Treating Pain with Phytocannabinoids

Treating Pain with Phytocannabinoids A Leader in Cannabinoid Research and Development www.cbdscience.com

Dear Oncologist Enclosed is important information about the use of Cannabis Based Medical Extracts or CBMEs for treatment of pain associated with various cancers and chemotherapy. You may be surprised to learn how certain cannabinoid compounds relieve severe pain due to inflammation. CNN's chief medical correspondent, Dr.Sanjay Gupa MD says, I am more convinced than ever that it is irresponsible to not provide the best care we can, care that often may involve marijuana. I am not backing down on medical marijuana; I am doubling down. You have read pros and cons about the use of THC and CBD but the big news is the remarkable effectiveness of THCA. Studies show that non-psychoactive THCA or Tetrahydrocannabinolic acid compounded with other cannabinoids is superior to THC and CBD for relieving pain due to inflammation while building the endocannabinoid system functions in four ways: (a) Releases CO- 1, (b) Inhibits CO-2, (c) Inhibits TNFAlpha, (d) Releases interleukin-10. THC or CBD combined do not have the same wide spectrum of effects as THCA. Digestive THCA extracts are not only safe and low cost but proven exceptionally effective for reducing pain due to inflammation without intoxication while enhancing quality of life for infirmed and hospice patients. GW Pharmaceuticals, the leading developer of phytocannabinoid medicine including Sativex has published extensively about THCA and THC, CBD, and their role in maintaining the endocannabinoid system in all mammals. You can review these studies and U.S. patent information at GWpharm.com and CBDScience.com. Complimentary samples of Pain Relief Tincture are available to you by request at no cost of obligation. This compound is distributed by Alta California Botanicals to licensed dispensaries throughout California. It contains an approximate dosage of 10 mg/ml THCA compound with natural flavors in an ethanol base digestive for fast effective relief. Product information and patient protocols are included in this document to help acquaint you with the benefits of THCA based extracts for affected patients. Contact me directly for additional samples or questions about the use of THCA or other cannabinoids known for medical use. Sincerely, Albert Coles, Jr. Principal, CBD Science, LLC E: Albert.Coles.gmail.com P: (415) 868-2160 CBD Science, LLC, www.cbdscinece.com (415) 295-4663 584 Castro Street, #139, San Francisco, CA 94114, and visit us on Face book

Pain Relief Tincture (Internal), One of our top sellers, this THCA tincture works quickly to relieve pain due to inflammation. It has also been shown to have anti-spasmodic and anticonvulsant properties. THCA is non-psychoactive and effective for all ages when used in the proper dosage. Ingredients: THCA, Grape Spirits, Honey, Distilled Water Anxiety Relief Tincture (Internal) The healing powers of CBD are well documented. This high CBD tincture delivers a calming effect shown to relieve anxiety. It is known as an anti-inflammatory, appetite suppressant and vasorelaxant for patients seeking the healing effects of CBD without the psychoactive effects of THC. Ingredients: CBD, THC, Grape Spirits, Honey, Distilled Water Spasm Relief Tincture (Internal) This tincture features an equal balance of CBD and THC. The combination offers mild psychoactivity along with relief from pain symptoms. This compound is known as an analgesic, anti-spasmodic, anticonvulsant, and a neuroprotective agent. It has been shown to be effective for MS and certain kinds of epilepsy. Ingredients: CBD, THC, Grape Spirits, Honey, Distilled Water Stress Relief Tincture (Internal) Stress is one of the plagues in our culture. This high THC tincture provides psychoactivity with the added healing benefits of CBD, which has been shown as effective in relieving anxiety and depression due to stress. It is regarded as an antispasmodic, anticonvulsant, anti-emetic, appetite and bone growth stimulant. This tincture is ideal for patients seeking the euphoric effects of marijuana but do not wish to smoke raw cannabis. Ingredients: CBD, THC, Grape Spirits, Honey, Distilled Water Pain Relief Tincture (External) is a potent topical tincture that has been shown to work well on its own or in conjunction with other cannabis tinctures. In addition to providing relief from pain due to inflammation, it is known for its antipruritic properties for itching, swelling, due to bruises, abrasions, insect bites, sunburns, and certain skin rashes. Cover affected area to avoid staining clothing. Ingredients: THCA, Grape Spirits, Distilled Water Better Ingredients, Better Formulas, Better Health Locally Produced and Available at Licensed Dispensaries and Delivery Services within California Find the location nearest you at www.altacaliforniabotanicals.com or call (415) 295-4663

