Latin America Hugo Marsiglia (Chile) Role of SBRT in Early Stage NSCLC Moises Russo (Chile) Role of SBRT in Advanced NSCLC Silvia Zunino (Argentina) Role of Proton in Lung Cancer Ana Botero (USA) 15
Saturday, August 18, 2018 2:00-3:00 p.m. 3:15-4:15 p.m. INDEPENDENT SATELLITE SYMPOSIUM Location: Salon Las Sierras GENERAL SESSION 13: Novel Therapies Targeting Lung Cancer Pathways Chairs: Paul A. Bunn, Jr. (USA), Luis E. Raez (USA) 3:15 p.m. 3:25 p.m. 3:35 p.m. 3:45 p.m. 3:55 p.m. RET/BRAF Paul A. Bunn, Jr. (USA) MET and MET exon 14 skipping Rafael Rosell (Spain) DNA Repair Inhibitors David Gandara (USA) NF-1 David Carbone (USA) NTRK Giorgio Scagliotti (Italy) GENERAL SESSION 14: Mesothelioma, Thymoma, and Thymic Carcinoma Chairs: Brian Hunis (USA), Jorge Madrid (Chile) 3:15 p.m. 3:25 p.m. 3:45 p.m. 3:55 p.m. VATS and Robotic Surgery in Mesothelioma Ricardo Santos (Brazil) Biological insights and Novel Therapy for Malignant Mesothelioma Luis Corrales-Rodriguez (Costa Rica) Current standard of care for the treatment of thymoma: What s new? Manuel Magallanes (Mexico) Immunotherapy rationale in Small cell and miscellaneous Francisco Orlandi (Chile) 4:15-4:45 p.m. Networking Break and Poster Viewing (Poster Session 2) Location: Exhibit Hall 16
Saturday, August 18, 2018 4:45 5:45 p.m. GENERAL SESSION 15: Epidermal Growth Factor Receptor, Mutation as Targeted Therapy Chairs: Edgardo S. Santos (USA), Luis Mas (Peru) 4:45 p.m. 5:00 p.m. 5:15 p.m. 5:30 p.m. Actual status of First and Second-Generation EGFR TKIs in the treatment of NSCLC Fred R. Hirsch (USA) Targeting T790M in lung cancer Christian Rolfo (USA) New Insights of EGFR Inhibition: EGF816, ASP8273, and others Rafael Rosell (Spain) EGFR TKIs with Central Nervous System Penetration for Management of Lung Cancers Paul A. Bunn, Jr. (USA) GENERAL SESSION 16: ALK/EML4 Translocation as Targeted Therapy Chairs: Alfredo Aguilar (Peru), Osvaldo Aren (Chile) 4:45 p.m. 5:00 p.m. 5:15 p.m. 5:30 p.m. Novel molecular mechanisms of resistance to ALK inhibition Brian Hunis (USA) Novel molecular mechanisms of resistance to ALK inhibition Brian Hunis (USA) ALK inhibitors with Central Nervous System Penetration for Management of Lung Cancers Jorge Alatorre (Mexico) ALK inhibitors in combination with other targeted therapies and radiotherapy in patients with ALK+ NSCLC Luis Ubillos (Uruguay) 17
Saturday, August 18, 2018 6:00-6:30 p.m. Closing Ceremony Location: TBA Chairs: Eduardo Richardet (Argentina), Normal Pilnik (Argentina), Christian Rolfo (USA) Award Presentations: Norma Pilnik (Argentina) Closing Remarks: Eduardo Richardet (Argentina) Introducing LALCA 2019- Mexico City, Mexico /Col : Fred R. Hirsch (USA) 18