The Life Cycle of Cannabis and Cannabinoid Production Early Stage The young plant produces cannabinoids that are the building blocks to maturity. THCA CO-1, CO-2, TNF-Alpha, and Interleukin-10 Reduces pain due to inflammation Builds the endocannabinoid system Product: Alta California Botanicals Pain Relief Tincture Internal References: US Patent: 7,807,710B2, 2002 RM, and W. Courtney, MD CBDA CO-1, CO-2, TNF-Alpha, and Interleukin-10 Reduces pain due to inflammation Builds the endocannabinoid system Product: N/A References: 2002 RM CBGA CO-1, CO-2, TNF-Alpha, and Interleukin-10 Reduces pain due to inflammation Builds the endocannabinoid system Product: N/A CBCA CO-1, CO-2, TNF-Alpha, and Interleukin-10 Reduces pain due to inflammation Builds the endocannabinoid system Product: N/A Middle Stage The mature plant produces cannabinoids that maintain vitality for fertilization and seed production. THC Neuro Receptor CB1 agonist Increases CB1 Receptor activity Maintain functions Product: Alta California Botanicals Stress Relief Tincture High THC/Low CBD References: Dr. Hegenrather CBD Neuro Receptor CB1 antagonist Decreases CB1 Receptor activity Maintain functions Product: Alta California Botanicals Anxiety Relief Tincture High CBD/Low THC References: Dr. Allan CBG Neuro Receptor CB2 agonist Increases CB2 Receptor activity Maintain vitality Product: N/A CBC Neuro Receptor CB2 antagonist Decreases CB2 Receptor activity Maintains vitality Product: N/A THC and CBD Neuro Receptor CB1 and CB2 balance : decreases CB1 and increases CB2 activity Improves mood while decreasing spasms Product: Alta California Botanicals Spasm Relief Tincture 50% THC/50% CBD Late Stage The aging plant produces cannabinoids that shut down growth and seed production. CBN Neuro Receptor CB1 and CB2 decreases CB1 and CB2 activity Sedation/Sleep CBL Neuro Receptor CB1 and CB2 N/A N/A Learn more about cannabinoids and the people that use them at www.altacaliforniabotanicals.com

A Summary Comparison of THC, THCA, and CBD THCA has been shown to be more effective than THC or CBD for regulating the functions that support the endocannabinoid system while reducing pain caused by inflammation. It is well known that THC and CBD are effective for improving mood in response to physical pain, however they do a little to influence the causes of pain or systemic disease in comparison to THCA. Patients that use THCA prefer it to CBD or THC for long-term synergistic benefits that restore health and wellness which influences mood. The chart below demonstrates that cannabinoids are biphasic in nature and work in yin yang relationship. CBD acts as an indirect antagonist and THC as an agonist when it contacts CB1 receptors. Known dosage effects THC THCA CBD Psychoactivity INCREASES NONE DECREASES Mood enhancement INCREASES NONE INCREASES Appetite INCREASES NONE DECREASES Inflammation SLIGHT DECREASE DECREASES NONE Physical Pain SLIGHT DECREASE DECREASES NONE Neuropathic Pain SLIGHT DECREASE DECREASES SLIGHT DECREASE Known over dosage effects THC THCA CBD Psychoactivty DECREASES NONE INCREASES Mood enhancement DECREASES NONE DECREASES Appetite DECREASES NONE NONE Inflammation SLIGHT DECREASE NONE NONE Physical Pain SLIGHT DECREASE NONE NONE Neuropathic Pain SLIGHT DECREASE NONE NONE The comparison indicates that the effects of THCA influence the endocannabinoid system and not the CB1 receptors. THCA influences the system in contrast to the in-direct effects of THC or CBD after it has been converted to THCA and CBDA in trace amounts during the process of metabolization. See together, these charts demonstrate that THC and CBD are biphasic and have the inverse effects when consumed at excessive levels. Over dose levels are variable from person to person. How THCA works: THCA affects four functions of the endocannabinoid system: (a) Releases CO-1, (b) Inhibits CO-2, (c) Inhibits TNF- Alpha, (d) Releases interleukin-10. THC and CBD do not have the same wide spectrum of effects on the system as THCA. Know uses: THCA modulates the autonomic nervous system, the auto immune system, and microcirculation. It is known to relieve pain due to inflammation and to have anti-convulsant, anti-spasmodic, and antioxidant properties. It is reported to be imune supportive and be antiproliferative (anticancer) however, clinical resutls are currently unavailable. Applications: May be used internally as a digestive or as a suppository for infirmed patients. May be used as a topical for sore muscles, bruising, insect bites, rashes, mild abrasions, and certain skin conditions. THCA is known to be compatible with other cannabinoids including THC, CBD, CBN, and CBG. Information sources: Publications and lectures of Professor Raphael Mechoulam PhD. His main contributions are in the field of the constitents of cannabis and the endogenous cannabinoids found in the brain and the periphery. Lectures of William Courtney, MD. His main contributions are in the field of uses of THCA in the form of raw juiced cannabis for treatment of diseases. Medical Acids Cannabinoids, United States Patent Number US 7,807,710 B2 Jerry Reilly was the first end-stage cancer patient on record to use the Alta California Botanicals high CBD tincture and THCA. The tinctures were successful for complete pain control. December 2013, Sarah Reilly CNE, CNC, daughter of Jerry Reilly Learn more about THC, THCA, CBD and the people that use them at www.cbdscience.com

Jerry s Protocol Gender: Male Age: 80 Disorder: Pain due to pancreatic cancer and chemotherapy Background Jerry Reilly was diagnosed with rectal adenocarcinoma in December of 2011. In February, 2012 he had a resection surgery followed by conventional treatment of chemotherapy and radiation. In July, 2013 he was experiencing pain at unbearable levels and sought treatment. In September, 2013 he learned that the cancer had spread to his pancreas. Treatments and Results 7/23/13 10/5/13 Jerry was perscirbed Vicodin and Acetaminophen 1. by his treating physician. His initial response was an immediate successful reduction of the pain but the side effects were significantly unpleasant. They included poor digestion and radical mood shifts accompanied by prolonged sleepiness. His body weight and muscle mass decrease accelerated. After two weeks, the dose was substantally increased to achieve tolerable pain threasholds but howerver side effects grew proportantily to a the point where it was unbearable. 9/24/13 Jerry was taken to MediCann in search of medical marijuana consultation as a possible solution for alternative pain relief and to be used as an appetite stimulant. The MD at Medicann recommended he try Rick Simson Oil 2, a popular extract with high THC or tetrahydrocannabinol, the psychoactive component of cannabis. 9/24/13 9/28/13 The Rick Simson Oil was taken digestively and quickly reduced levels of pain to tolerable levels. The dosages of Vicodin was also reduced. The repeated dosages of THC resulted in severe psychoactivity and hallucinations that made the treatment intolerable for Jerry. 9/28/13 Jerry tried two new cannabis extract medications. Anxiety Relief Tincture 3 made by Alta California Botanicals containing high amounts of CBD or cannabidiol 4,5 was given to naturalize the hallucinations caused by the psychoactiveity. The hallucinations and extreme psychoactivity ceased within 15 minutes however, he begain experienceing greater pain began as the THC wore off. Once his psychoactivity normalized, Pain Relief Tincture 6 containing high THCA or tetrahydracannabinolac Acid made by Alta California Botanicals was given. His response was a steady reduction of pain accompanied by comfort and better sleep. 9/29/13 10/29/13 Jerry continued to take Pain Relief Tincture on a daily basis 7. Over the next 5 days, Jerry was waned off Vicodin and enjoyed pain free comfort, better appetite, elimination, and sleep. He became very lucid and peaceful in his final days and was able to connect with his family and friends that visited him 8. Jerry passed away on October 29, 2013 with a smile on his face. A complete report by Jerry s daughter and resource notes are posted on AltaCaliforniaBotanicical.com.

Notes: (1) Vicodin/Acetaminophen side effects http://www.rxlist.com/vicodin-side-effects-drug-center.htm (2) Rick Simpson Oil http://www.simpson-oil.com/ (3) Anxiety Relief Tincture branded by Alta California Botanicals is approximately a 10:1 compound of CBD or Cannabidiol and THC or tetrahydrocannabinol. Patients and patient groups report optimal results using medicine with ratios between 10:1 and 20:1 but not higher than 30:1. (4) CBD is an indirect agonist of the CB1 receptor (3) and it as such it relieved the over stimulation of the CB1 receptor caused by too much THC (5) CBD Science Guide to Medical Marijuana (6) Pain Relief Tincture made by Alta California Botanicals is high in THCA or tetrahydrocannabinol acid in ratios above 10 parts THCA to 1 part THC (7) The appropriate dose has been shown to be 5 to 10 mgs per 100 lbs, 3 times a day, one hour before meals. a) The acidic cannabinoids specifies approximately 10 mg per body weight of 100 lbs http://naihc.org/ hemp_information/content/nova_report/part1.html b) Specifies the active amount according to mean plasma levels. http://www.cannabis-med.org/data/pdf/2003-03-04-3.pdf, and http://www.google.com/patents/ WO2005000830A1. (8) THCA has been shown more effective than CBD at reducing the enzymes that cause inflammation. Medical Acids Cannabinoids, Patent Number US 7,807,710 B2 http:// tinyurl.com/ktluwpf show that non psychoactive THCA effects the endocannabinoid system functions in four ways; (a) Releases CO-1, (b) Inhibits CO-2, (c) Inhibits TNF-Alpha, (d) Releases interleukin-10. Download this portocol and the summary of Jerry s treatment along with additional information about medical cannabis at www.cbdscience.com

Brooke s Protocol Gender: Female Age: 18 Disorder: Rett Syndrome Background Brooke Sergeant began having severe seizures at the age of two and was diagnosed with Rett Syndrome. By the age of 18, Brooke was having life threatening grand mal seizures every 4 days on average, along with frequent hospitalization and emergency room visits. In desperation and against their doctors warnings, her mother began to administer medical marijuana in the form of Cannabis Based Medical Extracts (CBMEs). This is a summary of Brooke s treatments. Treatments and Results 5/9 6/20/13 Brooke began taking CBD or Cannabidiol in the form of Dixie Dew Drops Hemp Oil Supplement Tincture made by Dixie Elixirs 1 in the appropriate dose 2 along with Zonegran, Carbatrol, and Onfi 3. Brooke had been taking these and other prescription drugs regularly since she was first diagnosed with Rett Syndrome. Over the next five weeks, the number of seizures decreased on average from one every 4 days to one every 7 days. Her mood and alertness also improved noticeably 4. 6/20/13 7/17/13 Brooke began taking THCA Tetrahydrocannabinolic Acid in the form of Pain Relief Tincture by Alta California Botanicals 5 in conjunction with Dixie Dew Drops Hemp Oil Supplement with her prescribed pharmaceuticals 6. On 7/1/13, Brooke s mother started to notice substantial improvement in Brooke s condition and decided to stop using Onfi and gradually reduce the doses of Zonegran and Carbatrol. During this period Brooke had no seizures. Her mood and attentiveness continued to improve. She spontaneously began to vocalize and physically move of her own volition. She exhibited significant improvement in her immune system functions by resisting flu and colds when her school age sisters got sick. Brooke s sleep cycles became more regular instead of short, broken, and irregular. 7/17/13 8/20/13 Brooke ran out of Dixie Dew Drops Hemp Oil Supplement Tincture on 4/17 so her mother substituted a CBME with high CBD or Cannabidiol in the form of Anxiety Relief Tincture made by Alta California Botanicals 7. During this period Brooke had no seizures. Her mood and attentiveness, movement, vocalization, and sleep patterns continued to improve. She began to smile and laugh for the first time when relating to her family members. 8/20/13 1/20/14 Brooke ran out high CBD, Anxiety Relief Tincture, due to supply shortages but continued to take regular doses of Pain Relief Tincture 8. Her mother began to gradually reduce doses of Zonegran, and Carbatrol on 1/18/14, Brooke took her final micro doses of Zonegran and Carbatrol but continued three daily doses of Pain Relief Tincture as she had been doing since 8/20/13. On January 1/20/14, Brooke said Mom for the first time in her life.

2/10/14 As of this date, Brooke continues to be free of seizures, is in general good health, experiences regular sleep patterns and is learning to talk. She continues taking regular daily doses of Pain Relief Tincture. Brooke s complete story written by her mother has been shared on Facebook and is posted at http://altacaliforniabotanicals.com/news-and-sharing/altas-high-cbd-tincture-what-a-godsend/ Notes: (1) High CBD or cannabidiol and THC or tetrahydrocannabinol may contain trace amounts of other cannabinoids in ratios above 4:1 and below 25:1. Patients report that optimal effects occur using ratios ranging from 10:1 to 20:1. (2) The appropriate dose has been shown to be 5 to 10 mgs per 100 lbs, 3 times a day, one hour before meals. a) The acidic cannabinoids specifies approximately 10 mg per body weight of 100 lbs http://naihc.org/ hemp_information/content/nova_report/part1.html b) Specifies the active amount according to mean plasma levels. http://www.cannabis-med.org/data/pdf/2003-03-04-3.pdf, and http://www.google.com/patents/ WO2005000830A1. (3) Zonegran is prescribed for adjunctive treatment of partial seizures in adults. Carbatrol is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy. Onfi is for adjunctive use in tonic-clonic, complex partial, and myoclonic seizures. (4) A similar treatment and response was widely reported of Jayden David as the first boy in California to be treated with CBD. 9/13/12, Lee Romney, Los Angeles Times. The CNN documentary Weed, by Sanjay Gupta, MD featured a similar treatment response with a young girl named Charlie that drew national attention. http://www.youtube.com/watch? v=dn9etc1mntk (5) Pain Relief Tincture made by Alta California Botanicals is high in THCA or tetrahydrocannabinolic acid in ratios above 10 parts THCA to 1 part THC (6) Brooke s mother decided to add Pain Relief Tincture based on the reports and studies published by: (a) GW Pharmaceuticals shows that inflammation is the primary driver of seizure activity. http://www.gwpharm.com/ Rationale%20and%20Preclinical.aspx (b) published articles by CBD Science, LLC, http://www.cbdscience. com/about.html (c) Vezzani A., Inflammation and epilepsy, Epilepsy Curr. 2005 Jan-Feb, 5(1):1-6. http:// www.ncbi.nlm.nih.gov/pmc/articles/pmc1176317/ (7) Anxiety Relief Tincture branded by Alta California Botanicals is approximately a 10:1 compound of CBD or cannabidiol and and THC or tetrahydrocannabinol. Patients and patient groups report optimal results using medicine with ratios between 10:1 and 20:1 but not higher then 30:1. (8) THCA has been shown more effective than CBD at reducing the enzymes that cause inflammation. Medical Acids Cannabinoids, Patent Number US 7,807,710 B2, http:// tinyurl.com/ktluwpf show that non psychoactive THCA effects the endocannabinoid system functions in four ways; (a) Releases CO-1, (b) Inhibits CO-2, (c) Inhibits TNF-Alpha, (d) Releases interleukin-10. Download this portocol and more information about medical cannabis at www.cbdscience.com

Excerpt form The CBD Science Guide to Medical Marijuana The following five page excerpt features content originally published in The CBD Science Guide to Medical Marijuana. This excerpt contains the original notes and references used in the publication. A complementary copy of the complete manuscript with linked references is available as a PDF for download at www.cbdscience.com. CBD Science LLC, www.cbdscience.com, Phone (415) 295-4663 584 Castro Street, #139, San Francisco, CA 94114

Cannabinoids Scientific research has discovered over 100 cannabinoids as of 2012. THC and CBD are the two dominant cannabinoids across all Marijuana Strains. Over 95% of the research has focused on THC and CBD. The medicinal effects unique to THC and CBD outlined below are based on the general principals uncovered by scientific analysis over the past 50 years. That research was made available to a layman through the pioneering work of Martin Lee, Fred Gardner and Ethan Russo (32) and publications such as O Shaughnessy s and web sites such as ProjectCBD (www.projectcbd.org). What follows is my understanding of the research presented in the publications mentioned above, the patents submitted by GW Pharmaceutical between 2003 and 2012, and my personal experience since 1996 under my doctor s approval and oversight (33). How do Cannabinoids Work? Cannabinoids work by influencing the Endo-Cannabinoid System (34). The Endo-Cannabinoid system (ECS) refers to a group of endogenous lipid signaling molecules and their receptors. The term "endocannabinoid" is derived from the word "endogenous" (meaning "originating from within an organism") and "cannabinoid" (referring to the molecular compounds unique to Marijuana). The ECS regulates the activity both within and between the central nervous system (CNS) (35) and the peripheral nervous system (PNS) (36). Cannabinoid receptors are a class of cell membrane receptors in your ECS. There are currently two known subtypes, termed CB 1 and CB 2 (37). CB 1 receptors are expressed mainly in the brain and spinal column but also in the lungs, liver and kidneys. CB 1 receptors mediate the activity generated by the central nervous system. CB 2 receptors are expressed in the immune system and in hematopoietic cells. CB 2 receptors mediate the activity in the peripheral nervous system. The first pass of the metabolic process hydrolyzes (adds hydrogen) the cannabinoids to create active compounds that effect (stimulate or inhibit) ECS receptors. CBD and the first pass metabolites of CBD also bind to (stimulate) receptors outside the ECS system such as: TRPV-1 : pain perception, inflammation and body temperature (38) A2A : anti-inflammation and anti anxiety by mediating dopamine and glutamate indirectly (39) 5-HTP: anxiety, addiction, appetite, sleep, pain perception, nausea, vomiting (40) GPR55: modulates blood pressure and bone density (41) The second pass of the metabolic process oxidizes (adds oxygen) to create compounds that inhibit inflammatory enzymes (42).

Effects Unique to THC To understand the medicinal benefits of the primary cannabinoids (THC and CBD) it is useful to divide its effects into two categories; those effects that are unique to THC and CBD (and their metabolites) and those effects that are delivered by both THC and CBD. THC and its first metabolite (11-OH-THC) stimulate (i.e. agonist) the CB 1 receptor which mediates the activity (mental activity) in the central nervous system. They also stimulate CB (2) but not as strong as the effect on CB (1) (43). The second metabolite of THC (THC-COOH) provides anti-inflammation effects by inhibiting CO-1 and CO-2. (44)(45). Psychoactive (46) (47) Appetite Stimulate (48) Night Vision (49) Tachycardia (50) Effects Unique to CBD CBD and its first metabolite 7-OH-CBD reduces (it is an antagonist) the activity of the CB 1 receptors thereby reducing mental activity. They also increase the levels of endo-cannabinoids in the system that stimulates the ECS brain receptors (CB 1 and CB 2 ) by inhibiting the enzymes that destroy them (51). Anti Psychotic (52) (53) Appetite Suppressant (54) Anti depressant (55) Bradycardia (56) Effects of both THC and CBD Combining THC and CBD delivers the effects of THC and CBD (and their metabolites). Research has shown that there is a synergistic (1+1=5) effect when you combine THC and CBD. When THC and CBD are combined the negative effects of each (paranoia/ memory extinction) are reduced and positive medicinal benefits outlined below are increased. Anti-Inflammatory (57) Anticonvulsant (Spasticity) (58) Muscle Relaxant (59) Neuroprotective Antioxidant (60) Antiemetic (61) Antinociceptive (62) Anti-Glaucoma (64)

How should I use Cannabinoids? While the general effects have been articulated, each individual is a special case (i.e. variation) of the general principal. For example, for most people CBD generates an increase in alertness, but there are some who take CBD and fall asleep almost immediately. And for most people THC is sedative, but there are some who cannot sleep after taking THC. This is because the metabolism of each human is unique (like fingerprints) and the only way to know for sure what the effects will be for you is to test the general principal on your unique metabolism. Given that each individual is a special case of the general effects how does one determine what is the best for their unique metabolism? The only way to find out is to test what works via selftitration (personal trial and error). The easiest way to understand how THC and CBD work together is to look at THC as the Agonist (i.e. stimulant mental activity) and CBD as the Antagonist (suppresses mental activity). THC is psychoactive, while CBD is anti-psychotic. THC = Agonist Increase Mental Activity Psychoactive CNS stimulate Appetite Stimulate Tachycardia CBD = Antagonist Decrease Mental Activity Anti-psychotic Anti-Depressant Appetite Suppressant Bradycardia According to Traditional Chinese Medicine (65) when the active (Agonist) and deactivating (Antagonist) forces are balanced, the living system exhibits physical health; when they are unbalanced, a diseased state results. Either imbalance results in physical illness. If one goes too far one direction i.e. too much stimulation (Agonist) with THC and paranoia emerges (too much thinking), or too much Suppression (Antagonist) with CBD and memory extinction emerges (no thinking), then they can simply balance with the opposite. In addition to the medicinal benefits (refer to Chart #2) outlined above, there are five unique ways of combining THC and CBD to balance your CNS and PNS: THC alone CBD alone THC and CBD at the same time THC followed (wait 15 minutes) with CBD CBD followed (wait 15 minutes) with THC What is the best? Only you can answer that question via the process of self-titration. I suggest that you start with the cannabinoid (THC or CBD) or a combination of THC/CBD that the research indicated has the highest medicinal effects you seek.

Issues (analysis paralysis, spacey etc. ) caused by thinking too much Paranoia Insomnia To reduce the paranoia induced by THC, add CBD and the paranoia will disappear within 10 minutes. Another example is someone who is depressed and is seeking relief, they should start with high CBD and add high THC if the effects of CBD need to be reduced. For example, two signs appear with frequent use of CBD: Issues (forgetfulness, anxious) caused by not thinking enough Memory Extinction Insomnia If short term memory extinction occurs and it does not suit your needs, the active mind can be stimulated by taking THC. Another example concerns Multiple Sclerosis, Alzheimer s, and Parkinson s diseases. Someone who is seeking relief from spasticity wants to maximize the anti-convulsant effects of cannabinoids should start with 50% THC and 50% CBD. As outlined above, when you combine THC and CBD you maximize the anti-consulvant effects and minimize the negative of THC or CBD alone. If they find that they need to be active we suggest that they add CBD, on the other hand if they need to be passive (rest) we would suggest that they add THC. If you go too far one direction i.e. too much agonist with THC and paranoia emerges, or too much antagonist with CBD and memory extinction emerges, simply balance with the opposite.

Medical Marijuana Therapy THC and CBD Treatments Vertical: Target Diseases Horizontal: Chemo Type: Classes based on THC/CBD ratios High THC 50/50 High CBD Agonist Antagonist ADD (66) ADHD (67) AIDS (68) Alzheimer s (69) Arthritis (70) Cancer Pain / Chemo (71) Colon (72) Breast (73) Skin (74) Depression (75) Diabetes (76) Epilepsy (77) Fibromyalgia (78) Glaucoma (79) Huntington (80) Irritable Bowel Diseases Crohn s disease (81) Ulcerative Colitis (82) Migraines (83) Motor neuron diseases (ALS) (84) Multiple Sclerosis (85) Nausea (86) Osteoarthritis (87) Parkinson s (88) Psoriasis (89) PTSD (90) Withdrawal symptoms reduction (91) Notes and references are available at www.cbdscience.com